GRIN1 Protein, glutamate receptor, ionotropic, N-methyl D-aspartate 1


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Official Full Name glutamate receptor, ionotropic, N-methyl D-aspartate 1
Background The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Synonyms GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NR1; MRD8; GluN1; NMDA1; NMDAR1; glutamate receptor ionotropic, NMDA 1; NMD-R1; glutamate [NMDA] receptor subunit zeta 1; glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; N-methyl-D-aspartate receptor channel, subunit zeta-1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Grin1-1064M Recombinant Mouse Grin1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human GRIN1-217H Recombinant Human GRIN1 Mammalian Cell His
    Human GRIN1-2361H Recombinant Human GRIN1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GRIN1-5343H Recombinant Human GRIN1 Protein Wheat Germ N/A
    Human GRIN1-5344H Recombinant Human GRIN1 Protein, GST-tagged Wheat Germ GST
    Human GRIN1-5745HCL Recombinant Human GRIN1 293 Cell Lysate HEK293 N/A
    Rat GRIN1-2700R Recombinant Rat GRIN1 Protein Mammalian Cell His
    Chicken GRIN1-7102C Recombinant Chicken GRIN1 Mammalian Cell His

    GRIN1 involved in several pathways and played different roles in them. We selected most pathways GRIN1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway FGF16; RAB5C; GNG11; FGF18; CALM2; PIK3CB; IKBKB; RGL2; PLA2G10; PLD2
    Rap signaling pathway FGF7; PLCB4; ITGB3; PLCG1; ANGPT4; GNAS; MAP2K1; RASGRP3; MAPK11; PIK3CA
    Calcium signaling pathway ATP2B1; ORAI1B; PLCD1A; AGTR1B; TRHR; ATP2B3B; CCKBR; ATP2A1; ATP2A2; HTR4
    cAMP signaling pathway GRIN3B; HTR1E; GABBR1; GLI1; ROCK1; CAMK2B; VIPR2; HCAR3; PRKACA; CNGA3
    Neuroactive ligand-receptor interaction TAAR12I; NMUR2; TBXA2R; PTGER3; HCRTR2; CCKAR; TACR3; GABRE; CHRNB3A; GHSRA
    Circadian entrainment GNB2; GUCY1B3; GNAS; GNAO1; ITPR1; GRIN1; RYR2; GNG11; GNG12; GNGT2
    Long-term potentiation RPS6KA6; PRKACG; PLCB2; PPP1CC; GRIN1; ARAF; RPS6KA3; GRM1; HRAS; PPP3CC
    Glutamatergic synapse HOMER2; GRM1; GLUL; GNG11; SLC1A7; GNG10; GLS2; GRIN2D; GNG12; DLGAP1
    Alzheimers disease UQCRC2; ERN1; NDUFB9; NDUFB10; CASP8; NDUFS4; NDUFS7; UQCRQ; LRP1; PLCB1
    Amyotrophic lateral sclerosis (ALS) SLC1A2; GPX1; MAP2K6; NEFH; DAXX; BAD; NEFM; PPP3CA; CAT; APAF1
    Huntingtons disease NDUFA12; NDUFA1; POLR2F; NDUFC1; GPX1; HDAC2; NDUFB2; PLCB2; COX7A1; NDUFV1
    Cocaine addiction MAOA; CREB3L2; GRM3; GNAI3; DRD1; GRIN2D; GNAS; CREB3L4; GNAI2; GRIA2
    Amphetamine addiction FOSB; PRKACG; CAMK2G; CREB3L1; CALML3; FOS; JUN; CREB5; PPP3CC; PRKCA
    Nicotine addiction GABRA4; GABRG2; SLC17A6; GRIN1; GRIA1; GABRA1; SLC17A7; GABRR1; GRIN2C; GABRP
    Alcoholism NTRK2; SHC2; PDYN; MAPK1; HIST3H2A; HIST2H3C2; GNG4; ATF2; ATF6B; ADORA2A

    GRIN1 has several biochemical functions, for example, contributes_to NMDA glutamate receptor activity, contributes_to calcium channel activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIN1 itself. We selected most functions GRIN1 had, and list some proteins which have the same functions with GRIN1. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to NMDA glutamate receptor activity GRIN3A; PTK2B; GRIN1; GRIN2A
    contributes_to calcium channel activity GRIN1; GRIN2A; GRIN3B
    calcium ion binding EFCAB6; BGLAP; CALU; PCDH17; PITPNM3; ALOX15B; MYL13; NUCB2A; CALM; CAMKK2
    calmodulin binding CNN2; CAMK2D1; NOS1; RASGRF2; AEBP1; SNTB1; CAMK2A; ADD3; MYO6; AKAP5
    enzyme binding AKIRIN2; UGT1A2; PARK2; PARK7; KMT2E; LAMB1; DNMT3L; GSTM2; PLCB1; SIRT3
    extracellular-glutamate-gated ion channel activity GRIN1B; GRIA1B; GRIN2D; GRIN2BB; GRIA3B; GRIA4B; GRIA2A; GRIK4; KBP; GRIN1
    glutamate binding SLC1A1; GRIN1; CPS1; GLUL; GRIN2A; GRIK1; GAD2; GCLC; GRM7; SLC1A3
    glutamate receptor binding PLCG1; SYNDIG1; CAMK2A; GRIN1; GRIN2A
    glycine binding GNMT; GRIN3A; SRR; GRIN3B; ALAS2; GLDC; GLRA2; GLRA4B; GLRA1; GSS
    neurotransmitter binding GRIN1; NIPSNAP1; SLC6A11; GRIN3B; GRIN2A; SLC6A13
    protein binding PSG5; RFESD; SLA; SRPK2; MVP; PHF19; ABCF1; HESX1; STRN; ASGR2
    protein heterodimerization activity NTSR1; GTF2A2; MTTP; H2AFVA; PIK3R2; DVL3; BHLHE40; CHRNA5; DDX1; KCNH1
    voltage-gated cation channel activity GRIK1; GRIN1; PKD2; HVCN1; GRIN2A

    GRIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIN1.

    Tiam1; Tiam2; PLCB4; ERBB4

    Contreras-Vallejos, E; Utreras, E; et al. Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5(-/-) Mice. PLOS ONE 9:-(2014).
    Lieberman, R; Levine, ES; et al. Pilot Study of iPS-Derived Neural Cells to Examine Biologic Effects of Alcohol on Human Neurons In Vitro. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 36:1678-1687(2012).

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