ikbkg
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  • Official Full Name
  • IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
  • Background
  • NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-gamma) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IkappaB kinase that activates NF-kappaB. The human gene for IKBKG is located on chromosome Xq28. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; incontinentia pigmenti , IP1, IP2; NF-kappa-B essential modulator; FIP 3; FIP3; Fip3p; IKK gamma; NEMO; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; FIP-3; AMCBX1; IKK-gamma;
Cat.#:IKBKG-489HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKBKG Protein, MYC/DDK-tagged
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Cat.#:IKBKG-14134HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG, GST-tagged
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Cat.#:IKBKG-195HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG, GST-tagged
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Cat.#:IKBKG-196HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG(D311N), GST-tagged
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Cat.#:IKBKG-3022RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IKBKG Protein
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Cat.#:IKBKG-2265ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IKBKG
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Cat.#:IKBKG-1028HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-cells, Kinase Gamma, GST-tagged
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Involved Pathway

IKBKG involved in several pathways and played different roles in them. We selected most pathways IKBKG participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKG were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
STK3; FGF12; Pdgfa&Pdgfb; PPP5C; RELA; FGF8; MAPK14B; PRKCBB; TGFB1A; FGF9
Ras signaling pathway
PLCE1; CALML3; MAPK10; PAK3; PIK3R5; FGFR1; PLA2G2E; RHOA; FGFR2; IKBKG
Chemokine signaling pathway
CCR3; SHC4; PLCB3; CCL24; CXCL1; CCL15; JAK2; CXCL3; CCL23; PIK3R3
NF-kappa B signaling pathway
TNFSF13B; IL1B; BTK; CXCL12; TNFSF14; TLR4; LTB; BLNK; CCL13; RELB
PIK-Akt signaling pathway
GNG4; IL7R; Kitl; GNG8; FGF21; NRAS; HRAS; THBS4; KLK1B4; TCL1B1
Apoptosis
PIK3R3A; DIABLO; BIRC3; NFKBIA; IKBKG; PIK3R5; IRAK1; NTRK1; BOK; TNF
Osteoclast differentiation
PPP3CC; NFATC1; cgr2b; MAPK1; AKT2; PIK3CD; SOCS3; LILRA4; NFKBIA; TGFBR2
Toll-like receptor signaling pathway
IRF7; FOS; TLR1LA; RIPK1; MAP2K3; IFNA17; MAPK13; LY96; TLR5B; NFKBIAA
NOD-like receptor signaling pathway
NAIP6; CASP1; NLRP1; CARD8; MAPK3; IL-8; HSP90AA1; CXCL1; CCL2; SGUT1
RIG-I-like receptor signaling pathway
NLRX1; IFNK; MAVS; NFKBIA; TBK1; IFNA2; IFIH1; FADD; TBKBP1; IFNA16
Cytosolic DNA-sensing pathway
POLR2E; POLR3C; POLR3H; ZBP1; MAVS; ADAR; RIPK1L; NFKB1; IFNA8; IFNA7
T cell receptor signaling pathway
IL5; PPP3R1; MAPK13; DLG1; CD8B; MAP2K2; IFNG; CDC42; CD8A; DEF6A
B cell receptor signaling pathway
MAP4K1; PRKCB; ARPC1B; CRKL; NFATC2; SLA2; DOK3; MALT1; CARD11; NFKBIE
TNF signaling pathway
CXCL2; MAP2K4; TNFRSF1B; LIF; MAPK3; MAP2K6; MAPK12; CCL2; PIK3CB; CASP7
Adipocytokine signaling pathway
TRADD; AKT3A; PTPN11; RXRA; SLC2A4; LEPR; CHUK; AGRP; NFKBIA; ACSL3A
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1G3; MAPK11; ATP6V1A; ATP6V1G2; ATP6V1C1; PAK1; MAP2K4; SRC; IKBKG; ATP6V1D
Shigellosis
U2AF1; IKBKB; BTRC; MAPK10; ABL1; DIAPH1; MAPK1; HCLS1; SRC; CD44
Chagas disease (American trypanosomiasis)
IL10; CD3D; TICAM1; IRAK4; TGFB3; CD3E; PPP2CB; SMAD2; IL12A; CALR
Toxoplasmosis
LAMA1; BIRC3; Casp3; CYCS; TAB2; MAPK1; GNAI3; XIAP; MAPK10; PIK3R2
Hepatitis C
IFNA13; PIK3R5; CLDN5; IL-8; NFKBIA; AKT1; PIK3CB; MAVS; CLDN3; TNF
Hepatitis B
HBXIP; KRAS; DDX58; NFATC2; IFNA21; PIK3R1; SRC; NFATC4; TLR4; Ifna11
HTLV-I infection
XPO1; TBP; IL2RB; HLA-A; RANBP3; STAT5A; ELK4; ICAM1; CREM; HLA-DRA
Herpes simplex infection
TAF4B; OAS1B; IFNG1-2; STAT1B; TAF5; FADD; SRPK1; TLR2-1; NFKBIAA; IFNA8
Epstein-Barr virus infection
SFPI1; POLR1C; XPO1; POLR2K; PSMD7; PSMD11; PSMD1; AKAP8L; HDAC5; VIM
Pathways in cancer
ARNT2; RAC1; EGLN2; PLD1; Flt3l; EGLN1; ARAF; WNT16; ITGB1; TGFBR2
Viral carcinogenesis
HIST1H2BI; HIST1H2BH; BAD; CREB3L3; REL; HIST1H2BD; RELA; ATP6V0D1; HIST1H2BN; TRAF5
Pancreatic cancer
STAT3; PIK3R1; PIK3CG; TGFB2; STAT1; RB1; BRCA2; KRAS; RELA; PLD1
Prostate cancer
FGFR2; FOXO1; ARAF; NDRG1; HSP90AB1; TRP53; CPN1; MTOR; PDGFC; GRB2
Chronic myeloid leukemia
CDK6; NFKB1; IKBKB; TGFB1; SHC3; TRP53; AKT1; SMAD3; CBLC; TP53
Acute myeloid leukemia
GRB2; SPI1; RUNX1; SOS1; PIK3CB; AKT2; KIT; AKT1; LEF1; RUNX1T1
Small cell lung cancer
TRAF3; BIRC7; NOS2; LAMB4; TP53; PTK2; COL4A1; FN1; ITGA6; SKP2
Primary i
RFX5; TAP1; CD4; CD8B1; ORAI1; TNFRSF13B; PTPRC; CD3D; DCLRE1C; CD8A
nodeficiency
DCLRE1C; CD8B; LCK; PTPRC; RAG1; CD8B1; ICOS; BLNK; IKBKG; RFXANK

