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HMGB2

  • Official Full Name

    high mobility group box 2

  • Overview

    This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles.These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
  • Synonyms

    HMGB2; high mobility group box 2; high mobility group (nonhistone chromosomal) protein 2 , high mobility group box 2 , HMG2; high mobility group protein B2; HMG-2; high-mobility group box 2; high mobility group protein 2; high-mobility group (nonhistone;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|Flag|StrepII
  • Myc
  • DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HMGB2-711H Recombinant Human HMGB2 Protein, His-tagged E.coli His
Human HMGB2-13842H Recombinant Human HMGB2, GST-tagged E.coli GST 1-195a.a.
Human HMGB2-4869H Recombinant Human HMGB2 Protein, GST-tagged Wheat Germ GST
Human HMGB2-4868H Active Recombinant Human HMGB2 Protein, His-Flag-StrepII-tagged Human Cell His/Flag/StrepII
Human HMGB2-3598H Recombinant Human HMGB2 protein, His-tagged Insect Cell His
Human HMGB2-712H Recombinant Human HMGB2 Protein, His-tagged HEK293 His
Human HMGB2-5477HCL Recombinant Human HMGB2 293 Cell Lysate HEK293 N/A
Human HMGB2-3390H Recombinant Human HMGB2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HMGB2-2002HFL Recombinant Full Length Human HMGB2 Protein, C-Flag-tagged Mammalian cells Flag
Human HMGB2-3644HF Recombinant Full Length Human HMGB2 Protein, GST-tagged In Vitro Cell Free System GST 195 amino acids
Human HMGB2-147H Recombinant Human HMGB2 Protein (Met1-Glu209), C-His tagged, Animal-free, Carrier-free E.coli C-His Met1-Glu209
Human HMGB2-1080H-B Recombinant Human HMGB2 Protein Pre-coupled Magnetic Beads HEK293
Human HMGB2-1080H Recombinant Human HMGB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HMGB2-2738H Recombinant Human HMGB2 Protein (Gly2-Glu209), C-His tagged Mammalian cells C-His Gly2-Glu209
Human HMGB2-148H Recombinant Human HMGB2 Protein (Met1-Pro187), N-His-SUMO tagged, Animal-free, Carrier-free HEK293 N-His-SUMO Met1-Pro187
Human HMGB2-2739H Recombinant Human HMGB2 Protein (Gly2-Pro187), His tagged E.coli His Gly2-Pro187
Human HMGB2-177H Recombinant Human HMGB2 Protein, His-tagged E.coli His Gly2~Pro187
Mouse HMGB2-7729M Recombinant Mouse HMGB2 Protein Mammalian Cell His
Mouse HMGB2-4237M-B Recombinant Mouse HMGB2 Protein Pre-coupled Magnetic Beads HEK293
Mouse HMGB2-4237M Recombinant Mouse HMGB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hmgb2-3412M Recombinant Mouse Hmgb2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat HMGB2-2866R Recombinant Rat HMGB2 Protein Mammalian Cell His
Rat HMGB2-2521R Recombinant Rat HMGB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Hmgb2-1626R Recombinant Rat Hmgb2 Protein, His-tagged E.coli N-His Gly2-Pro187
Rat HMGB2-2521R-B Recombinant Rat HMGB2 Protein Pre-coupled Magnetic Beads HEK293
Chicken HMGB2-7035C Recombinant Chicken HMGB2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HMGB2 Related Articles

HMGB2 involved in several pathways and played different roles in them. We selected most pathways HMGB2 participated on our site, such as Activation of DNA fragmentation factor, Apoptosis, Apoptosis induced DNA fragmentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of DNA fragmentation factorDFFA;HMGB2;HIST1H1A;H1F0;HIST1H1D;HIST1H1C;HMGB2A;HIST1H1E;HIST1H1B
ApoptosisPRKACA;VIML;FASLG;AKT1;Gzmg;CAPN1A;BAXB;PPP3CB;GZME
Apoptosis induced DNA fragmentationH1F0;HIST1H1A;HIST1H1D;HMGB2A;DFFA;HIST1H1C;HIST1H1B;HMGB2;HIST1H1E
Apoptotic execution phaseHMGB2;OCLN;DNM1L;HIST1H1E;H1F0;DBNLA;CTNNB2;DFFA;CASP6L2
Programmed Cell DeathCASP6L1;DBNL;BMX;MLKL;DNM1L;STK24;STK26;DSG1;DIABLOA
RB in CancerTOP2A;RBP1;RABIF;SMARCA2;FAF1;HMGB2;DCK;HLTF;PRMT2

