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Official Full Name SMAD family member 2
Background SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
Synonyms SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD2-4039H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Smad2-5950M Recombinant Mouse Smad2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human SMAD2-6129H Recombinant Human SMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SMAD2-1093H Recombinant Human SMAD Family Member 2, GST-tagged E.coli GST
    Human SMAD2-118H Recombinant Human SMAD2 protein, T7/His-tagged E.coli T7/His
    Human SMAD2-1915H Recombinant Human SMAD2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMAD2-294H Recombinant Human SMAD2 protein, GST-tagged E.coli GST
    Human SMAD2-30446TH Recombinant Human SMAD2, His-tagged E.coli His
    Human SMAD2-30447TH Recombinant Human SMAD2 E.coli N/A
    Human SMAD2-306H Recombinant Human SMAD2 Protein, His-tagged E.coli His
    Human SMAD2-324H Recombinant Human SMAD2 protein, His/MBP-tagged E.coli His/MBP
    Human SMAD2-392H Recombinant Human SMAD Family Member 2, His-tagged Insect Cell His
    Human SMAD5-1096H Recombinant Human SMAD Family Member 5, GST-tagged E.coli GST
    Mouse SMAD2-001MCL Recombinant Mouse SMAD2 cell lysate Insect Cell N/A
    Mouse Smad2-307M Recombinant Mouse Smad2 Protein, His-tagged E.coli His
    Mouse SMAD2-901M Recombinant Mouse SMAD2 Protein, GST & His-tagged Insect Cell GST/His
    Rat SMAD2-5607R Recombinant Rat SMAD2 Protein Mammalian Cell His
    Rhesus Macaque SMAD2-4330R Recombinant Rhesus monkey SMAD2 Protein, His-tagged Mammalian Cell His
    Chicken SMAD2-6130C Recombinant Chicken SMAD2 Mammalian Cell His
    Zebrafish SMAD2-8420Z Recombinant Zebrafish SMAD2 Mammalian Cell His

    smad2 involved in several pathways and played different roles in them. We selected most pathways smad2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with smad2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway FOXO4; SLC2A4; GRM1; SGK3; GABARAPL1; PLK3; FOXO1A; PRKAA1; PRKAG3; PRKAA2
    Cell cycle CCNB2; CKS1B; MAD2L1; FOXM1; TBC1D8; GORASP2; DKC1; CHEK1; CEP72; CDC14A
    Endocytosis H2-Q10; RAB11BB; SPG20A; ASAP3; EHD2B; CAPZA2; PSD3; DNAJC6; BIN1B; FAM21A
    TGF-beta signaling pathway ACVR1L; TNF; BMP5; TGFBR1A; INHBE; SMURF1; GDF7; BMPR1AB; BMP2B; SMAD2
    Hippo signaling pathway PARD3; FBXW11; TGFB1; TEAD1; PPP2CA; YWHAG; WWTR1; PPP2R2C; FZD5; MPP5
    Adherens junction SMAD2; CTNNA1; CSNK2B; TGFBR1; SNAI2; IGF1RA; NLK1; AASS; INSRA; MAPK1
    Signaling pathways regulating pluripotency of stem cells REST; GSK3B; STAT3; WNT7A; INHBE; FZD9; WNT10B; FZD5; MAPK11; SMAD2
    Chagas disease (American trypanosomiasis) GNAO1; IFNB1; MAP2K4; MAPK10; CCL2; CALR; TLR2; IL1B2; MAPK1; C1QB
    Pathways in cancer FZD10; GNG3; STAT3; RXRG; FASLG; HDAC1; PDGFA; LAMA3; HDAC2; Fasl
    Proteoglycans in cancer ELK1; ERBB2; CTTN; FGF2; FZD2; CBLC; RPS6KB2; GRB2; FN1; WNT1
    Colorectal cancer PIK3R1; TGFB1; MAPK8; Casp3; MAPK3; BCL2; MAPK9; RAC2; MAP2K1; SMAD2
    Pancreatic cancer CASP9; SMAD3; TGFB3; MAPK8; PIK3CG; PIK3CB; RAC1; TGFA; BCL2L1; IKBKB
    Inflammatory bowel disease (IBD) IL12B; TLR4; IL21; HLA-DRB5; TGFB1; HLA-DPB1; HLA-DMB; RORC; STAT4; IL12A

