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HSPA8

  • Official Full Name

    heat shock 70kDa protein 8

  • Overview

    This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    2410008N15Rik; Constitutive heat shock protein 70; Heat shock 70 kDa protein 8; Heat shock 70kD protein 10; Heat shock 70kD protein 8; Heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; Heat shock cognate 71 kDa protein.; Heat shock cognate protein 54; Heat shock cognate protein 71 kDa; Heat shock cognate protein 71-kDa; Heat shock protein 8; Heat shock protein A8; Heat-shock70-KD protein 10, formerly; <br/>HSC54; HSC71; Hsc73; HSP71; HSP73; HSP7C_HUMAN; HSPA10; HSPA8; LAP1; Lipopolysaccharide associated protein 1; LPS associated protein 1; LPS associated protein; MGC102007; MGC106514; MGC114311; MGC118485; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; NIP71;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSPA8-28200TH Active Recombinant Human HSPA8, His-tagged E.coli His
Human HSPA8-1558H Active Recombinant Human HSPA8 protein, His-tagged E.coli His
Human HSPA8-274H Recombinant Human HSPA8 protein, His/MBP-tagged E.coli His/MBP 419-601 aa
Human HSPA8-489H Recombinant Human HSPA8 Mammalian Cell His
Human HSPA8-1809H Recombinant Human Heat Shock 70kDa Protein 8 E.coli N/A
Human HSPA8-4712H Recombinant Human Heat Shock 70kDa Protein 8, His-tagged Human His
Human HSPA8-275H Recombinant Human HSPA8 protein, His/MBP-tagged E.coli His/MBP 222-369 aa
Human HSPA8-3897H Recombinant Human HSPA8, His tagged E.coli His
Human HSPA8-276H Recombinant Human HSPA8 protein, His/MBP-tagged E.coli His/MBP 22-120 aa
Human HSPA8-5111H Recombinant Human HSPA8 Protein, GST-tagged Wheat Germ GST
Human HSPA8-5353HCL Recombinant Human HSPA8 293 Cell Lysate HEK293 N/A
Human HSPA8-5430H Recombinant Human HSPA8 protein, His-tagged Yeast His 2-646aa
Human HSPA8-1121H Recombinant Human HSPA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HSPA8-018H Recombinant Human HSPA8 Protein, His-tagged E.coli His 2-646
Human HSPA8-069H Recombinant Human HSPA8 Protein, His-tagged E. coli His 2-646
Human HSPA8-342HFL Recombinant Full Length Human HSPA8 Protein, C-Flag-tagged Mammalian cells Flag
Human HSPA8-3962HF Recombinant Full Length Human HSPA8 Protein, GST-tagged In Vitro Cell Free System GST 646 amino acids
Human HSPA8-1121H-B Recombinant Human HSPA8 Protein Pre-coupled Magnetic Beads HEK293
Human HSPA8-3441H Recombinant Human HSPA8 Protein (Asp534-Gly615), N-His tagged E.coli N-His Asp534-Gly615
Mouse Hspa8-8259M Recombinant Mouse Hspa8 protein, His-tagged E.coli His Asp534~Gly615 (Accession # P63017)
Mouse HSPA8-7911M Recombinant Mouse HSPA8 Protein Mammalian Cell His
Mouse Hspa8-1174M Recombinant Mouse Hspa8 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HSPA8-4358M Recombinant Mouse HSPA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HSPA8-49M Recombinant Mouse HSPA8 Protein, His-tagged E.coli His
Mouse HSPA8-4358M-B Recombinant Mouse HSPA8 Protein Pre-coupled Magnetic Beads HEK293
Rat Hspa8-8260R Recombinant Rat Hspa8 protein, His-tagged E.coli His Asp534~Gly615 (Accession # P63018)
Rat HSPA8-2949R Recombinant Rat HSPA8 Protein Mammalian Cell His
Rat HSPA8-2604R-B Recombinant Rat HSPA8 Protein Pre-coupled Magnetic Beads HEK293
Rat HSPA8-2604R Recombinant Rat HSPA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine HSPA8-2650B Recombinant Bovine Heat Shock 70kDa Protein 8 E.coli N/A
Cattle HSPA8-8257C Recombinant Cattle HSPA8 protein, His-tagged E.coli His Asp534~Gly615 (Accession # P19120)
Rhesus Macaque HSPA8-2166R Recombinant Rhesus monkey HSPA8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HSPA8-1987R Recombinant Rhesus Macaque HSPA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HSPA8-1987R-B Recombinant Rhesus Macaque HSPA8 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HSPA8-6163Z Recombinant Zebrafish HSPA8 Mammalian Cell His
Chicken HSPA8-8258C Recombinant Chicken HSPA8 protein, His-tagged E.coli His Asp534~Gly615 (Accession # O73885)
Chicken HSPA8-6561C Recombinant Chicken HSPA8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSPA8 Related Articles

