ikbkg
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  • Official Full Name
  • IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
  • Background
  • NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-gamma) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IkappaB kinase that activates NF-kappaB. The human gene for IKBKG is located on chromosome Xq28. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; incontinentia pigmenti , IP1, IP2; NF-kappa-B essential modulator; FIP 3; FIP3; Fip3p; IKK gamma; NEMO; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; FIP-3; AMCBX1; IKK-gamma;
Cat.#:IKBKG-489HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKBKG Protein, MYC/DDK-tagged
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Cat.#:IKBKG-14134HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG, GST-tagged
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Cat.#:IKBKG-195HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG, GST-tagged
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Cat.#:IKBKG-196HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG(D311N), GST-tagged
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Cat.#:IKBKG-3022RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IKBKG Protein
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Cat.#:IKBKG-2265ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IKBKG
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Cat.#:IKBKG-1028HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-cells, Kinase Gamma, GST-tagged
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Involved Pathway

IKBKG involved in several pathways and played different roles in them. We selected most pathways IKBKG participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGFR3; MAP2K3; PLA2G4AA; ARRB1; MAPK7; RRAS; RAP1B; FGF19; PLA2G4D; FGF10A
Ras signaling pathway
Fgf15; RAF1; NRAS; RAP1B; PIK3CG; VEGFB; ABL2; KSR1; FGFR4; FGF8
Chemokine signaling pathway
GM2506; GNG11; PLCB3; CCR10; SHC3; MAP2K1; CCL6; CCL26; PIK3CA; CXCL12
NF-kappa B signaling pathway
CD40; Bcl2a1b; BIRC3; LCK; TNFSF11; ATM; GM13304; NFKBIA; BCL2L1; BTK
PIK-Akt signaling pathway
FGF1; PPP2R5B; AKT2; Fgf15; GNG3; ITGB5; BCL2L1; EIF4E2; EPOR; LPAR5
Apoptosis
CASP4; NFKBIA; RELA; DSG1; BOK; GAS2; JUN; PRKAR2B; H1F0; HIST1H1E
Osteoclast differentiation
PPP3CC; cgr2b; IL1B; MAPK10; SOCS1; PPARG; TAB2; PIK3R2; NCF4; LILRB1
Toll-like receptor signaling pathway
IL8L1; AKT3A; RIPK1L; Ifna15; MAPK3; MAPK12; MAP2K2A; LBP; RAC1A; IFNA21
NOD-like receptor signaling pathway
NFKB1; MAPK8; NAIP7; NFKBIB; HSP90AB1; MAPK8B; MAPK8A; CXCL2; IKBKB; CCL2
RIG-I-like receptor signaling pathway
IFNW1; IFNK; IFNA17; NFKBIA; Ifna11; DHX58; RIPK1L; TANK; IFNB; MAPK14A
Cytosolic DNA-sensing pathway
IFNB; NFKBIB; IL18; IKBKB; IFNPHI3; IFNA1; IFNA13; DDX58; POLR3A; CCL4
T cell receptor signaling pathway
AKT1; RHOA; MAP3K14; MUC1; NFATC3; PAK2; NCK2; AKT2; CBLB; IL4
B cell receptor signaling pathway
VAV3; NFATC3; LAT2; PRKCB; PPP3R1; PLEKHA1; VAV1; LILRB3; NRAS; MAP4K1
TNF signaling pathway
MMP9; MAP3K7; NFKBIA; MAP2K1; TRAF2; CXCL3; BAG4; MAPK13; SOCS3; MAGI2
Adipocytokine signaling pathway
PRKAG3B; JAK2; G6PCA.2; PPARGC1A; AKT3A; PRKAG1; PRKAB2; PPARA; SOCS3B; ACSL3A
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1C1; ATP6V1H; ATP6V1E2; ATP6V1D; ATP6V0D1; ATP6V1G2; MAPK8; CDC42; IKBKG; ATP6V1G3
Shigellosis
RIPK2; PFN1; HCLS1; ELMO2; SRC; MAPK1; ROCK1; UBE2D2; U2AF1L4; CTTN
Chagas disease (American trypanosomiasis)
CASP8; GNA14; TGFBR2; PIK3CA; TGFB1; GNAQ; PLCB4; IL10; IKBKG; PPP2R1A
Toxoplasmosis
TLR4; PDPK1; GNAI1; IL10RA; MAP2K3; IKBKB; IL12B; GNAO1; Casp3; H2-AB1
Hepatitis C
TLR3; RIPK1; CLDN3; EIF2AK3; IFNA1; CLDN2; OAS1B; IRF1; PIK3CG; LDLR
Hepatitis B
SRC; ATF4; PIK3CG; VDAC3; OSTN; IRF7; Fasl; CREB5; IFNA16; STAT5B
HTLV-I infection
Fzd4; CCND1; PDGFRB; SLC25A6; RAN; PIK3CB; IL2RB; KAT2B; XBP1; VDAC3
Herpes simplex infection
TNFRSF14; CYCS; MHC1UXA2; STAT2; HLA-DOB; POLR2A; IFNGR2; CASP3B; IFNGR1; MYD88
Epstein-Barr virus infection
CD38; CCNA1; MAP2K3; ENTPD8; HLA-DQA2; FCER2; TNFAIP3; NUP214; HLA-DPB1; HLA-DQA1
Pathways in cancer
GSTP1; EGLN2; FZD5; GNB4; GNG3; SFPI1; MMP2; IKBKB; PLCB4; BIRC7
Viral carcinogenesis
PIK3CD; HRAS; LYN; TRAF1; MDM2; STAT5A; PIK3CB; STAT5B; HPN; HIST1H2BC
Pancreatic cancer
MAPK3; MAP2K1; RELA; SMAD2; ERBB2; STAT3; PIK3R3; SMAD4; IKBKB; KRAS
Prostate cancer
PIK3CD; GSK3B; SMARCA4; ERBB2; MAPK3; NOXA1; CREB5; PDGFA; PIK3CG; SOS1
Chronic myeloid leukemia
STAT5B; BCL2L1; GRB2; BCR; TRP53; SMAD4; PTPN11; RB1; TGFB3; CTBP1
Acute myeloid leukemia
LEF1; BRAF; PIK3CG; PIK3R3; PIK3CB; RARA; CCNA1; PML; TCF7L2; RPS6KB2
Small cell lung cancer
CKS2; LAMC1; MAX; TRAF3; CASP9; PIK3CA; TP53; PIK3R5; LAMA1; LAMA3
Primary i
Cd79a, Cd79b; IL2RG; BTK; AIRE; UNG; RFXAP; ZAP70; CD8B1; ICOS; ORAI1
nodeficiency
ORAI1; IGLL1; RFX5; TAP2; CD79A; PTPRC; CD40LG; RFXAP; CD3E; IL2RG

