fos
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  • Official Full Name
  • FBJ murine osteosarcoma viral oncogene homolog
  • Background
  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
  • Synonyms
  • FOS; FBJ murine osteosarcoma viral oncogene homolog; p55; AP-1; C-FOS; proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS);
Cat.#:FOS-4893HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOS Protein, His-tagged
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Cat.#:FOS-26602THTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FOS, GST-tagged
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Cat.#:FOS-27240THTag:His
Source (Host):Species:Human
Product nameRecombinant Human FOS, His-tagged
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Cat.#:FOS-32HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FOS protein, GST-tagged
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Cat.#:FOS404HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOS Protein, His-tagged
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Cat.#:FOS-4846HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FBJ Murine Osteosarcoma Viral Oncogene Homolog, GST-tagged
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Cat.#:FOS-5971MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FOS Protein
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Cat.#:Fos-6775MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fos protein, His & GST-tagged
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Cat.#:FOS-2380RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FOS Protein
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Cat.#:FOS-1738RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FOS Protein, His-tagged
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Cat.#:FOS-7057CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FOS
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Cat.#:FOS-11611ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FOS
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Cat.#:FOS-6168HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FOS 293 Cell Lysate
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Involved Pathway

FOS involved in several pathways and played different roles in them. We selected most pathways FOS participated on our site, such as MAPK signaling pathway, cAMP signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PRKACAB; PDGFAB; SRF; RRAS2; ATF4; MAPK4; IKBKG; MAPK7; FGF19; STMN1
cAMP signaling pathway
PLD2; CNGA1; GLI3; VAV2; ROCK1; CAMK2A; FSHR; BRAF; PIK3CA; NFKB1
Osteoclast differentiation
LILRB1; TNF; LILRA4; IFNGR1; GAB2; NFATC1; MAPK13; IL1R1; NOX1; TYROBP
Toll-like receptor signaling pathway
TLR5B; TLR7; MAPK12; AKT3A; MAPK13; IFNA17; MAPK9; CCL3; NFKBIAB; MYD88
T cell receptor signaling pathway
NCK1; SOS1; TNF; PIK3CB; SHB; CBL; PAK6; NFKBIB; IKBKG; EVLB
B cell receptor signaling pathway
TTC6; ARPC4; CDK7; PIK3R3; NFATC1; CD79A; LCP2A; BLNK; PIK3AP1; FCGR2B
TNF signaling pathway
MMP9; TNFRSF1A; SELE; MAPK3; MAPK9; Ccl12; MAPK10; PIK3R2; ITCH; IL18R1
Circadian entrainment
PRKACB; PRKACA; AKR1C1; GNG8; PLCB4; CALML5; KCNJ5; CALML3; GRIN2C; NOS1
Cholinergic synapse
CHRM4; KCNQ2; GNG11; AKT2; GNAO1; KCNQ1; PRKACG; PIK3CG; CAMK4; AKR1C1
Dopaminergic synapse
KIF5B; PRKACB; PRKCA; GNGT1; PPP2CA; PPP2R3C; PLCB1; CALM4; GRIN2B; KCNJ6
Estrogen signaling pathway
SHC2; ITPR1; PRKACA; PRKCD; MMP2; GRM1; PLCB4; CALML3; HSPA1B; PIK3CA
Prolactin signaling pathway
NFKB1; MAPK9; SOS1; PIK3R1; SOCS4; SRC; GRB2; STAT1; AKT2; NRAS
Oxytocin signaling pathway
CD38; HRAS; CACNB2; PPP1R12B; MAP2K1; PPP1CC; GUCY1A3; RYR2; PIK3R3; CAMK1D
Amphetamine addiction
SIRT1; CALML5; PRKCB; STX1A; PRKCA; CAMK2D; DRD1A; GRIN2A; TH; CREB3L1
Salmonella infection
MAPK1; CCL3L3; MAPK12A; RHOGC; ACTG1; MAPK3; DYNC1I2A; IFNGR1; CDC42L; MAPK11
Pertussis
NOS2; MAPK13; CFL2; C4BPB; CALML3; IL1A; C4BP; CXCL6; GM5077; CASP7
Leishmaniasis
MAP3K7; FCGR2A; PTPN6; FCGR3B; ELK1; NCF2; STAT1; FCGR2C; PTGS2; FCGR3A
Chagas disease (American trypanosomiasis)
MAP2K4; SERPINE1; IL12B; TLR9; PLCB1; CCL5; TLR6; FADD; TNF; IL-8
Hepatitis B
MAPK1; AKT2; HRAS; TLR4; CASP12; IFNAR1; FAS; STAT3; IFNA7; CCNE2
HTLV-I infection
ANAPC4; TGFB1; HLA-DPA1; Fzd4; IL1R1; PIK3CD; PIK3R2; WNT4; TRP53INP1; STAT5B
Herpes simplex infection
EEF1DB; IL12A; HLA-C; HLA-DRB5; IRF3; TP53; TNFRSF1A; PER2; SFRS9; Fasl
Pathways in cancer
ARAF; PIK3CB; AKT1; LPAR2; MMP2; Fzd4; GNAI2; BCL2L1; TRAF5; VHL
Colorectal cancer
PIK3R1; APC2; LEF1; BAD; KRAS; MAPK8; PIK3R2; SMAD3; AKT2; PIK3R5
Choline metabolism in cancer
PLA2G4B; DGKB; DGKQ; MAPK10; PIK3R5; MAPK1; WASF3; PDGFA; RPS6KB2; PPAP2C
Rheumatoid arthritis
HLA-DPB1; CXCL5; ATP6V1G1; IL17A; IL15; MMP1A; IL6; CCL2; TNFSF13; CCL3L1

