SMAD2 Protein


Home / Products / SMAD2


Official Full Name SMAD family member 2
Background SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
Synonyms SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MBP
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD2-1093H Recombinant Human SMAD Family Member 2, GST-tagged E.coli GST
    Human SMAD2-118H Recombinant Human SMAD2 protein, T7/His-tagged E.coli T7/His
    Human SMAD2-294H Recombinant Human SMAD2 protein, GST-tagged E.coli GST
    Human SMAD2-30446TH Recombinant Human SMAD2, His-tagged E.coli His
    Human SMAD2-30447TH Recombinant Human SMAD2 E.coli N/A
    Human SMAD2-324H Recombinant Human SMAD2 protein, His/MBP-tagged E.coli His/MBP
    Human SMAD2-392H Recombinant Human SMAD Family Member 2, His-tagged Insect Cell His
    Human SMAD5-1096H Recombinant Human SMAD Family Member 5, GST-tagged E.coli GST
    Mouse SMAD2-901M Recombinant Mouse SMAD2 Protein, GST & His-tagged Insect Cell GST/His
    Rat SMAD2-5607R Recombinant Rat SMAD2 Protein Mammalian Cell His
    Rhesus Macaque SMAD2-4330R Recombinant Rhesus monkey SMAD2 Protein, His-tagged Mammalian Cell His
    Chicken SMAD2-6130C Recombinant Chicken SMAD2 Mammalian Cell His
    Zebrafish SMAD2-8420Z Recombinant Zebrafish SMAD2 Mammalian Cell His
    Mouse SMAD2-001MCL Recombinant Mouse SMAD2 cell lysate Insect Cell N/A
    Human SMAD2-4398H Recombinant Human SMAD2 protein, His-SUMO-tagged E.coli His-SUMO
    Human SMAD2-1915H Recombinant Human SMAD2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMAD2-306H Recombinant Human SMAD2 Protein, His-tagged E.coli His
    Human SMAD2-4039H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SMAD2-6129H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Smad2-307M Recombinant Mouse Smad2 Protein, His-tagged E.coli His
    Mouse Smad2-5950M Recombinant Mouse Smad2 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    SMAD2 involved in several pathways and played different roles in them. We selected most pathways SMAD2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway SMAD4; RBL2; MAPK11; PTEN; ATG12; FOXO6; MAPK9; PTENB; HRASB; FOXO3A
    Cell cycle CHEK1; CCNA2; HDAC5; NINL; SMAD4; E2F4; HIST4H4; DSN1; MSH4; CDKN1C
    TGF-beta signaling pathway BMP2; SMURF1; RHOA; BAMBI; INHBAB; IFNG1-2; CUL1B; ACVR1; ACVR1BA; TFDP1
    Hippo signaling pathway LATS1; FZD10; TCF7; WNT2; SERPINE1; WNT16; WNT4; FZD2; BMP4; FZD6
    Adherens junction PVRL2; SMAD3; RAC3A; SMAD3A; TCF7L2; SSX2IPA; PARD3; CTNNB1; CSNK2A2A; FYNA
    Signaling pathways regulating pluripotency of stem cells WNT9A; POU5F1; WNT7B; PIK3R5; WNT7A; AKT2; GSK3B; FZD8; NRAS; ACVR2A
    Chagas disease (American trypanosomiasis) PLCB1; PIK3R3; MAPK1; PIK3CA; AKT2; TLR9; TRAF6; PPP2R1A; MAP2K4; IL12B
    HTLV-I infection HLA-DQA1; PDGFB; FZD2; WNT7B; HLA-DRB5; HLA-DPB1; MAP3K1; IL15; ETS2; TGFB3
    Pathways in cancer WNT7A; LPAR2; PTCH2; GNG10; GLI2; FGF6; PIK3R2; FIGF; BDKRB2; WNT7B
    Proteoglycans in cancer ITGA2; Fasl; TGFB1; PDCD4; THBS1; MAPK12; PRKCB; VTN; KRAS; PXN
    Colorectal cancer TGFB2; MAPK9; MAPK8; AXIN2; TGFBR1; BIRC5; PIK3R3; PIK3R5; RAC1; MAPK10
    Pancreatic cancer AKT1; CCND1; CDC42; RAD51; MAP2K1; SMAD3; RALBP1; SMAD4; RAC1; BCL2L1
    Inflammatory bowel disease (IBD) HLA-DPB1; HLA-DPA1; TLR2; STAT3; STAT4; GATA3; FOXP3; TBX21; HLA-DRB4; HLA-DRB1

