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GPNMB

  • Official Full Name

    glycoprotein (transmembrane) nmb

  • Overview

    Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. The mouse and rat orthologues of GPNMB are known as DC-HIL and Osteoactivin (OA), respectively. Two transcript variants encoding 560 and 572 amino acid isoforms have been characterized for this gene in humans. GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein. GPNMB has been reported to be expressed in various cell types, including: melanocytes, osteoclasts, osteoblasts, dendritic cells, and it is overexpressed in various cancer types. In melanocytic cells and osteoclasts the GPNMB gene is transcritionally regulated by Microphthalmia-associated transcription factor. In osteoblast progenitor cells, Osteoactivin works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. In addition, using a rat fracture model, Osteoactivin (OA) enhances the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis (soft callus) and osteogenesis (hard callus) compared to the intact femurs that is why Osteoactivin (OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, Osteoactivin expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells.
  • Synonyms

    GPNMB; HGFIN; NMB; glycoprotein (transmembrane) nmb; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; dendritic cell-associated transmembrane protein; iris pigment dispersion; osteoactivin; transmembrane glycoprotein NMB;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • DYKDDDDK
  • Fc
  • Fc Chimera
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GPNMB-747H Active Recombinant Human GPNMB, Fc Chimera Mammalian cells Fc Chimera
Human GPNMB-747HAF488 Active Recombinant Human GPNMB Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells Fc
Human GPNMB-747HAF555 Active Recombinant Human GPNMB Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells Fc
Human GPNMB-747HAF647 Active Recombinant Human GPNMB Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells Fc
Human GPNMB-747HF Active Recombinant Human GPNMB Protein, Fc-tagged, FITC conjugated Mammalian cells Fc
Human GPNMB-555H Recombinant Human GPNMB, Fc tagged Human Cell His
Human GPNMB-3783H Recombinant Human GPNMB protein, His-tagged HEK293 His 465
Human GPNMB-2280H Recombinant Human GPNMB, His-tagged E.coli His 476aa
Human GPNMB-3782H Recombinant Human GPNMB protein(Met1-Pro474), His-tagged HEK293 C-His Met1-Pro474
Human GPNMB-13430H Recombinant Human GPNMB, GST-tagged E.coli GST 22-181a.a.
Human GPNMB-1886HCL Recombinant Human GPNMB cell lysate Human Cell N/A
Human GPNMB-2980H Recombinant Human GPNMB protein, His-tagged E.coli His 38-158 aa
Human GPNMB-5162H Recombinant Human GPNMB Protein, GST-tagged Wheat Germ GST
Human GPNMB-2238H Recombinant Human GPNMB Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GPNMB-748H Recombinant Human GPNMB Protein, hFc-tagged HEK293 hFc Met1-Pro474
Human GPNMB-5557HF Recombinant Full Length Human GPNMB Protein, GST-tagged In Vitro Cell Free System GST 572 amino acids
Human GPNMB-747HA Recombinant Human GPNMB protein, Fc-tagged, APC labeled Mammalian cells Fc
Human GPNMB-747HP Recombinant Human GPNMB protein, Fc-tagged, R-PE labeled Mammalian cells Fc
Human GPNMB-82H Recombinant Human GPNMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GPNMB-01H Recombinant Human GPNMB Protein, His-Tagged Insect Cell His 462aa
Human GPNMB-151H Recombinant Human GPNMB Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human GPNMB-402H Recombinant Human GPNMB Protein, His-tagged HEK293 His 572
Human GPNMB-321HFL Active Recombinant Full Length Human GPNMB Protein, C-Flag-tagged Mammalian cells Flag
Human GPNMB-1579H Recombinant Human GPNMB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GPNMB-1265H Recombinant Human GPNMB protein, hFc&His-tagged HEK293 hFc&His Met1-Pro474
Human GPNMB-82H-B Recombinant Human GPNMB Protein Pre-coupled Magnetic Beads HEK293
Mouse GPNMB-872M Recombinant Mouse GPNMB Protein, His-tagged HEK293 His
Mouse GPNMB-1423MCL Recombinant Mouse GPNMB cell lysate Human Cell N/A
Mouse Gpnmb-3290M Recombinant Mouse Gpnmb Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque GPNMB-1939R Recombinant Rhesus monkey GPNMB Protein, His-tagged Mammalian Cell His
Rhesus Macaque GPNMB-1759R-B Recombinant Rhesus Macaque GPNMB Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GPNMB-1759R Recombinant Rhesus Macaque GPNMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GPNMB Related Articles
  • GPNMB Related Research Area

GPNMB involved in several pathways and played different roles in them. We selected most pathways GPNMB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GPNMB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

GPNMB has several biochemical functions, for example, heparin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPNMB itself. We selected most functions GPNMB had, and list some proteins which have the same functions with GPNMB. You can find most of the proteins on our site.

Function Related Protein
heparin bindingCCDC80;LTBP2;ABI3BP;CTGF;WISP2;ADAMTS8;WISP1A;ABP1;FGFR2
integrin bindingTSPAN8;EGFL6;FBN1;KDR;ESM1;VCAM1;CTGF;COL5A1;ADAM9

GPNMB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPNMB here. Most of them are supplied by our site. Hope this information will be useful for your research of GPNMB.

SMAD4

Torres, C; Linares, A; et al. The Potential Role of the Glycoprotein Osteoactivin/Glycoprotein Nonmetastatic Melanoma Protein B in Pancreatic Cancer. PANCREAS 44:302-310(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How to prepare GPNMB recombinant protein in the experiment? 02/21/2022

In the experiment, the GPNMB gene can be introduced into the expression vector by gene cloning technology, and then the GPNMB recombinant protein can be expressed in Escherichia coli or eukaryotic cells.

How to use animal models to study the function and disease mechanism of GPNMB recombinant protein? 02/18/2022

Animal models carrying human mutant genes can be constructed using transgenic or gene editing technology to study the role and disease mechanism of GPNMB recombinant protein in vivo. These animal models can be used to study the effects of GPNMB recombinant proteins on tumor growth, metastasis, and drug resistance.

What are the treatments for GPNMB recombinant protein? 07/22/2021

The current treatments for GPNMB recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for cell surface receptors and signal transduction processes.

What is the significance of GPNMB recombinant protein in tumor diagnosis and treatment? 08/26/2020

By detecting the expression level and modification status of GPNMB recombinant protein, it can be used to diagnose certain tumor diseases. In addition, the recombinant protein of GPNMB may also become a new target for the treatment of tumors, providing new ideas and methods for tumor treatment.

How does GPNMB recombinant protein interact with other proteins? 08/13/2020

GPNMB recombinant protein can interact with other proteins, such as cell surface receptors such as integrin, and participate in cell signal transduction processes.

If the level of GPNMB recombinant protein is abnormal, what should be treated? 03/06/2020

If the level of GPNMB recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.

Customer Reviews (3)

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Reviews
06/29/2022

    The potency and power of this protein met my expectations.

    02/01/2022

      There are no adverse reactions and few side effects.

      08/08/2021

        The quality of this one is very good, and they also have a long lifespan, and I am very satisfied with this product.

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