CALML5
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Official Full Name
Calmodulin-like 5
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Overview
This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. -
Synonyms
CALML5;Calmodulin-like 5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CALML5 involved in several pathways and played different roles in them. We selected most pathways CALML5 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CALML5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | ANGPT1;CALM1;PLA2G4D;ETS2;EFNA4;FGF9;RALGDS;PLA1A;FGF4 |
| Rap signaling pathway | LPAR3;VEGFC;ITGB1;RAP1B;FGF2;FGF10;RRAS;HGF;FGF7 |
| Calcium signaling pathway | CALM4;CHRNA7;HTR6;P2RX3A;CACNA1SA;ERBB4;ATP2A3;GNAQ;MLCK2 |
| cGMP-PKG signaling pathway | CALM4;PLCB3;CREB5;BDKRB2;MYH7;ATP1B1;CREB3L1;PRKG1;PDE3B |
| cAMP signaling pathway | CAMK2D;GNAS;PIK3CA;TSHR;RAF1;HTR1F;MAPK3;ROCK1;CREB3L2 |
| Phosphatidylinositol signaling system | TMEM55B;PLCE1;SYNJ1;PIK3R1;MTMR6;INPP5D;IPMKB;IPMK;INPP5L |
| Oocyte meiosis | ESPL1;PTTG1;MAPK1;STAG3;CCNE1;CPEB1B;CDC25C;MAP2K1;CALM2B |
| Adrenergic signaling in cardiomyocytes | MAPK11;CREB1A;CACNG7A;ATP1B1;ADRB2;CACNB1;PPP2R5CB;ACTC1A;ATP2B3B |
| Vascular smooth muscle contraction | PTGIR;PLCB1;CALML3;GNA11A;PPP1R14A;ADORA2AB;CALM3A;MAP2K2B;PPP1R12B |
| Circadian entrainment | PRKCG;GNG4;RYR3;CALM2;MTNR1A;GNG2;GNG13;PLCB3;AKR1C1 |
| Long-term potentiation | PPP3CC;PRKACG;PPP1CB;MAP2K2;GNAQ;CAMK4;ITPR1;CAMK2A;RPS6KA1 |
| Neurotrophin signaling pathway | IRAK1;SHC4;KRAS;SOS1;PIK3R2;RPS6KA1;ARHGDIB;CAMK4;MAP2K1 |
| Dopaminergic synapse | KCNJ6;ATF6B;SCN1A;KCNJ5;GNG4;GNG2;CALM2;GNAS;GSK3A |
| Olfactory transduction | SLC8A1;OR10C1;OR5V1;OLFR508;PDC;OLFR149;OR52B4;OLFR154;OR52B2 |
| Phototransduction | CALM1;CALM3B;GUCA1C;RGS9A;GRK7;GNB1B;GUCA1B;GUCY2F;CALML5 |
| Inflammatory mediator regulation of TRP channels | ASIC2;PRKACG;PLCB4;PPP1CC;CYP2C38;ASIC5;CYP4A10;KLK1B4;ASIC4 |
| Insulin signaling pathway | G6PCA.1;PRKAB2;CALM1A;PRKAG1;FBP1A;FLOT1;SOCS1A;FOXO1;MAPK3 |
| GnRH signaling pathway | CALM2;ITPR3;PRKCBB;SRC;LHB;MAPK14B;MAP2K2A;GNRHR4;Adcy4 |
| Estrogen signaling pathway | HSP90B1;AKT2;PIK3CD;CALM1;ATF4;CREB5;GRB2;ESR2;CALML3 |
| Melanogenesis | CREB3L2;MAPK3;FZD7B;GNAQ;PRKCBA;GNAI3;MITFB;CAMK2G;CREB3L3A |
| Oxytocin signaling pathway | PRKACA;PLA2G4A;ROCK1;NPR2;MYLK4;ELK1;CALML5;PIK3R2;PPP3R2 |
| Renin secretion | PPP3CC;ACE;PDE1C;PLCB3;PDE3B;PPP3R2;ITPR3;PRKG2;PRKACB |
| Aldosterone synthesis and secretion | LDLR;HSD3B2;ADCY1;AKR1C1;ATF6B;CACNA1G;PDE2A;CALML3;ATF1 |
| Salivary secretion | PRKCB;HTN1;MUC5B;Slc4a2;GNAS;ATP1A2;PRKG2;AMY1A;PRKACA |
| Gastric acid secretion | KCNJ2;MYLK2;CAMK2A;GNAI2;CALM4;GNAS;GNAQ;ATP1A3;CCKBR |
| Alzheimers disease | NDUFA6;COX5A;UQCR11;CASP12;SDHC;COX4I2;UQCRFS1;ITPR2;PLCB1 |
| Alcoholism | HIST1H3E;HDAC9;HIST4H4;GNAI1;HIST1H2BE;HIST1H2AG;HIST2H3A;HIST1H3G;NPY |
| Pertussis | TLR4;IL12A;Il23a;CASP7;MAPK8;C2;C1S;AMCF-II;TRAF6 |
| Tuberculosis | CALM2;CD209B;IL1B;H2-AB1;IFNA10;LAMP1;HLA-DMA;IRAK1;IFNB1 |
| Glioma | PIK3R3;PIK3R2;KRAS;MAP2K1;PRKCB;CALM1;CALML3;CAMK2D;MTOR |
CALML5 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CALML5 itself. We selected most functions CALML5 had, and list some proteins which have the same functions with CALML5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | MAN1A2;CDH13;MYO5A;EFEMP2B;PCDH12;FKBP10B;EFEMP1;MATN3;MYL6B |
CALML5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALML5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CALML5.
USP1; YWHAQ; PPP4C; USF2; MAGED1; CD81; K3; Smarcc1; STK4; LRRK2; SLX4; GABARAPL1
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