TLN1

  • Official Full Name

    talin 1

  • Overview

    Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-235 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations. Talin 2 is related to talin 1. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton.
  • Synonyms

    TLN1; talin 1; talin-1; Tln; MGC116305; Tln1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Chicken
  • Human
  • Mouse
  • Rat
  • Turkey
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Turkey Smooth muscle
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLN1-3256H Recombinant Human TLN1, His-tagged E.coli His 2193-2541aa
Human TLN1-354H Recombinant Human TLN1 Protein, His-tagged E.coli His Thr2293~Glu2536
Human TLN1-31442TH Recombinant Human TLN1, His-tagged E.coli His
Human TLN1-353H Recombinant Human TLN1 Protein, His-tagged E.coli His Ala975-Ser1181
Human TLN1-1737H Recombinant Human TLN1 Protein (92-399 aa), His-tagged Yeast His 92-399 aa
Human TLN1-4982H Recombinant Human TLN1 protein, GST-tagged E.coli GST 92-399aa
Human TLN1-301604H Recombinant Human TLN1 protein, GST-tagged E.coli GST Gly2193-His2541
Mouse Tln1-355M Recombinant Mouse Tln1 Protein, His-tagged E.coli His Ala975~Ser1181
Mouse TLN1-16819M Recombinant Mouse TLN1 Protein Mammalian Cell His
Mouse TLN1-9235M-B Recombinant Mouse TLN1 Protein Pre-coupled Magnetic Beads HEK293
Mouse TLN1-9235M Recombinant Mouse TLN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tln1-356R Recombinant Rat Tln1 Protein, His-tagged E.coli His Ala975~Ser1181
Turkey TLN1-890T Native Turkey TLN1 Protein Turkey Smooth muscle N/A
Zebrafish TLN1-1950Z Recombinant Zebrafish TLN1 Mammalian Cell His
Chicken TLN1-6092C Recombinant Chicken TLN1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

TLN1 involved in several pathways and played different roles in them. We selected most pathways TLN1 participated on our site, such as Rap signaling pathway, Focal adhesion, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayGRIN2A;SIPA1L2;FGF12;AKT2;PARD3;PLCE1;HGF;PRKD1;FGF21
Focal adhesionLAMA5;ITGA9;COL11A1A;ACTN1;ITGA6B;ITGA4;FLT1;CDC42;MYL12B
Platelet activationGNAI3;PPP1CA;PPP1R12A;RAP1B;MAPK1;MYLK;ITPR3;PRKCI;SRC
HTLV-I infectionBUB3;WNT3;KAT2B;HLA-DPB1;MYB;NFKB1;WNT7B;PPP3R2;CD3E

TLN1 has several biochemical functions, for example, LIM domain binding, actin filament binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLN1 itself. We selected most functions TLN1 had, and list some proteins which have the same functions with TLN1. You can find most of the proteins on our site.

Function Related Protein
LIM domain bindingLDB1;RIPK2;RPH3AL;LDB1A;ACTN2;LDB2A;LDB2;TLN1;CSRP2BP
actin filament bindingRCSD1;NEXN;FSCN1;VPS16;VIL1;ANTXR1;ERMN;MYH11;CORO1C
integrin bindingADAMTS5;ACTN1;P4HB;Tcam1;FAP;COL4A3;ADAM25;SFRP2;ADAM9
protein bindingPDCD2;PPP2R1A;FCGR1A;GPR37L1;NCBP1;MYPOP;SNX3;DNM3;LRRC4
structural constituent of cytoskeletonTUBA3E;TLN2A;TUBA7L;TUBA3D;TUBA1L;ARPC5;MSN;TUBE1;TNNT2A
vinculin bindingPXN;ACTN1;C22orf28;DMD;SORBS3;TLN1;DAG1;SYNM;NRAP

TLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLN1.

ITGB3; VCAM1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; ITGB1; pip; EGFR; ERBB2; YWHAZ

Research Area

Related articles

O'Rourke, DJ; DiJohnson, DA; et al. Autoantibody signatures as biomarkers to distinguish prostate cancer from benign prostatic hyperplasia in patients with increased serum prostate specific antigen. CLINICA CHIMICA ACTA 413:561-567(2012).
Hajagos, BE; Turetzky, JM; et al. Molecular Dissection of Novel Trafficking and Processing of the Toxoplasma gondii Rhoptry Metalloprotease Toxolysin-1. TRAFFIC 13:292-304(2012).
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