• Official Full Name
  • growth differentiation factor 2
  • Background
  • Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene. GDF2 belongs to the transforming growth factor beta superfamily. GDF2 has a role in inducing and maintaining the ability of embryonic basal forebrain cholinergic neurons (BFCN) to respond to a neurotransmitter called acetylcholine; BFCN are important for the processes of learning, memory and attention.[2] GDF2 is also important for the maturation of BFCN. Another role of GDF2 has been recently suggested. GDF2 is a potent inducer of hepcidin (a cationic peptide that has a antimicrobial properties) in liver cells (hepatocytes) and can regulate iron metabolism.[3] The physiological receptor of GDF2 is thought to be activin receptor-like kinase 1, ALK1 (also called ACVRL1), an endothelial-specific type I receptor of the TGF-beta receptor family. GDF2 is one of the most potent BMPs to induce orthotopic bone formation in vivo. BMP3, a blocker of most BMPs seems not to affect GDF2.
  • Synonyms
  • BMP-9; BMP9; GDF2; growth differentiation factor 2; GDF-2; bone morphogenetic protein 9; growth/differentiation factor 2; Human BMP9 ELISA KIT; Human; BMP9 ELISA KIT; ELISA KIT; BMP9 ELISA; KIT; ELISA
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GDF2 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDF2, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Differentiation Factor 2, His-tagged
Source (Host):CHOSpecies:Human
Product nameRecombinant Human GDF2 protein
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gdf2 protein, His-tagged
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gdf2 protein, His-tagged
Source (Host):CHO cellsSpecies:Mouse
Product nameRecombinant Mouse Gdf2
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GDF2 Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GDF2
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GDF2
Source (Host):Species:Human
Product nameRecombinant Human GDF2 293 Cell Lysate

Involved Pathway

GDF2 involved in several pathways and played different roles in them. We selected most pathways GDF2 participated on our site, such as ALK1 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ALK1 signaling events

Protein Function

GDF2 has several biochemical functions, for example, cytokine activity, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF2 itself. We selected most functions GDF2 had, and list some proteins which have the same functions with GDF2. You can find most of the proteins on our site.
Related Protein
Function cytokine activity
Related Protein IFNA13; IFNK; CMTM3; Il1f8; GM13285; WNT5A; IFNA16; GDF11; BMP7A; SCGB3A1
Function growth factor activity
Related Protein NRG2; GDF7; REG1A; OSGIN1; CNTF; FGF12; FGF6A; TGFB1; AGT; BMP1
Function protein binding
Related Protein CINP; MRFAP1; KDM6B; SCO1; PROC; DRD1; FOXP1; PAXIP1; RAD52; PLOD3
Function transforming growth factor beta receptor binding
Related Protein NODAL; SMURF2; TGFBR3; NDR1; MSTN; GDF5; USP15; GDF9; BMP8B; GDF10

GDF2 Related Articles

Srinivasan, C; Siddiqui, A; et al. Stability characterization and appearance of particulates in a lyophilized formulation of a model peptide hormone-human secretin. INTERNATIONAL JOURNAL OF PHARMACEUTICS 481:104-113(2015).
Li, YJ; El Mozen, LA; et al. Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint. SCIENTIFIC REPORTS 5:-(2015).

GDF2 Related Gene Family