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Official Full Name high mobility group box 2
Background This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles.These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
Synonyms HMGB2; high mobility group box 2; high mobility group (nonhistone chromosomal) protein 2 , high mobility group box 2 , HMG2; high mobility group protein B2; HMG-2; high-mobility group box 2; high mobility group protein 2; high-mobility group (nonhistone
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Flag
    • StrepII
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HMGB2-13842H Recombinant Human HMGB2, GST-tagged E.coli GST
    Human HMGB2-177H Recombinant Human HMGB2 Protein, His-tagged E.coli His
    Human HMGB2-3598H Recombinant Human HMGB2 protein, His-tagged Insect Cell His
    Human HMGB2-4868H Recombinant Human HMGB2 Protein, His-Flag-StrepII-tagged Human Cell His/Flag/StrepII
    Human HMGB2-4869H Recombinant Human HMGB2 Protein, GST-tagged Wheat Germ GST
    Human HMGB2-5477HCL Recombinant Human HMGB2 293 Cell Lysate HEK293 N/A
    Human HMGB2-711H Recombinant Human HMGB2 Protein, His-tagged E.coli His
    Human HMGB2-712H Recombinant Human HMGB2 Protein, His-tagged HEK293 His
    Mouse HMGB2-7729M Recombinant Mouse HMGB2 Protein Mammalian Cell His
    Rat HMGB2-2866R Recombinant Rat HMGB2 Protein Mammalian Cell His
    Chicken HMGB2-7035C Recombinant Chicken HMGB2 Mammalian Cell His

    HMGB2 involved in several pathways and played different roles in them. We selected most pathways HMGB2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of DNA fragmentation factor HMGB2A; HIST1H1B; HIST1H1C; H1F0; DFFA; HIST1H1D; HIST1H1A; HIST1H1E; HMGB2
    Apoptosis induced DNA fragmentation DFFA; HIST1H1E; HIST1H1D; HMGB2A; HIST1H1B; H1F0; HMGB2; HIST1H1A; HIST1H1C
    Apoptotic execution phase DSG3; DBNLB; LMNB1; GAS2; DSP; STK26; BMX; PLECA; CASP6L1; CASP8L1
    Programmed Cell Death RNF8; BCAP31; STK24A; HMGB2; PLECA; DBNL; DAPK3; VIML; STK24B; DBNLA

    HMGB2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGB2 itself. We selected most functions HMGB2 had, and list some proteins which have the same functions with HMGB2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZNF571; TRIM26; HIST1H4J; ING2; DHX9; MYCLA; NR2F1A; NUCB2; HIST4H4; MXTX1
    DNA binding, bending HMGB1; FOXC1; LEF1; TOP2B; TFAM; TERF1; HHEX; HMGB3; FOXI1; FOXD1
    RAGE receptor binding S100A8; S100B; FPR1; HMGB1; S100A13; S100P; S100A4; S100A9; S100A12; S100A7
    chemoattractant activity HGF; LGALS3; BMP4; VEGFC; PDGFB; VHL; VEGFA; VEGFB; SCG2; SAA1
    chromatin binding RBPJL; NPM2; PAF1; NCAPD3; RELA; TDRD3; NOC2L; BEND6; SP140; TTC5
    damaged DNA binding PNKP; TRPC2; RAD23AB; RPS3; TRP53; TP53BP1; TP73; XPA; PCNA; APEX1
    double-stranded DNA binding TRP63; XRCC2; MEN1; HNRPDL; MTERFD2; HNRNPDL; TRP53; RAD51D; SP1; RAD51
    drug binding GLRB; PDE10A; SLC6A4A; HMGB2; PPARA; PYGL; TLR8; HTR1B; FOLR2; CHRNA3
    enhancer sequence-specific DNA binding TFAP2B; GATA1; KLF6A; KLF7B; TWIST1B; TBX19; GATA4; SOX9; SOX11; MYT1
    four-way junction DNA binding HMGB1; MEN1; RAD51L3; DMC1; YY1; HMGB2; HMGB3; RAD51L1; RAD51
    non-sequence-specific DNA binding, bending HMGB2
    poly(A) RNA binding MARK2; UBFD1; MRPS11; TPR; SRPK1; SRSF4; EEF1A1; MYBBP1A; ATP5A1; RPS12
    protein binding SPATA2; ERBB2; ECE1; RNH1; PBX2; INO80B; CSTF1; DAZAP2; PCP4; HM13
    protein domain specific binding ARFIP2; DDX6; YWHAQB; IGBP1; NEDD4; TNFAIP1; COX4I2; YWHABB; CHMP1B; NEFL
    single-stranded DNA binding WBP11; SSBP4; SSBP3A; SUB1; HNRPDL; TREX1; LUZP4; SSBP2; NEIL3; HMGB1
    supercoiled DNA binding PSIP1; HMGB2; HMGB1; RPS3
    transcription factor activity, sequence-specific DNA binding GATA6; MAFBB; FOSL1A; ZNF8; GATAD1; RCOR2; SCMH1; HOXC5; ZBTB25; AHRRB
    transcription factor binding PIAS2; TCF7L2; NAB1; NFATC3; GTF2A1; GTF2F1; AHR; GATA2; PPID; NAAA
    transcription regulatory region DNA binding KLF2A; REST; YAP1; IKZF3; POU5F1; GLI1; CTCF; SIX1; RFX6; ZNF567

    HMGB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGB2.

    PKNOX1; CSNK1A1; 4505953; EIF1B; NFKB1; TRAF6; q81k61_bacan; mdm2_human_probe

    Cottone, L; Capobianco, A; et al. 5-Fluorouracil causes leukocytes attraction in the peritoneal cavity by activating autophagy and HMGB1 release in colon carcinoma cells. INTERNATIONAL JOURNAL OF CANCER 136:1381-1389(2015).
    Xu, PC; Lin, S; et al. C-reactive protein enhances activation of coagulation system and inflammatory response through dissociating into monomeric form in antineutrophil cytoplasmic antibody-associated vasculitis. BMC IMMUNOLOGY 16:-(2015).

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