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Recombinant Human GRIN1 Protein, GST-tagged

Cat.No. : GRIN1-5344H
Product Overview : Human GRIN1 partial ORF ( NP_015566, 21 a.a. - 120 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 36.74 kDa
AA Sequence : ACDPKIVNIGAVLSTRKHEQMFREA VNQANKRHGSWKIQLNATSVTHKPN AIQMALSVCEDLISSQVYAILVSHP PTPNDHFTPTPVSYTAGFYRIPVLG
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 [ Homo sapiens ]
Official Symbol : GRIN1
Synonyms : GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NMDAR1; glutamate [NMDA] receptor subunit zeta-1; GluN1; NMD-R1; glutamate [NMDA] receptor subunit zeta 1; N-methyl-D-aspartate receptor subunit NR1; N-methyl-D-aspartate receptor channel, subunit zeta-1; NR1; MRD8; NMDA1;
Gene ID : 2902
mRNA Refseq : NM_000832
Protein Refseq : NP_000823
MIM : 138249
UniProt ID : Q05586

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is the GRIN1 protein involved in neurodegenerative diseases? 08/10/2022

Dysregulation of the NMDA receptor, due to GRIN1 mutations, has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's.

What neurological disorders are associated with GRIN1 mutations? 06/09/2022

Disorders such as epilepsy, autism spectrum disorders, and schizophrenia have been linked to GRIN1 mutations.

Is there a genetic test for GRIN1 mutations? 01/12/2021

Yes, genetic testing can identify mutations in the GRIN1 gene, which may be helpful in diagnosing certain neurological conditions.

How does the GRIN1 protein contribute to synaptic plasticity? 03/15/2020

The NMDA receptor, with GRIN1 as a subunit, is crucial for long-term potentiation, a process underlying memory formation and learning.

Can variations in the GRIN1 gene affect response to antidepressants? 02/28/2018

Some studies suggest that genetic variations in GRIN1 may influence an individual's response to antidepressant medications.

Customer Reviews (3)

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Reviews
02/25/2022

    This strong track record of excellence further attests to the GRIN1 protein's capability to meet the rigorous demands of research projects.

    12/02/2019

      Whether measuring analyte concentrations, screening for specific interactions, or monitoring immune responses, this protein's exceptional performance in ELISA experiments is truly commendable.

      07/01/2016

        Its high quality, reliability, and exceptional performance make it an excellent choice for a wide range of experimental applications.

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