ikbkg
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  • Official Full Name
  • IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
  • Background
  • NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-gamma) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IkappaB kinase that activates NF-kappaB. The human gene for IKBKG is located on chromosome Xq28. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; incontinentia pigmenti , IP1, IP2; NF-kappa-B essential modulator; FIP 3; FIP3; Fip3p; IKK gamma; NEMO; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; FIP-3; AMCBX1; IKK-gamma;
Cat.#:IKBKG-489HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKBKG Protein, MYC/DDK-tagged
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Cat.#:IKBKG-14134HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG, GST-tagged
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Cat.#:IKBKG-195HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG, GST-tagged
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Cat.#:IKBKG-196HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG(D311N), GST-tagged
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Cat.#:IKBKG-3022RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IKBKG Protein
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Cat.#:IKBKG-2265ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IKBKG
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Cat.#:IKBKG-1028HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-cells, Kinase Gamma, GST-tagged
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Involved Pathway

IKBKG involved in several pathways and played different roles in them. We selected most pathways IKBKG participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
KRAS; MAP3K14; FGF5; MAP4K1; ELK1; JIP1; PRKACBB; MEF2CB; ARRB2B; NTRK2
Ras signaling pathway
MAP2K2; GNG13; PIK3R1; FGFR1; CALM3; RAC2; RAP1B; RASA3; FGF7; CALM2
Chemokine signaling pathway
GNGT1; CXCL5; GSK3A; PIK3R3; CX3CL1; CXCL1; GNB2; CCL26; PRKACG; PRKACB
NF-kappa B signaling pathway
BCL2A1A; GM1987; IRAK1; MAP3K7IP3; SYK; GM13304; LCK; CCL4; TRAF3; LTBR
PIK-Akt signaling pathway
GNB3; COL6A6; FGF18; PPP2R5A; KIT; PRKAA1; FASLG; RPS6KB2; NFKB1; PIK3R1
Apoptosis
BCL2L11; FASLG; CDK5RAP2; PRKACA; PRKAR1A; NFKBIAA; CAPN1A; DSP; PLECA; PRKAR1AB
Osteoclast differentiation
SYK; PIK3R3; IKBKB; STAT1; LILRB1; CAMK4; RELB; IL1R1; IFNB1; BTK
Toll-like receptor signaling pathway
IRF5; TLR5; IRF7; IFNA2; IFNA8; TMED7-TICAM2; IFNAR2; IFNPHI3; IKBKG; RAC1
NOD-like receptor signaling pathway
HSP90B1; BIRC2; PSTPIP1B; MAPK12; MAPK14B; HSP90AB1; CARD9; MAPK10; CASP8; MAPK14A
RIG-I-like receptor signaling pathway
SIKE1; DHX58; TRAF2; RNF207B; MAP3K1; TRAF3; IFNB; Ifna11; CXCL10; MAPK10
Cytosolic DNA-sensing pathway
IFNA3; POLR1C; IFNA17; IFNA2; POLR2L; NFKBIAB; CASP1; IKBKB; ADAR; POLR3E
T cell receptor signaling pathway
RAF1; PPP3R2; PIK3R5; TNF; CBL; IKBKG; MUC1; RELA; EVLB; MAPK11
B cell receptor signaling pathway
PLCG2; PTPN6; PTPN18; BCL10; NFKBIA; NEDD9; CD81; CDK4; ACTR3; NFATC3
TNF signaling pathway
ITCH; IKBKB; RPS6KA4; ICAM1; CASP8; BIRC3; CXCL1; PTGS2; FADD; VCAM1
Adipocytokine signaling pathway
STAT3; NFKBIE; IKBKG; PRKAA2; SOCS3; IRS2; TRAF2; PTPN11; RXRGA; PRKAB1B
Epithelial cell signaling in Helicobacter pylori infection
LYN; ATP6V1H; ATP6V1F; SRC; MAPK11; F11R; ATP6V0D1; MAPK13; MAPK10; ATP6V1B2
Shigellosis
UBE2D2; MAPK1; PFN4; ITGB1; ELMO2; FBXW11; WASL; MAPK12; ELMO3; ACTB
Chagas disease (American trypanosomiasis)
SMAD3; PPP2R2C; CCL5; TICAM1; TGFB1; TLR2; GNA15; CCL3L3; FAS; MAPK8
Toxoplasmosis
XIAP; MAPK10; BAD; CASP8; SOCS1; CD40LG; STAT1; LAMC1; LAMA5; CASP9
Hepatitis C
CD81; PIK3CB; TLR3; IKBKE; CLDN14; IKBKG; TNF; CLDN20; PPARA; GRB2
Hepatitis B
MAP3K1; NFATC4; PTK2B; TP53; MYD88; STAT5B; DDX58; TGFB3; ATP6AP1; YWHAZ
HTLV-I infection
DVL3; ANAPC1; TGFB3; RANBP1; PIK3CB; FZD5; NFKB2; HLA-DQA2; ANAPC11; APC
Herpes simplex infection
TAF4B; BMA2; TRAF1; IFNA4; SRPK1; NFKBIAA; SRSF5B; TNFSF14; CASP3A; IFNA2
Epstein-Barr virus infection
HSPA1A; PIK3R3; PSMD13; SNW1; RAN; TRAF1; EIF2AK2; POLR1C; PSMD7; POLR2G
Pathways in cancer
GNG8; NKX3; GNB2; PLCB3; GNGT1; ERBB2; CSF3R; BRCA2; HSP90AA1; EGLN2
Viral carcinogenesis
RELA; HRAS; GSN; HIST2H2BB; HLA-F; UBR4; VAC14; PKM; LYN; HIST1H2BD
Pancreatic cancer
AKT1; TGFA; BAD; NFKB1; CASP9; PLD1; TGFBR1; TGFB2; RAF1; RALGDS
Prostate cancer
AKT1; MDM2; FOXO1; CASP9; TRP53; PIK3R1; PIK3CB; PDGFD; MAPK3; CCNE1
Chronic myeloid leukemia
SHC3; TGFB1; SOS1; CRKL; HDAC1; SHC4; TGFBR2; MAPK1; CTBP2; SHC1
Acute myeloid leukemia
CHUK; HRAS; RUNX1T1; PIK3CD; CCNA1; MTOR; MAP2K2; KRAS; JUP; LEF1
Small cell lung cancer
FN1; CASP9; FHIT; TRAF5; COL4A1; RARB; PIK3CA; BIRC7; BIRC8; LAMA3
Primary i
CD40LG; BLNK; CD19; LCK; IKBKG; DCLRE1C; IL2RG; PTPRC; ICOS; CD3D
nodeficiency
AICDA; BLNK; CD8B1; IL7R; IL2RG; RAG2; UNG; IGLL1; IKBKG; RAG1

