srebf2 Protein, sterol regulatory element binding transcription factor 2


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Official Full Name sterol regulatory element binding transcription factor 2
Background This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
Synonyms SREBF2; sterol regulatory element binding transcription factor 2; sterol regulatory element-binding protein 2; bHLHd2; SREBP2; AI608257; Class D basic helix-loop-helix protein 2; OTTHUMP00000028740; Processed sterol regulatory element-binding protein 2; SRBP2_HUMAN; SREBF 2; SREBF2 protein; SREBP 2; SREBP-2; SREBP2gc; sterol regulatory element binding factor 2; Sterol regulatory element binding protein 2; Sterol regulatory element-binding transcription factor 2
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SREBF2-31395TH Recombinant Human SREBF2 Wheat Germ N/A
    Mouse SREBF2-15974M Recombinant Mouse SREBF2 Protein Mammalian Cell His
    Rat SREBF2-5737R Recombinant Rat SREBF2 Protein Mammalian Cell His
    Zebrafish SREBF2-5575Z Recombinant Zebrafish SREBF2 Mammalian Cell His

    srebf2 involved in several pathways and played different roles in them. We selected most pathways srebf2 participated on our site, such as Activation of gene expression by SREBF (SREBP), Cholesterol biosynthesis, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with srebf2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of gene expression by SREBF (SREBP) CARM1; CYP51A1; DHCR7; NCOA2; NFYBB; MTF1; HELZ2; SREBF2; CREBBP; NFYAL
    Cholesterol biosynthesis DHCR24; EBP; DHCR7; LBR; ARV1; SREBF2; PMVK; CYP51A1
    Developmental Biology AP2M1; EVL; CDON; DPYSL2B; EFNA2; DUSP10; PAQR3A; RANBP9; SEMA4D; MED9
    Fatty acid, triacylglycerol, and ketone body metabolism MED29; CYP7A1; MED22; ACOT2; CTGF; ACOT13; ACOT11B; MED15; CDK8; SLC25A1
    Metabolism of lipids and lipoproteins ACOT7; ELOVL1A; PTGR1; CYP2V1; CPTP; SLC25A1; CYP4F11; NEU4; CDS1; AKR1C4
    PPARA activates gene expression MED18; G0S2; MED21; APOA5; MED29; MED16; CDK19; MED19; PLIN2; MED6
    Regulation of cholesterol biosynthesis by SREBP (SREBF) SREBF2; INSIG1; MTF1; NFYBB; PMVK; NFYBA; NFYAL; YY2; INSIG2; DHCR7

    srebf2 has several biochemical functions, for example, NOT C-8 sterol isomerase activity, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by srebf2 itself. We selected most functions srebf2 had, and list some proteins which have the same functions with srebf2. You can find most of the proteins on our site.

    Function Related Protein
    NOT C-8 sterol isomerase activity SREBF2
    E-box binding TCF3; MYOD1; ARNTL; ASCL2; C1orf51; NEUROD1; PER1; TWIST1; ASCL1; AHR
    RNA polymerase II core promoter proximal region sequence-specific DNA binding KLF16; SOX1; FOSB; RBPJA; TFAP4; T; GRHL1; ZNF92; CREB3; MITF
    protein C-terminus binding ECM1; ERCC1; FOXN3; SDCBP2; COIL; VIM; PEX1; CEP120; CACNA1B; SREBF2
    protein binding SPINK7; CLDN18; FUT11; NUDT1; BMP4; BLVRA; LIMK1; SLC2A1; GRM6; ARMC8
    protein dimerization activity MXD3; HER9; FBXW11A; FIGLA; TFAP2A; SLC4A11; MSC; PEF1; SRFB; ZBED6
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ZBTB20; GFI1; SFPI1; EN1; NFE2L3; KLF17; ZFP90; GCFC2; ZGPAT; TFAP2A

    srebf2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with srebf2 here. Most of them are supplied by our site. Hope this information will be useful for your research of srebf2.

    SP1; HNF4A; TP53; ldlr_human_sre_dna-probe; Kpnb1; HNF4A; SMAD3; b3kqf8_human; ABLIM1; PIAS1; PIAS2; HSPA5

    Barderas, R; Babel, I; et al. An optimized predictor panel for colorectal cancer diagnosis based on the combination of tumor-associated antigens obtained from protein and phage microarrays. JOURNAL OF PROTEOMICS 75:4647-4655(2012).
    Khaidakov, M; Mitra, S; et al. Oxidized LDL Receptor 1 (OLR1) as a Possible Link between Obesity, Dyslipidemia and Cancer. PLOS ONE 6:-(2011).
    Babel, I; Barderas, R; et al. Identification of MST1/STK4 and SULF1 Proteins as Autoantibody Targets for the Diagnosis of Colorectal Cancer by Using Phage Microarrays. MOLECULAR & CELLULAR PROTEOMICS 10:-(2011).

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