SMAD2 Protein

SMAD2

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SMAD2

Official Full Name SMAD family member 2
Background SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
Synonyms SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MBP
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD2-1093H Recombinant Human SMAD Family Member 2, GST-tagged E.coli GST
    Human SMAD2-118H Recombinant Human SMAD2 protein, T7/His-tagged E.coli T7/His
    Human SMAD2-294H Recombinant Human SMAD2 protein, GST-tagged E.coli GST
    Human SMAD2-30446TH Recombinant Human SMAD2, His-tagged E.coli His
    Human SMAD2-30447TH Recombinant Human SMAD2 E.coli N/A
    Human SMAD2-324H Recombinant Human SMAD2 protein, His/MBP-tagged E.coli His/MBP
    Human SMAD2-392H Recombinant Human SMAD Family Member 2, His-tagged Insect Cell His
    Human SMAD5-1096H Recombinant Human SMAD Family Member 5, GST-tagged E.coli GST
    Mouse SMAD2-901M Recombinant Mouse SMAD2 Protein, GST & His-tagged Insect Cell GST/His
    Rat SMAD2-5607R Recombinant Rat SMAD2 Protein Mammalian Cell His
    Rhesus Macaque SMAD2-4330R Recombinant Rhesus monkey SMAD2 Protein, His-tagged Mammalian Cell His
    Chicken SMAD2-6130C Recombinant Chicken SMAD2 Mammalian Cell His
    Zebrafish SMAD2-8420Z Recombinant Zebrafish SMAD2 Mammalian Cell His
    Mouse SMAD2-001MCL Recombinant Mouse SMAD2 cell lysate Insect Cell N/A
    Human SMAD2-4398H Recombinant Human SMAD2 protein, His-SUMO-tagged E.coli His-SUMO
    Human SMAD2-1915H Recombinant Human SMAD2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMAD2-306H Recombinant Human SMAD2 Protein, His-tagged E.coli His
    Human SMAD2-4039H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SMAD2-6129H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Smad2-307M Recombinant Mouse Smad2 Protein, His-tagged E.coli His
    Mouse Smad2-5950M Recombinant Mouse Smad2 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    SMAD2 involved in several pathways and played different roles in them. We selected most pathways SMAD2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway GADD45BB; MAPK14B; MAPK13; BCL6; CCNB3; RAF1; CCNB2; CCND1; SMAD3A; PRKAG2
    Cell cycle STAG2A; SGOL2; MAD2L2; ODF2B; BLZF1; TP53BP1; SETA; ANAPC4; SFN; CDKN2B
    Endocytosis ARAP2; WASLA; CAV3; PIP5K1A; ARAP1; SMURF2; VPS4B; VPS37C; ACAP3B; ARPC5A
    TGF-beta signaling pathway BMPR1B; SMURF2; ACVR2B; INHBAB; RBL1; BMP8A; LEFTY2; BMP8B; SMAD5; BMPR1A
    Hippo signaling pathway WNT9B; BMP8B; CRB2; SCRIB; DVL3; SMAD7; PPP2R1B; PRKCI; BMP5; FZD10
    Adherens junction PVRL3B; IGF1R; WASF3; PVRL2; FYNA; PARD3; NLK2; TCF7L2; LEF1; AASS
    Signaling pathways regulating pluripotency of stem cells GRB2; PAX6; PIK3R5; IL6ST; ACVR2A; LIFR; NEUROG1; FZD8; PIK3R3; SMAD4
    Chagas disease (American trypanosomiasis) TGFB1; PIK3CG; MYD88; CD3E; CD3D; Il2; GNA11; MAPK9; CD3G; IFNGR1; SERPINE1
    HTLV-I infection RRAS2; POLE2; WNT10B; BUB3; ATF3; TNFRSF1A; NRAS; WNT5B; STAT5B; ZFP36
    Pathways in cancer GNG13; RASSF5; CCND1; SMAD2; SLC2A1; PLCB1; NFKB1; FGF7; XIAP; FGF14
    Proteoglycans in cancer ROCK1; ARAF; MET; HGF; PIK3R2; RAF1; FGF2; AKT2; ITPR1; PLCG1
    Colorectal cancer MAPK9; RHOA; AXIN2; RAF1; AKT2; MAPK8; CCND1; KRAS; TGFB1; BAD
    Pancreatic cancer MAPK10; BAD; CASP9; PIK3CG; TGFB2; RALGDS; BRAF; TGFB1; RAC3; TGFBR1
    Inflammatory bowel disease (IBD) IL17F; STAT1; HLA-DRB4; IL1A; IL18R1; HLA-DQA2; RORA; H2-AB1; SMAD2; IL18RAP

