GRIN2A Protein, glutamate receptor, ionotropic, NMDA2A (epsilon 1)


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Official Full Name glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Background The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function. The NMDAR is a specific type of ionotropic glutamate receptor. NMDA (N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations. A unique property of the NMDA receptor is its voltage-dependent activation, a result of ion channel block by extracellular Mg2+ ions. This allows the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell to be voltage-dependent. Calcium flux through NMDARs is thought to play a critical role in synaptic plasticity, a cellular mechanism for learning and memory. The NMDA receptor is distinct in two ways: First, it is both ligand-gated and voltage-dependent; second, it requires co-activation by two ligands - glutamate and glycine (Rang et al (July 2010). Pharmacology. pp. 466.).
Synonyms Grin2a; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDAR2A; NR2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; OTTHUMP0000016013; OTTHUMP00000174531; glutamate [NMDA] receptor subunit epsilon-1; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA receptor subtype 2A; glutamate receptor, ionotropic, NMDA2A (epsilon1); GluN2A; GluRepsilon1; OTTMUSP00000017426
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRIN2A-1264H Recombinant Human GRIN2A Protein (501-550 aa & 601-630 aa & 701-750 aa), His-tagged E.coli His
    Human GRIN2A-1353H Recombinant Human GRIN2A protein, His-tagged E.coli His
    Mouse GRIN2A-7270M Recombinant Mouse GRIN2A Protein Mammalian Cell His

    GRIN2A involved in several pathways and played different roles in them. We selected most pathways GRIN2A participated on our site, such as Ras signaling pathway, Rap signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIN2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway RAPGEF5; FASLG; ARF6; RELA; HRAS; MLLT4; ETS1; PLD2; FGFR2; GNG8
    Rap signaling pathway GRIN2B; TEK; PRKCZ; PLCB2; FGF22; VEGFB; CDH1; F2R; FGF12; GNAO1
    Calcium signaling pathway CALM2B; EDNRBA; BDKRB1; PRKCB; PRKACBA; GRM1; PRKACAB; ATP2A3; GRPR; TBXA2R
    cAMP signaling pathway PPP1CA; RHOA; GRIN1; RYR2; GLP1R; FFAR2; PRKACG; GRIN3A; PDE4D; GPR81
    Neuroactive ligand-receptor interaction HCRTR1; TAAR5; TAAR14A; APLNRA; DRD7; HTR6; GRM2A; PTH1R; GABRA6; DRD2A
    Circadian entrainment GUCY1B3; CACNA1G; MTNR1B; GNG11; Adcy4; PLCB1; ITPR3; RYR2; KCNJ3; GNAI2
    Long-term potentiation CALM1; RAP1A; RPS6KA3; GRIN2D; MAPK3; PPP3R2; CAMK2D; MAP2K2; ATF4; CALML5
    Glutamatergic synapse GRIK2; GNG13; GRM1; GNB1; GNB3; PLA2G4F; GNGT1; GRIN3A; GRM2; GRM5
    Dopaminergic synapse PRKACB; ATF6B; GNG5; PRKCA; TH; ITPR1; ATF4; CREB3; PPP2R5B; CALM2
    Alzheimers disease MAPK1; PLCB2; CDK5R1; NDUFB11; PPP3CB; SDHD; CASP12; SNCA; IL1B; NDUFS5
    Amyotrophic lateral sclerosis (ALS) CAT; GRIA2; BCL2L1; MAPK11; PPP3R2; NOS1; NEFH; CASP9; PPP3R1; ALS2
    Cocaine addiction GRIN3B; ATF4; BDNF; CREB5; PRKACB; GPSM1; GNAI2; SLC6A3; CREB3; SLC18A1
    Amphetamine addiction PRKCA; CALML5; CAMK2G; CREB5; NETO2; TH; CALM4; GRIN2D; PRKACA; PPP3R1
    Nicotine addiction GRIA4; GRIN3B; GRIN2A; GABRE; GABRB3; GRIN2B; GRIA3; GABRA6; CHRNA6; SLC17A7
    Alcoholism HIST1H4K; H2AFY; HAT1; GM6026; HIST1H2AJ; MAP2K1; HIST1H2BC; SLC6A3; HRAS; HIST1H2AO
    Systemic lupus erythematosus C9; HIST3H3; SSB; C6; HIST2H2AA4; HIST1H2AD; HIST2H3C1; HIST1H2AO; HIST1H4F; HLA-DPA1