    SMAD2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD2 itself. We selected most functions SMAD2 had, and list some proteins which have the same functions with SMAD2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA binding FOXH1; GTF3C3; MAFGA; SMAD4; NFE2L2A; RFC3; TCF3; GTF3C4; MCM7; ARNTL1B
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GATA4; NR2C1; ALS2CR8; FUBP3; EP300; CTCF; PHOX2B; OTX1; ZBTB7A; TCF4
    activating transcription factor binding EP300; MEF2C; MEF2D; EEF1D; HDAC7A; GATA4; HDAC1; RELA; ZFP516; HDAC7
    chromatin binding KAT2A; HMG20A; MSL1; FOXO1; PBX2; HDAC2; HMGB2B; SP140L; GATA4; JARID2B
    co-SMAD binding GATA4; TRIM33; FOXH1; SMAD6; CITED1; USP9X; TGIF1; SMAD1; SMAD3; SMAD2
    double-stranded DNA binding AKAP8; LSM14A; HMGB1; PIN4; XRCC3; DDX11; DMC1; SP8B; NKX2-8; RAD51L1
    enhancer binding ARNT; SMAD2; RAI1; MESP1; FOXH1; TCF3; TIPARP; SP1; ELL3; TCF12
    metal ion binding RNF148; CENPT; FTR54; NUDT17; MARCH4; ZNF615; ZNF576; NR2F1A; RPS27.2; PRICKLE1A
    phosphatase binding SH3RF2; MAPK1; SLC9A3R2; SH2D4A; MAPK3; ELFN2; PPARA; DYSFIP1; CHCHD3; PPP1R37
    protein binding PROX1; AFG3L2; PBRM1; HDDC3; PCGF6; UBE2N; SERPINA3K; WNT3; SCG5; USH1C
    protein heterodimerization activity BCL2L10; HIST1H2BI; ZHX1; IRAK3; HIST1H2BE; NOTCH1; KATNA1; SLC51B; NEFL; UGT1A1
    protein homodimerization activity XBP1; CBX1; PAH; IRAK1; CARD9; NADK2; NUDT21; NPR3; PKD2; SYNE1
    transcription factor activity, sequence-specific DNA binding NFYAL; HOXC6B; THRAA; MXD1; CHES1; NFYB; CREB3; KLF10; CREBL2; RFX5
    contributes_to transcription factor activity, sequence-specific DNA binding NKX2; NKX2-5; SOX1B; GATA4; HNRNPAB; TAF12; TAF6; MAFGB; TAF7; TRIM28
    transcription factor binding EGR1; PAX6; TMEM173; TLE1; UBE2I; TCF12; POU1F1; NFIA; ATF7; PARP1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding SREBF1; TP53; HMGA2; PBX1; ONECUTL; CREB3L1; NFIB; PPARA; NR2E1; CREB3L2
    transforming growth factor beta receptor binding GDF9; SMAD2; TGFB1A; BMP2B; LEFTY2; SMURF2; INHBC; GDF1; BMP7A; BMP3
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity SMAD9; SMAD1; SMAD3; SMAD2
    type I transforming growth factor beta receptor binding SMAD6; SMAD7; TGFB3; ENG; FKBP1A; TGFBR2; SNX25; TGFB1; SMAD2
    ubiquitin protein ligase binding NEDD8; NFKBIA; UBE2B; PRKAR2B; SMAD2; CDKN1A; FAF1; MAGEA2; CALR; CUL5

    SMAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD2.


    Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
    Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).


    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2022 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy