ikbkg
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  • Official Full Name
  • IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
  • Background
  • NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-gamma) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IkappaB kinase that activates NF-kappaB. The human gene for IKBKG is located on chromosome Xq28. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; incontinentia pigmenti , IP1, IP2; NF-kappa-B essential modulator; FIP 3; FIP3; Fip3p; IKK gamma; NEMO; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; FIP-3; AMCBX1; IKK-gamma;
Cat.#:IKBKG-489HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKBKG Protein, MYC/DDK-tagged
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Cat.#:IKBKG-14134HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG, GST-tagged
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Cat.#:IKBKG-195HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG, GST-tagged
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Cat.#:IKBKG-196HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKBKG(D311N), GST-tagged
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Cat.#:IKBKG-3022RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IKBKG Protein
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Cat.#:IKBKG-2265ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IKBKG
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Cat.#:IKBKG-1028HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-cells, Kinase Gamma, GST-tagged
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Involved Pathway

IKBKG involved in several pathways and played different roles in them. We selected most pathways IKBKG participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKG were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
ARR3B; NLK; GNA12A; CD14; PTPRR; MAP2K2; NFATC1; NTRK1; CACNG8; RASGRF2
Ras signaling pathway
CDC42; FGF2; NRAS; NGF; FGFR2; FGF10; CALM1; GNG8; PLA2G2F; PAK7
Chemokine signaling pathway
CCL21; CCR10; PIK3CG; AMCF-II; CCL13; PF4; STAT3; PRKACG; MAPK1; CCL28
NF-kappa B signaling pathway
LAT; MYD88; VCAM1; ATM; ERC1; PIDD1; IL-8; TNFSF14; PLAU; IL1B
PIK-Akt signaling pathway
FLT1; ITGA7; PPP2R2D; VEGFC; PPP2CB; GNB4; GNG12; STK11; PDPK1; MCL1
Apoptosis
TP53; IRF6; BIRC5A; DERL3; BIDA; HMGB2; HIST1H1E; IRF2; CDK5RAP2; STK24B
Osteoclast differentiation
BLNK; NFKB1; IL1B; BTK; IFNG; LILRA5; NCF4; LCK; PPP3CC; CSF1R
Toll-like receptor signaling pathway
AKT2L; MAP2K2B; IFNA16; NFKBIAA; RIPK1L; PIK3CB; FADD; TOLLIP; MAP2K2; TLR2-2
NOD-like receptor signaling pathway
IL-8; MAPK11; CXCL2; SGUT1; CXCL8B.3; RELA; LOC100033925; Ccl12; NLRP3; MAPK10
RIG-I-like receptor signaling pathway
IFNA21; TANK; MAVS; IL12A; MAPK9; OTUD5; SIKE1; DHX58; IFNA5; IFNPHI1
Cytosolic DNA-sensing pathway
POLR2EB; CXCL10; RIPK1L; POLR2L; CCL4L1; IFNA10; POLR2H; RELA; IFNA4; AIM2
T cell receptor signaling pathway
CD4; VAV3; KRAS; DLG1; RELA; RHOA; CBL; NFATC3; PIK3R3; BCL10
B cell receptor signaling pathway
ACTR2; IFITM1; BTK; PPP3CA; NFKBIE; RAF1; STAP1; NFATC2; LCP2A; IKBKB
TNF signaling pathway
MAGI2; TNF; AKT1; MAPK8; CXCL1; PIK3CD; CASP10; ICAM1; BIRC2; PTGS2
Adipocytokine signaling pathway
PTPN11B; RXRAA; ACSL1B; RXRG; POMC; SLC2A4; PPARA; ADIPOR1; PRKAB1B; RXRB
Epithelial cell signaling in Helicobacter pylori infection
NFKBIA; ATP6AP1; NOD1; ATP6V1H; MAPK9; IL-8; PTPN11; ATP6V0B; JAM2; MAP3K14
Shigellosis
WAS; MAD2L2; IKBKB; MAPK13; U2AF1L4; ITGA5; MAPK11; VCL; MAPK3; BTRC
Chagas disease (American trypanosomiasis)
GNAQ; IL12A; CFLAR; CCL3L1; PPP2R2C; IL-8; PIK3R1; MAPK1; IFNG; PIK3CG
Toxoplasmosis
GNAI2; TNF; ITGA6; HSPA8; LAMA3; MAPK11; HSPA1L; TLR2; ALOX5; IFNGR1
Hepatitis C
CLDN16; STAT3; IFIT1; CLDN15; CLDN3; CLDN11; TRP53; SOS1; PPP2R2D; DDX58
Hepatitis B
AKT2; STAT4; IL-8; DDX58; EGR3; FAS; EGR2; CASP10; CREB3L2; PRKCB
HTLV-I infection
NRAS; WNT2B; PPP3R2; HLA-G; SRF; SLC25A4; PRKACA; FZD5; MYBL1; BAX
Herpes simplex infection
HLA-B; EIF2AK2; CFP; USP7; MYD88; FOS; ABCB3L1; PML; TAF13; FAS
Epstein-Barr virus infection
NCOR2; HLA-DQB1; SKP2; TP53; NEDD4; HDAC5; HDAC1; MAP2K6; TRADD; HLA-DRB3
Pathways in cancer
APC; MSH3; SUFU; ARNT; TRAF1; WNT5A; WNT7B; AHA-1; GLI3; RET
Viral carcinogenesis
HIST1H2BN; RAC1; TBPL2; HDAC3; HLA-B; IRF3; SRC; HIST1H4N; TRAF2; GTF2H1
Pancreatic cancer
ARAF; CDC42; CCND1; MAP2K1; BRCA2; SMAD2; SMAD4; IKBKG; RAC1; PIK3CD
Prostate cancer
ATF4; MAP4K1; GSK3B; PTEN; RB1; SMARCA4; SRD5A2; SMARCD1; HSP90AA1; BRAF
Chronic myeloid leukemia
GRB2; RAF1; AKT1; STAT5B; CDK6; PTPN11; SMAD3; RUNX1; BRAF; NRAS
Acute myeloid leukemia
MTOR; KRAS; PIK3CD; PIK3CG; CEBPA; IKBKG; PIK3CB; RARA; PIK3CA; MAPK3
Small cell lung cancer
ITGA2B; RXRG; PIK3CB; LAMC1; CCNE1; APAF1; ITGB1; LAMC2; PIK3R3; IKBKB
Primary i
TAP2; UNG; CD8B; IL7R; CD8B1; IKBKG; CD3E; CD3D; AICDA; RAG2
nodeficiency
AICDA; CD8B1; AIRE; UNG; IGLL1; BLNK; CD79A; CD3E; RAG1; CD3D

