HSPA8 Protein, heat shock 70kDa protein 8


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Official Full Name heat shock 70kDa protein 8
Background This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms 2410008N15Rik; Constitutive heat shock protein 70; Heat shock 70 kDa protein 8; Heat shock 70kD protein 10; Heat shock 70kD protein 8; Heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; Heat shock cognate 71 kDa protein.; Heat shock cognate protein 54; Heat shock cognate protein 71 kDa; Heat shock cognate protein 71-kDa; Heat shock protein 8; Heat shock protein A8; Heat-shock70-KD protein 10, formerly; <br/>HSC54; HSC71; Hsc73; HSP71; HSP73; HSP7C_HUMAN; HSPA10; HSPA8; LAP1; Lipopolysaccharide associated protein 1; LPS associated protein 1; LPS associated protein; MGC102007; MGC106514; MGC114311; MGC118485; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; NIP71
    • Species :
    • Bovine
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MBP
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSPA8-018H Recombinant Human HSPA8 Protein, His-tagged E.coli His
    Mouse Hspa8-1174M Recombinant Mouse Hspa8 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human HSPA8-1558H Recombinant Human HSPA8 protein, His-tagged E.coli His
    Human HSPA8-1809H Recombinant Human Heat Shock 70kDa Protein 8 E.coli N/A
    Human HSPA8-274H Recombinant Human HSPA8 protein, His/MBP-tagged E.coli His/MBP
    Human HSPA8-275H Recombinant Human HSPA8 protein, His/MBP-tagged E.coli His/MBP
    Human HSPA8-276H Recombinant Human HSPA8 protein, His/MBP-tagged E.coli His/MBP
    Human HSPA8-28200TH Recombinant Human HSPA8, His-tagged E.coli His
    Human HSPA8-3897H Recombinant Human HSPA8, His tagged E.coli His
    Human HSPA8-4712H Recombinant Human Heat Shock 70kDa Protein 8, His-tagged Human His
    Human HSPA8-489H Recombinant Human HSPA8 Mammalian Cell His
    Human HSPA8-5111H Recombinant Human HSPA8 Protein, GST-tagged Wheat Germ GST
    Human HSPA8-5353HCL Recombinant Human HSPA8 293 Cell Lysate HEK293 N/A
    Mouse HSPA8-7911M Recombinant Mouse HSPA8 Protein Mammalian Cell His
    Mouse Hspa8-8259M Recombinant Mouse Hspa8 protein, His-tagged E.coli His
    Rat HSPA8-2949R Recombinant Rat HSPA8 Protein Mammalian Cell His
    Rat Hspa8-8260R Recombinant Rat Hspa8 protein, His-tagged E.coli His
    Rhesus Macaque HSPA8-2166R Recombinant Rhesus monkey HSPA8 Protein, His-tagged Mammalian Cell His
    Bovine HSPA8-2650B Recombinant Bovine Heat Shock 70kDa Protein 8 E.coli N/A
    Chicken HSPA8-6561C Recombinant Chicken HSPA8 Mammalian Cell His
    Chicken HSPA8-8258C Recombinant Chicken HSPA8 protein, His-tagged E.coli His
    Zebrafish HSPA8-6163Z Recombinant Zebrafish HSPA8 Mammalian Cell His
    Cattle HSPA8-8257C Recombinant Cattle HSPA8 protein, His-tagged E.coli His

