HSPA8
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Official Full Name
heat shock 70kDa protein 8
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Overview
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
2410008N15Rik; Constitutive heat shock protein 70; Heat shock 70 kDa protein 8; Heat shock 70kD protein 10; Heat shock 70kD protein 8; Heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; Heat shock cognate 71 kDa protein.; Heat shock cognate protein 54; Heat shock cognate protein 71 kDa; Heat shock cognate protein 71-kDa; Heat shock protein 8; Heat shock protein A8; Heat-shock70-KD protein 10, formerly; <br/>HSC54; HSC71; Hsc73; HSP71; HSP73; HSP7C_HUMAN; HSPA10; HSPA8; LAP1; Lipopolysaccharide associated protein 1; LPS associated protein 1; LPS associated protein; MGC102007; MGC106514; MGC114311; MGC118485; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; NIP71;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Cattle
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Human
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- His|MBP
- MYC
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- HSPA8 Related Articles
HSPA8 involved in several pathways and played different roles in them. We selected most pathways HSPA8 participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Spliceosome | NCBP2;SNRPD1;SRSF9;SFRS3B;SART1;RP9;SNRPD3L;PQBP1;SNRPA |
MAPK signaling pathway | PPM1BB;DDIT3;FGF18A;CACNG6A;CACNA1G;CDC42L;MAPK8B;BRAF;PAK2 |
Protein processing in endoplasmic reticulum | UBE2J2;NPLOC4;CRYAB;UBQLN1;DNAJC5;HSPA8;SAR1A;DNAJC5G;VIMP |
Endocytosis | CAPZA3;IQSEC3;CYTH1B;HRASB;IL2RA;GRK5;GRK1B;KIF5B;ADRB3 |
Antigen processing and presentation | NFYC;HLA-B;IFI30;HLA-DPA1;HSPA2;PSME1;HLA-C;KIR2DL4;KLRC3 |
Estrogen signaling pathway | PIK3CA;SHC2;HSPA1B;GNAO1;PIK3R2;PLCB2;CREB3L3;AKT1;PIK3CG |
Legionellosis | HBS1L;TLR4;C3;SEC22B;IL6;HSPA1B;MYD88;HSPA2;CYCS |
Toxoplasmosis | MAP2K6;AKT1;BAD;RELA;BIRC2;CASP8;HLA-DQA1;PIK3R3;H2-AA |
Measles | IL6;IRAK1;IFNA14;AKT2;IL2RG;TLR9;STAT3;TRP53;NFKB1 |
Influenza A | NLRP3;ACTG1;TNFSF10;TYK2;IKBKB;BCL2L2-PABPN1;IFNA6;TNFRSF10C;HLA-DQA2 |
Epstein-Barr virus infection | HLA-DQA1;AKT2;PSMD11;SNW1;HDAC4;PIK3R1;EP300;ITGAL;HLA-B |
HSPA8 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA8 itself. We selected most functions HSPA8 had, and list some proteins which have the same functions with HSPA8. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | ADCK2;ABCA1;SARS;SMARCAL1;EPRS;TRIP13;CLP1;EPHA8;PRKG1 |
ATPase activity | DDX3X;KIF9;DNAH5;KIF2B;ABCD1;HSPA8;ABCA1B;KIF3CB;SMARCA5 |
ATPase activity, coupled | VPS4A;HSP104;VPS4B;HSPA8;CCT8;HSPA1A;HSPA6;HSPA1B;ABCB1A |
C3HC4-type RING finger domain binding | DNAJA1;HSPA1B;PINK1;KCNH2;HSPA1A;HSPA8 |
G-protein coupled receptor binding | HSPA8;PACRG;ADORA1;GNA15;AKAP5;GNA11A;GNA14;PARK2;GNAT3 |
MHC class II protein complex binding | HLA-DOB;ATP1B1;PKM2;CD74;CD81;HSP90AA1;ANXA11;HLA-DOA;PKM |
enzyme binding | Txn1;GSTM7;ARRB2;PLCB1;CTNNB1;PPP1R3D;HIST1H2AD;LDB1;CUTA |
heat shock protein binding | CDC37;PARK2;DNAJA3A;HSPA1A;LIMK1;GPR37;FKBP5;DMPK;TOMM34 |
poly(A) RNA binding | C1orf35;CCAR1;SERPINH1;RSRC2;TXN;MRPL54;RPS23;RBM38;DARS |
protein binding | CIRH1A;PPM1F;CEP63;UBL4B;BRSK1;VENTX;CD70;SSX5;GTF3C5 |
ubiquitin protein ligase binding | WASH;TRAF2;TCEB2;SKI;GPI1;YWHAE;WFS1;HERC2;UBE2NA |
unfolded protein binding | HSP90AA1;MKKS;SCG5;CHAF1B;GRPEL1;TOR1A;PFDN1;HTRA2;RUVBL2 |
HSPA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA8.
STUB1; LRRK2; HSPBP1; EGFR
- Q&As
- Reviews
Q&As (5)
Ask a questionHSPA8 is a central player in the heat shock response, assisting in the refolding of denatured proteins. It modulates downstream pathways such as HSF1 activation, orchestrating a cellular survival response.
HSPA8 plays a role in neurodegenerative diseases, mitigating protein aggregation and neuronal dysfunction. Its chaperone activity is crucial for maintaining protein homeostasis in the nervous system.
HSPA8 exhibits anti-apoptotic functions by interacting with pro-apoptotic proteins and preventing their activation. Its role in apoptosis regulation contributes to cell survival during stress.
HSPA8 is involved in autophagy, facilitating the clearance of misfolded proteins and damaged organelles. It interacts with autophagy receptors, promoting their recognition by autophagosomes.
HSPA8 participates in antigen presentation and modulates immune cell functions. It chaperones antigens for presentation on major histocompatibility complexes, influencing immune recognition and response.
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