HSPA8 involved in several pathways and played different roles in them. We selected most pathways HSPA8 participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SpliceosomeNCBP2;SNRPD1;SRSF9;SFRS3B;SART1;RP9;SNRPD3L;PQBP1;SNRPA
MAPK signaling pathwayPPM1BB;DDIT3;FGF18A;CACNG6A;CACNA1G;CDC42L;MAPK8B;BRAF;PAK2
Protein processing in endoplasmic reticulumUBE2J2;NPLOC4;CRYAB;UBQLN1;DNAJC5;HSPA8;SAR1A;DNAJC5G;VIMP
EndocytosisCAPZA3;IQSEC3;CYTH1B;HRASB;IL2RA;GRK5;GRK1B;KIF5B;ADRB3
Antigen processing and presentationNFYC;HLA-B;IFI30;HLA-DPA1;HSPA2;PSME1;HLA-C;KIR2DL4;KLRC3
Estrogen signaling pathwayPIK3CA;SHC2;HSPA1B;GNAO1;PIK3R2;PLCB2;CREB3L3;AKT1;PIK3CG
LegionellosisHBS1L;TLR4;C3;SEC22B;IL6;HSPA1B;MYD88;HSPA2;CYCS
ToxoplasmosisMAP2K6;AKT1;BAD;RELA;BIRC2;CASP8;HLA-DQA1;PIK3R3;H2-AA
MeaslesIL6;IRAK1;IFNA14;AKT2;IL2RG;TLR9;STAT3;TRP53;NFKB1
Influenza ANLRP3;ACTG1;TNFSF10;TYK2;IKBKB;BCL2L2-PABPN1;IFNA6;TNFRSF10C;HLA-DQA2
Epstein-Barr virus infectionHLA-DQA1;AKT2;PSMD11;SNW1;HDAC4;PIK3R1;EP300;ITGAL;HLA-B

HSPA8 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA8 itself. We selected most functions HSPA8 had, and list some proteins which have the same functions with HSPA8. You can find most of the proteins on our site.

Function Related Protein
ATP bindingADCK2;ABCA1;SARS;SMARCAL1;EPRS;TRIP13;CLP1;EPHA8;PRKG1
ATPase activityDDX3X;KIF9;DNAH5;KIF2B;ABCD1;HSPA8;ABCA1B;KIF3CB;SMARCA5
ATPase activity, coupledVPS4A;HSP104;VPS4B;HSPA8;CCT8;HSPA1A;HSPA6;HSPA1B;ABCB1A
C3HC4-type RING finger domain bindingDNAJA1;HSPA1B;PINK1;KCNH2;HSPA1A;HSPA8
G-protein coupled receptor bindingHSPA8;PACRG;ADORA1;GNA15;AKAP5;GNA11A;GNA14;PARK2;GNAT3
MHC class II protein complex bindingHLA-DOB;ATP1B1;PKM2;CD74;CD81;HSP90AA1;ANXA11;HLA-DOA;PKM
enzyme bindingTxn1;GSTM7;ARRB2;PLCB1;CTNNB1;PPP1R3D;HIST1H2AD;LDB1;CUTA
heat shock protein bindingCDC37;PARK2;DNAJA3A;HSPA1A;LIMK1;GPR37;FKBP5;DMPK;TOMM34
poly(A) RNA bindingC1orf35;CCAR1;SERPINH1;RSRC2;TXN;MRPL54;RPS23;RBM38;DARS
protein bindingCIRH1A;PPM1F;CEP63;UBL4B;BRSK1;VENTX;CD70;SSX5;GTF3C5
ubiquitin protein ligase bindingWASH;TRAF2;TCEB2;SKI;GPI1;YWHAE;WFS1;HERC2;UBE2NA
unfolded protein bindingHSP90AA1;MKKS;SCG5;CHAF1B;GRPEL1;TOR1A;PFDN1;HTRA2;RUVBL2

HSPA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA8.

STUB1; LRRK2; HSPBP1; EGFR

Meleady, P; Doolan, P; et al. Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype. BMC BIOTECHNOLOGY 11:-(2011).
Carpenter, JE; Jackson, W; et al. Insulin-Degrading Enzyme Binds to the Nonglycosylated Precursor of Varicella-Zoster Virus gE Protein Found in the Endoplasmic Reticulum. JOURNAL OF VIROLOGY 84:847-855(2010).
  • Q&As
  • Reviews

Q&As (5)

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In the context of cellular stress, how does HSPA8 contribute to the heat shock response, and what downstream signaling pathways does it modulate to promote cell survival? 03/14/2022

HSPA8 is a central player in the heat shock response, assisting in the refolding of denatured proteins. It modulates downstream pathways such as HSF1 activation, orchestrating a cellular survival response.

Can you discuss the involvement of HSPA8 in neurodegenerative diseases, and how does its chaperone activity influence protein aggregation and neuronal dysfunction? 10/03/2021

HSPA8 plays a role in neurodegenerative diseases, mitigating protein aggregation and neuronal dysfunction. Its chaperone activity is crucial for maintaining protein homeostasis in the nervous system.

How does HSPA8 participate in the regulation of apoptosis, and what anti-apoptotic mechanisms does it employ to maintain cellular viability under stress conditions? 04/11/2020

HSPA8 exhibits anti-apoptotic functions by interacting with pro-apoptotic proteins and preventing their activation. Its role in apoptosis regulation contributes to cell survival during stress.

What is the significance of HSPA8 in autophagy, and how does it influence the selective degradation of misfolded proteins and damaged organelles? 09/27/2019

HSPA8 is involved in autophagy, facilitating the clearance of misfolded proteins and damaged organelles. It interacts with autophagy receptors, promoting their recognition by autophagosomes.

What are the mechanisms by which HSPA8 regulates the immune response, particularly its involvement in antigen presentation and the modulation of immune cell functions? 07/22/2018

HSPA8 participates in antigen presentation and modulates immune cell functions. It chaperones antigens for presentation on major histocompatibility complexes, influencing immune recognition and response.

Customer Reviews (3)

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Reviews
12/01/2021

    The lab product's precision and quality are noteworthy.

    10/25/2020

      The customer service team was accommodating, and the delivery exceeded my expectations.

      05/10/2018

        This lab product is synonymous with excellence.

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