Protein Function

IKBKG has several biochemical functions, for example, K63-linked polyubiquitin binding, linear polyubiquitin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKG itself. We selected most functions IKBKG had, and list some proteins which have the same functions with IKBKG. You can find most of the proteins on our site.
Function
Related Protein
Function K63-linked polyubiquitin binding
Related Protein RNF169; SPRTN; ZRANB1B; RNF168; ZRANB3; PRPF8; OTUD7B; ZRANB1; IKBKG; UIMC1
Function linear polyubiquitin binding
Related Protein IKBKG
Function metal ion binding
Related Protein NR6A1A; MKRN4; FREM1; ZFP521; ARL3; ZSCAN23; TH2; ZFP41; ZNF557; HINFP
Function peroxisome proliferator activated receptor binding
Related Protein PPARGC1A; MED1; NFATC4; HMGA1; NR0B2; EP300; ASXL2; PRMT2; CREBBP; ASXL1
Function protein binding
Related Protein TARS; UVRAG; RBM41; CLIC5; HSPA9; TSG101; NAA11; RAB1B; POLR2E; FIBCD1
Function protein domain specific binding
Related Protein YWHAQB; CENPJ; HIST2H4; FOXA2; HPCAL4; MYO1D; GSN; VPS11; TACC3; PRKCI
Function protein heterodimerization activity
Related Protein BTBD11; CEBPB; SOX8; GABPB2; SPTA1; USF1; UBXN6; PDSS2; SYCP2; HIST1H2BA
Function protein homodimerization activity
Related Protein PYGL; APOBEC3G; PDXK; PLEKHB1; CBX1; PRPS1L1; CACYBP; RBM44; ANO2; TBC1D22A
Function signal transducer activity
Related Protein TAS2R137; OLFR78; TAAR13C; TAAR7B; HCAR1-2; TAS2R140; IL1R1; OPN3; SH2B2; TRIM13
Function ubiquitin protein ligase binding
Related Protein EIF4E2; GABARAPL2; PER3; RNF40; PDE4D; UBE2H; TPI1; SUMO2; HSPA1L; PRKAR2B

Interacting Protein

IKBKG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKG here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKG.
IKBKB