Recombinant Human Menkes Protein, Domain 3

Cat.No. : ATP7A-456H
Product Overview : Recombinant human Menkes Protein (ATP7A), cloned from human cDNA with a C-terminal purification tag, ATP7A was expressed inE. coli. The protein consists of the third soluble domain of the human Menkes protein (residues 275-352 swissprot accessionQ04656) and has a molecular mass of 8.4 kDa.
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Cat. No. : ATP7A-456H
Description : ATP7A (ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)) is a human gene that provides instructions to make a protein that is important for regulating copper levels in the body. This protein is found in most tissues, but it is absent from the liver. In the small intestine, the ATP7A protein helps control the absorption of copper from food. In other organs and tissues, the ATP7A protein has a dual role and shuttles between two locations within the cell. The protein normally resides in a cell structure called the Golgi apparatus, which modifies and transports newly produced enzymes and other proteins. Here, the ATP7A protein supplies copper to certain enzymes that are critical for the structure and function of bone, skin, hair, blood vessels, and the nervous system. If copper levels in the cell environment are elevated, however, the ATP7A protein moves to the cell membrane and eliminates excess copper from the cell.
Source : Escherichia Coli.
Supplied As : 1.0 mg at 1.0 mg/ml in 50 mM Tris/Mes pH 8.0, 2 mM DTT (Dithiothreitol). The concentration is calculated from the absorbance at 280nm (ε280 = 1400 M-1cm-1).
Purity : >95% by SDS-PAGE. The protein was observed as a single band migrating at a molecular weight <14 kDa.
Characteristics : to avoid precipitation handle the proteinin an inert atmosphere. The product can be concentrated to a maximum of 2 mM.
Storage : -20º C. The protein is stable at 4 ºC for at least 2 week and at 25 ºC for at least several hours. After initial defrost, aliquot product into individual tubes and refreeze at -20º C. Avoid repeated freeze/defrost cycles.
Gene Name : ATP7A ATPase, Cu++ transporting, alpha polypeptide [ Homo sapiens ]
Synonyms : MK; MNK; FLJ17790; ATP7A; ATPase, Cu++ transporting, alpha polypeptide; copper pump 1; copper-transporting ATPase 1; Cu++-transporting P-type ATPase; Menkes disease-associated protein
Gene ID : 538
mRNA Refseq : NM_000052
Protein Refseq : NP_000043
MIM : 309400
UniProt ID : Q04656
Function : ATP binding; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; copper ion binding; copper ion transmembrane transporter activity; copper-dependent protein binding; copper-exporting ATPase activity; hydrolase activity; hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; magnesium ion binding; metal ion transmembrane transporter activity; nucleotide binding; superoxide dismutase copper chaperone activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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