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Official Full Name FBJ murine osteosarcoma viral oncogene homolog
Background The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
Synonyms FOS; FBJ murine osteosarcoma viral oncogene homolog; p55; AP-1; C-FOS; proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FOS-4893H Recombinant Human FOS Protein, His-tagged E. coli His
    Human FOS-26602TH Recombinant Human FOS, GST-tagged Sf9 Insect Cell GST
    Human FOS-27240TH Recombinant Human FOS, His-tagged His
    Human FOS-32H Recombinant Human FOS protein, GST-tagged Wheat Germ GST
    Human FOS404H Recombinant Human FOS Protein, His-tagged E.coli His
    Human FOS-4846H Recombinant Human FBJ Murine Osteosarcoma Viral Oncogene Homolog, GST-tagged Sf9 Insect Cell GST
    Human FOS-6168HCL Recombinant Human FOS 293 Cell Lysate HEK293 N/A
    Mouse FOS-5971M Recombinant Mouse FOS Protein Mammalian Cell His
    Mouse Fos-6775M Recombinant Mouse Fos protein, His & GST-tagged E.coli His/GST
    Rat FOS-2380R Recombinant Rat FOS Protein Mammalian Cell His
    Rhesus Macaque FOS-1738R Recombinant Rhesus monkey FOS Protein, His-tagged Mammalian Cell His
    Chicken FOS-7057C Recombinant Chicken FOS Mammalian Cell His
    Zebrafish FOS-11611Z Recombinant Zebrafish FOS Mammalian Cell His

    FOS involved in several pathways and played different roles in them. We selected most pathways FOS participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPK13; MAP4K4; MAPKAPK3; PRKACAB; MRAS; CACNA2D1A; ECSIT; PPP3R1B; MAP3K11; MAP2K4
    cAMP signaling pathway CALM3; RAC1; GRIN1; SOX9; RELA; PDE4B; GNAS; MAPK8; MLLT4; GPR119
    Osteoclast differentiation FCGR2B; NFKB1; AKT2; CSF1; PIK3R2; FCGR1; PPP3R1; FHL2; MAP3K7; MAPK1
    Toll-like receptor signaling pathway NFKBIAA; CD86; TLR4BB; RAC1B; CD14; RELA; TBK1; FOS; IFNA21; TLR7
    T cell receptor signaling pathway PTPRC; MAP2K2; ZAP70; PIK3CB; DBNLB; CARD11; FYN; CD8B; CD8B1; MAP2K1
    B cell receptor signaling pathway MAP4K1; DAPP1; PDK2B; MAPK4; CDK6; RASGRP3; PIK3R5; AKT1; NRAS; BLNK
    TNF signaling pathway PTGS2; CASP7; MAP3K5; MAP2K7; FAS; RIPK1; IKBKB; CCL20; PIK3CB; CFLAR
    Circadian entrainment GRIN2A; PRKG2; NOS1AP; PER2; GNAS; KCNJ5; PLCB1; ITPR1; GNAO1; ITPR3
    Cholinergic synapse AKT1; CHRM1; GNAI3; KRAS; ACHE; KCNJ12; PLCB2; GNG10; CREB3L4; AKT2
    Dopaminergic synapse KCNJ5; GRIA4; ITPR1; CAMK2D; MAOB; CREB5; MAPK12; SLC18A2; PPP3CC; GNB4
    Estrogen signaling pathway HSPA1B; NRAS; ATF4; CALM4; PIK3CD; GNAS; GNAI1; HSP90B1; SHC2; PRKACA
    Prolactin signaling pathway SOCS2; ELF5; TH; SOCS5; STAT5A; PRL; RAF1; GALT; STAT1; CCND1
    Oxytocin signaling pathway KCNJ14; MYLK; PIK3R5; HRAS; MAP2K2; CALM1; CACNG6; CACNB3; EEF2K; RAF1
    Amphetamine addiction ARC; PRKCB; CALM1; CAMK2D; NETO2; CAMK2A; SIRT1; FOS; HDAC1; CREB3L2
    Salmonella infection MAPK11; IFNG1-2; ACTB1; WAS; MAPK8A; ACTB2; ACTB; CXCL8B.3; ARPC5LA; ARPC4L
    Pertussis MAPK9; IRF3; NFKB1; Hc; MAPK3; MAPK10; IL6; ITGA5; Il23a; Il12b; C4BP
    Leishmaniasis FCGR1A; TGFB3; HLA-DOA; IL12A; MAP3K7; Itgam&Itgb2; ITGB2; HLA-DMB; HLA-DQB1; HLA-DRB5
    Chagas disease (American trypanosomiasis) PIK3CD; C3; PIK3R2; PPP2CB; RELA; SMAD3; IL12A; IL6; PLCB3; AKT2
    Hepatitis B CCNA2; ATP6AP1; NFATC1; TBK1; PIK3R1; TLR3; FOS; CREB3L1; BIRC5; IFNB1
    HTLV-I infection ETS1; ZFP36; BUB3; HLA-DRA; WNT3A; FOS; HLA-DOA; PDGFRB; PTTG1; H2-Q10
    Herpes simplex infection STAT2; TBPL2; IFNA3; IFNA16; TLR2-2; TRAF5; HLA-A; TRAF1; IFNA5; CYCSB
    Pathways in cancer MAPK3; NKX3-1; CCNE1; TRP53; FGF19; WNT3A; FGF14; GNG11; PPARG; PAX8
    Colorectal cancer APC; DCC; ARAF; LEF1; GSK3B; MAP2K1; RHOA; MLH1; AXIN2; BRAF
    Choline metabolism in cancer DGKE; CHKA; DGKB; LYPLA1; PIP5K1A; SLC44A1; RAC1; RHEB; RALGDS; SLC44A2
    Rheumatoid arthritis CD80; Ccl12; ATP6V0B; ATP6V1E1; ITGB2L; ATP6V1B1; ATP6V0E1; IL15; H2-AA; HLA-DRB1