    SMAD2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD2 itself. We selected most functions SMAD2 had, and list some proteins which have the same functions with SMAD2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA binding MRE11A; RFC3; GTF3C6; ARNTL1A; GTF3C5; GTF3C2; GTF3C3; ARNTL1B; MCM7; FOXH1
    I-SMAD binding SMAD4; TGFB1I1; SMAD1; SMAD7; SMURF1; AXIN2; CTNNB1; SMAD6; AXIN1; SMAD2
    R-SMAD binding C18orf1; RANBP3; TRIM33; MYOCD; AXIN1; SMAD2; SMAD6; PAX6; ZEB2; SMAD4
    RNA polymerase II core promoter proximal region sequence-specific DNA binding MTF1; MYF5; MYC; STAT3; MYF6; JUNB; NKX2-8; ELF4; TCF4; CUX2
    SMAD binding TGFBR2; FKBP1A; ACVR1B; TGFBR3; TOB1; PURB; ACVRL1; BMPR1A; SKI; EID2
    activating transcription factor binding PSIP1; ATOH8; HDAC1; RELA; EEF1D; ZFP516; MEF2D; HDAC4; DGKQ; MEF2A
    chromatin binding BAHD1; TLE1; PRDM11; TOX3; SIX1; MSGN1; SKOR2; SMC3; PHF21B; CSNK2B
    co-SMAD binding SMAD1; SMAD6; SMAD3; CITED1; TGIF1; SMAD2; USP9X; GATA4; FOXH1; TRIM33
    double-stranded DNA binding TDG; MCM10; MRE11A; SETMAR; AIM2; CSDA; SATB1; GTF2H4; RBMS1; MTERFD3
    enhancer binding SMAD2; ELL3; MESP1; SMAD3; LEF1; RAI1; AHR; SOX9; TCF3; ARNT
    metal ion binding VEZF1B; ZBTB43; ZNF227; CUBN; ADCY9; ZFP827; BMPR1BB; ZNF621; PPP5C; ELMSAN1A
    phosphatase binding CRY2; CHCHD3; TRPC4AP; CNST; SLC9A3R1; SMAD2; DLG3; SH3YL1; DZIP3; DLG1L
    protein binding ZNF187; TBX15; SRSF3; INVS; HOMER2; ALDH18A1; SNX19; MAGEE1; ACMSD; ABI2
    protein heterodimerization activity MID2; HIST1H2BM; SDCBP; HIST1H2A9; TIMELESS; BTBD11; ANO2; USF1; DDX1; PML
    protein homodimerization activity TBC1D22A; KCNN2; CECR1; PDGFC; MECOM; SMAD1; TREX2; TSC2; TP53I3; TYW5
    transcription factor activity, sequence-specific DNA binding ZNF232; ELF3; IKZF2; NR6A1A; RBPJL; HOXC4; Ar; ZBTB14; ZFP14; MYPOP
    contributes_to transcription factor activity, sequence-specific DNA binding VDRA; HNRNPAB; VDRB; SMAD3; SMAD4; SOX1B; TAF10; RXRA; SOX19B; TAF7
    transcription factor binding HMGA1; TFDP1; CDKN2A; DRAP1; SUMO1; HES4; PPP1R13L; BRD7; LMO4; SMAD3
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding PATZ1; Ar; RBPJ; NOBOX; TFAP2A; NUCKS1; TFE3B; PITX1; MAFA; MYOG
    transforming growth factor beta receptor binding NODAL; INHBAB; GDF5; GDF3; SPAW; INHBE; BMP8A; INHBB; GDF7; BMP5
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity SMAD1; SMAD9; SMAD2; SMAD3
    type I transforming growth factor beta receptor binding TGFBR2; SMAD7; FKBP1A; SMAD2; SNX25; TGFB1; SMAD6; ENG; TGFB3
    ubiquitin protein ligase binding UBE2B; RBX1; UBE2V2; CASP8; DAXX; CKB; UBE2W; RPA2; KCNQ3; BID

    SMAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD2.

    SMAD4

    Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
    Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).

    TGF
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