SMAD2

  • Official Full Name

    SMAD family member 2

  • Overview

    SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
  • Synonyms

    SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SMAD2-350HFL Active Recombinant Full Length Human SMAD2 Protein, C-Flag-tagged Mammalian cells Flag
Human SMAD2-392H Recombinant Human SMAD Family Member 2, His-tagged Insect Cell His
Human SMAD2-118H Recombinant Human SMAD2 protein, T7/His-tagged E.coli T7/His
Human SMAD2-1093H Recombinant Human SMAD Family Member 2, GST-tagged E.coli GST
Human SMAD2-30447TH Recombinant Human SMAD2 E.coli N/A
Human SMAD5-1096H Recombinant Human SMAD Family Member 5, GST-tagged E.coli GST
Human SMAD2-30446TH Recombinant Human SMAD2, His-tagged E.coli His
Human SMAD2-294H Recombinant Human SMAD2 protein, GST-tagged E.coli GST
Human SMAD2-324H Recombinant Human SMAD2 protein, His/MBP-tagged E.coli His/MBP 19-254 aa
Human SMAD2-4398H Recombinant Human SMAD2 protein, His-SUMO-tagged E.coli His-SUMO 2-467aa
Human SMAD2-306H Recombinant Human SMAD2 Protein, His-tagged E.coli His Trp274~Ser467
Human SMAD2-1915H Recombinant Human SMAD2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SMAD2-4039H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SMAD2-2040H-B Recombinant Human SMAD2 Protein Pre-coupled Magnetic Beads HEK293
Human SMAD2-6129H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SMAD2-5866H Recombinant Human SMAD2 Protein (Lys20-Ile355), N-His tagged E.coli N-His Lys20-Ile355
Human SMAD2-2040H Recombinant Human SMAD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SMAD2-901M Recombinant Mouse SMAD2 Protein, GST & His-tagged Insect Cell GST/His
Mouse SMAD2-001MCL Recombinant Mouse SMAD2 cell lysate Insect Cell N/A
Mouse Smad2-5950M Recombinant Mouse Smad2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Smad2-307M Recombinant Mouse Smad2 Protein, His-tagged E.coli His Ala272~Ser467
Rat SMAD2-5607R Recombinant Rat SMAD2 Protein Mammalian Cell His
Rat SMAD2-5266R Recombinant Rat SMAD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SMAD2-5266R-B Recombinant Rat SMAD2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SMAD2-4330R Recombinant Rhesus monkey SMAD2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SMAD2-4146R-B Recombinant Rhesus Macaque SMAD2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SMAD2-4146R Recombinant Rhesus Macaque SMAD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SMAD2-8420Z Recombinant Zebrafish SMAD2 Mammalian Cell His
Chicken SMAD2-6130C Recombinant Chicken SMAD2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • SMAD2 Related Signal Pathway

SMAD2 involved in several pathways and played different roles in them. We selected most pathways SMAD2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayCCNB3;NLK1;PRKAB1A;IGF1RB;GADD45AA;MAP2K2;MAPK14B;TNFSF10;PRKAB1
Cell cycleCDC6;CDK11B;AURKB;YWHABL;DHFR;ESCO2;MSH5;H3F3D;RB1
EndocytosisLDLRAP1B;DDL-2;PIP5K1BB;CAPZA1A;FGFR2;PSD;SH3GLB2A;CLTCA;HGS
TGF-beta signaling pathwayNODAL;TNF;RHOAC;IFNG;PPP2CB;TGIF1;TGFBR1;RHOAB;BAMBIB
Hippo signaling pathwayACTG1;GSK3B;WNT2B;PRKCI;LATS1;BMPR2;YWHAG;PPP2R1B;FZD2
Adherens junctionCDC42L;FGFR1;ACTN3B;PTPRF;FYN;IGF1RB;FARP2;CTNNB1;ACTN3A
Signaling pathways regulating pluripotency of stem cellsFzd4;INHBC;SOX2;WNT2B;ISL1;SMAD5;HESX1;MAPK3;AXIN1
Chagas disease (American trypanosomiasis)TGFB2;CD3E; CD3D;GNAS;PPP2CB;PPP2R1B;PPP2CA;PPP2R2B;NOS2;GNAI3
HTLV-I infectionBAX;CD3E;HLA-G;CDC16;HLA-DOB;ELK1;WNT5B;FOSL1;VDAC3
Pathways in cancerITGAV;VEGFB;WNT8B;MSH6;LAMB4;F2RL3;PIK3CG;MAP2K2;LPAR2
Proteoglycans in cancerITGB3;ERBB3;PIK3CG;RAC1;SOS1;FZD9;PIK3R1;PAK1;PXN
Colorectal cancerMSH2;PIK3CA;AXIN1;RHOA;AKT2;PIK3R3;TRP53;BIRC5;TP53
Pancreatic cancerIKBKG;TGFB3;SMAD2;AKT2;SMAD4;ARHGEF6;RELA;RB1;BCL2L1
Inflammatory bowel disease (IBD)IL21;HLA-DRB1;HLA-DQB1;HLA-DPA1;TLR5;IL6;IL18RAP;IFNG;HLA-DOA

