Recombinant Human USP13 Protein, Myc/DDK-tagged
| Cat.No. : | USP13-2649H |
| Product Overview : | Recombinant protein of human ubiquitin specific peptidase 13 (isopeptidase T-3) (USP13) with a C-Myc/DDK tag was expressed in HEK293T. |
- Specification
- Gene Information
- Related Products
| Description : | Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data. |
| Source : | HEK293T |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 97.1 kDa |
| Purity : | > 80 % as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : | Store at -80 centigrade. |
| Concentration : | >50 μg/mL as determined by microplate BCA method |
| Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
| Gene Name : | USP13 ubiquitin specific peptidase 13 [ Homo sapiens (human) ] |
| Official Symbol : | USP13 |
| Synonyms : | USP13; ubiquitin specific peptidase 13; ISOT3; IsoT-3; ubiquitin carboxyl-terminal hydrolase 13; deubiquitinating enzyme 13; ubiquitin specific peptidase 13 (isopeptidase T-3); ubiquitin specific protease 13 (isopeptidase T-3); ubiquitin thioesterase 13; ubiquitin thiolesterase 13; ubiquitin-specific-processing protease 13; EC 3.4.19.12 |
| Gene ID : | 8975 |
| mRNA Refseq : | NM_003940 |
| Protein Refseq : | NP_003931 |
| MIM : | 603591 |
| UniProt ID : | Q92995 |
Products Types
| ◆ Recombinant Protein | ||
| USP13-4933R | Recombinant Rhesus Macaque USP13 Protein, His (Fc)-Avi-tagged | +Inquiry |
| Usp13-6864M | Recombinant Mouse Usp13 Protein, Myc/DDK-tagged | +Inquiry |
| USP13-0351H | Recombinant Human USP13 Protein (Q2-S863), Tag Free | +Inquiry |
| USP13-9949M | Recombinant Mouse USP13 Protein, His (Fc)-Avi-tagged | +Inquiry |
| USP13-0352H | Recombinant Human USP13 Protein (Q2-S863), GST tagged | +Inquiry |
| ◆ Lysates | ||
| USP13-472HCL | Recombinant Human USP13 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Ask a Question for All USP13 Products
Required fields are marked with *
My Review for All USP13 Products
Required fields are marked with *
0
Inquiry Basket
