SMAD2

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SMAD2

Official Full Name SMAD family member 2
Background SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
Synonyms SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD2-1093H Recombinant Human SMAD Family Member 2, GST-tagged E.coli GST
    Human SMAD2-118H Recombinant Human SMAD2 protein, T7/His-tagged E.coli T7/His
    Human SMAD2-1915H Recombinant Human SMAD2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMAD2-294H Recombinant Human SMAD2 protein, GST-tagged E.coli GST
    Human SMAD2-30446TH Recombinant Human SMAD2, His-tagged E.coli His
    Human SMAD2-30447TH Recombinant Human SMAD2 E.coli N/A
    Human SMAD2-306H Recombinant Human SMAD2 Protein, His-tagged E.coli His
    Human SMAD2-324H Recombinant Human SMAD2 protein, His/MBP-tagged E.coli His/MBP
    Human SMAD2-392H Recombinant Human SMAD Family Member 2, His-tagged Insect Cell His
    Human SMAD2-4039H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SMAD2-6129H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SMAD5-1096H Recombinant Human SMAD Family Member 5, GST-tagged E.coli GST
    Mouse SMAD2-001MCL Recombinant Mouse SMAD2 cell lysate Insect Cell N/A
    Mouse Smad2-307M Recombinant Mouse Smad2 Protein, His-tagged E.coli His
    Mouse Smad2-5950M Recombinant Mouse Smad2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse SMAD2-901M Recombinant Mouse SMAD2 Protein, GST & His-tagged Insect Cell GST/His
    Rat SMAD2-5607R Recombinant Rat SMAD2 Protein Mammalian Cell His
    Rhesus Macaque SMAD2-4330R Recombinant Rhesus monkey SMAD2 Protein, His-tagged Mammalian Cell His
    Chicken SMAD2-6130C Recombinant Chicken SMAD2 Mammalian Cell His
    Zebrafish SMAD2-8420Z Recombinant Zebrafish SMAD2 Mammalian Cell His

    SMAD2 involved in several pathways and played different roles in them. We selected most pathways SMAD2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway GABARAP; PIK3R3; BCL6A; TGFBR1A; SOD2; PRKAG2A; FOXO4; RAG2; CAT; PRKAG2
    Cell cycle PTTG2; CDC6; HUS1; CLSPN; B9D2; ESCO2; DNA2; KIF2B; ANAPC11; CENPA
    Endocytosis RAB5AA; SH3GL1A; IL2RGA; ZFP652; GRK6; CHMP5B; PARD6A; TGFBR1; RHOAD; TGFBR1A
    TGF-beta signaling pathway ACVR1BA; BMPR2A; ACVR1C; GDF7; ACVR2AA; E2F5; SMURF1; RHOA; EP300; BMP7
    Hippo signaling pathway FBXW11; FZD5; APC; CCND1; PARD3; SCRIB; PPP1CB; ITGB2L; PARD6A; TCF7L2
    Adherens junction TGFBR1; FARP2; SNAI2; ACTN3; MAPK3; INSRA; PVRL4; CDC42L; CSNK2A2; PTPRF
    Signaling pathways regulating pluripotency of stem cells WNT10B; Fzd4; SMAD2; WNT16; PIK3CB; WNT9B; WNT5B; FZD1; ID2; SMAD1
    Chagas disease (American trypanosomiasis) PLCB3; IFNGR1; ACE; CD3E; CD3D; AKT1; TGFB3; PIK3CD; GNAO1; TGFBR1; TNFRSF1A
    HTLV-I infection DVL1; CD3G; HLA-DRB4; WNT10B; IL15RA; WNT16; RANBP1; IL2RB; CANX; BCL2L1
    Pathways in cancer IKBKG; BRCA2; WNT7A; GSTP1; PIK3CA; FGF12; BIRC5; PRKACG; MET; PTK2
    Proteoglycans in cancer WNT2; FZD6; HSPG2; NUDT16L1; COL21A1; PTCH1; WNT7A; FZD8; TNF; WNT3A
    Colorectal cancer TP53; RHOA; PIK3CD; MAPK1; PIK3CA; PIK3R3; MLH1; MAPK3; AXIN1; GSK3B
    Pancreatic cancer RB1; BRAF; RELA; ARAF; RAC2; TGFB2; MAPK10; PIK3R5; TGFBR1; ERBB2
    Inflammatory bowel disease (IBD) TGFB2; HLA-DQA2; IL18; NFATC1; HLA-DPB1; STAT4; IL12RB2; IL4; IL1A; IFNG

