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Recombinant Human GPNMB protein, His-tagged

Cat.No. : GPNMB-3783H
Product Overview : Recombinant Human GPNMB protein (Ala22-Pro486), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).
  • Specification
  • Gene Information
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Description : Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 52.9 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : 465
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : GPNMB
Official Symbol : GPNMB
Synonyms : GPNMB; glycoprotein (transmembrane) nmb; transmembrane glycoprotein NMB; glycoprotein NMB; glycoprotein nmb like protein; HGFIN; NMB; osteoactivin; transmembrane glycoprotein; glycoprotein nmb-like protein; transmembrane glycoprotein HGFIN
Gene ID : 10457
mRNA Refseq : NM_001005340
Protein Refseq : NP_001005340
MIM : 604368
UniProt ID : Q14956

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to prepare GPNMB recombinant protein in the experiment? 02/21/2022

In the experiment, the GPNMB gene can be introduced into the expression vector by gene cloning technology, and then the GPNMB recombinant protein can be expressed in Escherichia coli or eukaryotic cells.

How to use animal models to study the function and disease mechanism of GPNMB recombinant protein? 02/18/2022

Animal models carrying human mutant genes can be constructed using transgenic or gene editing technology to study the role and disease mechanism of GPNMB recombinant protein in vivo. These animal models can be used to study the effects of GPNMB recombinant proteins on tumor growth, metastasis, and drug resistance.

What are the treatments for GPNMB recombinant protein? 07/22/2021

The current treatments for GPNMB recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for cell surface receptors and signal transduction processes.

What is the significance of GPNMB recombinant protein in tumor diagnosis and treatment? 08/26/2020

By detecting the expression level and modification status of GPNMB recombinant protein, it can be used to diagnose certain tumor diseases. In addition, the recombinant protein of GPNMB may also become a new target for the treatment of tumors, providing new ideas and methods for tumor treatment.

How does GPNMB recombinant protein interact with other proteins? 08/13/2020

GPNMB recombinant protein can interact with other proteins, such as cell surface receptors such as integrin, and participate in cell signal transduction processes.

If the level of GPNMB recombinant protein is abnormal, what should be treated? 03/06/2020

If the level of GPNMB recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.

Customer Reviews (3)

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Reviews
06/29/2022

    The potency and power of this protein met my expectations.

    02/01/2022

      There are no adverse reactions and few side effects.

      08/08/2021

        The quality of this one is very good, and they also have a long lifespan, and I am very satisfied with this product.

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