HMGB2 has several biochemical functions, for example, DNA binding, DNA binding, bending, RAGE receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGB2 itself. We selected most functions HMGB2 had, and list some proteins which have the same functions with HMGB2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingTCF4;SP4;ZNF800;ALX3;YBX2;ZFP335;ZFP488;HIVEP3;ZNF292A
DNA binding, bendingFOXD1;HMGB3;HMGA2;LEF1;TERF1;TOP2B;HHEX;SRY;FOXI1
RAGE receptor bindingS100P;HMGB1;HMGB2;S100A13;S100B;S100A8;S100A12;S100A9;FPR1
chemoattractant activityVHL;PDGFB;CXCL12B;CCL15;FGF2;VEGFA;VEGFB;FGF8;CCL5
chromatin bindingPSIP1;ING2;BEND6;ERCC6;RBMX;SIN3A;CBFA2T3;PROP1;NFIA
damaged DNA bindingTRP53;NEIL3;POLI;RAD23A;APEX1;RAD1;TP63;OGG1;APTX
double-stranded DNA bindingEGFR;GTF2H4;MRE11A;TP73;MTERF2;HMGB1;SATB1;PRKDC;TEF
drug bindingMT2A;CHRNA2;IL2RA;CHRNA7;PDE2A;ACE;PDE4C;PPARD;P2RX1
enhancer sequence-specific DNA bindingLMO4;ISL1;GATA1;KLF7B;KLF6A;LDB1;SOX11;MYT1;SOX9
four-way junction DNA bindingHMGB3;MEN1;YY1;HMGB1;HMGB2;DMC1;RAD51L1;RAD51;RAD51L3
non-sequence-specific DNA binding, bending
poly(A) RNA bindingEIF5A;CDC42EP4;PTCD1;PPIG;RPL7A;SBDS;HIST1H4H;SRSF5;EIF3C
protein bindingPROC;PRR16;PRKD1;RPS15;SH3GL1;GSG1;Ctsl;SPZ1;KSR1
protein domain specific bindingHIST1H4E;YWHAE2;ARFIP2A;SNCA;AIDA;CNTLN;PTPN11;STRN4;PRKCI
single-stranded DNA bindingRAD23A;YBX1;ERCC1;TDP2;LONP1;RAD23B;HNRNPDL;SSBP3A;FBXO18
supercoiled DNA bindingHMGB1;RPS3;HMGB2;PSIP1
transcription factor activity, sequence-specific DNA bindingPRDM15;ZNF812;VAX2;ZNF263;RORAA;EGR2B;ZNF354B;GTF2I;E2F4
transcription factor bindingGATA6;NAB1;NFATC3;TRIM11;CREG1;E2F2;PPARG;MDFI;POU5F1
transcription regulatory region DNA bindingGATA3;ARRB1;TNF;TOMM20A;SMAD7;PAX2;MSX2;KCNA3;TAF9

HMGB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGB2.

PKNOX1; CSNK1A1; 4505953; EIF1B; NFKB1; TRAF6; q81k61_bacan; mdm2_human_probe

Cottone, L; Capobianco, A; et al. 5-Fluorouracil causes leukocytes attraction in the peritoneal cavity by activating autophagy and HMGB1 release in colon carcinoma cells. INTERNATIONAL JOURNAL OF CANCER 136:1381-1389(2015).
Xu, PC; Lin, S; et al. C-reactive protein enhances activation of coagulation system and inflammatory response through dissociating into monomeric form in antineutrophil cytoplasmic antibody-associated vasculitis. BMC IMMUNOLOGY 16:-(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there a treatment strategy for HMGB2, and what are there? 06/24/2022

Therapeutic strategies for HMGB2 include inhibition of its activity, modulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against HMGB2 to inhibit its aberrant activity in disease, or the regulation of HMGB2 expression through gene knockout or overexpression techniques.

What diseases are HMGB2 associated with? 07/06/2021

Studies have shown that the aberrant expression of HMGB2 is associated with the occurrence of a variety of diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. In cancer, high expression of HMGB2 is closely related to tumor initiation, development, and metastasis.

Which biomolecules can be used as molecular markers of HMGB2? 11/05/2020

Certain biomolecules can serve as molecular markers of HMGB2, such as mRNA or protein of HMGB2 detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.

Which drugs can act on HMGB2? 09/21/2020

At present, some drugs have been developed to act on HMGB2, including some small molecule inhibitors and antibody drugs. These drugs can inhibit the activity of HMGB2 or modulate its expression, thereby treating diseases associated with abnormal expression of HMGB2.

How is the role of HMGB2 assessed in disease? 07/13/2020

The role of HMGB2 in disease can be assessed through in-depth analysis of the patient's genomic data, combined with the results of studies in cell and animal models. This can help doctors better understand the patient's condition and develop more effective treatment plans.

What are the detection methods for HMGB2? 06/12/2020

Detection methods for HMGB2 include immunohistochemistry, western blotting, real-time PCR, etc. These methods can detect the expression level of HMGB2 in tissues or cells to assess its status in the disease.

Customer Reviews (3)

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Reviews
04/02/2023

    After using HMGB2, my experiments are very reproducible, which is convenient for subsequent data analysis and experimental operation.

    09/01/2022

      The structure is stable and not easy to mutate.

      08/24/2020

        HMGB2 has a very high catalytic activity, which can greatly reduce the time and energy required for chemical reactions, and its economic value is immeasurable.

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