IKBKG
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Official Full Name
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -
Overview
NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-gamma) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IkappaB kinase that activates NF-kappaB. The human gene for IKBKG is located on chromosome Xq28. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
IKBKG;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma;incontinentia pigmenti , IP1, IP2;NF-kappa-B essential modulator;FIP 3;FIP3;Fip3p;IKK gamma;NEMO;IKKG;IKKAP1;incontinentia pigmenti;IkB kinase gamma subunit;ikB kinase subunit gamma;NFkappaB essential modulator;NF-kappa-B essential modifier;I-kappa-B kinase subunit gamma;ikB kinase-associated protein 1;inhibitor of nuclear factor kappa-B kinase subunit gamma;IP;IP1;IP2;IPD2;FIP-3;AMCBX1;IKK-gamma
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- GST
- His
- DDK
- Myc
- Flag
- Avi
- Fc
Involved Pathway
IKBKG involved in several pathways and played different roles in them. We selected most pathways IKBKG participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chronic myeloid leukemia | HDAC1,STAT5A,GRB2,CDK6,SMAD4,MECOM,TGFB1,RAF1,BAD,KRAS |
| Toll-like receptor signaling pathway | LBP,PIK3CD,CXCL10,IL12B,IFNA5,TLR3,TLR1LB,CD14,TMED7-TICAM2,TLR7 |
| Osteoclast differentiation | SFPI1,SYK,FCGR2B,PPP3CA,LILRB3,TNFRSF11B,PIK3R5,IL1B,PPP3R1,FYN |
| Epstein-Barr virus infection | TRAF5,CD38,NCOR2,TRP53,YWHAG,HSPB1,GTF2E2,HLA-DRB4,YWHAZ,CCNA1 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V0D1,ATP6AP1,MAPK13,CCL5,CDC42,NFKBIA,CXCL1,PTPN11,MAPK10,ATP6V0A2 |
| Adipocytokine signaling pathway | NPY,SOCS3B,ACSL3B,AKT2,POMCA,ADIPOQB,SLC2A1,NFKBIAB,IRS1,CPT1A |
| T cell receptor signaling pathway | TNF,CD8B1,PIK3R5,PTPRC,AKT1,GRB2,MAP2K2,PPP3CB,ZAP70,VAV2 |
| Chagas disease (American trypanosomiasis) | LOC100033925,CXCL8,IFNG,PIK3R2,GNAO1,MAPK8,CCL3L3,PLCB1,NOS2,PPP2CA |
| Chemokine signaling pathway | FOXO3,GM13304,GNG12,CXCL8,CCL4L2,PAK1,ROCK1,CXCR3,CCL13,PLCB4 |
Protein Function
IKBKG has several biochemical functions, for example, K63-linked polyubiquitin binding,linear polyubiquitin binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKG itself. We selected most functions IKBKG had, and list some proteins which have the same functions with IKBKG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | NFKB1,OSTA,HPGD,SUMF1,PRLR,GSTM1,SMAD4,SERPINF2,C9orf142,EFR3A |
| peroxisome proliferator activated receptor binding | NR0B2,HMGA1,NFATC4,PRMT2,CREBBP,ASXL1,ASXL2,EP300,HMGA1-RS1,MED1 |
| metal ion binding | SHHA,CYP2AA6,ZBTB49,FBXO40.1,SIRT7,OVOL3,ZSCAN1,INO80B,DNAJA4,CAR1 |
| ubiquitin protein ligase binding | STUB1,GRIK2,CDC34A,NDUFS2,ANAPC2,CD40,CDKN1A,WASH1,CCT2,FHIT |
| K63-linked polyubiquitin binding | TAB2,ZRANB3,SPRTN,SQSTM1,PRPF8,RNF169,OTUD7B,UIMC1,TNFAIP3,RNF168 |
| protein domain specific binding | HOMER3,IL1B,TUBB,RCC2,STAMBP,AIDA,RXRA,AKAP5,CHMP1A,WNT5A |
| protein binding | CMTM5,NAA38,DEF6,ABCD2,KRT38,RRM2,RAB11FIP2,SOCS5,NHLH2,FCGR2B |
| signal transducer activity | CXCR3.1,PLCD1B,TRADD,MADD,TRHR2,MAPKAPK2,PLCD3A,PLCB4,GNA15.1,Sectm1a |
| protein heterodimerization activity | CA,BAXA,TYRO3,GTF2A1,MAFGA,UNC13A,BAX,PVRL1,SIM2,BOK |
Interacting Protein
IKBKG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKG here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKG.
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