Active Recombinant Human GDF2 protein
| Cat.No. : | GDF2-27488TH |
| Product Overview : | Recombinant human GDF-2 is a 24.1 kDa disulfide linked homodimeric protein consisting of two 110 amino acid polypeptide chains. |
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| Description : | GDF-2 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-2 is expressed mainly in nonparenchymal cells of the liver, but is also found in other various cells and tissues. GDF-2 can signal through the ALK1 receptor and has been implicated in a number of physiologic events. These include regulation of the hepatic reticuloendothelial system, glucose homeostasis, and iron homeostasis, as well as the inhibition of angiogenesis. |
| Source : | CHO |
| Species : | Human |
| Form : | Sterile filtered through a 0.2 micron filter. Lyophilized with no additives. |
| Bio-activity : | Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.9 ng/ml. |
| AA Sequence : | SAGAGSHCQ KTSLRVNFE DIGWDSWII APKEYEAYE CKGGCFFPL ADDVTPTKH AIVQTLVHL KFPTKVGKA CCVPTKLSP ISVLYKDDM GVPTLKYHY EGMSVAECG CR |
| Endotoxin : | Endotoxin level is < 0.1 ng/μg of protein (<1EU/μg). |
| Purity : | Above 95% as determined by SDS-PAGE Analysis. |
| Storage : | Store at -20 centigrade. |
| Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 centigrade to -80 centigrade |
| Tag : | Non |
| Gene Name : | GDF2 growth differentiation factor 2 [ Homo sapiens ] |
| Official Symbol : | GDF2 |
| Synonyms : | GDF2; growth differentiation factor 2; growth/differentiation factor 2; BMP 9; BMP9; GDF-2; bone morphogenetic protein 9; BMP-9; |
| Gene ID : | 2658 |
| mRNA Refseq : | NM_016204 |
| Protein Refseq : | NP_057288 |
| MIM : | 605120 |
| UniProt ID : | Q9UK05 |
| Chromosome Location : | 10q11.22 |
| Pathway : | ALK1 signaling events, organism-specific biosystem; |
| Function : | cytokine activity; growth factor activity; protein binding; |
Products Types
| ◆ Lysates | ||
| GDF2-5970HCL | Recombinant Human GDF2 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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