• Official Full Name
  • high mobility group box 3
  • Background
  • HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906), HMGB3;contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily;are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (Wilke et al., 1997;(PubMed 9370291); Nemeth et al., 2006 (PubMed 16945912)).
  • Synonyms
  • HMGB3; high mobility group box 3; high mobility group (nonhistone chromosomal) protein 4 , high mobility group box 3 , HMG4; high mobility group protein B3; HMG2A; MGC90319; non histone chromosomal protein; High mobility group protein 2a; High mobility group protein HMG4; HMG 4; HMGB 3; Nonhistone chromosomal protein HMG4; high-mobility group box 3; high mobility group protein 4; non-histone chromosomal protein; high-mobility group (nonhistone chromosomal) protein 4; HMG4; HMG-4; HMG-2a
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HMGB3 Protein, GST-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human HMGB3, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGB3, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HMGB3 Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HMGB3
Source (Host):Species:Human
Product nameRecombinant Human HMGB3 cell lysate

Protein Function

HMGB3 has several biochemical functions, for example, DNA binding, bending, chromatin binding, double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGB3 itself. We selected most functions HMGB3 had, and list some proteins which have the same functions with HMGB3. You can find most of the proteins on our site.
Related Protein
Function DNA binding, bending
Related Protein FOXD4; FOXL1; TERF1; GATA1; HMGB3; TOP2A; HMGB1; TOP2B; HMGB2; SRY
Function chromatin binding
Related Protein RDBP; DNMT3A; PRKAA2; NKX2-5; LHX2; C10orf119; ANKRD2; PLAC8; TAF2; JMJD5
Function double-stranded DNA binding
Related Protein TRP63; HES2; HLF; NTHL1; RAD51AP1; TDP1; ZNF638; TP53; DDX11; ERCC5
Function four-way junction DNA binding
Related Protein HMGB1; HMGB3; RAD51L3; MEN1; DMC1; RAD51; RAD51L1; HMGB2; YY1
Function poly(A) RNA binding
Related Protein RPS26; RBM8A; EEF1A1; PA2G4; SFPQ; HIST1H1C; HDAC2; LRP1; CSDE1; NAT10
Function protein binding
Related Protein FTCD; CALU; TMEM231; CLASP1; GPN3; SRP14; SENP6; PIM2; SKIV2L2; FAM103A1

Interacting Protein

HMGB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGB3.
SDCBP; TERF2IP; mdm2_human_probe

HMGB3 Related Articles

de Souza, AWS; Abdulahad, WH; et al. Are urinary levels of high mobility group box 1 markers of active nephritis in anti-neutrophil cytoplasmic antibody-associated vasculitis?. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:270-278(2014).
Kim, HY; Park, SY; et al. Inhibition of HMGB1-Induced Angiogenesis by Cilostazol via SIRT1 Activation in Synovial Fibroblasts from Rheumatoid Arthritis. PLOS ONE 9:-(2014).