hmgb2
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  • Official Full Name
  • high mobility group box 2
  • Background
  • This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles.These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
  • Synonyms
  • HMGB2; high mobility group box 2; high mobility group (nonhistone chromosomal) protein 2 , high mobility group box 2 , HMG2; high mobility group protein B2; HMG-2; high-mobility group box 2; high mobility group protein 2; high-mobility group (nonhistone
Cat.#:HMGB2-177HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGB2 Protein, His-tagged
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Cat.#:HMGB2-4868HTag:His-Flag-StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human HMGB2 Protein, His-Flag-StrepII-tagged
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Cat.#:HMGB2-4869HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HMGB2 Protein, GST-tagged
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Cat.#:HMGB2-13842HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGB2, GST-tagged
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Cat.#:HMGB2-3598HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human HMGB2 protein, His-tagged
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Cat.#:HMGB2-711HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGB2 Protein, His-tagged
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Cat.#:HMGB2-712HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human HMGB2 Protein, His-tagged
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Cat.#:HMGB2-7729MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HMGB2 Protein
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Cat.#:HMGB2-2866RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HMGB2 Protein
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Cat.#:HMGB2-7035CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HMGB2
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Cat.#:HMGB2-5477HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HMGB2 293 Cell Lysate
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Involved Pathway

HMGB2 involved in several pathways and played different roles in them. We selected most pathways HMGB2 participated on our site, such as Activation of DNA fragmentation factor, Apoptosis, Apoptosis induced DNA fragmentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of DNA fragmentation factor
HIST1H1D; HMGB2A; HMGB2; DFFA; H1F0; HIST1H1C; HIST1H1B; HIST1H1E; HIST1H1A
Apoptosis
BID; PTBP3; BIRC7; DBNLB; IL1RAP; BNIP3L; CYCS; PRKACBA; BNIP3LB; PRKAR1B
Apoptosis induced DNA fragmentation
HIST1H1D; HIST1H1B; HMGB2; H1F0; HIST1H1A; HIST1H1C; DFFA; HIST1H1E; HMGB2A
Apoptotic execution phase
PKP1; PTBP3; PLECA; CASP6L2; VIML; H1F0; STK26; PLEC; CASP6L1; SPNA2
Programmed Cell Death
DAPK1; VIML; RIPK3; STK24B; CASP6L2; DNM1L; MLKL; STK26; GAS2; CASP6L1
RB in Cancer
RABIF; HMGB2; TOP2A; PRMT2; RBP1; FAF1; SMARCA2; DCK; HLTF; ANLN

Protein Function

HMGB2 has several biochemical functions, for example, DNA binding, DNA binding, bending, RAGE receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGB2 itself. We selected most functions HMGB2 had, and list some proteins which have the same functions with HMGB2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein RAD51L1; NR5A5; FOXL2; ZNF566; MIER1B; IMPDH2; ELMSAN1A; PAPD7; ZFP93; HER6
Function DNA binding, bending
Related Protein FOXD1; FOXI1; HHEX; HMGA2; HMGB3; TFAM; CRIP1; HMGB1; FOXL1; LEF1
Function RAGE receptor binding
Related Protein S100A4; S100A8; S100A13; S100A12; HMGB2; S100A7; FPR1; HMGB1; S100B; S100P
Function chemoattractant activity
Related Protein FGF2; CCL3; FGF7; SAA3; CXCL12; CXCL12A; SAA1; SCG2; HMGB1; LGALS3
Function chromatin binding
Related Protein KDM1A; JUN; SHMT2; NEUROD1; ATAD2; ATOH1A; POU1F1; SMC3; BAHD1; YBX2
Function damaged DNA binding
Related Protein RAD18; TP73; XRCC1; TDG; APEX1; H2AFX; EP300; RAD23A; RPA3; RAD23AB
Function double-stranded DNA binding
Related Protein PYDC3; FBXO18; ZNF638; SP8B; TDP1; TP73; TP53; EGFR; TDG; SP1
Function drug binding
Related Protein PDE2A; GABRA1; SIGMAR1; HMGB2; PYGM; DRD3; FABP1; MT2A; P2RX1; Alb
Function enhancer sequence-specific DNA binding
Related Protein GATA3; GATA5; LMO4; SOX9; GATA2; TFAP2B; TWIST1B; FOXN4; KLF6A; LDB1
Function four-way junction DNA binding
Related Protein MEN1; DMC1; YY1; RAD51L3; RAD51L1; RAD51; HMGB2; HMGB1; HMGB3
Function non-sequence-specific DNA binding, bending
Related Protein HMGB2
Function poly(A) RNA binding
Related Protein RPS10; HSPA9; DIAP1; U2AF2; DDX46; NCL; PRPF40A; ZNF326; NUSAP1; RBM47
Function protein binding
Related Protein APOD; IGF2; OCA2; ARPC4; POLB; PLSCR4; SAP18; PRDM14; PTPN23; RHO
Function protein domain specific binding
Related Protein SERPINB1A; EFS; CAPG; RHOA; PICK1; PRKCI; LIN7B; RAN; BASP1; CNTLN
Function single-stranded DNA binding
Related Protein CSDA; TDP2; TDP1; PMS1; NEIL3; MCM7; FBXO18; HMGB2; CTC1; HNRPDL
Function supercoiled DNA binding
Related Protein HMGB2; RPS3; PSIP1; HMGB1
Function transcription factor activity, sequence-specific DNA binding
Related Protein HOXC8; ELF1; POU3F2B; FOXQ1A; MYCL1; ZNF263; SMAD6A; CIR1; GTF2IRD1; GCM2
Function transcription factor binding
Related Protein FOXO1; HMGA1-RS1; GNPTAB; ESRRB; KDM1A; BCL10; TP73; PITX2; PURA; Trl
Function transcription regulatory region DNA binding
Related Protein HNF1A; KLF1; TAF7L; NFE2L2; TFEB; ZFP335; GLIS2; GRHL2B; NKX2-5; CDK5RAP2

Interacting Protein

HMGB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGB2.
PKNOX1; CSNK1A1; 4505953; EIF1B; NFKB1; TRAF6; q81k61_bacan; mdm2_human_probe

HMGB2 Related Articles

Cottone, L; Capobianco, A; et al. 5-Fluorouracil causes leukocytes attraction in the peritoneal cavity by activating autophagy and HMGB1 release in colon carcinoma cells. INTERNATIONAL JOURNAL OF CANCER 136:1381-1389(2015).
Xu, PC; Lin, S; et al. C-reactive protein enhances activation of coagulation system and inflammatory response through dissociating into monomeric form in antineutrophil cytoplasmic antibody-associated vasculitis. BMC IMMUNOLOGY 16:-(2015).