• Official Full Name

    SMAD family member 2

  • Background

    SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
  • Synonyms

    SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Cell & Tissue Lysates
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Flag
    • GST
    • GST|His
    • His
    • His (Fc)
    • Avi
    • His|MBP
    • SUMO
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    • T7|His
    Species Cat.# Product name Source (Host) Tag Price
    Human SMAD2-392H Recombinant Human SMAD Family Member 2, His-tagged Insect Cell His
    Human SMAD2-118H Recombinant Human SMAD2 protein, T7/His-tagged E.coli T7/His
    Human SMAD2-1093H Recombinant Human SMAD Family Member 2, GST-tagged E.coli GST
    Human SMAD2-30447TH Recombinant Human SMAD2 E.coli N/A
    Human SMAD5-1096H Recombinant Human SMAD Family Member 5, GST-tagged E.coli GST
    Human SMAD2-30446TH Recombinant Human SMAD2, His-tagged E.coli His
    Human SMAD2-294H Recombinant Human SMAD2 protein, GST-tagged E.coli GST
    Human SMAD2-324H Recombinant Human SMAD2 protein, His/MBP-tagged E.coli His/MBP
    Human SMAD2-4398H Recombinant Human SMAD2 protein, His-SUMO-tagged E.coli His-SUMO
    Human SMAD2-306H Recombinant Human SMAD2 Protein, His-tagged E.coli His
    Human SMAD2-350HFL Active Recombinant Full Length Human SMAD2 Protein, C-Flag-tagged Mammalian cells Flag
    Human SMAD2-1915H Recombinant Human SMAD2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMAD2-4039H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SMAD2-2040H-B Recombinant Human SMAD2 Protein Pre-coupled Magnetic Beads HEK293
    Human SMAD2-6129H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SMAD2-2040H Recombinant Human SMAD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse SMAD2-901M Recombinant Mouse SMAD2 Protein, GST & His-tagged Insect Cell GST/His
    Mouse SMAD2-001MCL Recombinant Mouse SMAD2 cell lysate Insect Cell N/A
    Mouse Smad2-5950M Recombinant Mouse Smad2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Smad2-307M Recombinant Mouse Smad2 Protein, His-tagged E.coli His
    Rat SMAD2-5607R Recombinant Rat SMAD2 Protein Mammalian Cell His
    Rat SMAD2-5266R Recombinant Rat SMAD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat SMAD2-5266R-B Recombinant Rat SMAD2 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque SMAD2-4330R Recombinant Rhesus monkey SMAD2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque SMAD2-4146R-B Recombinant Rhesus Macaque SMAD2 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque SMAD2-4146R Recombinant Rhesus Macaque SMAD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Zebrafish SMAD2-8420Z Recombinant Zebrafish SMAD2 Mammalian Cell His
    Chicken SMAD2-6130C Recombinant Chicken SMAD2 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • SMAD2 Related Articles
    • SMAD2 Related Gene Family
    • SMAD2 Related Research Area
    • SMAD2 Related Signal Pathway

    SMAD2 involved in several pathways and played different roles in them. We selected most pathways SMAD2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathwayMAPK13;MDM2;IL7R;GRM1;NRAS;PLK3;CCNG2;GRB2A;KLF2B
    Hippo signaling pathwayGLI2;BMP4;CTNNA2;CCND1;SOX2;WWC1;WNT8B;WNT5B;BMP6
    Signaling pathways regulating pluripotency of stem cellsSMARCAD1;SMAD2;KRAS;BMP2;SMAD5;WNT11;POU5F1;FZD1;PCGF3
    Chagas disease (American trypanosomiasis)FASLG;CCL2;CD3E; CD3D;IL-8;FOS;GNAI1;NOS2;GNA15;MAPK10
    Proteoglycans in cancerACTG1;PDCD4;MAPK3;HOXD10;GRB2;WNT3A;SDC1;HCLS1;HPSE2
    Colorectal cancerMSH2;AKT2;TCF7L2;TRP53;RALGDS;PIK3CA;RAC2;PIK3CB;MSH6
    Inflammatory bowel disease (IBD)RELA;HLA-DQB1;HLA-DRB3;IL18;HLA-DQA2;IL23R;HLA-DRA;TLR2;STAT3

    SMAD2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD2 itself. We selected most functions SMAD2 had, and list some proteins which have the same functions with SMAD2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA bindingGTF3C3;MLXIPL;MCM7;RFC3;SMAD2;FOXH1;GTF3C2;CLOCKA;TCF3
    RNA polymerase II core promoter proximal region sequence-specific DNA bindingONECUT2;ASCL2;ELK1;NFIB;ATOH1;CEBPZ;AEBP2;SP1;NFKB2
    activating transcription factor bindingMEF2C;GATA4;PSIP1;DGKQ;EP300;ATOH8;ZFP516;PRDM16;RELA
    chromatin bindingLDB2A;RNF168;ATXN7;NFIA;MLL1;AAAS;CHD8;ZMYND11;CDC45
    double-stranded DNA bindingCTNNB1;DMC1;MTERF;PNKP;FEV;HMGB1;FBXO18;CSDA;KIN
    enhancer bindingTCF3;TIPARP;FOXH1;SMAD2;SOX9;TCF12;LEF1;MESP1;ELL3
    metal ion bindingEXTL3;TMEM129;KLF12B;TOPAZ1;ZNF286A;LIMCH1A;ZNF608;GNAO1;ZNF12
    phosphatase bindingELFN1;KLRAQ1;PPP1R37;CARHSP1;SMAD3;MAPK3;ELFN2;SLC9A3R2;DLG3
    protein bindingSCNN1B;OGN;HIST1H2AL;TMEM173;SH2B2;DPEP1;THOC2;NUS1;FAM101A
    protein heterodimerization activityTAF6;TXLNG;HIST1H4J;POLA2;H2AFX;UBA3;BCL2L2;FLOT2;SNX2
    protein homodimerization activityTrl;PDGFC;HSD17B4;TBX18;CRYAB;BMP7A;CHKA;PVRL1;UGT1A6
    transcription factor activity, sequence-specific DNA bindingHLFA;LEF1;CEBPA;RBPJL;GBX2;EGR3;RORCA;MAFA;IRF4
    contributes_to transcription factor activity, sequence-specific DNA bindingRXRA;MAFGA;SOX1A;SMAD3;TAF7;NKX2-5;FOXH1;SMAD2;MAFGB
    transcription factor bindingHDAC9;MAPK9;SIRT2;DAXX;FOXA1;PPRC1;HDAC1;FOS;TMEM173
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingPLAG1;NRL;NFYC;DLX5;ATF2;AKNA;CTCFL;ALS2CR8;POU4F2
    transforming growth factor beta receptor bindingSPAW;GDF6B;LRG1;TGFBR3;SMAD2;BMP6;BMP2B;BMP10;LFT2
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activitySMAD9;SMAD3;SMAD1;SMAD2
    type I transforming growth factor beta receptor bindingSMAD6;ENG;TGFB3;TGFB1;SNX25;TGFBR2;SMAD2;FKBP1A;SMAD7
    ubiquitin protein ligase bindingUBE2S;XRCC5;TOLLIP;WFS1;MUL1;NKD2;SMAD2;PRKACB;KCNH2

    SMAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD2.


    Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
    Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).
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