Official Full Name
SMAD family member 2
BackgroundSMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
SynonymsSMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440;