Active Recombinant Human GDF2 protein

• Cat.No.: GDF2-27488TH
• Product Overview: Recombinant human GDF-2 is a 24.1 kDa disulfide linked homodimeric protein consisting of two 110 amino acid polypeptide chains.

Specification

• Species: Human
• Source: CHO
• Tag: Non
• Description: GDF-2 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-2 is expressed mainly in nonparenchymal cells of the liver, but is also found in other various cells and tissues. GDF-2 can signal through the ALK1 receptor and has been implicated in a number of physiologic events. These include regulation of the hepatic reticuloendothelial system, glucose homeostasis, and iron homeostasis, as well as the inhibition of angiogenesis.
• Form: Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
• Bio-activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.9 ng/ml.
• AA Sequence: SAGAGSHCQ KTSLRVNFE DIGWDSWII APKEYEAYE CKGGCFFPL ADDVTPTKH AIVQTLVHL KFPTKVGKA CCVPTKLSP ISVLYKDDM GVPTLKYHY EGMSVAECG CR
• Endotoxin: Endotoxin level is < 0.1 ng/μg of protein (<1EU/μg).
• Purity: Above 95% as determined by SDS-PAGE Analysis.
• Storage: Store at -20 centigrade.
• Reconstitution: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 centigrade to -80 centigrade

Gene Information

• Gene Name: GDF2 growth differentiation factor 2 [ Homo sapiens ]
• Official Symbol: GDF2
• Synonyms: GDF2; growth differentiation factor 2; growth/differentiation factor 2; BMP 9; BMP9; GDF-2; bone morphogenetic protein 9; BMP-9
• Gene ID: 2658
• mRNA Refseq: NM_016204
• Protein Refseq: NP_057288
• MIM: 605120
• UniProt ID: Q9UK05
• Chromosome Location: 10q11.22
• Pathway: ALK1 signaling events, organism-specific biosystem
• Function: cytokine activity; growth factor activity; protein binding