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Official Full Name IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Background NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-gamma) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IkappaB kinase that activates NF-kappaB. The human gene for IKBKG is located on chromosome Xq28. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; incontinentia pigmenti , IP1, IP2; NF-kappa-B essential modulator; FIP 3; FIP3; Fip3p; IKK gamma; NEMO; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; FIP-3; AMCBX1; IKK-gamma;
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IKBKG-1028H Recombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-cells, Kinase Gamma, GST-tagged Sf9 Insect Cell GST
    Human IKBKG-14134H Recombinant Human IKBKG, GST-tagged E.coli GST
    Human IKBKG-195H Recombinant Human IKBKG, GST-tagged E.coli GST
    Human IKBKG-196H Recombinant Human IKBKG(D311N), GST-tagged E.coli GST
    Human IKBKG-489H Recombinant Human IKBKG Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Rat IKBKG-3022R Recombinant Rat IKBKG Protein Mammalian Cell His
    Zebrafish IKBKG-2265Z Recombinant Zebrafish IKBKG Mammalian Cell His

    IKBKG involved in several pathways and played different roles in them. We selected most pathways IKBKG participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPK14A; TGFBR1A; MAPK12A; ARRB2B; STMN1B; C11orf52; TMEM37; FGF14; CACNG8; ATF4B1
    Ras signaling pathway MRAS; RGL1; CALM4; FGF4; ZAP70; INS1; PRKACB; GAB2; GNB4; GRIN2A
    Chemokine signaling pathway CCL6; CRKL; CRK; GNB1; NFKB1; Ccl27a; RHOA; CCR10; CCL3L3; CCR3
    NF-kappa B signaling pathway IL1B; Ccl21a; ICAM1; BCL10; TNFSF11; CD14; TNFRSF11A; IRAK1; BCL2L1; UBE2I
    PIK-Akt signaling pathway MET; FGF1; COL27A1; GSK3B; INS; THBS1; NGF; TLR4; PPP2CB; TSC1
    Apoptosis AKT3A; CAPN2L; TNFRSF1A; IRF2; AKT1; IL1R1; DBNLB; IRF4; DAPK3; BCAP31
    Osteoclast differentiation NFATC1; PPARG; PPP3R1; LILRA3; TGFB1; SOCS1; LILRA4; CYLD; CALCR; IFNB1
    Toll-like receptor signaling pathway CCL4; Ifna11; TLR3; IKBKB; IFNA12; RIPK1; IFNB; IFNA3; PIK3R2; MAPK8B
    NOD-like receptor signaling pathway Ccl12; PSTPIP1; MAPK8B; MAPK10; CASP5; CXCL8B.3; CASPA; MAPK8; CXCL2; SGUT1
    RIG-I-like receptor signaling pathway TRADD; TNF; IRF7; RIPK1; TRAF3; IFNA2; IFNA13; IFNPHI3; MAPK14A; IKBKG
    Cytosolic DNA-sensing pathway IFNA13; POLR3H; IFI202B; IL6; IKBKG; ADAR; IFNA3; NFKBIAA; IFNA14; POLR3G
    T cell receptor signaling pathway CD8A; NFATC1; FYN; NRAS; CD8B1; KRAS; SOS1; PAK1; TEC; MAPK9
    B cell receptor signaling pathway IFITM1; PDPK1A; BCL2L11; CRKL; CR2; CD72; RAC1; TTC6; PIK3R2; cgr2b
    TNF signaling pathway NFKB1; CXCL3; CREB3L2; CASP7; IKBKG; IL18R1; FAS; PIK3CD; IL15; ATF4
    Adipocytokine signaling pathway PCK2; NFKBIA; JAK2B; ACSL1A; IRS4; RXRGB; CAMKK1; AKT3A; NPY; PRKAA2
    Epithelial cell signaling in Helicobacter pylori infection ATP6V1A; ADAM17; ATP6V1D; CXCR1; RELA; ATP6V1B1; MAPK11; ATP6V1F; PLCG1; CCL5
    Shigellosis FBXW11; PFN4; WASL; RAC1; U2AF1; CDC42; ACTB; PFN3; ARPC5L; PFN2
    Chagas disease (American trypanosomiasis) MYD88; IKBKB; IFNG; TNF; ACE; IL1B; GNAQ; PPP2CB; PIK3CA; NFKB1
    Toxoplasmosis CYCS; MAPK12; LAMC1; IKBKG; CD40LG; MYD88; BIRC3; STAT3; STAT1; SOCS1
    Hepatitis C TP53; IFNA17; TNF; EIF2AK3; IL-8; IFNB1; TRAF6; PIK3CA; MAPK11; NFKBIA
    Hepatitis B MAPK8; PIK3R5; CCNA2; MYD88; FADD; STAT4; TGFB2; STAT5A; PTK2B; AKT1
    HTLV-I infection HLA-DMA; CRTC2; ETS1; DVL3; HLA-A; CREM; HRAS; WNT3; VAC14; AKT2
    Herpes simplex infection OAS2; HLA-B; TAF3; TRAF3; MAPK8B; HLA-DRB3; PPP1CA; HLA-DQA2; TLR2-1; CFP
    Epstein-Barr virus infection PIK3CB; EIF2AK1; PIK3R1; POLR3K; PSMC6; MAPK8; PIK3CA; HLA-G; RAN; HDAC4
    Pathways in cancer GNB3; FN1; FGFR1; PRKACA; MAPK3; GNAI3; WNT1; CSF1R; WNT4; MAPK10
    Viral carcinogenesis H2BFWT; PKM2; HIST1H2BK; SRF; YWHAH; GTF2A1L; HIST1H4F; VDAC3; LTBR; DNAJA3
    Pancreatic cancer PIK3R2; KRAS; ARHGEF6; BAD; CASP9; RAF1; MAPK10; TGFBR2; TP53; CCND1
    Prostate cancer MTOR; IKBKG; TCF7L2; TP53; ERBB2; FOXA1; SPRY1; MAP2K2; ARAF; NDRG1
    Chronic myeloid leukemia PIK3CD; PTPN11; CBLC; IKBKG; MECOM; SHC4; TGFBR2; CRKL; SOS1; CDK6
    Acute myeloid leukemia STAT5B; KRAS; ARAF; STAT3; RAF1; PIK3CG; PIM2; PML; LEF1; CCNA1
    Small cell lung cancer LAMC2; TRAF1; IKBKB; RELA; ITGA2B; TRAF6; PIK3CA; BCL2; IKBKG; LAMC1
    Primary i RFX5; CD4; CD8B; ORAI1; BLNK; IL7R; CD8B1; CD19; CD3E; CD40
    nodeficiency ORAI1; BLNK; UNG; IL2RG; TNFRSF13B; CD79A; ZAP70; BTK; CD8B1; RFXAP

