YAP1

  • Official Full Name

    Yes-associated protein 1

  • Overview

    This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
  • Synonyms

    YAP1; Yes-associated protein 1; YAP; YKI; YAP2; YAP65; yorkie homolog; yes-associated protein 2; 65 kDa Yes-associated protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • B2M
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human YAP1-18H Recombinant Human YAP1 protein, GST-tagged Wheat Germ GST
Human YAP1-3761H Recombinant Human YAP1, GST-tagged E.coli GST
Human YAP1-19H Recombinant Human YAP1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human YAP1-250HCL Recombinant Human YAP1 293 Cell Lysate HEK293 N/A
Human YAP1-3775H Recombinant Human YAP1 protein, His-B2M-tagged E.coli His-B2M
Human YAP1-9292HFL Recombinant Full Length Human YAP1 protein, Flag-tagged Mamanlian cells Flag
Human YAP1-1556H Recombinant Human YAP1 Protein (1-504 aa), His-tagged Yeast His
Human YAP1-600H Recombinant Human YAP1 Protein, His-tagged E.coli N-His
Human YAP1-31H Recombinant Human YAP1 protein, His-tagged E.coli His
Human YAP1-5533H Recombinant Human YAP1 Protein E.coli Tag Free
Human YAP1-32H Recombinant Human YAP1 protein, His-tagged E.coli His
Human YAP1-662HF Recombinant Full Length Human YAP1 Protein, GST-tagged In Vitro Cell Free System GST
Human YAP1-5534H Recombinant Human YAP1 Protein (Ala347-Leu504), N-His tagged E.coli N-His
Human YAP1-33H Recombinant Human YAP1 protein, GST-tagged E.coli GST
Mouse YAP1-18648M Recombinant Mouse YAP1 Protein Mammalian Cell His
Mouse YAP1-10247M-B Recombinant Mouse YAP1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Yap1-7027M Recombinant Mouse Yap1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse YAP1-10247M Recombinant Mouse YAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat YAP1-6622R Recombinant Rat YAP1 Protein Mammalian Cell His
Rat YAP1-6278R Recombinant Rat YAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat YAP1-6278R-B Recombinant Rat YAP1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish YAP1-7230Z Recombinant Zebrafish YAP1 Mammalian Cell His
Chicken YAP1-6796C Recombinant Chicken YAP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • YAP1 Related Articles
  • YAP1 Related Research Area
  • YAP1 Related Signal Pathway

YAP1 involved in several pathways and played different roles in them. We selected most pathways YAP1 participated on our site, such as ErbB4 signaling events, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with YAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB4 signaling eventsYAP1;CBFA2T3;WWOX;WWP1
Fatty acid, triacylglycerol, and ketone body metabolismGLIPR1;APOA5;CYP4A11;MED22;MED20;ACOT9.2;TIAM2;AGPAT1;PPARGC1B
Gene ExpressionZNF668;PRDM7;ZNF26;TRIM33;SNAPC5;ZNF445;TET2;ZNF791;FKBP6
Generic Transcription PathwayZNF71;ZNF460;RARG;ZNF230;ZFP1;ZNF264;ZNF222;ZNF114;PSTPIP2
Hippo signaling pathwayBMPR2;TGFBR2;FGF1;SMAD4;WNT7B;WNT8B;BTRC;ACTB;BMP8A
MetabolismKCNC2;ETFB;LPA;B3GAT2;SLC5A4;NHLRC1;DCK;PTGDSA;MED25
Metabolism of lipids and lipoproteinsCDK19;APOEA;DECR1;CYP46A1;PPM1L;CPNE7;FAAH2;GLTPA;PPM1LB
Nuclear signaling by ERBB4WWOX;YAP1;PRLRB;CSHL1;GHRB;CSH1;CSN2