Protein Function

IKBKG has several biochemical functions, for example, K63-linked polyubiquitin binding, linear polyubiquitin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKG itself. We selected most functions IKBKG had, and list some proteins which have the same functions with IKBKG. You can find most of the proteins on our site.
Function
Related Protein
Function K63-linked polyubiquitin binding
Related Protein TAB2; ZRANB1B; SPRTN; PRPF8; ZRANB3; RNF169; UIMC1; ZRANB1; TNFAIP3; IKBKG
Function linear polyubiquitin binding
Related Protein IKBKG
Function metal ion binding
Related Protein KSR1; NUDT8; ZNF295; PNLIP; RNF26; SMYD1A; KDM5BA; ZNF703; PHLPP1; PKMYT1
Function peroxisome proliferator activated receptor binding
Related Protein NFATC4; ASXL2; CREBBP; PRMT2; IKBKG; EP300; NR0B2; MED1; PPARGC1A; HMGA1
Function protein binding
Related Protein SPATA13; GRHL3; TRIM2; PLN; KCTD15; RIBC2; GIMAP7; NAPB; HNRNPH1; BOLA1
Function protein domain specific binding
Related Protein HIST1H4E; XPA; ICA1; AKAP1; SKI; CALM1; CASP2; TWIST1; OSBP; BHLHE40
Function protein heterodimerization activity
Related Protein PDSS2; H3F3C; YWHAH; TFAP2E; SLC3A1; ATF6; TCF12; TOP2A; BCL2A; HIST1H2BF
Function protein homodimerization activity
Related Protein NTRK1; SLC39A13; TRIM5; SRGAP2; PVRL1A; LSM1; BCL2A1; CHMP3; ABCG2; NR6A1
Function signal transducer activity
Related Protein RGS11; MGAA; PTGER1C; PLEKHB1; TAS2R126; PTK2BB; OPN1MW4; GNB1; CHRM2A; OLFR154
Function ubiquitin protein ligase binding
Related Protein RNF34; HSPA1B; HM13; FOXO1; HSPA9; KCNQ3; SKI; SMC6; UBE2Z; UBE2J1

Interacting Protein

IKBKG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKG here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKG.
IKBKB