nr3c2
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  • Official Full Name
  • nuclear receptor subfamily 3, group C, member 2
  • Background
  • This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Synonyms
  • NR3C2; nuclear receptor subfamily 3, group C, member 2; MR; MCR; MLR; NR3C2VIT; mineralocorticoid receptor; aldosterone receptor; mineralocorticoid receptor 1; mineralocorticoid receptor delta;
Cat.#:NR3C2-6092HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR3C2 Protein, GST-tagged
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Cat.#:NR3C2-105HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mineralocorticoid receptor LBD/Hsp90 complex, GST-tagged
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Cat.#:NR3C2-17HCLTag:Myc/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NR3C2 overexpression cell lysate
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Cat.#:NR3C2-504HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NR3C2
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Cat.#:NR3C2-693HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR3C2 Protein, His/GST-tagged
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Cat.#:NR3C2-4069RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NR3C2 Protein
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Cat.#:NR3C2-3940CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NR3C2
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Cat.#:NR3C2-5892ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NR3C2
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Involved Pathway

NR3C2 involved in several pathways and played different roles in them. We selected most pathways NR3C2 participated on our site, such as Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR3C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aldosterone-regulated sodium reabsorption
ATP1A2; PIK3R2; INSR; ATP1B3; KRAS; FXYD4; SCNN1G; PDPK1; IRS1; PIK3CD

Protein Function

NR3C2 has several biochemical functions, for example, protein binding, sequence-specific DNA binding, steroid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR3C2 itself. We selected most functions NR3C2 had, and list some proteins which have the same functions with NR3C2. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein TRAPPC2; FAM123A; SETDB1; E2F6; ZFAND5; ILF3; NOP10; C10orf81; MDM2; RPLP1
Function sequence-specific DNA binding
Related Protein ARX; ZBTB14; DLX1A; NKX2-5; NKX3.3; MXTX2; EVX1; UNCX; HOXA9A; MTA3
Function steroid binding
Related Protein CYP21A2; ESRRGA; ESR2B; CYP3A4; PDIA2; CYP21A1; SULT1E1; PAQR5A; HSD3B4; FAM84B
Function steroid hormone receptor activity
Related Protein RORA; NR0B1; NR1H3; PPARDB; RARGA; NR2F5; NR4A3; GPR30; NR1D2A; NR5A2
Function transcription factor activity, sequence-specific DNA binding
Related Protein AFF4; NR3C2; TSC22D2; GABPA; SIN3A; ZIC3; RELA; ZBTB25; ZNF831; TCF7L1B
Function zinc ion binding
Related Protein NR4A3; RSPRY1; RFPL1; CPXM2; PRKCB; ZFP622; RFPL4; ADH6; ADAM28; ZDHHC16A

Interacting Protein

NR3C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR3C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR3C2.
HSP90AB1; RXRA; ACSL1; RABAC1

NR3C2 Related Articles

Kolla, V; Robertson, NM; et al. Identification of a mineralocorticoid/glucocorticoid response element in the human Na/K ATPase alpha 1 gene promoter. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 266:5-14(1999).