• Official Full Name
  • ATPase, Cu++ transporting, alpha polypeptide
  • Background
  • This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked cutis laxa, and occipital horn syndrome.
  • Synonyms
  • ATP7A; ATPase, Cu++ transporting, alpha polypeptide; Menkes syndrome , MNK; copper-transporting ATPase 1; copper pump 1; Cu++-transporting P-type ATPase; Menkes disease-associated protein; MK; MNK; DSMAX; SMAX3; FLJ17790
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ATP7A protein, GST-tagged
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ATP7A
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ATP7A Protein
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ATP7A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Menkes Protein, Domain 1
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP7A, Domain 2
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Menkes Protein, Domain 3
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP7A, Domain 5
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATPase, Cu++ Transporting, Alpha Polypeptide
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATPase, Cu++ Transporting, Alpha Polypeptide, His-tagged

Involved Pathway

ATP7A involved in several pathways and played different roles in them. We selected most pathways ATP7A participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mineral absorption
ATP1A4; FXYD2; TRPM6; ATP1B2; Trf; MT1E; ATP1A2; SLC11A1; SLC40A1; MT1X

Protein Function

ATP7A has several biochemical functions, for example, ATP binding, copper ion binding, copper ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP7A itself. We selected most functions ATP7A had, and list some proteins which have the same functions with ATP7A. You can find most of the proteins on our site.
Related Protein
Function ATP binding
Related Protein UBE2J2; ACTR1B; ATP1A1A.5; SLC14A2; KIFC3; NOL9; GSK3A; ATP2B4; PRKACG; RNASEL
Function copper ion binding
Function copper ion transmembrane transporter activity
Related Protein SLC31A1; ATP7A; ATOX1; SLC31A2; SLC11A2; MMGT2
Function copper-dependent protein binding
Related Protein FKBP4; ATP7A; ATOX1
Function copper-exporting ATPase activity
Related Protein ATP7A; ATP7B
Function protein binding
Related Protein MAGEA11; IRF8; GINS2; EIF3L; Tnfrsf23; IGFL1; DPYSL5; DDX55; KRT8; GSS
Function superoxide dismutase copper chaperone activity
Related Protein PARK7; ATP7A; CCS

Interacting Protein

ATP7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP7A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP7A.

ATP7A Related Articles

Yi, L; Kaler, S; et al. ATP7A trafficking and mechanisms underlying the distal motor neuropathy induced by mutations in ATP7A. HUMAN DISORDERS OF COPPER METABOLISM I 1314:49-54(2014).
Palm-Espling, ME; Lundin, C; et al. Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells. PROTEIN AND PEPTIDE LETTERS 21:63-68(2014).