    FOS has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by FOS itself. We selected most functions FOS had, and list some proteins which have the same functions with FOS. You can find most of the proteins on our site.

    Function Related Protein
    R-SMAD binding MYOCD; C18orf1; RANBP3; SMURF1; SMAD4; PAX6; FOS; CTNNB1; ANKRD1; SMAD2
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ZNF562; MYC; NFIA; ATOH1; TBX15; HHEX; NFAT5; OVOL1; FOXK2; MYOD1
    RNA polymerase II core promoter sequence-specific DNA binding TFAP2B; H3F3A; SOX3; SP3; SUZ12; GATA6; SOX8; STAT6; SMYD3; MITF
    chromatin binding NEUROG1; UBE2T; SOX9; NFATC2; HMGB2; MSGN1; RBPJL; PARP1; BARX2; YBX2
    protein binding ERP27; IFIT2; DCDC2; TLR13; C11orf46; UBE2Z; GPX7; OPA1; BAK1; ITGB4
    transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding ATF3; JDP2; ARNTL; FOSB; MSX1; HIST2H3A; RBPJL; FOS; FOSL1A; DDN
    transcription factor activity, sequence-specific DNA binding LCOR; POUV; SMAD3A; ZKSCAN14; ZNF311; HEY2; POU5F1; ZNF19; TBX19; FOXP4
    transcription factor binding DIP2B; JUNB; PIAS1; EP300; CRY1; GTF2B; PPARGC1B; NKX3; RPS3; MED12
    transcription regulatory region DNA binding ARRB1; KCNA3; TP53; GATA3; TA; BCOR; Arid4b; XRCC6; NKX3-1; ZFP746
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding NFATC2; CEBPE; BATF; MYC; PITX2; POU2F2; NEUROG3; MTF1; CREB3; BCL11B

    FOS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOS here. Most of them are supplied by our site. Hope this information will be useful for your research of FOS.


    Ming, J; Zhang, QF; et al. Anti-Lymphangiogenesis Effects of a Specific Anti-Interleukin 7 Receptor Antibody in Lung Cancer Model In Vivo. MOLECULAR CARCINOGENESIS 54:148-155(2015).
    Fahrenkrug, J; Falktoft, B; et al. Phosphorylation of Rat Melanopsin at Ser-381 and Ser-398 by Light/Dark and Its Importance for Intrinsically Photosensitive Ganglion Cells (ipRGCs) Cellular Ca2+ Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 289:35482-35493(2014).

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