rcan1
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  • Official Full Name
  • regulator of calcineurin 1
  • Background
  • The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
  • Synonyms
  • RCAN1; regulator of calcineurin 1; Down syndrome critical region gene 1 , DSCR1; calcipressin-1; Adapt 78; Adapt78; Calcipressin 1; Calcium and oxidant inducible mRNA; CSP 1; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; DSC 1; DSC1; DSCR 1; DSCR1; MCIP 1; MCIP1; Modulatory calcineurin interacting protein 1; Myocyte enriched calcineurin interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; Near DSCR proline rich protein; RCAN1_HUMAN; RCN 1; RCN1; OTTHUMP00000108619; OTTHUMP00000108620; OTTHUMP00000108621; OTTHUMP00000108622; OTTHUMP00000214669; OTTHUMP00000214670; near DSCR proline-rich protein; calcium and oxidant-inducible mRNA; Down syndrome critical regi
Cat.#:RCAN1-4029HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human RCAN1 Protein, GST-tagged
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Cat.#:RCAN1-088HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RCAN1 Protein, HIS-tagged
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Cat.#:RCAN1-27792THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RCAN1
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Cat.#:RCAN1-4972RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RCAN1 Protein
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Cat.#:RCAN1-5347CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RCAN1
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Cat.#:RCAN1-298HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Regulator of Calcineurin 1
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Cat.#:RCAN1-510HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RCAN1 cell lysate
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Involved Pathway

RCAN1 involved in several pathways and played different roles in them. We selected most pathways RCAN1 participated on our site, such as Calcium signaling in the CD4+ TCR pathway, MicroRNAs in cardiomyocyte hypertrophy, Notch-mediated HES/HEY network, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCAN1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling in the CD4+ TCR pathway
RCAN2; JUNB; POU2F1; CSF2; BATF3; FKBP1A; AKAP5; CHP; RCAN1
MicroRNAs in cardiomyocyte hypertrophy
CTF1; MYEF2; RCAN1
Notch-mediated HES/HEY network
GATA6; ASCL1; TLE1; BGLAP; YY1; MYOD1; CTBP1; GATA1; HEY1; MYB
Oxytocin signaling pathway
SRC; ELK1; PIK3CA; HRAS; CAMK1D; PPP3CC; PIK3R3; CACNG6; PIK3CB; PPP1CB
Role of Calcineurin-dependent NFAT signaling in lymphocytes
RCAN1; RCAN2; CHP; FKBP8
Thyroid hormone signaling pathway
PIK3R5; PLCE1; DIO1; BMP4; RAF1; HDAC1; KAT2A; HDAC3; NCOA1; ITGB3

Protein Function

RCAN1 has several biochemical functions, for example, DNA binding, calcium-dependent protein serine/threonine phosphatase regulator activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCAN1 itself. We selected most functions RCAN1 had, and list some proteins which have the same functions with RCAN1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein XRN1; PSMC3IP; PTGES2; VDRA; PHC2; AGFG1; TRIM30A; MGMT; ZNF670; DICER1
Function calcium-dependent protein serine/threonine phosphatase regulator activity
Related Protein RCAN1A; RCAN3; RCAN1; RCAN2
Function identical protein binding
Related Protein DDX58; SRPX2; COL1A1; DNM1; IFI203; SNX1; COL1A2; Serpina1c; DCP1A; COL2A1
Function protein binding
Related Protein CDKN3; GRM6; PUS7L; RDH12; H2-AB1; PKHD1L1; DCAF7; KIAA1199; NIPAL1; STOML1
Function transcription factor activity, sequence-specific DNA binding
Related Protein ESR2A; POU3F2B; ZNF548; LCOR; POU3F2A; TEFB; NFIL3-4; KDM1A; PKNOX1; PPARDB

Interacting Protein

RCAN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCAN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCAN1.
PRKACB

RCAN1 Related Articles

Kang, S; Ren, D; et al. Cell Line Profiling to Improve Monoclonal Antibody Production. BIOTECHNOLOGY AND BIOENGINEERING 111:748-760(2014).
Ermak, G; Pritchard, MA; et al. Do RCAN1 proteins link chronic stress with neurodegeneration?. FASEB JOURNAL 25:3306-3311(2011).