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GRIN2A

  • Official Full Name

    glutamate receptor, ionotropic, NMDA2A (epsilon 1)

  • Overview

    The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function. The NMDAR is a specific type of ionotropic glutamate receptor. NMDA (N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations. A unique property of the NMDA receptor is its voltage-dependent activation, a result of ion channel block by extracellular Mg2+ ions. This allows the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell to be voltage-dependent. Calcium flux through NMDARs is thought to play a critical role in synaptic plasticity, a cellular mechanism for learning and memory. The NMDA receptor is distinct in two ways: First, it is both ligand-gated and voltage-dependent; second, it requires co-activation by two ligands - glutamate and glycine (Rang et al (July 2010). Pharmacology. pp. 466.).
  • Synonyms

    Grin2a; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDAR2A; NR2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; OTTHUMP0000016013; OTTHUMP00000174531; glutamate [NMDA] receptor subunit epsilon-1; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA receptor subtype 2A; glutamate receptor, ionotropic, NMDA2A (epsilon1); GluN2A; GluRepsilon1; OTTMUSP00000017426;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRIN2A-1353H Recombinant Human GRIN2A protein, His-tagged E.coli His Pro31~Ala555
Human GRIN2A-1264H Recombinant Human GRIN2A Protein (501-550 aa & 601-630 aa & 701-750 aa), His-tagged E.coli His 501-550 aa & 601-630 aa & 701-750 aa
Human GRIN2A-4399H Recombinant Human GRIN2A protein, His-tagged E.coli His 23-555aa
Human GRIN2A-301466H Recombinant Human GRIN2A protein, GST-tagged E.coli GST Asp933-Gly1127
Human GRIN2A-2543H Recombinant Human GRIN2A Protein (Pro401-Arg539), N-His tagged E.coli N-His Pro401-Arg539
Human GRIN2A-2835H Recombinant Human GRIN2A protein(971-1050 aa), C-His-tagged E. coli C-His 971-1050 aa
Human GRIN2A-2545H Recombinant Human GRIN2A Protein (Pro23-Ala555), His tagged E.coli His Pro23-Ala555
Mouse GRIN2A-7270M Recombinant Mouse GRIN2A Protein Mammalian Cell His
Mouse GRIN2A-3931M Recombinant Mouse GRIN2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GRIN2A-3931M-B Recombinant Mouse GRIN2A Protein Pre-coupled Magnetic Beads HEK293
Mouse Grin2a-1590M Recombinant Mouse Grin2a Protein, His-tagged E.coli N-His Thr31-Ala555
Rat Grin2a-1591R Recombinant Rat Grin2a Protein, His-tagged E.coli N-His Pro31-Ala555
  • Involved Pathway
  • Protein Function
  • Interacting Protein

GRIN2A involved in several pathways and played different roles in them. We selected most pathways GRIN2A participated on our site, such as Ras signaling pathway, Rap signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIN2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwaySHC4;FGFR2;RAF1;RAB5B;FGF14;GNG12;FGFR3;PRKCA;PLA1A
Rap signaling pathwayPGF;ACTB;MLLT4;GNAS;PLCB1;MAPK12;RAPGEF5;VEGFA;PDGFD
Calcium signaling pathwayITPKA;PRKCA;P2RX3B;TACR2;AVPR1A;MYLK4;ATP2B3B;SLC25A4;PLCG1
cAMP signaling pathwayGRIA4;CNGA1;ARAP3;HTR1F;CALM1;ATP1A1;MAPK9;PTGER3;CREB3L1
Neuroactive ligand-receptor interactionGRIN1B;LPAR3;F2;TAAR11;MCHR1;GRPR;DRD2B;MLNR;GHRA
Circadian entrainmentCALM1;PLCB2;GNG2;GNGT1;GRIN2C;FOS;PRKG1;PLCB1;MTNR1A
Long-term potentiationRAF1;RAP1B;PPP3R2;RPS6KA3;RPS6KA2;CALM2;NRAS;CAMK4;PPP3CB
Glutamatergic synapsePPP3R2;PLCB2;GLS;PPP3CB;PRKCA;GNAS;GRM2;DLGAP1;SLC1A7
Dopaminergic synapsePPP3CC;PPP1CB;CALML3;KCNJ9;ARNTL;CREB3L4;PRKACB;ARRB2;GNG8
Alzheimers diseaseMAPT;BAD;CALML5;TNFRSF1A;NDUFAB1;NDUFV3;FADD;IDE;ATP5G1
Amyotrophic lateral sclerosis (ALS)CASP1;TNFRSF1A;GRIN2C;TRP53;MAPK13;NEFM;TNFRSF1B;NOS1;GRIN2D
Cocaine addictionPRKACG;PRKACB;GNAI3;CDK5R1;BDNF;RELA;FOSB;DLG4;CREB3L3
Nicotine addictionGABRP;GABRB2;GABRA1;GRIN3B;SLC17A6;GABRA3;GRIN2B;GABRA6;GABRE
AlcoholismGNG12;H2AFZ;CREB3L2;GNG3;GM14483;H3F3C;HIST3H2BB;HDAC8;HDAC1
Systemic lupus erythematosusACTN4;C4A;FCGR1A;HIST1H2BF;H3F3B;CD40;C1QB;HIST1H2BD;C5

