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Recombinant Human RIPK2 protein, His-tagged

Cat.No. : RIPK2-932H
Product Overview : Recombinant Human RIPK2(Gln432~Met540) fused with 10-his tag at C-terminal was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 16.2kDa
Protein length : Gln432~Met540
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 95%
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others.
Gene Name : RIPK2 receptor-interacting serine-threonine kinase 2 [ Homo sapiens ]
Official Symbol : RIPK2
Synonyms : RIPK2; receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; RICK; RIP2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor interacting protein 2; receptor-interacting protein 2; RIP-like-interacting CLARP kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; GIG30;
Gene ID : 8767
mRNA Refseq : NM_003821
Protein Refseq : NP_003812
MIM : 603455
UniProt ID : O43353
Chromosome Location : 8q21
Pathway : Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Downstream TCR signaling, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem; IL12-mediated signaling events, organism-specific biosystem;
Function : ATP binding; CARD domain binding; CARD domain binding; LIM domain binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What role does RIPK2 play in the inflammatory response, particularly in the context of autoimmune diseases? 06/11/2020

RIPK2 plays a significant role in driving inflammatory responses, implicated in autoimmune disease mechanisms.

How does RIPK2 mediate signal transduction in the NOD1 and NOD2 pathways involved in innate immunity? 04/30/2020

RIPK2 is crucial in NOD1/NOD2 signaling, activating innate immune responses against microbial intrusions.

How do alterations in RIPK2 expression or signaling affect cancer development and progression? 12/29/2019

Changes in RIPK2 signaling can impact cancer development, influencing tumor cell survival and immune interactions.

How does RIPK2 contribute to the regulation of NF-κB activation and cytokine production? 02/04/2019

RIPK2 regulates NF-κB activation and cytokine production, crucial for immune response and inflammation.

What are the mechanisms by which RIPK2 modulates the host defense against bacterial pathogens? 03/30/2018

RIPK2 modulates defense mechanisms against bacterial pathogens, coordinating immune signaling and responses.

How does RIPK2 influence cell survival and apoptosis, especially under conditions of stress or infection? 03/24/2018

RIPK2 influences cell survival and apoptosis decisions, particularly in response to stress or microbial infection.

What is the impact of RIPK2 dysregulation on the development and progression of inflammatory bowel disease (IBD)? 02/21/2018

Dysregulation of RIPK2 is linked to IBD, affecting intestinal inflammation and immune responses.

Customer Reviews (3)

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Reviews
12/13/2019

    Precise mass spectrometry analysis, key for our proteomics investigations.

    04/07/2019

      Dependable protein purification, consistently delivers high yield and purity.

      11/23/2018

        Great antibody validation, enhances our immunoprecipitation success.

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