YAP1 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, chromatin binding, proline-rich region binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YAP1 itself. We selected most functions YAP1 had, and list some proteins which have the same functions with YAP1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter sequence-specific DNA bindingTRP53;H3F3B;SFPI1;EP300;SUZ12;TFAP2A;ZFPM1;HEYL;SMAD1
chromatin bindingUBTFL;SP140;NR5A1B;NOC2L;HMG20B;MED1;TP63;SAFB;CITED2
proline-rich region bindingRABAC1;GAREM;GHR;BAIAP2;PFN1;CSK;NEDD4;CCND1;PRPF40A
protein C-terminus bindingVAMP2;CAV3;JAK2;SDCBP2;SREBF2;LCK;PXK;HESX1;SCLT1
protein bindingHNRNPH2;HMGCR;CHORDC1;HIST1H4J;MRPL15;TBX6;HINFP;PDE6D;SDCCAG3
transcription coactivator activitySTIL;MED17;NR1H4;RXRA;TAF6L;SAP130;KAT5;TFAP2A;TADA2B
transcription corepressor activityTBL1X;NSD1;LIMD1;FEV;PIAS1;SKI;WWTR1;TDP2;HDAC7
transcription factor activity, RNA polymerase II transcription factor bindingMAMSTR;ATF2;YAP1;ZNF296;HIF1A;SMAD4;MYOCD;NACC2;ATF4
transcription regulatory region DNA bindingMSX2;TBL1X;ATF5;ZNF821;TCF7L1A;XRCC5;MESP1;HMGB2;JUND

YAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of YAP1.

CTNNB1; TEAD1; LATS1

Jerhammar, F; Johansson, AC; et al. YAP1 is a potential biomarker for cetuximab resistance in head and neck cancer. ORAL ONCOLOGY 50:832-839(2014).
Lindskog, C; Kuhlwilm, M; et al. Analysis of Candidate Genes for Lineage-Specific Expression Changes in Humans and Primates. JOURNAL OF PROTEOME RESEARCH 13:3596-3606(2014).
Takatsume, Y; Maeta, K; et al. Enrichment of yeast thioredoxin by green tea extract through activation of Yap1 transcription factor in Saccharomyces cerevisiae. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 53:332-337(2005).
Ramos, CW; Guldener, U; et al. Molecular analysis of the Saccharomyces cerevisiae YHR076w gene. IUBMB LIFE 50:371-377(2000).
  • Q&As
  • Reviews

Q&As (6)

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What are the research and development directions of anti-tumor drugs for YAP1 protein? 07/17/2022

The research and development directions of antitumor drugs of YAP1 protein include inhibitors targeting YAP1, drugs that regulate the downstream signaling pathway of YAP1, and combination drug strategies.

In which signaling pathways are YAP1 proteins regulated? 07/13/2022

YAP1 protein is regulated in multiple signaling pathways such as Wnt/β-catenin, Hippo, and FGF, thereby affecting cell proliferation and growth.

What signaling pathways does the YAP1 protein play a key role? 11/12/2021

YAP1 protein plays a key role in the HIPPO signaling pathway, and its activation or inactivation affects cell proliferation, apoptosis, and differentiation.

How does the YAP1 protein participate in tumor invasion and metastasis? 02/27/2021

YAP1 protein participates in tumor invasion and metastasis by regulating epithelial-mesenchymal transformation, cell migration and the expression of invasion-related factors.

How is YAP1 protein involved in the regulation of cell proliferation and growth? 01/19/2021

The YAP1 protein is involved in regulating cell proliferation and growth, mainly through nuclear translocation and interaction with nuclear transcription factors to regulate the expression of related genes.

What are the effects of post-translational modifications of the YAP1 protein? 12/02/2020

Post-translational modifications of YAP1 protein, such as phosphorylation and acetylation, can regulate its transcriptional activity and subcellular localization, thereby affecting tumor development.

Customer Reviews (3)

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Reviews
11/19/2022

    This short half-life and high clearance of YAP1 allow it to penetrate the tissue and reach the lesion site, which improves the therapeutic effect.

    09/23/2022

      The green production process of YAP1 not only improves the production efficiency, but also minimizes the environmental impact, truly realizing a win-win situation of economic and environmental benefits.

      10/13/2019

        The potent biological activity of YAP1 combined with its high purity makes the experimental results highly reliable.

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