elane
Share
  • Official Full Name
  • elastase, neutrophil expressed
  • Background
  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the proteins release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
  • Synonyms
  • ELANE; elastase, neutrophil expressed; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E; neutrophil elastase; elastase-2; medullasin; PMN elastase; leukocyte elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclear elastase; bone marrow serine protease; granulocyte-derived elastase;
Cat.#:ELANE-1197HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ELANE Protein, GST-tagged
+Inquiry
Cat.#:ELANE-3222HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ELANE Protein, GST-tagged
+Inquiry
Cat.#:ELANE-1653HTag:
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameHuman Elastase
+Inquiry
Cat.#:ELANE-172HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ELANE Protein, His/GST-tagged
+Inquiry
Cat.#:ELANE-201HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ELANE
+Inquiry
Cat.#:Elane-694MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Elane Protein, His-tagged
+Inquiry
Cat.#:Elane-906MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Elane, His tagged
+Inquiry
Cat.#:ELANE-001HTag:
Source (Host):Human NeutrophilsSpecies:Human
Product nameNative Human ELANE Protein
+Inquiry
Cat.#:ELANE-27537THTag:
Source (Host):Species:Human
Product nameNative Human ELANE
+Inquiry
Cat.#:ELANE-3221HTag:
Source (Host):Human bloodSpecies:Human
Product nameNative Human ELANE Protein
+Inquiry
Cat.#:ELANE-8104HTag:N/A
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameNative Human Neutrophil Elastase
+Inquiry
Cat.#:ELANE-8236HTag:N/A
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameNative Human Neutrophil Elastase (ELA-2)
+Inquiry
Cat.#:ELANE-2381MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ELANE cell lysate
+Inquiry
Cat.#:Kit-0322Tag:
Source (Host):Species:
Product nameNeutrophil Elastase Activity Assay Kit
+Inquiry
Cat.#:Kit-0323Tag:
Source (Host):Species:
Product nameNeutrophil elastase colorimetric drug discovery Kit
+Inquiry
Cat.#:Kit-0321Tag:
Source (Host):Species:
Product nameELANE Inhibitor Screening Kit
+Inquiry

Involved Pathway

Elane involved in several pathways and played different roles in them. We selected most pathways Elane participated on our site, such as Activation of Matrix Metalloproteinases, C-MYB transcription factor network, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Elane were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of Matrix Metalloproteinases
ELANE; CTSL2; CTSLL; FURINB; CMA1; CTSG; CTRB1; MMP13; MGC174857; MMP17
C-MYB transcription factor network
TOM1; CDKN1B; MYC; COL1A2; ADORA2B; PIAS3; MYOD1; SKI; MYF6; PPID
Collagen degradation
MMP20; COL13A1; ADAM10; COL9A3; MGC174857; MGC174152; MMP19; COL9A1; COL19A1; COL25A1
Degradation of the extracellular matrix
TIMP2B; FURINA; CTSS; LOC100686744; BMP1; MMP11; COL9A1; CTRB1; TIMP2A; KLK7
Extracellular matrix organization
TLL2; COL6A3; F11R.2; COL16A1; EFEMP1; COL2A1; COL4A6; PCOLCE2B; FBN1; LTBP2
Systemic lupus erythematosus
HIST1H2BK; H3F3B; HIST1H2AF; GRIN2A; ACTN3; C8B; HLA-DOB; HIST1H4N; HIST1H2BF; GM14478
Transcriptional misregulation in cancer
TP53; RARA; RXRB; SIX1; TGFBR2; MMP3; IL-8; KLF3; BIRC3; HDAC2
amb2 Integrin signaling
HP; ELANE; NIPAL1; CYR61; LPA; MST1; MST1R

Protein Function

Elane has several biochemical functions, for example, RNA polymerase II transcription corepressor activity, cytokine binding, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Elane itself. We selected most functions Elane had, and list some proteins which have the same functions with Elane. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription corepressor activity
Related Protein BEND6; TFAP2B; TXLNB; SIN3B; NFIB; URI1; N4BP2L2; SIN3A; TBX15; TBX18
Function cytokine binding
Related Protein NOG; TNFRSF11A; ELANE; KITA; CSF1R; IL17F; IFNGR1; CHRD; NRP1; IL31RA
Function endopeptidase activity
Related Protein TMEM59; AP1S2; HTRA4; PSMA7; PSMA2; PSMB7; KLK1B5; TPP2; TPP1; PSMA4
Function heparin binding
Related Protein C6orf25; APPA; LTF; PCOLCE; AAMP; RSPO4; PCOLCE2; FGF1; COL20A1; FGF14
Function peptidase activity
Related Protein GZMC; KLK12; TMPRSS11F; MMP13A; FURINB; SPG7; TMPRSS11G; PSMB11; DESI1; lon
Function protease binding
Related Protein ITGB1; FN1; STIM1; RYR1; CSTA; DERL1; CD28; BDKRB2; SERPINB9; SERPINB6
Function protein binding
Related Protein FGF19; DGKZ; CPNE7; RCN2; SS18; GSS; ZNF398; MAP3K11; CEP164; VAC14
Function serine-type endopeptidase activity
Related Protein MASP2; TRY; EGFBP2; TMPRSS4A; KLK9; HTRA3; PRSS2; PRSS23; KLK1B26; CTSH

Interacting Protein

Elane has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Elane here. Most of them are supplied by our site. Hope this information will be useful for your research of Elane.
SERPINA1; SLPI; iovo_melga; Col17a1; GZMB; P/V/C