    IKBKG has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKG itself. We selected most functions IKBKG had, and list some proteins which have the same functions with IKBKG. You can find most of the proteins on our site.

    Function Related Protein
    K63-linked polyubiquitin binding TAB2; UIMC1; OTUD7B; ZRANB3; TNFAIP3; IKBKG; ZRANB1; ZRANB1B; PRPF8; ATRIP
    linear polyubiquitin binding IKBKG
    metal ion binding SP1; CYP2N13; KDM2AA; ATP1A1A.4; CYP8B2; BGLAP2; ATP2C1; PLEKHM3; MTL5; ATX1
    peroxisome proliferator activated receptor binding HMGA1-RS1; MED1; NFATC4; CREBBP; NR0B2; HMGA1; IKBKG; PRMT2; EP300; ASXL1
    protein binding KIF20B; RPL19; NKX3-1; CPEB4; ALPL; Cd24a; ANK2; Fert2; SAP18; PVRL2
    protein domain specific binding WNT1; STX1A; RAN; ST13; ZNF521; PPP3R1; TUBA1A; ACSL3; DICER1; TBL1X
    protein heterodimerization activity TPD52; SOX14; PDGFA; CUL5; H2-AB1; NEUROD1; H2AFB3; ATF4; DDX1; ARNT2
    protein homodimerization activity TBX1; SLC24A6; GABRR1; PYGL; SETMAR; MFF; CISD2; CPOX; PITX2; NADKD1
    signal transducer activity PTH1RB; ZDHHC13; HTR1AA; ADRB2B; GPR98; PPP1R12A; TAAR10C; CCR6A; GNGT2A; PLCD4
    ubiquitin protein ligase binding CUL1A; POU5F1; MFN2; GABARAPL2; RRAGA; FANCL; PRKACA; UBOX5; PARK2; TCEB2

    IKBKG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKG here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKG.


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