GRIN2A has several biochemical functions, for example, ATPase binding, NMDA glutamate receptor activity, contributes_to NMDA glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIN2A itself. We selected most functions GRIN2A had, and list some proteins which have the same functions with GRIN2A. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingATP6V1E1;FXYD4;PEX19;SELS;S100A1;FBL;NUFIP1;TAF9;PIH1D1
NMDA glutamate receptor activityGRIN2B;GRIN3B;GRIN1A;GRIN2BB;GRIN2A;GRIN2D;GRIN3A;GRIN1B;GRIN2C
contributes_to NMDA glutamate receptor activityGRIN2A;GRIN1;GRIN3A;PTK2B
contributes_to calcium channel activityGRIN1;GRIN2A;GRIN3B
calcium channel activityTRPC3;PKD2L1;GRIN3A;CACNA1SB;SLC24A5;CACNA1DA;TRPV6;TRPV4;CACNG2A
cation channel activityTRPM1B;ASIC4B;TRPC1;ASIC3;FAM38A;TRPM1;GRIN2C;FAM26D;CALHM3
contributes_to cation channel activityGRIN2A;PKD1L3
cell adhesion molecule bindingCRTAM;DSG2;PVRL1A;SMAGP;SELL;FGG;PTBP3;NCR3;Fert2
extracellular-glutamate-gated ion channel activityGRIN2C;GRIN1B;GRIN3B;GRIK3;GRIK1;GRIN2D;GRIA3B;GRIA1;GRIK4
contributes_to extracellular-glutamate-gated ion channel activity
glutamate bindingGRIN1;CPS1;GLUL;GRM7;SLC1A1;GRIN2A;GAD2;SLC1A3;GRIK1
glutamate receptor bindingGRIN1;CAMK2A;SYNDIG1;PLCG1;GRIN2A
ion channel activityKCNC1B;KCNH5A;SCN8AA;TPCN1;SCN1LAB;GRIA2A;CLCN4-2;P2RX4A;TRPM4A
ionotropic glutamate receptor activityGRIK5;GRIN2BB;GRIA4A;GRID2;GRID1;KBP;GRIN1A;GRIA3B;GRIN1B
contributes_to ionotropic glutamate receptor activity
metal ion bindingPLAG1;ATP11A;PPP4CB;APOA1BP;GNA14;ZDHHC22;EFCAB5;PDLIM5A;ZNF620
neurotransmitter bindingSLC6A11;SLC6A13;GRIN2A;GRIN1;NIPSNAP1;GRIN3B
protein bindingMAP4K4;BFAR;CRB3;GRAP2;RELB;MEPE;ZNF664-FAM101A;PEF1;CCR1
protein complex bindingTRADD;CDKN1B;PPARA;RPTOR;UFD1L;PLK2;PFKP;VDAC1;UGT1A6B
protein dimerization activityEBF2;ASCL1A;HER4.3;MEF2B;NHLH2;DAO1;MNT;MYCH;MEF2CB
protein heterodimerization activityMYO5A;CHRNA3;TAF6L;KCNIP1;PKNOX1;BAD;HIST1H2AA;H2AFZ;UGT1A6A
protein kinase bindingHSP90AB1;VRK2;ZBTB4;SMAD1;ZFP36;RAB8A;CEP68;TENC1;PGAM1
receptor activityOPN1SW;TNFRSF10B;VMN1R43;LDLR;MED12;CD2;GRIA4B;LILRB4;EDAR
receptor bindingINSL4;IL28A;CD72;NOS2;NRG2B;FGF11;GCG;TIGIT;NRXN1
scaffold protein bindingCRIPT;TREM2;NLGN1;LRP4;KCNA5;PANX1;VIM;TREM1;CHRNA7
voltage-gated cation channel activityHVCN1;GRIN2A;GRIN1;GRIK1;PKD2
zinc ion bindingBTR06;TRIM10;MMP9;KDM5BA;ZCCHC18;ZNF331;MT1B;APOBEC3H;PGLYRP4

GRIN2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIN2A here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIN2A.

Dlg4; Grin1; Grin2b; Il16; Inadl

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