ikbkg
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  • Official Full Name
  • IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
  • Background
  • NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-gamma) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IkappaB kinase that activates NF-kappaB. The human gene for IKBKG is located on chromosome Xq28. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; incontinentia pigmenti , IP1, IP2; NF-kappa-B essential modulator; FIP 3; FIP3; Fip3p; IKK gamma; NEMO; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; FIP-3; AMCBX1; IKK-gamma;
Cat.#:IKBKG-489HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKBKG Protein, MYC/DDK-tagged
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Cat.#:IKBKG-14134HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG, GST-tagged
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Cat.#:IKBKG-195HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG, GST-tagged
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Cat.#:IKBKG-196HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG(D311N), GST-tagged
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Cat.#:IKBKG-3022RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IKBKG Protein
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Cat.#:IKBKG-2265ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IKBKG
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Cat.#:IKBKG-1028HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-cells, Kinase Gamma, GST-tagged
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Involved Pathway

IKBKG involved in several pathways and played different roles in them. We selected most pathways IKBKG participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKG were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP2K2A; TGFB3; MAP3K11; STK4; ELK1; FGF2; RELA; TAB2; GNA12A; FGF17
Ras signaling pathway
PLCG2; PLA2G2E; GNG2; VEGFA; GNG7; RAF1; PRKCB; PAK1; LOC608458; CALM1
Chemokine signaling pathway
CCL18; CXCL5; PAK1; GNG2; HRAS; CCL7; PRKACB; VAV3; PF4; GRK7
NF-kappa B signaling pathway
PRKCQ; MAP3K7; Ccl21c; CCL19; BLNK; BCL10; GM1987; LCK; TNFRSF13C; LYN
PIK-Akt signaling pathway
RPS6KB1; COL4A1; GHR; ITGA4; ITGA1; ITGA3; PPP2CB; GSK3B; PPP2R3A; IFNB1
Apoptosis
YWHAQ; HRK; AKT1; PIK3CA; GAS2; CAPN1B; BCL2; PRKACBA; CASP10; GZME
Osteoclast differentiation
NFATC1; TGFB1; IFNGR1; FHL2; IFNB1; LILRA1; LILRB5; TEC; MITF; CYLD
Toll-like receptor signaling pathway
AKT2; IFNA1; CD14; TBK1; MAPK12A; MYD88; CCL4L2; IFNA13; TRAF3; IFNPHI3
NOD-like receptor signaling pathway
NAIP1; IL8L1; NFKB1; IL18; IL1B; MAPK12; IKBKG; SUGT1; PYCARD; MAPK11
RIG-I-like receptor signaling pathway
IFIH1; IFNPHI3; IFNA13; IFNE; NT5C3; IFNA21; RNF207B; MAPK9; CASP8; RIPK1L
Cytosolic DNA-sensing pathway
IKBKE; IL1B; IFNA8; MB21D1; IFNA3; IFNA16; POLR3H; NFKBIB; POLR1C; IFNA4
T cell receptor signaling pathway
IL4; RELA; GRAP2; PLCG1; PIK3CD; CD8B; MAPK13; VAV2; VAV3; NFKB1
B cell receptor signaling pathway
RELA; CARD11; cgr2b; PPP3R1; CDK6; RAP2A; PDK2B; ARPC3; CDK7; CD79B
TNF signaling pathway
CCL2; IL18R1; TRAF1; NFKB1; MAP2K4; TRADD; CASP8; PGAM5; CXCL10; MAP2K7
Adipocytokine signaling pathway
SLC2A1A; STAT3; JAK2; RXRAA; MAPK8A; NFKBIAB; PPARA; AKT1; ADIPOR1B; MAPK10
Epithelial cell signaling in Helicobacter pylori infection
ATP6V0A2; MAP3K14; CDC42; PLCG2; ATP6AP1; ATP6V1E2; RELA; MAPK9; ADAM17; IKBKB
Shigellosis
MAPK10; MAD2L2; ABL1; CD44; MAPK13; WAS; RHOG; MAPK3; BTRC; IKBKG
Chagas disease (American trypanosomiasis)
GNAI2; FASLG; MAPK11; GNAO1; MAP2K4; Ccl12; MAPK12; MYD88; PPP2R1A; PIK3CG
Toxoplasmosis
PIK3CA; HSPA8; PIK3R1; PIK3R2; HLA-DPA1; NFKB1; HLA-DOB; LDLR; RELA; LAMC1
Hepatitis C
PDPK1; MAPK13; PPP2R1A; MAPK9; MAPK3; IRF1; CLDN2; IFNB1; MAPK8; GRB2
Hepatitis B
MAP2K2; MAP2K4; IKBKE; ATP6AP1; IFNA5; PIK3R2; IL6; EGR2; HBXIP; DDB2
HTLV-I infection
LTBR; WNT2; MSX1; TLN1; TCF3; TERT; ITGB2; TBP; NFKB1; SLC25A31
Herpes simplex infection
EEF1DB; TAP2; H2-AB1; MAPK10; PVRL1B; STAT1A; TAF6L; GTF2I; TAB2; OAS2
Epstein-Barr virus infection
HLA-C; CD58; POLR2C; EP300; POLR2G; POLR3GL; HSPA8; CD38; PRKACB; POLR2J
Pathways in cancer
EPAS1; LAMA4; PTGS2; PLEKHG5; FGF20; WNT11; CTBP2; FZD3; Pdgfa&Pdgfb; PDGFA
Viral carcinogenesis
HIST3H2BB-PS; YWHAE; HIST1H2BB; VDAC3; HIST1H2BK; MAPKAPK2; TRADD; H2BFWT; HIST1H2BC; TRAF2
Pancreatic cancer
MAPK10; CDC42; SMAD2; STAT1; TGFB3; AKT2; PIK3CG; MAPK3; KRAS; RAC1
Prostate cancer
AKT1; TRP53; CREB3L3; PIK3CA; NKX3; CREB5; GRB2; PIK3R2; TCF7; PIK3CD
Chronic myeloid leukemia
CTBP2; BCL2L1; BCR; CCND1; AKT1; IKBKB; SHC2; CTBP1; MAPK3; ABL1
Acute myeloid leukemia
RARA; RAF1; EIF4EBP1; PIK3CG; PIK3R5; PIK3CB; MYC; CHUK; CCND1; MAP2K1
Small cell lung cancer
PIK3R3; LAMB2; BIRC8; RELA; TRAF2; PIK3R5; TRAF3; LAMB3; ITGA6; PIAS2
Primary i
ICOS; ORAI1; TAP2; AIRE; AICDA; TNFRSF13B; CD40LG; TAP1; CD8A; UNG
nodeficiency
CD79A; BTK; TAP1; CD3E; PTPRC; AIRE; RFXAP; CD19; IL7R; CD8B