Protein Function

IKBKG has several biochemical functions, for example, K63-linked polyubiquitin binding, linear polyubiquitin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKG itself. We selected most functions IKBKG had, and list some proteins which have the same functions with IKBKG. You can find most of the proteins on our site.
Function
Related Protein
Function K63-linked polyubiquitin binding
Related Protein ATRIP; TAB2; SPRTN; ZRANB1B; RNF169; RNF168; IKBKG; ZRANB1; OTUD7B; UIMC1
Function linear polyubiquitin binding
Related Protein IKBKG
Function metal ion binding
Related Protein CLCA5; ECE2; AMY1B; NUDT14; CYP2X8; THAP4; LIMK1A; ISL2A; NOTCH1A; ZBTB48
Function peroxisome proliferator activated receptor binding
Related Protein IKBKG; PRMT2; ASXL2; HMGA1-RS1; EP300; ASXL1; NFATC4; MED1; HMGA1; PPARGC1A
Function protein binding
Related Protein RALGDS; STXBP4; ZBTB24; CYP1A1; HNRNPA1; STAT6; VCL; AKR1C1; TSPAN2; IRF3
Function protein domain specific binding
Related Protein ZBTB16; HIST1H4D; YWHAH; STX1A; Ar; TH; SKI; TNFAIP1; SHC4; VCP
Function protein heterodimerization activity
Related Protein HIST2H2AC; HIST1H2BI; BCL2L10; HNF1B; GABRR1; SDCBP; ARNT; GRIN2A; BCL11A; CENPA
Function protein homodimerization activity
Related Protein HEXB; SLC6A4; ADRB2; BCL2L1; IKZF4; BAXA; GPD1A; ROPN1B; ERN1; BCL2A
Function signal transducer activity
Related Protein DKKL1; RGRB; EEF1D; OLFR998; AVP; RGS7; OLFR958; FAM126A; TRIM54; OLFR495
Function ubiquitin protein ligase binding
Related Protein STX8; SLC25A5; YOD1; TMEM189; NLK; UBE2NB; SMAD2; RNF40; PRKAR2B; ZFP746

Interacting Protein

IKBKG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKG here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKG.
IKBKB