GPNMB
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Official Full Name
glycoprotein (transmembrane) nmb
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Overview
Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. The mouse and rat orthologues of GPNMB are known as DC-HIL and Osteoactivin (OA), respectively. Two transcript variants encoding 560 and 572 amino acid isoforms have been characterized for this gene in humans. GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein. GPNMB has been reported to be expressed in various cell types, including: melanocytes, osteoclasts, osteoblasts, dendritic cells, and it is overexpressed in various cancer types. In melanocytic cells and osteoclasts the GPNMB gene is transcritionally regulated by Microphthalmia-associated transcription factor. In osteoblast progenitor cells, Osteoactivin works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. In addition, using a rat fracture model, Osteoactivin (OA) enhances the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis (soft callus) and osteogenesis (hard callus) compared to the intact femurs that is why Osteoactivin (OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, Osteoactivin expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells. -
Synonyms
GPNMB; HGFIN; NMB; glycoprotein (transmembrane) nmb; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; dendritic cell-associated transmembrane protein; iris pigment dispersion; osteoactivin; transmembrane glycoprotein NMB;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human cells
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- DYKDDDDK
- Fc
- Fc Chimera
- Flag
- GST
- hFc
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- GPNMB Related Articles
- GPNMB Related Research Area
GPNMB involved in several pathways and played different roles in them. We selected most pathways GPNMB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GPNMB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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GPNMB has several biochemical functions, for example, heparin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPNMB itself. We selected most functions GPNMB had, and list some proteins which have the same functions with GPNMB. You can find most of the proteins on our site.
Function | Related Protein |
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heparin binding | CCDC80;LTBP2;ABI3BP;CTGF;WISP2;ADAMTS8;WISP1A;ABP1;FGFR2 |
integrin binding | TSPAN8;EGFL6;FBN1;KDR;ESM1;VCAM1;CTGF;COL5A1;ADAM9 |
GPNMB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPNMB here. Most of them are supplied by our site. Hope this information will be useful for your research of GPNMB.
SMAD4
- Q&As
- Reviews
Q&As (6)
Ask a questionIn the experiment, the GPNMB gene can be introduced into the expression vector by gene cloning technology, and then the GPNMB recombinant protein can be expressed in Escherichia coli or eukaryotic cells.
Animal models carrying human mutant genes can be constructed using transgenic or gene editing technology to study the role and disease mechanism of GPNMB recombinant protein in vivo. These animal models can be used to study the effects of GPNMB recombinant proteins on tumor growth, metastasis, and drug resistance.
The current treatments for GPNMB recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for cell surface receptors and signal transduction processes.
By detecting the expression level and modification status of GPNMB recombinant protein, it can be used to diagnose certain tumor diseases. In addition, the recombinant protein of GPNMB may also become a new target for the treatment of tumors, providing new ideas and methods for tumor treatment.
GPNMB recombinant protein can interact with other proteins, such as cell surface receptors such as integrin, and participate in cell signal transduction processes.
If the level of GPNMB recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.
Customer Reviews (3)
Write a reviewThe potency and power of this protein met my expectations.
There are no adverse reactions and few side effects.
The quality of this one is very good, and they also have a long lifespan, and I am very satisfied with this product.
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