Protein Function

IKBKG has several biochemical functions, for example, K63-linked polyubiquitin binding, linear polyubiquitin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKG itself. We selected most functions IKBKG had, and list some proteins which have the same functions with IKBKG. You can find most of the proteins on our site.
Function
Related Protein
Function K63-linked polyubiquitin binding
Related Protein TAB2; TNFAIP3; ZRANB1B; PRPF8; UIMC1; ATRIP; ZRANB1; SPRTN; SQSTM1; OTUD7B
Function linear polyubiquitin binding
Related Protein IKBKG
Function metal ion binding
Related Protein ACY1; RNF169; INO80B; UNC13C; MEP1A.1; ZDHHC18; SMPD3; BRCC3; ROCK2A; MYCBP2
Function peroxisome proliferator activated receptor binding
Related Protein EP300; ASXL1; NR0B2; IKBKG; HMGA1; ASXL2; HMGA1-RS1; PRMT2; PPARGC1A; CREBBP
Function protein binding
Related Protein LIPE; MYO9B; PLCB4; ZNF83; EFHA1; RECQL; DGAT1; MYO5B; PSMB9; SLX4
Function protein domain specific binding
Related Protein LAMP1; HIST1H4K; FOXA3; STX18; ABCC2; HIST1H4A; PTPN11; CEP68; CNTROB; YWHAG1
Function protein heterodimerization activity
Related Protein HER1; NEFL; TAS1R1; NKX2; CYBA; ATP4A; CD3G; TTR; SOX15; Itgam&Itgb2
Function protein homodimerization activity
Related Protein IRF3; PITX2; GIPC1; HHEX; GALE; CREB3; OLFM4; GIMAP7; DAPK3; C16orf89
Function signal transducer activity
Related Protein PTK2AA; TAAR10C; NPFFR1L1; NPFFR1L3; PLCD1B; MRGPRB2; ECT2; GNA12; GPR173; MTNR1BA
Function ubiquitin protein ligase binding
Related Protein H2-AB1; GABARAP; HM13; ATP6V0C; FZD6; UBE2KB; TRIB2; DERL1; TRAF6; EGFR

Interacting Protein

IKBKG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKG here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKG.
IKBKB