clns1a
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  • Official Full Name
  • chloride channel, nucleotide-sensitive, 1A
  • Background
  • This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6.
  • Synonyms
  • CLNS1A; chloride channel, nucleotide-sensitive, 1A; CLCI; methylosome subunit pICln; ICln; nucleotide sensitive 1A; Chloride channel; Chloride channel nucleotide sensitive 1A; Chloride channel regulatory protein; Chloride conductance regulatory protein ICln; Chloride ion current inducer protein; CLNS 1A; CLNS1B; I(Cln); ICLN_HUMAN; Reticulocyte pICln; OTTHUMP00000228612; OTTHUMP00000228613; OTTHUMP00000228614; OTTHUMP00000228843; OTTHUMP00000228845; reticulocyte protein ICln; chloride
Cat.#:CLNS1A-1509HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLNS1A Protein, GST-tagged
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Cat.#:CLNS1A-27276THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLNS1A, His-tagged
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Cat.#:CLNS1A-360HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human chloride channel, nucleotide-sensitive, 1A, His-tagged
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Cat.#:CLNS1A-1458RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CLNS1A Protein
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Cat.#:CLNS1A-8993ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CLNS1A
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Cat.#:CLNS1A-7437HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CLNS1A 293 Cell Lysate
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Involved Pathway

CLNS1A involved in several pathways and played different roles in them. We selected most pathways CLNS1A participated on our site, such as Gene Expression, Metabolism of non-coding RNA, RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLNS1A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
SET; ZNF597; TRIM28; MAPKAPK2B; NR6A1A; ZNF167; FKBP6; ZNF436; ZNF253; LAMTOR1
Metabolism of non-coding RNA
PRMT5; DDX20; CLNS1A; PEAK1; WDR77; SNUPN
RNA transport
XPOT; KPNB1; NXF3; EIF4A1A; RPP30; EIF5; NCBP2; NUP214; SEH1L; EIF4E1C
snRNP Assembly
DDX20; PEAK1; CLNS1A; SNUPN; WDR77

Protein Function

CLNS1A has several biochemical functions, for example, poly(A) RNA binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLNS1A itself. We selected most functions CLNS1A had, and list some proteins which have the same functions with CLNS1A. You can find most of the proteins on our site.
Function
Related Protein
Function poly(A) RNA binding
Related Protein GLRX3; ANKHD1; SRP54A; IFI203; ZCRB1; SRSF10; IGF2BP3; MRPS21; ZC3H15; RPL32
Function protein binding
Related Protein DAK; CRH; ACKR4; FAM101A; MAP3K4; HLA-A; ANKS4B; PTRH2; RAD9A; IFT27
Function protein heterodimerization activity
Related Protein KATNB1; GRIN2A; CUL5; ADRA1B; NOTCH1; NFE2L2A; Itgam&Itgb2; EGFR; PML; KCNK9

Interacting Protein

CLNS1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLNS1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CLNS1A.
SNRPD1; SNRPD2; SNRPD3