Active Recombinant Human GDF2 Protein

• Cat.No.: GDF2-019H
• Product Overview: The mature recombinant human BMP-9 protein consists of 110 amino acids (320-429) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 320-429 a.a.
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia.
• Bio-activity: Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.4-1.6 ng/mL.
• Molecular Mass: 12 kDa
• Product-Related Proteins: 320-429
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: GDF2 growth differentiation factor 2 [ Homo sapiens (human) ]
• Official Symbol: GDF2
• Synonyms: GDF2; growth differentiation factor 2; BMP9; HHT5; BMP-9; growth/differentiation factor 2; bone morphogenetic protein 9
• Gene ID: 2658
• mRNA Refseq: NM_016204
• Protein Refseq: NP_057288
• MIM: 605120
• UniProt ID: Q9UK05