Recombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-cells, Kinase Gamma, GST-tagged
Cat.No. : | IKBKG-1028H |
Product Overview : | Recombinant full-length human IKBKG was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IKBKG-1028H |
Description : | IKBKG is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. IKBKG forms dimers and trimers and interacts preferentially with IKKbeta but not IKKalpha. IKBKG associates with activated ATM after the induction of DNA double-strand breaks. ATM phosphorylates serine-85 of IKBKG to promote its ubiquitin-dependent nuclear export. |
Applications : | Western Blot |
Molecular Weight : | 73 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0,25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
Purity : | > 95 % |
Concentration : | 0.2 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Activated TLR4 signalling; Acute myeloid leukemia; Adaptive Immunity Signaling; Adipocytokine signaling pathway; Apoptosis; Epithelial cell signaling in Helicobacter pylori infection; FAS (CD95) signaling pathway; HTLV-I infection; IRAK1 recruits IKK comlex; MAPK signaling pathway; NLR proteins; Pancreatic cancer; p75(NTR)-mediated signaling |
Gene Name : | IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [ Homo sapiens ] |
Official Symbol : | IKBKG |
Synonyms : | IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; IP; IP1; IP2; FIP3; IPD2; NEMO; FIP-3; Fip3p; AMCBX1; IKK-gamma; NF-kappa-B essential modulator; IKKG; IKKAP1; OTTHUMP00000026026; OTTHUMP00000026027; OTTHUMP00000026028; OTTHUMP00000026029; OTTHUMP00000026030; OTTHUMP00000196183; OTTHUMP00000196183; OTTHUMP00000196186; OTTHUMP00000207079; OTTHUMP00000212188; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma |
Gene ID : | 8517 |
mRNA Refseq : | NM_003639 |
Protein Refseq : | NP_003630 |
MIM : | 300248 |
UniProt ID : | Q9Y6K9 |
Chromosome Location : | Xq28 |
Function : | metal ion binding; protein binding; protein domain specific binding; signal transducer activity |
Products Types
◆ Recombinant Protein | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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