Protein Function

IKBKG has several biochemical functions, for example, K63-linked polyubiquitin binding, linear polyubiquitin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKG itself. We selected most functions IKBKG had, and list some proteins which have the same functions with IKBKG. You can find most of the proteins on our site.
Function
Related Protein
Function K63-linked polyubiquitin binding
Related Protein TAB2; TNFAIP3; SPRTN; IKBKG; SQSTM1; PRPF8; RNF169; ZRANB1; UIMC1; ZRANB1B
Function linear polyubiquitin binding
Related Protein IKBKG
Function metal ion binding
Related Protein CEPT1; STK24; MKNK2; MTL5; RXRAB; NT5C2; ATP2B1; PXNA; SMAD1; ISL2B
Function peroxisome proliferator activated receptor binding
Related Protein EP300; HMGA1-RS1; NFATC4; MED1; ASXL1; CREBBP; PPARGC1A; ASXL2; NR0B2; PRMT2
Function protein binding
Related Protein MRPL12; CTR9; BSCL2; GFOD1; TAS2R16; ZFP2; DIXDC1; PSMB10; SYNJ2BP; IL13
Function protein domain specific binding
Related Protein DRD3; YWHAB; FAF1; XPA; CASP2; CNTROB; STMN3; ATP1A1; Ar; THRA
Function protein heterodimerization activity
Related Protein ATF6; HIST1H2BF; ATP4A; HIST1H4E; PDGFA; KCNN1; PVRL1; HIST1H2B7; BDKRB2; BCL11A
Function protein homodimerization activity
Related Protein JUP; TOP2A; SDCBP2; HMOX1; BARD1; AP1S2; PRPS2; GRM6; Pdgfa&Pdgfb; GHR
Function signal transducer activity
Related Protein V2RH14; BCAR1; HTR1AA; PKP1; MRGPRA7; TAS1R2.1; GNB1; ADRB2A; GRM6A; TAS2R110
Function ubiquitin protein ligase binding
Related Protein PINK1; ANAPC2; CUL2; PIAS4; DBT; UBE2K; UBE2N; TMEM173; TRAF4; DLG3

Interacting Protein

IKBKG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKG here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKG.
IKBKB