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CRYAA

  • Official Full Name

    crystallin, alpha A

  • Overview

    Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).
  • Synonyms

    CRYAA; crystallin, alpha A; CRYA1; alpha-crystallin A chain; HSPB4; Heat shock protein beta 4; short form; Acry 1; Acry-1; Alpha crystallin A chain; CRYA 1; CRYAA_HUMAN; Crystallin Alpha 1; Crystallin alpha A; Heat shock protein beta-4; HSPB 4; Zonular Central Nuclear Cataract; OTTHUMP00000109430; crystallin, alpha-1; human alphaA-crystallin (CRYA1);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CRYAA-26991TH Recombinant Human CRYAA, His-tagged E.coli His 173 amino acids
Human CRYAA-26676TH Recombinant Human CRYAA E.coli N/A
Human CRYAA-309H Recombinant Human Crystallin Alpha A E.coli N/A
Human CRYAA-1925H Recombinant Human CRYAA Protein, GST-tagged Wheat Germ GST
Human CRYAA-7267HCL Recombinant Human CRYAA 293 Cell Lysate HEK293 N/A
Human CRYAA-2127HF Recombinant Full Length Human CRYAA Protein, GST-tagged In Vitro Cell Free System GST 173 amino acids
Human CRYAA-1133HFL Recombinant Full Length Human CRYAA Protein, C-Flag-tagged Mammalian cells Flag
Human CRYAA-2879H Recombinant Human CRYAA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CRYAA-001H Recombinant Human CRYAA Protein E.coli 173
Human CRYAA-667H Recombinant Human CRYAA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CRYAA-667H-B Recombinant Human CRYAA Protein Pre-coupled Magnetic Beads HEK293
Human CRYAA-850H Recombinant Human CRYAA Protein, His-tagged E.coli N-His Asp2-Ser173
Human CRYAA-1819H Recombinant Human CRYAA Protein (Met1-Ser173), C-His tagged E.coli C-His Met1-Ser173
Mouse CRYAA-3933M Recombinant Mouse CRYAA Protein Mammalian Cell His
Mouse Cryaa-851M Recombinant Mouse Cryaa Protein, His-tagged E.coli N-His Asp2-Ser173
Mouse Cryaa-2325M Recombinant Mouse Cryaa Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CRYAA-1994M Recombinant Mouse CRYAA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CRYAA-1994M-B Recombinant Mouse CRYAA Protein Pre-coupled Magnetic Beads HEK293
Mouse Cryaa-7175M Recombinant Mouse Cryaa Protein E.coli 1-175
Rat Cryaa-3344R Recombinant Rat Cryaa, His-tagged E.Coli or Yeast His 173
Zebrafish CRYAA-9417Z Recombinant Zebrafish CRYAA Mammalian Cell His
Chicken CRYAA-2495C Recombinant Chicken CRYAA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CRYAA involved in several pathways and played different roles in them. We selected most pathways CRYAA participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYAA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumUBE2E3;ERO1L;EDEM1;BAXA;SVIP;PLAA;RPN2;CANX;RAD23B

CRYAA has several biochemical functions, for example, identical protein binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYAA itself. We selected most functions CRYAA had, and list some proteins which have the same functions with CRYAA. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingAPLP2;VWF;CHEK2;BCL2L1;CALHM1;NOXO1;CPT1A;TRIP13;SLK
metal ion bindingRFK;ZNF35;ZFP473;BCL11AB;KCND2;KCNIP3B;HIVEP2A;NAALADL1;ZDHHC1
protein bindingMTM1;METTL21C;MAPK13;SULT1C2;ELMO3;CCDC86;PCSK2;USP15;TGFBRAP1
structural constituent of eye lensLIM2.1;CRYBB2;BFSP2;LIM2.4;HSPB6;CRYAA;CRYABA;ASL2;CRYBA4
unfolded protein bindingNDUFAF1;HSP90AA1;GRPEL2;LMAN1;AHSP;CCDC102A;DNAJA1;AFG3L2;TAPBP

CRYAA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYAA here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYAA.

CRYAB; CRYGC; CRYBB2

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