    SMAD2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD2 itself. We selected most functions SMAD2 had, and list some proteins which have the same functions with SMAD2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA binding MCM7; CLOCKA; SMAD4; MRE11A; SMAD2; NFE2L2A; MAFGA; AHR2; GTF3C3; ARNTL1B
    I-SMAD binding SMAD7; AXIN2; SMAD4; SMAD1; CTNNB1; SMAD6; SMAD2; AXIN1; SMURF1; TGFB1I1
    R-SMAD binding SMURF1; PAX6; SMAD2; MEN1; PMEPA1; ZEB2; JUN; ANKRD1; PPM1A; TRIM33
    RNA polymerase II core promoter proximal region sequence-specific DNA binding POU3F2; ZNF114; MITF; RFX4; RFX1; YBX1; PAX8; ZNF264; BATF3; ZNF92
    SMAD binding ACVRL1; SOD3; BMPR1B; MAGI2; SKOR1A; CTNNB1; TGFBRAP1; YY1; SKIA; PML
    activating transcription factor binding HDAC1; SMAD2; DGKQ; MEF2D; EEF1D; PRDM16; EP300; HDAC7; HDAC7A; PSIP1
    chromatin binding GATA4; CRX; NKX2; NFIA; PRIMPOL; LDB1; MEN1; ERCC6; JARID2; GATA2
    co-SMAD binding TRIM33; USP9X; SMAD6; GATA4; SMAD1; SMAD2; FOXH1; TGIF1; SMAD3; CITED1
    double-stranded DNA binding MTERFD2; RAD51L3; MTERFD1; MTERF2; GATA1A; CTNNB1; HNRNPDL; RAD51B; NTHL1; FBXO18
    enhancer binding LEF1; SMAD2; SP1; ELL3; AHR; MESP1; TCF3; TCF12; SMAD3; FOXH1
    metal ion binding CALUB; TSHZ3; ZNF7; HMGCLL1; FUZ; Trl; PGCP; ACY3.1; ZSCAN4C; ZBTB46
    phosphatase binding MAST2; PPP1R21; PPP1R36; SMAD3; DLG1L; TRPC4AP; PPP1R26; CRY2; SYTL2; DZIP3
    protein binding GIPC1; FAM115A; Tnfrsf22; SOX6; NRBF2; BCKDHB; TNFRSF10A; SAFB; KMT2E; YRDC
    protein heterodimerization activity PIK3R2; NOTCH4; RRAGA; GABRR1; AXL; HER5; HEYL; HIST1H2AL; UGT1A6B; UGT1A9
    protein homodimerization activity PRPS1; DARS2; ODZ4; DNM1L; RBM44; NCR3; EIF2AK1; ERBB3; DEM1; MCL1B
    transcription factor activity, sequence-specific DNA binding CSRNP2; HOXC5; HOMEZA; EGR2; PHF1; NR2F6A; ZFP260; SKINT8; ZKSCAN17; GTF3A
    contributes_to transcription factor activity, sequence-specific DNA binding TAF12; SOX1A; MAFGA; RXRA; FOXH1; TAF6; NKX2-5; SOX1B; NKX2; TAF7
    transcription factor binding PIM1; PPP1R13BA; PURA; NFKBIA; FIGLA; BPTF; PSMD10; IGHMBP2; NFATC3; ESRRB
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RUNX2; FOXD1; HNF4A; TTC6; ARID3B; GABPA; NFATC3; IRF4; HOXA10; BARHL2
    transforming growth factor beta receptor binding GDF1; INHBB; USP15; GDF7; LEFTY1; NDR2; SMURF2; LRG1; TGFB1A; NODAL
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity SMAD3; SMAD1; SMAD9; SMAD2
    type I transforming growth factor beta receptor binding TGFBR2; SMAD6; SNX25; FKBP1A; TGFB1; TGFB3; SMAD7; SMAD2; ENG
    ubiquitin protein ligase binding PRKACB; SMAD3; UBE2V1; FOXO1; TNFRSF14; GPI; GABARAPL2; NKD2; GABARAPL1; CBS

    SMAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD2.

    SMAD4

    Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
    Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).

    TGF

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