Recombinant Human IKBKG Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: IKBKG-3089H
• Product Overview: IKBKG MS Standard C13 and N15-labeled recombinant protein (NP_001138727) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 36.8 kDa
• AA Sequence: MNRHLWKSQLCEMVQPSGGPAADQD VLGEESPLGKPAMLHLPSEQGAPET LQRCLEENQELRDAIRQSNQILRER CEELLHFQASQREEKEFLMCKFQEA RKLVERLGLEKLDLKRQKEQALREV EHLKRCQQQMAEDKASVKAQVTSLL GELQESQSRLEAATKECQALEGRRK LAQLQVAYHQLFQEYDNHIKSSVVG SERKRADIYKADFQAERQAREKLAE KKELLQEQLEQLQREYSKLKASCQE SARIEDMRKRHVEVSQAPLPPAPAY LSSPLALPSQRRSPPEEPPDFCCPK CQYQAPDMDTLQIHVMECIETRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [ Homo sapiens (human) ]
• Official Symbol: IKBKG
• Synonyms: IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; incontinentia pigmenti, IP1, IP2; NF-kappa-B essential modulator; FIP 3; FIP3; Fip3p; IKK gamma; NEMO; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; FIP-3; AMCBX1; IKK-gamma
• Gene ID: 8517
• mRNA Refseq: NM_001145255
• Protein Refseq: NP_001138727
• MIM: 300248
• UniProt ID: Q9Y6K9