Recombinant Full Length Human GPNMB Protein, GST-tagged

• Cat.No.: GPNMB-5557HF
• Product Overview: Human GPNMB full-length ORF ( AAH32783.1, 1 a.a. - 572 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 88.44 kDa
• Protein Length: 572 amino acids
• AA Sequence: MECLYYFLGFLLLAARLPLDAAKRF HDVLGNERPSAYMREHNQLNGWSSD ENDWNEKLYPVWKRGDMRWKNSWKG GRVQAVLTSDSPALVGSNITFAVNL IFPRCQKEDANGNIVYEKNCRNEAG LSADPYVYNWTAWSEDSDGENGTGQ SHHNVFPDGKPFPHHPGWRRWNFIY VFHTLGQYFQKLGRCSVRVSVNTAN VTLGPQLMEVTVYRRHGRAYVPIAQ VKDVYVVTDQIPVFVTMFQKNDRNS SDETFLKDLPIMFDVLIHDPSHFLN YSTINYKWSFGDNTGLFVSTNHTVN HTYVLNGTFSLNLTVKAAAPGPCPP PPPPPRPSKPTPSLATTLKSYDSNT PGPAGDNPLELSRIPDENCQINRYG HFQATITIVEGILEVNIIQMTDVLM PVPWPESSLIDFVVTCQGSIPTEVC TIISDPTCEITQNTVCSPVDVDEMC LLTVRRTFNGSGTYCVNLTLGDDTS LALTSTLISVPDRDPASPLRMANSA LISVGCLAIFVTVISLLVYKKHKEY NPIENSPGNVVRSKGLSVFLNRAKA VFFPGNQEKDPLLKNQEFKGVS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GPNMB glycoprotein (transmembrane) nmb [ Homo sapiens ]
• Official Symbol: GPNMB
• Synonyms: GPNMB; glycoprotein (transmembrane) nmb; transmembrane glycoprotein NMB; glycoprotein NMB; glycoprotein nmb like protein; HGFIN; NMB; osteoactivin; transmembrane glycoprotein; glycoprotein nmb-like protein; transmembrane glycoprotein HGFIN
• Gene ID: 10457
• mRNA Refseq: NM_001005340
• Protein Refseq: NP_001005340
• MIM: 604368
• UniProt ID: Q14956