SMAD2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD2 itself. We selected most functions SMAD2 had, and list some proteins which have the same functions with SMAD2. You can find most of the proteins on our site.

Function Related Protein
contributes_to DNA bindingGTF3C3;GTF3C5;RFC3;GTF3C2;ARNTL1B;NFE2L2A;MLXIPL;MCM7;TCF3
I-SMAD bindingCTNNB1;SMAD4;TGFB1I1;SMURF1;SMAD7;SMAD2;AXIN2;SMAD1;AXIN1
R-SMAD bindingC18orf1;PARP1;PMEPA1;SMAD4;ZC3H3;SMAD2;MYOCD;AXIN1;SMURF1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingRFX3;NFE2L3;ETV1;SIX2;ESRRA;SPI1;GLI3;HHEX;CREB3
SMAD bindingTGFBRAP1;SKOR1B;TGFBR3;BMPR1B;SKOR1;SKIL;BMPR1A;STUB1;FKBP1A
activating transcription factor bindingPSIP1;SMAD2;HDAC7;HDAC7A;RELA;MEF2A;MEF2D;HDAC4;ATOH8
chromatin bindingAIRE;NOC2L;TCF7L1A;CHD8;SMC1AL;TADA2B;NOC3L;DNMT1;MEIS3
co-SMAD bindingFOXH1;CITED1;SMAD1;USP9X;GATA4;SMAD2;TGIF1;TRIM33;SMAD6
double-stranded DNA bindingRAD51C;MTERFD2;KIN;NEIL3;HMGB1;TDG;RAD51AP1;HNRPDL;KLF6
enhancer bindingSMAD3;AHR;SP1;TIPARP;FOXH1;SOX9;TCF12;LEF1;ELL3
metal ion bindingSUV39H1A;ZSWIM7;CAPN8;BTR06;WBSCR17;Reln;CYBRD1;RTCB;ZNF311
phosphatase bindingWNK1;PPP1R26;SH3RF2;PPP1R21;TPRN;CRY1;ELFN2;CTSC;CRY2
protein bindingDZIP3;XAB2;CACYBP;RXRA;NOX1;TIMM9;TBC1D7;KRTAP19-5;GH1
protein heterodimerization activityTENM3;HIST1H4L;MID2;CUL3;LIMK2;HIST2H3C;CD3D;NTSR1;CXorf15
protein homodimerization activityCREB3;BCL2;PDCD6IP;IKZF4;IMPA2;ADH5;APOBEC3G;EIF2AK3;DMRT1
transcription factor activity, sequence-specific DNA bindingPRDM1;TCF7L1B;SOX32;ZNF544;IKZF1;CSRNP2;INSM1B;SOX11A;TBR1B
contributes_to transcription factor activity, sequence-specific DNA bindingRXRA;VDRA;SMAD4;GATA4;SMAD3;TAF10;TAF6;TAF7;HNRNPAB
transcription factor bindingRORA;E2F4;RBFOX2;EGR1;DNAJA3;SIX2;TFDP1A;ID1;KAT2B
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingNRL;ZNF750;ELK3;FOXK2;CDX4;SMAD4;DBP;ARNT2;CREB1
transforming growth factor beta receptor bindingLEFTY2;SMAD2;BMP15;BMP7A;AMH;GDF5;BMP2;GDF2;LFT1
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activitySMAD2;SMAD1;SMAD3;SMAD9
type I transforming growth factor beta receptor bindingSNX25;SMAD6;ENG;TGFB1;FKBP1A;SMAD2;TGFBR2;SMAD7;TGFB3
ubiquitin protein ligase bindingZFP746;XBP1;Fzd4;CUL1A;POLR2A;HSPA9;TUBB;CUL1;UQCRC1

SMAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD2.

SMAD4

Gene Family

TGF

Research Area

Related articles

Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).
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