Recombinant Rat Grin2a Protein, His-tagged

• Cat.No.: Grin2a-1591R
• Product Overview: Recombinant Rat Grin2a Protein (Pro31-Ala555) with N-His tag was expressed in E. coli.

Specification

• Description: Enables several functions, including enzyme binding activity; glutamate binding activity; and ligand-gated ion channel activity. Contributes to cation channel activity and extracellularly glutamate-gated ion channel activity. Involved in several processes, including cellular response to metal ion; central nervous system development; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; postsynaptic density; and synaptic membrane. Is integral component of plasma membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Used to study hyperhomocysteinemia. Biomarker of cognitive disorder; placental insufficiency; and status epilepticus. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A).
• Source: E. coli
• Species: Rat
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 62.5 kDa
  Accurate Molecular Mass: 63 kDa
• Protein length: Pro31-Ala555
• Purity: > 80%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Grin2a
• Synonyms: GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; NR2A; NMDAR2A
• Gene ID: 24409
• mRNA Refseq: NM_012573
• Protein Refseq: NP_036705
• UniProt ID: Q00959