| Description : |
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
48 kDa |
| AA Sequence : |
MNRHLWKSQLCEMVQPSGGPAADQD VLGEESPLGKPAMLHLPSEQGAPET LQRCLEENQELRDAIRQSNQ ILRERCEELLHFQASQREEKEFLMC KFQEARKLVERLGLEKLDLKRQKEQ ALREVEHLKRCQQQMAEDKA SVKAQVTSLLGELQESQSRLEAATK ECQALEGRARAASEQARQLESEREA LQQQHSVQVDQLRMQGQSVE AALRMERQAASEEKRKLAQLQVAYH QLFQEYDNHIKSSVVGSERKRGMQL EDLKQQLQQAEEALVAKQEV IDKLKEEAEQHKIVMETVPVLKAQA DIYKADFQAERQAREKLAEKKELLQ EQLEQLQREYSKLKASCQES ARIEDMRKRHVEVSQAPLPPAPAYL SSPLALPSQRRSPPEEPPDFCCPKC QYQAPDMDTLQIHVMECIETRTRPL EQKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, Transcription Factors |
| Protein Pathways : |
Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, MAPK signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway |
