Recombinant Full Length Human ALK, Flag-tagged

Cat.No. : ALK-1801HFL
Product Overview : Recombinant Full Length Human ALK, fused with C-terminal Flag tag, was expressed in mamanlian cells.
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Source : Mamanlian cells
Species : Human
Tag : Flag
Molecular Mass : 176.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Storage : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Concentration : >50 ug/mL as determined by microplate BCA method
Shipping : The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Gene Name : ALK anaplastic lymphoma receptor tyrosine kinase [ Homo sapiens (human) ]
Official Symbol : ALK
Synonyms : ALK; CD246; NBLST3; anaplastic lymphoma receptor tyrosine kinase; ALK tyrosine kinase receptor; CD246 antigen; mutant anaplastic lymphoma kinase; NP_004295.2; EC 2.7.10.1
Gene ID : 238
mRNA Refseq : NM_004304
Protein Refseq : NP_004295
MIM : 105590
UniProt ID : Q9UM73

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (17)

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How do common mutations of ALK and other genes affect the prognosis of lung cancer? 01/11/2023

The common mutation of ALK and other genes may affect the prognosis and therapeutic effect of lung cancer, and provide new ideas for individualized treatment.

How does the phosphorylation process of ALK affect its activity? 12/06/2022

Phosphorylation of ALK can affect its activity and signal transmission efficiency, which has an impact on the biological process of cells.

What is the application prospect of ALK in breast cancer treatment? 08/06/2022

The application prospect of ALK in the treatment of breast cancer needs to be further studied and discussed, and the expression level in breast cancer cells is not clear.

What is the interaction of ALK with other tumor suppressor genes? 12/23/2021

The interaction between ALK and other tumor suppressor genes may affect the occurrence and development of tumors, and provide new ideas for tumor treatment.

What role does ALK play in lung cancer signaling pathways? 08/06/2021

This is involved in a variety of lung cancer signaling pathways, such as PI3K/Akt, MAPK/ERK, STAT3 and other pathways.

What diseases is ALK associated with? 04/29/2021

It is associated with lung cancer, thyroid cancer, lymphoma and neuroblastoma.

Which pathway of ALK as a targeted drug? 02/12/2021

As a targeted drug, ALK is mainly used by oral administration and intravenous injection, which can help in the treatment of diseases such as lung cancer.

What is the expression of ALK in lung cancer? 01/05/2021

ALK is overexpressed in a small number of lung cancer patients and is involved in the occurrence and development of lung cancer.

How does ALK mutation affect the prognosis of lung cancer? 12/03/2020

The mutation may affect the prognosis and therapeutic effect of lung cancer, suggesting the importance of ALK targeted therapy.

How the role of ALK in nervous system tumors? 09/05/2020

ALK is involved in signal transduction and cell growth in nervous system tumors, and has a certain influence on the occurrence and development of nervous system tumors.

In what physiological processes does ALK play a role? 07/04/2020

ALK plays an important role in many physiological processes such as neuron migration, embryonic development and osteoblast differentiation.

Can ALK be used as a screening indicator for lung cancer? 06/27/2020

ALK can be used as one of the screening indicators for lung cancer, which can help the early diagnosis and treatment of lung cancer.

In which cell types is ALK expressed? 06/15/2020

ALK is expressed in a variety of cell types such as the nervous system, lymphatic system, and immune system, and is involved in a variety of biological processes.

What are the regulatory mechanisms of ALK? 11/05/2019

The regulatory mechanisms of ALK mainly include gene mutation, gene expression regulation, quality control and signal pathway regulation.

Does the prognostic impact of ALK targeted therapy on lung cancer? 11/04/2019

The effect of ALK targeted therapy on the prognosis of lung cancer may be related to a variety of factors, including tumor stage, pathological type, treatment regimen, etc.

What is the role of ALK in the treatment of lung cancer? 10/12/2019

ALK can be used as an important marker of targeted therapy in the treatment of lung cancer, providing an individualized treatment strategy.

Whether there is the relationship between ALK and colorectal cancer? 06/17/2019

The relationship between ALK and colorectal cancer is unclear and needs further study.

Customer Reviews (4)

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Reviews
07/05/2021

    ALK has strict quality control and complies with relevant industry standards.

    02/11/2021

      The yield of ALK is high and has good economic benefits.

      12/22/2020

        The enzymatic activity of ALK reached the expected level and was able to play a role in specific reactions.

        01/07/2019

          Stable and reproducible results can be obtained when experiments are performed using ALK.

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