hmgb2
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  • Official Full Name
  • high mobility group box 2
  • Background
  • This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles.These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
  • Synonyms
  • HMGB2; high mobility group box 2; high mobility group (nonhistone chromosomal) protein 2 , high mobility group box 2 , HMG2; high mobility group protein B2; HMG-2; high-mobility group box 2; high mobility group protein 2; high-mobility group (nonhistone
Cat.#:HMGB2-177HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGB2 Protein, His-tagged
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Cat.#:HMGB2-4868HTag:His-Flag-StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human HMGB2 Protein, His-Flag-StrepII-tagged
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Cat.#:HMGB2-4869HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HMGB2 Protein, GST-tagged
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Cat.#:HMGB2-13842HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGB2, GST-tagged
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Cat.#:HMGB2-3598HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human HMGB2 protein, His-tagged
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Cat.#:HMGB2-711HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGB2 Protein, His-tagged
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Cat.#:HMGB2-712HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human HMGB2 Protein, His-tagged
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Cat.#:HMGB2-7729MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HMGB2 Protein
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Cat.#:HMGB2-2866RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HMGB2 Protein
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Cat.#:HMGB2-7035CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HMGB2
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Cat.#:HMGB2-5477HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HMGB2 293 Cell Lysate
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Involved Pathway

HMGB2 involved in several pathways and played different roles in them. We selected most pathways HMGB2 participated on our site, such as Activation of DNA fragmentation factor, Apoptosis, Apoptosis induced DNA fragmentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of DNA fragmentation factor
HIST1H1C; DFFA; HIST1H1A; HIST1H1B; H1F0; HIST1H1E; HIST1H1D; HMGB2A; HMGB2
Apoptosis
TICAM1; PIK3CD; BAX; PRKAR1B; PIK3R2; PRKACAA; TRAF2; STK24B; DSG2; CASP2
Apoptosis induced DNA fragmentation
DFFA; HIST1H1B; HIST1H1D; HMGB2A; H1F0; HMGB2; HIST1H1A; HIST1H1C; HIST1H1E
Apoptotic execution phase
VIML; STK24A; OCLN; CLSPN; PLEC; DSP; BMX; PKP1; DSG2; STK24
Programmed Cell Death
GZMC; DSG2; GZMF; GAS2; DSG3; ADD1; VIML; DAPK1; PKP1; DNM1L
RB in Cancer
RABIF; ANLN; PRMT2; HMGB2; DCK; TOP2A; SMARCA2; HLTF; FAF1; RBP1

Protein Function

HMGB2 has several biochemical functions, for example, DNA binding, DNA binding, bending, RAGE receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGB2 itself. We selected most functions HMGB2 had, and list some proteins which have the same functions with HMGB2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein APLP2; KHDRBS1; ZNF182; ZNF333; NR5A1A; DEK; H3F3B.1; SSBP3B; ZSCAN2; POU4F1
Function DNA binding, bending
Related Protein TOP2A; HHEX; LEF1; GATA1; HMGB2; HMGA2; HMGB1; FOXI1; HMGB3; SRY
Function RAGE receptor binding
Related Protein HMGB2; S100A13; S100A12; S100P; S100A7; S100B; FPR1; HMGB1; S100A4; S100A8
Function chemoattractant activity
Related Protein FGF10; HMGB1; VEGFC; CCL15; VEGFB; CCL5; FGF2; SAA1; VHL; FIGF
Function chromatin binding
Related Protein TRP63; ZKSCAN3; RNF20; ACTL6A; PAF1; PBX2; MEN1; DLX2; CBFA2T3; SMARCA2
Function damaged DNA binding
Related Protein RAD1; POLK; TRPC2; H2AFX; TRP53; MGMT; RPA2; NEIL3; FEN1; XRCC1
Function double-stranded DNA binding
Related Protein PIN4; HMGB2; XRCC2; AFF3; MTERF3; CTNNB1; FBXO18; PYDC3; NTHL1; GATA1A
Function drug binding
Related Protein HTR1B; TYMS; Alb; PPARA; DHODH; ABP1; PPARD; TLR8; CYP2D6; HMGCS1
Function enhancer sequence-specific DNA binding
Related Protein ATF2; HMGB2; KLF7B; GATA2; LDB1; SOX9; SOX11; GATA5; GATA1; YY1
Function four-way junction DNA binding
Related Protein RAD51L1; HMGB1; HMGB3; MEN1; RAD51L3; DMC1; YY1; RAD51; HMGB2
Function non-sequence-specific DNA binding, bending
Related Protein HMGB2
Function poly(A) RNA binding
Related Protein TRMT10C; NOLC1; RPL31; PCSK9; TIA1; MRPL15; TAF15; D19BWG1357E; HDGF; RBM26
Function protein binding
Related Protein SCN5A; PLP1; CLIC1; CYTIP; C17orf28; IL17F; SGOL2; EXOSC8; TSPAN15; TBX3
Function protein domain specific binding
Related Protein NFASC; TJP1; ZBTB16; KPNB1; MYH9; WNT1; ODF1; HIST1H4B; YWHAQ; ACSL3
Function single-stranded DNA binding
Related Protein PEO1; SSBP4; PMS1; FBXO18; SWSAP1; MCM6; HSPD1; CSDA; YBX1; MCM7
Function supercoiled DNA binding
Related Protein RPS3; PSIP1; HMGB1; HMGB2
Function transcription factor activity, sequence-specific DNA binding
Related Protein STAT2; MYRFL; CREB3L3L; BSX; GRHL2B; ZFP879; TBP; HIC1; FOXQ1B; CNBP
Function transcription factor binding
Related Protein SMAD3; ARRB1; PIAS1; TAF1; RB1; NCOR2; TWIST1; SNF8; KAT6B; IRF4
Function transcription regulatory region DNA binding
Related Protein NKX3; CALCOCO1; CTCFL; HDAC1; SMAD7; CTCF; CREB3L1; SOX7; XRCC6; ZNF567

Interacting Protein

HMGB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGB2.
PKNOX1; CSNK1A1; 4505953; EIF1B; NFKB1; TRAF6; q81k61_bacan; mdm2_human_probe

HMGB2 Related Articles

Cottone, L; Capobianco, A; et al. 5-Fluorouracil causes leukocytes attraction in the peritoneal cavity by activating autophagy and HMGB1 release in colon carcinoma cells. INTERNATIONAL JOURNAL OF CANCER 136:1381-1389(2015).
Xu, PC; Lin, S; et al. C-reactive protein enhances activation of coagulation system and inflammatory response through dissociating into monomeric form in antineutrophil cytoplasmic antibody-associated vasculitis. BMC IMMUNOLOGY 16:-(2015).