Recombinant Human NR3C2 Protein, GST-tagged

• Cat.No.: NR3C2-6092H
• Product Overview: Human NR3C2 partial ORF ( NP_000892, 1 a.a. - 110 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 37.84 kDa
• AA Sequence: METKGYHSLPEGLDMERRWGQVSQA VERSSLGPTERTDENNYMEIVNVSC VSGAIPNNSTQGSSKEKQELLPCLQ QDNNRPGILTSDIKTELESKELSAT VAESMGLYMD
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: NR3C2 nuclear receptor subfamily 3, group C, member 2 [ Homo sapiens ]
• Official Symbol: NR3C2
• Synonyms: NR3C2; nuclear receptor subfamily 3, group C, member 2; MLR; mineralocorticoid receptor; MR; aldosterone receptor; mineralocorticoid receptor 1; mineralocorticoid receptor delta; MCR; NR3C2VIT; FLJ41052; MGC133092
• Gene ID: 4306
• mRNA Refseq: NM_000901
• Protein Refseq: NP_000892
• MIM: 600983
• UniProt ID: P08235