Protein Function

FOS has several biochemical functions, for example, R-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOS itself. We selected most functions FOS had, and list some proteins which have the same functions with FOS. You can find most of the proteins on our site.
Function
Related Protein
Function R-SMAD binding
Related Protein ZC3H3; SMAD2; JUN; TRIM33; MYOCD; SMURF1; AXIN1; PPM1A; SMAD3; RANBP3
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein EBF2; SMAD3; NKX2; MYF6; MYB; RFX1A; ETV4; FUBP3; PER1; SALL1
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein HOXB3; SOX8; RBPJ; SMYD3; SFPI1; H3F3B; TRP53; WBP2; SOX3; ZNF335
Function chromatin binding
Related Protein SATB1; NR5A1; POLR2B; CTBP2; ANKRD2; SP140; BAHD1; CSNK2B; NFKB2; SOX10
Function protein binding
Related Protein ABHD1; PGF; HMGN4; HNRNPC; SDCCAG3; IRAK1BP1; PTPN12; HNRPLL; SH3RF1; FOXB1
Function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein FOSL1A; ARNTL2; RBPJB; RBPJL; FOS; CREB3; CLOCK; TFAP2A; JDP2; IRF7
Function transcription factor activity, sequence-specific DNA binding
Related Protein IRF4; TP73; DLX4; ETV5A; HOXB4; NFE2L1B; DLX6; LCOR; ZFP746; FOXF2A
Function transcription factor binding
Related Protein FOXO4; PURB; RPS3; NAB1; KCTD1; DR1; TAF1; APBB2; KAT6B; MYOD1
Function transcription regulatory region DNA binding
Related Protein AHR; TFEB; ATF4; TCF7; WNT5A; BCL11AB; IKZF2; LEF1; KLF17; TRP63
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein HOXA5; TFAP2C; FUBP3; STK16; NCOA3; OTX1; HOXC13; EPAS1; BATF; NFYC

Interacting Protein

FOS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOS here. Most of them are supplied by our site. Hope this information will be useful for your research of FOS.
JUN

FOS Related Articles

Ming, J; Zhang, QF; et al. Anti-Lymphangiogenesis Effects of a Specific Anti-Interleukin 7 Receptor Antibody in Lung Cancer Model In Vivo. MOLECULAR CARCINOGENESIS 54:148-155(2015).
Fahrenkrug, J; Falktoft, B; et al. Phosphorylation of Rat Melanopsin at Ser-381 and Ser-398 by Light/Dark and Its Importance for Intrinsically Photosensitive Ganglion Cells (ipRGCs) Cellular Ca2+ Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 289:35482-35493(2014).