NR3C2 Protein, nuclear receptor subfamily 3, group C, member 2


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Official Full Name nuclear receptor subfamily 3, group C, member 2
Background This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Synonyms NR3C2; nuclear receptor subfamily 3, group C, member 2; MR; MCR; MLR; NR3C2VIT; mineralocorticoid receptor; aldosterone receptor; mineralocorticoid receptor 1; mineralocorticoid receptor delta;
    • Species :
    • Chicken
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NR3C2-105H Recombinant Human Mineralocorticoid receptor LBD/Hsp90 complex, GST-tagged Sf9 Insect Cell GST
    Human NR3C2-17HCL Recombinant Human NR3C2 overexpression cell lysate HEK293 Myc/DDK
    Human NR3C2-504H Recombinant Human NR3C2 Mammalian Cell His
    Human NR3C2-6092H Recombinant Human NR3C2 Protein, GST-tagged Wheat Germ GST
    Human NR3C2-693H Recombinant Human NR3C2 Protein, His/GST-tagged E.coli His/GST
    Rat NR3C2-4069R Recombinant Rat NR3C2 Protein Mammalian Cell His
    Chicken NR3C2-3940C Recombinant Chicken NR3C2 Mammalian Cell His
    Zebrafish NR3C2-5892Z Recombinant Zebrafish NR3C2 Mammalian Cell His

    NR3C2 involved in several pathways and played different roles in them. We selected most pathways NR3C2 participated on our site, such as Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR3C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aldosterone-regulated sodium reabsorption PRKCB; PRKCA; MAPK1; ATP1A2; ATP1B4; ALPHA-ENAC; FXYD4; PIK3R1; PDPK1; ATP1B1

    NR3C2 has several biochemical functions, for example, protein binding, sequence-specific DNA binding, steroid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR3C2 itself. We selected most functions NR3C2 had, and list some proteins which have the same functions with NR3C2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding POLH; RPS6KA5; TES; GJB6; THEG; HEATR5B; RAB8B; FLOT2; APLP1; HAX1
    sequence-specific DNA binding SALL3; ISL1L; NFIL3-6; NKX2-4; MKXB; WT1; HOXD10A; SLAMF7; EGR1; NR4A2B
    steroid binding HSD3B4; PGR; ESRRG; GPR30; ESRRB; ESRRGB; NR3C2; NR3C1; ESR2A; ESRRA
    steroid hormone receptor activity PAQR7; NR2F5; NR2C2; NR2F6; NR4A2A; OLFR78; RORB; PPARA; NR4A1; VDRA
    transcription factor activity, sequence-specific DNA binding MLXIPL; TBX18; HNF1A; PITX2; SPIB; DMRT2; ZNF43; TP63; ZNF192; HEYL
    zinc ion binding CA8; WT1; IRGF4; AGBL3; POLR3K; FANCL; MEX3C; UQCRC2B; ZNRF3; CA12

    NR3C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR3C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR3C2.


    Kolla, V; Robertson, NM; et al. Identification of a mineralocorticoid/glucocorticoid response element in the human Na/K ATPase alpha 1 gene promoter. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 266:5-14(1999).

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