    HSPA8 involved in several pathways and played different roles in them. We selected most pathways HSPA8 participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Spliceosome BUD31; SF3B3; SNRNP200; PRPF40A; CDC5L; THOC2; XAB2; PPIE; NCBP1; SRSF1B
    MAPK signaling pathway MAPK3; RPS6KA2; RAP1AA; FGF18; ARRB2A; CACNG6; DUSP16; PDGFAB; MAP3K3; MAPK14B
    Protein processing in endoplasmic reticulum BAG2; HSPA6; UGGT2; TRAF2; NSFL1C; VIMP; DNAJC3; HSP70; UBE2E3; RRBP1B
    Endocytosis SH3GL3A; RAB7A; PLD2; ARAP3; KIF5C; TRAF6; ZFYVE20; HLA-G; VPS26A; RAB11BB
    Antigen processing and presentation CD8A; H2-AA; HLA-F; PSME2; KLRC1; KIR3DL1; H2-Q10; TAPBP; CALR; NFYB
    Estrogen signaling pathway KRAS; GABBR2; FKBP4; SHC4; HSP90AA1; GNAI2; HSPA2; MAPK3; GNAQ; ESR2
    Legionellosis ITGAM; RAB1A; HSPD1; NFKBIA; SAR1A; HSF1; HSPA1A; HSPA6; TLR5; CD14
    Toxoplasmosis LAMB1; TGFB2; CD40; LAMB2; GNAO1; IFNG; BAD; ALOX5; IL10RA; BIRC3
    Measles IL4; TBK1; IL2RA; PIK3R3; Fasl; Il2; IFNA10; EIF2AK2; AKT2; TNFAIP3
    Influenza A IFNA1; IL8L2; LOC780933; TNF; IFNA13; MAPK3; CXCL10; EIF2AK4; AKT2; ADAR
    Epstein-Barr virus infection RELB; IL10RA; PSMD4; CD58; POLR2K; SKP2; SFPI1; POLR2C; IKBKB; ENTPD8

    HSPA8 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA8 itself. We selected most functions HSPA8 had, and list some proteins which have the same functions with HSPA8. You can find most of the proteins on our site.

    Function Related Protein
    ATPase activity DNAH5; BLM; EIF4A1B; IDE; ABCC5; ABCF1; SWSAP1; KIF22; KIF1B; ABCG5
    ATPase activity, coupled VPS4B; ABCB1A; HSPA1A; MYH3; CCT8; HSPA1B; HSPA8; MYO1E; HSPA6; NSF
    C3HC4-type RING finger domain binding HSPA8; PINK1; DNAJA1; HSPA1A; KCNH2; HSPA1B
    G-protein coupled receptor binding PROK1; HSPA1A; GNA13A; INSL3; GNAI2; FYN; S1PR2; USP33; GNA15.4; GNA12A
    MHC class II protein complex binding CD74; YWHAE; HSP90AA1; HLA-DRB1; CD81; HLA-DOB; HLA-DMB; MS4A1; ATP1B1; PKM2
    enzyme binding Slc4a2; KMT2E; Alb; TRAF2; UGT1A7; DAOA; CSF3; TBP; PEX7; ZNF346
    heat shock protein binding FKBP4; GRXCR2; PARK2; DNAJA3B; DNAJB6; PACRG; HSPA8; DNAJA3A; BAX; HSPA1A
    poly(A) RNA binding MBNL2; YTHDC1; C1orf35; LSM8; GNL3L; CPSF4; RAN; ABT1; MEX3C; RPS14
    protein binding TTF2; N4BP2L2; NDFIP1; SFRP1; ROPN1B; RBM10; RCHY1; WDFY3; MYL12A; CHST13
    ubiquitin protein ligase binding RANGAP1; CXCR4; AXIN2; USP2; GPI1; CCDC50; XBP1; LC3; DNM1L; PRKAR2A
    unfolded protein binding NAP1L4; DNAJB13; DNAJA1; DNAJB6; GRPEL2; CCT6A; RP2; AFG3L2; HSPD1; TAPBP

    HSPA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA8.


    Meleady, P; Doolan, P; et al. Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype. BMC BIOTECHNOLOGY 11:-(2011).
    Carpenter, JE; Jackson, W; et al. Insulin-Degrading Enzyme Binds to the Nonglycosylated Precursor of Varicella-Zoster Virus gE Protein Found in the Endoplasmic Reticulum. JOURNAL OF VIROLOGY 84:847-855(2010).

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