USP13
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Official Full Name
ubiquitin specific peptidase 13 (isopeptidase T-3)
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Overview
Ubiquitin carboxyl-terminal hydrolase 13 is an enzyme that in humans is encoded by the USP13 gene. -
Synonyms
USP13; ubiquitin specific peptidase 13 (isopeptidase T-3); ubiquitin specific protease 13 (isopeptidase T 3); ubiquitin carboxyl-terminal hydrolase 13; IsoT 3; isopeptidase T-3; ubiquitin thioesterase 13; deubiquitinating enzyme 13; ubiquitin thiolesteras;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
USP13 involved in several pathways and played different roles in them. We selected most pathways USP13 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
USP13 has several biochemical functions, for example, BAT3 complex binding, chaperone binding, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP13 itself. We selected most functions USP13 had, and list some proteins which have the same functions with USP13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| BAT3 complex binding | VCP;AMFR;SGTA;USP13 |
| chaperone binding | RNF207;DNAJA3A;DNAJA4;BAG4;GET4;TBCD;TSC1;ATP1A3;FGB |
| cysteine-type endopeptidase activity | USP24;CASPBL;CTSF;CTSB;CTSSB.1;USP28;UCHL1;USP6;USP18 |
| omega peptidase activity | USP5;USP13;UCHL1;UCHL5;ATXN3L;APEH;JOSD1;JOSD2;GGH |
| proteasome binding | UCHL5;ADRM1;DNAJB2;ID1;USP13;PSMD14;BAG6;PSMG1;USP14 |
| protein binding | SPPL3;TGFBRAP1;ASAP3;TUBGCP3;FYN;RCOR2;C1GALT1C1;RPL28;EN1 |
| ubiquitin binding | NBR1;CRY1;SMAD3;UBE2NB;TSG101;TRIM32;USP5;TOM1L1;D17WSU92E |
| ubiquitin protein ligase binding | CKB;CASC3;TRIB3;UBXN1;PDE4D;CCT2;DIO2;VCL;FHIT |
| ubiquitin-like protein ligase binding | CDK5RAP3;TRIP4;DDRGK1;VCP;CEBPB;USP13 |
| ubiquitin-specific protease activity | OTUB2;VCPIP1;USP49;USP24;USP42;FMNL3;USP9X;USP43A;COPS5 |
| ubiquitin-specific protease activity involved in positive regulation of ERAD pathway | |
| zinc ion binding | PIAS1;TRIM10;PCGF3;XRN2;MMP13A;PPARAA;PHF21B;MKRN1;RNF20 |
USP13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP13 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP13.
SMC1A; SMC3; UBL4A; DLST; USP5; BAG6; ATXN3; OGDH; NEDD8; NPLOC4; UFD1L; FAF2; ITCH; KCTD10; CACYBP; CYLD; DIABLO; TCAF1
Research Area
Related articles
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Customer Reviews (3)
Write a reviewIts purity, integrity, and consistency ensure reliable and reproducible results, which are essential for meaningful scientific discoveries.
Their in-depth understanding of the protein's characteristics, applications, and potential limitations allows for valuable insights and recommendations, ensuring the success of my experiments.
Whether it's troubleshooting, protocol optimization, or general inquiries, their knowledgeable and responsive team is readily available to assist and solve any problems that may arise during the experimental process.
Q&As (5)
Ask a questionThere is emerging research suggesting that USP13 may play a role in neurodegenerative diseases, and targeting it could be a potential avenue for therapeutic intervention.
USP13 interacts with various proteins, forming complexes that regulate different cellular pathways. Understanding these interactions is crucial for deciphering its role in health and disease.
Genetic variations in the USP13 gene have been studied, and certain polymorphisms may be associated with an increased risk of specific diseases. Further research is ongoing in this area.
Researchers are exploring the role of USP13 in neurodegenerative diseases, inflammatory disorders, and other conditions where ubiquitin-mediated processes play a crucial role.
USP13 has been found to regulate the stability of proteins involved in the DNA damage response, affecting how cells respond to stress and maintain genomic integrity.
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