ALK
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Official Full Name
anaplastic lymphoma receptor tyrosine kinase
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Overview
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X). -
Synonyms
Alk; ALK tyrosine kinase receptor; ALK Tyrosine Kinase Receptor Precursor; ALK/EML4 fusion gene, included; ALK/NPM1 fusion gene, included; ALK_HUMAN; anaplastic lymphoma kinase (Ki-1); Anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; CD246; CD246 Antigen; EC 2.7.10.1; Ki 1; Ki1; NBLST3; Tcrz; TFG/ALK;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Macaca nemestrina
- Mouse
- Rhesus monkey
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Insect cell
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf21 Insect Cell
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- DDK|His
- Flag
- GST
- GST|His
- hIgG1
- hIgG4
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ALK Related Articles
ALK involved in several pathways and played different roles in them. We selected most pathways ALK participated on our site, such as Non-small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Non-small cell lung cancer | PIK3R1;PLCG2;BAD;PDPK1;FOXO3;RB1;HRAS;RXRA;ARAF |
ALK has several biochemical functions, for example, ATP binding, NF-kappaB-inducing kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALK itself. We selected most functions ALK had, and list some proteins which have the same functions with ALK. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | MAPK9;ULK1;KIF5B;CLCN7;SMC2;AK5L;MAP3K5;CSNK1G2A;NWD1 |
NF-kappaB-inducing kinase activity | IRAK1;RIPK3;ALK;ALPK2;PPP4C;MAP3K14;IKBKE |
identical protein binding | CBS;RBM10;CASP6;GDF5;EPOR;B2M;SCAND1;CALHM1;CCDC91 |
protein binding | ARMC1;ARRB2;CXCR4;ITGA2B;IRF8;C19orf80;TMUB2;NUTF2;PRKAA2 |
protein tyrosine kinase activity | EPHB2;Fert2;INSRA;SHC1;FGFR1OP;FYNA;INSRB;TTN;TNK2 |
transmembrane receptor protein tyrosine kinase activity | FLT4;FGFR1B;FLT3;CADM2B;KDRL;CSF1RA;MERTK;ERBB3A;AXL |
ALK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALK here. Most of them are supplied by our site. Hope this information will be useful for your research of ALK.
crizotinib; ch5424802; PTPRZ1; HSP90AB1; EPHA1; EIF4B
- Q&As
- Reviews
Q&As (17)
Ask a questionThe common mutation of ALK and other genes may affect the prognosis and therapeutic effect of lung cancer, and provide new ideas for individualized treatment.
Phosphorylation of ALK can affect its activity and signal transmission efficiency, which has an impact on the biological process of cells.
The application prospect of ALK in the treatment of breast cancer needs to be further studied and discussed, and the expression level in breast cancer cells is not clear.
The interaction between ALK and other tumor suppressor genes may affect the occurrence and development of tumors, and provide new ideas for tumor treatment.
This is involved in a variety of lung cancer signaling pathways, such as PI3K/Akt, MAPK/ERK, STAT3 and other pathways.
It is associated with lung cancer, thyroid cancer, lymphoma and neuroblastoma.
As a targeted drug, ALK is mainly used by oral administration and intravenous injection, which can help in the treatment of diseases such as lung cancer.
ALK is overexpressed in a small number of lung cancer patients and is involved in the occurrence and development of lung cancer.
The mutation may affect the prognosis and therapeutic effect of lung cancer, suggesting the importance of ALK targeted therapy.
ALK is involved in signal transduction and cell growth in nervous system tumors, and has a certain influence on the occurrence and development of nervous system tumors.
ALK plays an important role in many physiological processes such as neuron migration, embryonic development and osteoblast differentiation.
ALK can be used as one of the screening indicators for lung cancer, which can help the early diagnosis and treatment of lung cancer.
ALK is expressed in a variety of cell types such as the nervous system, lymphatic system, and immune system, and is involved in a variety of biological processes.
The regulatory mechanisms of ALK mainly include gene mutation, gene expression regulation, quality control and signal pathway regulation.
The effect of ALK targeted therapy on the prognosis of lung cancer may be related to a variety of factors, including tumor stage, pathological type, treatment regimen, etc.
ALK can be used as an important marker of targeted therapy in the treatment of lung cancer, providing an individualized treatment strategy.
The relationship between ALK and colorectal cancer is unclear and needs further study.
Customer Reviews (4)
Write a reviewALK has strict quality control and complies with relevant industry standards.
The yield of ALK is high and has good economic benefits.
The enzymatic activity of ALK reached the expected level and was able to play a role in specific reactions.
Stable and reproducible results can be obtained when experiments are performed using ALK.
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