    smad2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by smad2 itself. We selected most functions smad2 had, and list some proteins which have the same functions with smad2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA binding GTF3C6; GTF3C4; TCF3; GTF3C3; FOXH1; MLXIPL; NFE2L2A; MAFGA; ARNTL1B; GTF3C2
    R-SMAD binding ZEB2; ANKRD1; SMAD4; MEN1; C18orf1; AXIN1; ZC3H3; SMAD6; JUN; PMEPA1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding SMAD3; ZNF502; GATA1; NFATC3; OTX2; LEF1; RBPJL; NKX2-5; TCF3; ZBTB7A
    activating transcription factor binding ZFP516; MEF2A; HDAC1; TAF9; EP300; GATA4; EEF1D; RELA; PPARG; SMAD2
    chromatin binding RELB; SP100; NFATC2; TDRD3; TAF2; FEZF2; NOC3L; TOX; JARID2; SMARCC1
    co-SMAD binding SMAD2; TRIM33; SMAD3; SMAD6; FOXH1; GATA4; TGIF1; USP9X; SMAD1; CITED1
    double-stranded DNA binding YBX1; RAD51L3; RAD51B; MTERFD1; SETMAR; TRP53; MTERF3; NEIL3; PRKDC; AIM2
    enhancer binding ARNT; SOX9; LEF1; ELL3; FOXH1; TCF12; SMAD3; TIPARP; TCF3; MESP1
    metal ion binding ZBTB7A; PRKD2; TRIM3B; ZNF189; MYCBP2; ZNF167; ADNPA; TESK2; ZNF224; BLF
    phosphatase binding DLG1; CNST; DYSFIP1; SYTL2; DZIP3; PPP1R26; MAGI2; SPRED1; TSC2; CRY2
    protein binding CTNNA3; PECAM1; NFKBID; ETNK1; CARD10; IKBIP; DUSP14; RNF115; XPO1; RALGDS
    protein heterodimerization activity HIST1H4F; PPP3CB; SUPT5H; UGT1A2; KCNN1; DRAP1; PHC2B; KCNH5; UBA3; NFYBA
    protein homodimerization activity GSTA4; RPS19; DRD2; PVRL1B; LRP4; DAPK3; EPHX2; ANO2; ERBB4; GABRR1
    transcription factor activity, sequence-specific DNA binding E2F3; TLX2; HEY2; SIX1; NKX6-2; NR2F6B; LEF1; FOXG1D; PLAGL2; DMRTC1C2
    contributes_to transcription factor activity, sequence-specific DNA binding TAF6; NKX2; SOX19A; TAF7; TAF10; TRIM28; SOX1A; VDRB; HNRNPAB; VDRA
    transcription factor binding TAF7L; RPS3; MED1; HMGA1-RS1; HMGA2; ENPP2; NR0B2; PURB; PARD6A; RNF19A
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ELK3; NPAS4; KLF4; SOX4; RBPJ; ETV6; HEYL; HOXD13; NR4A3; POU2F2
    transforming growth factor beta receptor binding LEFTY1; GDF2; MSTNB; BMP8B; BMP10; GDF15; SMAD3; GDF6B; TGFB2; GDF10
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity SMAD1; SMAD3; SMAD2; SMAD9
    type I transforming growth factor beta receptor binding SMAD2; TGFB1; SNX25; TGFBR2; SMAD6; ENG; FKBP1A; TGFB3; SMAD7
    ubiquitin protein ligase binding UBE2G1A; FHIT; CKB; TRIB3; CUL1B; DBT; UBOX5; JAK1; KCNH2; CXCR4

    smad2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with smad2 here. Most of them are supplied by our site. Hope this information will be useful for your research of smad2.


    Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
    Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).


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