    GRIN2A has several biochemical functions, for example, ATPase binding, NMDA glutamate receptor activity, contributes_to NMDA glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIN2A itself. We selected most functions GRIN2A had, and list some proteins which have the same functions with GRIN2A. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding ATP6V0A1A; ATPIF1A; ATP6V1G3; SDF2L1; CAV1; ESR1; SYVN1; TCIRG1; FXYD4; ANK2
    NMDA glutamate receptor activity GRIN1A; GRIN2A; GRIN2B; GRIN2D; GRIN2C; GRIN1B; GRIN2BB; GRIN3B; GRIN3A
    contributes_to NMDA glutamate receptor activity GRIN2A; GRIN1; PTK2B; GRIN3A
    contributes_to calcium channel activity GRIN1; GRIN2A; GRIN3B
    calcium channel activity GRIN2A; CATSPER2; TRPM8; TRPV4; CACNG8A; GRIN2B; CACNG2A; RYR1; TRPN1; PANX1
    cation channel activity GRIN2A; GRIN2C; PKD1; ACCN3; FAM38B; FAM38A; TRPV4; ASIC1C; GRIN3B; FAM26D
    contributes_to cation channel activity PKD1L3; GRIN2A
    cell adhesion molecule binding PKP3; PVR; ITGB7; NLGN1; PVRL2; TENM2; CADM1B; GRIN2A; POSTNB; NRXN2
    extracellular-glutamate-gated ion channel activity GRIA1B; GRIK5; GRIK4; GRIN3A; GRIA3; GRIA4; GRID1; GRIN3B; GRIK3; GRIN1
    contributes_to extracellular-glutamate-gated ion channel activity GRIN2A
    glutamate binding GRIK1; CPS1; SLC1A1; GAD2; GLUL; GCLC; GRIN1; GRM7; GRIN2A; SLC1A3
    glutamate receptor binding GRIN1; GRIN2A; PLCG1; SYNDIG1; CAMK2A
    ion channel activity GJD3; CHRNA4B; SCNN1G; KCNH5; GRIA3B; TPC3; CHRNB3A; GRIK3; CLCNK; HTR3B
    ionotropic glutamate receptor activity GRIA2B; GRIA4A; GRIA4B; GRIK5; GRIN2A; GRID1; GRIN1B; GRIA1B; GRIA2; GRIA4
    contributes_to ionotropic glutamate receptor activity GRIN2A
    metal ion binding GNA14; ZFP143; TRIM35-7; ZBTB8B; DMRTA1; ARAP2; THAP4; ZNF576; HE1A; NUFIP1
    neurotransmitter binding SLC6A11; GRIN2A; SLC6A13; GRIN1; NIPSNAP1; GRIN3B
    protein binding PSMC6; SPATA22; IQCE; DLAT; KIAA1267; CCDC153; NR2C2; CORO2B; CYB5R1; HOXB6
    protein complex binding TMED10; RAD18; RNF40; EP300; IST1; LRP2; ARRB2; TXN2; MYO7A; WASF1
    protein dimerization activity CLOCKB; SRFB; KIF9; MXD3; HPSE; HES2; HER12; PEF1; NPAS2; BETA3
    protein heterodimerization activity KCNB1; BCL2L1; BAD; PPP3CA; SRI; ENO2; SOX17; HEXB; MAFA; HIST1H2AK
    protein kinase binding TRAF4; GPRC5B; SPRED2; ITGB2; MAVS; CD8A; HDAC7; RAD9; EPHA1; ILK
    receptor activity AMHR2; LILRB4; RAMP1; NR2C1; PVRL2L; F2RL1; ADIPOR2; APLNR; RTN4RL1; Tnfrsf22
    receptor binding GSTK1; WNT7A; TMED1; CRH; NPFF; INSL4; BMP3; EDN3; NMU; SSFA2
    scaffold protein binding KRT15; SHANK1; CACNA1H; VIM; TREM1; NLGN4Y; NLGN4X; CHRNA7; DLG4; NLRP1
    voltage-gated cation channel activity GRIK1; HVCN1; GRIN1; GRIN2A; PKD2
    zinc ion binding ZADH2; FTR14; LANCL1; ADAMTSL3; SIAH1A; NEIL3; NR4A2; SQSTM1; ZFP37; THRAA

    GRIN2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIN2A here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIN2A.

    Dlg4; Grin1; Grin2b; Il16; Inadl

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