Active Recombinant Human GDF2 protein
| Cat.No. : | GDF2-27488TH |
| Product Overview : | Recombinant human GDF-2 is a 24.1 kDa disulfide linked homodimeric protein consisting of two 110 amino acid polypeptide chains. |
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| Species : | Human |
| Source : | CHO |
| Tag : | Non |
| Description : | GDF-2 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-2 is expressed mainly in nonparenchymal cells of the liver, but is also found in other various cells and tissues. GDF-2 can signal through the ALK1 receptor and has been implicated in a number of physiologic events. These include regulation of the hepatic reticuloendothelial system, glucose homeostasis, and iron homeostasis, as well as the inhibition of angiogenesis. |
| Form : | Sterile filtered through a 0.2 micron filter. Lyophilized with no additives. |
| Bio-activity : | Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.9 ng/ml. |
| AA Sequence : | SAGAGSHCQ KTSLRVNFE DIGWDSWII APKEYEAYE CKGGCFFPL ADDVTPTKH AIVQTLVHL KFPTKVGKA CCVPTKLSP ISVLYKDDM GVPTLKYHY EGMSVAECG CR |
| Endotoxin : | Endotoxin level is < 0.1 ng/μg of protein (<1EU/μg). |
| Purity : | Above 95% as determined by SDS-PAGE Analysis. |
| Storage : | Store at -20 centigrade. |
| Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 centigrade to -80 centigrade |
| Gene Name | GDF2 growth differentiation factor 2 [ Homo sapiens ] |
| Official Symbol | GDF2 |
| Synonyms | GDF2; growth differentiation factor 2; growth/differentiation factor 2; BMP 9; BMP9; GDF-2; bone morphogenetic protein 9; BMP-9; |
| Gene ID | 2658 |
| mRNA Refseq | NM_016204 |
| Protein Refseq | NP_057288 |
| MIM | 605120 |
| UniProt ID | Q9UK05 |
| Chromosome Location | 10q11.22 |
| Pathway | ALK1 signaling events, organism-specific biosystem; |
| Function | cytokine activity; growth factor activity; protein binding; |
Not For Human Consumption!
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