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CHAT

  • Official Full Name

    choline O-acetyltransferase

  • Overview

    Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement.
  • Synonyms

    CHAT; choline O-acetyltransferase; CHOACTase; choline acetylase; choline acetyltransferase;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHAT-176H Recombinant Human CHAT protein, GST-tagged Wheat Germ GST 1 a.a. - 630 a.a.
Human CHAT-172H Recombinant Human CHAT protein, His-tagged E.coli His Asp517~Pro732
Human CHAT-174H Recombinant Human CHAT Mammalian Cell His
Human CHAT-177H Recombinant Human CHAT protein, GST-tagged Wheat Germ GST 649 a.a. - 748 a.a.
Human CHAT-175HCL Recombinant Human CHAT HEK293T cell lysate HEK293T Myc/DDK
Human CHAT-2666H-B Recombinant Human CHAT Protein Pre-coupled Magnetic Beads HEK293
Human CHAT-1021H Recombinant Human CHAT Protein (Met1-Pro630), N-His tagged E.coli N-His Met1-Pro630
Human CHAT-2464H Recombinant Human CHAT protein, His-tagged E.coli His 399-748 aa
Human CHAT-1357H Recombinant Human CHAT protein, His-tagged E.coli His 120-733aa
Human CHAT-2666H Recombinant Human CHAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CHAT-1359H Recombinant Human CHAT protein, His&Myc-tagged E.coli His&Myc 120-733aa
Rat Chat-1836R Recombinant Rat Choline O-Acetyltransferase E.coli N/A
Chicken CHAT-6178C Recombinant Chicken CHAT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHAT Related Articles
  • CHAT Related Research Area

CHAT involved in several pathways and played different roles in them. We selected most pathways CHAT participated on our site, such as Acetylcholine Neurotransmitter Release Cycle, Acetylcholine Synthesis, Biogenic Amine Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Acetylcholine Neurotransmitter Release CyclePPFIA2;UNC13B;CHAT;RERG;CCDC167;CPLX2L;STXBP1A;CPLX1;PPFIA1
Acetylcholine SynthesisCHKA;PEMT;CHAT
Biogenic Amine SynthesisCHAT;DDC;COMT;DBH
Cholinergic synapseKCNJ4;PIK3R1;PRKCB;CHRM4;GNG10;KCNJ12;KCNQ1;KCNQ3;CAMK2B
Glycerophospholipid biosynthesisCPNE3;CPNE7;PLBD1;CHKA;CHAT;MGLL;BCHE;DGAT1B;ABHD4
Glycerophospholipid metabolismGPD1B;DGKAA;PNPLA7;MBOAT2;PLA2G2A;PLA2G5;DGKG;LPCAT1;GPD1
MetabolismCERS4A;SLCO1B1;IVD;CYP2C18;MED26;CA5B;SLC52A3;HPSE;NQO1
Metabolism of lipids and lipoproteinsCHKB;MED26;ACOT13;ACOT12;MED29;COL4A3BP;Agmo;CDIPT;ARV1

CHAT has several biochemical functions, for example, choline O-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHAT itself. We selected most functions CHAT had, and list some proteins which have the same functions with CHAT. You can find most of the proteins on our site.

Function Related Protein
choline O-acetyltransferase activityCHATA;CHAT

CHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of CHAT.

Wilhelm, M; Lawrence, JJ; et al. Enteric plexuses of two choline-acetyltransferase transgenic mouse lines: Chemical neuroanatomy of the fluorescent protein-expressing nerve cells. BRAIN RESEARCH BULLETIN 111:76-83(2015).
Wang, L; Ennis, M; et al. Characteristics of GABAergic and cholinergic neurons in perinuclear zone of mouse supraoptic nucleus. JOURNAL OF NEUROPHYSIOLOGY 113:754-767(2015).
  • Q&As
  • Reviews

Q&As (6)

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How to use the activity of CHAT protein for disease treatment? 10/14/2022

The activity of the CHAT protein can be modulated by drugs or other small molecule compounds to treat neurological disorders associated with CHAT protein abnormalities. For example, some drugs can promote the expression and activity of the CHAT protein, thereby increasing acetylcholine synthesis.

How is the expression level of CHAT protein regulated? 10/15/2021

Expression level of CHAT protein is regulated by a variety of factors, including gene expression, post-transcriptional modifications, nutritional status, etc. Some drugs or other small molecule compounds can also affect their expression levels by regulating gene expression or post-transcriptional modifications.

What diseases are mutations or abnormal expression of the CHAT protein associated with? 04/21/2021

Some studies have shown that mutations or abnormal expression of the CHAT protein may be related to neurological diseases, psychiatric diseases, etc. However, further research is needed to confirm the association.

How are CHAT proteins related to other neurotransmitters or signaling molecules? 11/24/2020

CHAT protein has some association with other neurotransmitters or signaling molecules. For example, it can interact with cholinergic neurons to co-regulate acetylcholine synthesis and release. In addition, it can interact with other neurotransmitters or signaling molecules such as dopamine, glutamate, etc.

How to use CHAT protein for disease diagnosis? 03/09/2020

The occurrence, progression and prognosis of neurological diseases can be assessed by detecting characteristics such as the expression level, activity and interaction of CHAT protein with other proteins. These features can also be used to develop new biomarkers and drug targets.

Why are CHAT proteins linked to disease development and progression? 06/15/2019

Some studies have shown that abnormal expression of CHAT protein may be related to the occurrence and progression of some neurological diseases, such as Alzheimer's disease and Parkinson's disease. In addition, the CHAT protein may also be a drug target for the treatment of these diseases.

Customer Reviews (3)

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Reviews
10/15/2022

    The resolution of CHAT in Western blot is high and can distinguish between similar protein molecular weights.

    02/14/2021

      This repeatability of CHAT is very good, which can greatly reduce the experimental error and allow me to evaluate the experimental results more accurately.

      04/25/2019

        Stability of CHAT is so good that a variety of experimental manipulations can be performed without concern for changes and effects on its properties.

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