SMAD2
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Official Full Name
SMAD family member 2
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Background
SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. -
Synonyms
SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440;
- Involved Pathway
- Protein Function
- Interacting Protein
- SMAD2 Related Articles
- SMAD2 Related Gene Family
- SMAD2 Related Research Area
- SMAD2 Related Signal Pathway
SMAD2 involved in several pathways and played different roles in them. We selected most pathways SMAD2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | MAPK13;MDM2;IL7R;GRM1;NRAS;PLK3;CCNG2;GRB2A;KLF2B |
| Cell cycle | LIN54;DSN1;NEK9;CDKN1C;GADD45AA;MIS18BP1;CCNA1;CHEK1;CENPJ |
| Endocytosis | TSG101;ARPC5LB;EHD4;RAB5B;RAB35;CYTH3;CCDC53;SNX2;CAPZA1A |
| TGF-beta signaling pathway | RHOA;SMAD4;BMP7B;BMPR1B;CHRD;ID2A;BMPR2A;INHBA;RHOAC |
| Hippo signaling pathway | GLI2;BMP4;CTNNA2;CCND1;SOX2;WWC1;WNT8B;WNT5B;BMP6 |
| Adherens junction | TCF7L2;PTPRM;RAC1B;RHOAC;IGF1RA;NLK2;ACTN2;WASF3;PTBP3 |
| Signaling pathways regulating pluripotency of stem cells | SMARCAD1;SMAD2;KRAS;BMP2;SMAD5;WNT11;POU5F1;FZD1;PCGF3 |
| Chagas disease (American trypanosomiasis) | FASLG;CCL2;CD3E; CD3D;IL-8;FOS;GNAI1;NOS2;GNA15;MAPK10 |
| HTLV-I infection | AKT2;POLB;VDAC1;H2-Q10;TCF3;AKT1;NRAS;ETS1;HLA-DPB1 |
| Pathways in cancer | HHIP;PRKCG;PRKACB;TCEB1;MAPK10;FGF21;MAPK8;CDC42;ARHGEF12 |
| Proteoglycans in cancer | ACTG1;PDCD4;MAPK3;HOXD10;GRB2;WNT3A;SDC1;HCLS1;HPSE2 |
| Colorectal cancer | MSH2;AKT2;TCF7L2;TRP53;RALGDS;PIK3CA;RAC2;PIK3CB;MSH6 |
| Pancreatic cancer | ARHGEF6;MAPK8;SMAD2;KRAS;PIK3CG;PIK3R5;AKT2;TGFB3;TGFB2 |
| Inflammatory bowel disease (IBD) | RELA;HLA-DQB1;HLA-DRB3;IL18;HLA-DQA2;IL23R;HLA-DRA;TLR2;STAT3 |
SMAD2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD2 itself. We selected most functions SMAD2 had, and list some proteins which have the same functions with SMAD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to DNA binding | GTF3C3;MLXIPL;MCM7;RFC3;SMAD2;FOXH1;GTF3C2;CLOCKA;TCF3 |
| I-SMAD binding | CTNNB1;SMURF1;SMAD1;SMAD2;TGFB1I1;AXIN1;TGFBR1;SMAD7;SMAD4 |
| R-SMAD binding | ZEB2;AXIN1;PAX6;SMAD4;MYOCD;FOS;PPM1A;ANKRD1;SMAD6 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ONECUT2;ASCL2;ELK1;NFIB;ATOH1;CEBPZ;AEBP2;SP1;NFKB2 |
| SMAD binding | SKOR1;COL1A2;USP15;SKOR1B;EID2;TCF12;PRDM16;SNW1;SKOR1A |
| activating transcription factor binding | MEF2C;GATA4;PSIP1;DGKQ;EP300;ATOH8;ZFP516;PRDM16;RELA |
| chromatin binding | LDB2A;RNF168;ATXN7;NFIA;MLL1;AAAS;CHD8;ZMYND11;CDC45 |
| co-SMAD binding | SMAD2;GATA4;TRIM33;FOXH1;SMAD1;SMAD6;USP9X;TGIF1;SMAD3 |
| double-stranded DNA binding | CTNNB1;DMC1;MTERF;PNKP;FEV;HMGB1;FBXO18;CSDA;KIN |
| enhancer binding | TCF3;TIPARP;FOXH1;SMAD2;SOX9;TCF12;LEF1;MESP1;ELL3 |
| metal ion binding | EXTL3;TMEM129;KLF12B;TOPAZ1;ZNF286A;LIMCH1A;ZNF608;GNAO1;ZNF12 |
| phosphatase binding | ELFN1;KLRAQ1;PPP1R37;CARHSP1;SMAD3;MAPK3;ELFN2;SLC9A3R2;DLG3 |
| protein binding | SCNN1B;OGN;HIST1H2AL;TMEM173;SH2B2;DPEP1;THOC2;NUS1;FAM101A |
| protein heterodimerization activity | TAF6;TXLNG;HIST1H4J;POLA2;H2AFX;UBA3;BCL2L2;FLOT2;SNX2 |
| protein homodimerization activity | Trl;PDGFC;HSD17B4;TBX18;CRYAB;BMP7A;CHKA;PVRL1;UGT1A6 |
| transcription factor activity, sequence-specific DNA binding | HLFA;LEF1;CEBPA;RBPJL;GBX2;EGR3;RORCA;MAFA;IRF4 |
| contributes_to transcription factor activity, sequence-specific DNA binding | RXRA;MAFGA;SOX1A;SMAD3;TAF7;NKX2-5;FOXH1;SMAD2;MAFGB |
| transcription factor binding | HDAC9;MAPK9;SIRT2;DAXX;FOXA1;PPRC1;HDAC1;FOS;TMEM173 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PLAG1;NRL;NFYC;DLX5;ATF2;AKNA;CTCFL;ALS2CR8;POU4F2 |
| transforming growth factor beta receptor binding | SPAW;GDF6B;LRG1;TGFBR3;SMAD2;BMP6;BMP2B;BMP10;LFT2 |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | SMAD9;SMAD3;SMAD1;SMAD2 |
| type I transforming growth factor beta receptor binding | SMAD6;ENG;TGFB3;TGFB1;SNX25;TGFBR2;SMAD2;FKBP1A;SMAD7 |
| ubiquitin protein ligase binding | UBE2S;XRCC5;TOLLIP;WFS1;MUL1;NKD2;SMAD2;PRKACB;KCNH2 |
SMAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD2.
SMAD4
Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).
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