rcan1
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  • Official Full Name
  • regulator of calcineurin 1
  • Background
  • The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
  • Synonyms
  • RCAN1; regulator of calcineurin 1; Down syndrome critical region gene 1 , DSCR1; calcipressin-1; Adapt 78; Adapt78; Calcipressin 1; Calcium and oxidant inducible mRNA; CSP 1; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; DSC 1; DSC1; DSCR 1; DSCR1; MCIP 1; MCIP1; Modulatory calcineurin interacting protein 1; Myocyte enriched calcineurin interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; Near DSCR proline rich protein; RCAN1_HUMAN; RCN 1; RCN1; OTTHUMP00000108619; OTTHUMP00000108620; OTTHUMP00000108621; OTTHUMP00000108622; OTTHUMP00000214669; OTTHUMP00000214670; near DSCR proline-rich protein; calcium and oxidant-inducible mRNA; Down syndrome critical regi
Cat.#:RCAN1-4029HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human RCAN1 Protein, GST-tagged
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Cat.#:RCAN1-088HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RCAN1 Protein, HIS-tagged
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Cat.#:RCAN1-27792THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RCAN1
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Cat.#:RCAN1-4972RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RCAN1 Protein
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Cat.#:RCAN1-5347CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RCAN1
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Cat.#:RCAN1-298HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Regulator of Calcineurin 1
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Cat.#:RCAN1-510HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RCAN1 cell lysate
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Involved Pathway

RCAN1 involved in several pathways and played different roles in them. We selected most pathways RCAN1 participated on our site, such as Calcium signaling in the CD4+ TCR pathway, MicroRNAs in cardiomyocyte hypertrophy, Notch-mediated HES/HEY network, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCAN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling in the CD4+ TCR pathway
RCAN2; FKBP1A; RCAN1; AKAP5; POU2F1; CSF2; CHP; JUNB; BATF3
MicroRNAs in cardiomyocyte hypertrophy
MYEF2; RCAN1; CTF1
Notch-mediated HES/HEY network
BGLAP; ASCL1; CTBP1; RCAN1; YY1; TLE1; GATA6; GATA1; MYOD1; HEY1
Oxytocin signaling pathway
MYL9; PLCB4; PPP1CB; KRAS; CALML5; PIK3R5; PLA2G4C; PRKCA; SRC; ACTB
Role of Calcineurin-dependent NFAT signaling in lymphocytes
RCAN2; RCAN1; CHP; FKBP8
Thyroid hormone signaling pathway
HDAC2; NCOR1; PRKACB; FOXO1; PLCZ1; NOTCH2; PIK3CA; NCOA3; NCOA1; PRKCA

Protein Function

RCAN1 has several biochemical functions, for example, DNA binding, calcium-dependent protein serine/threonine phosphatase regulator activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCAN1 itself. We selected most functions RCAN1 had, and list some proteins which have the same functions with RCAN1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein KDM2B; ASXL3; HIST1H2AN; HIST3H2BB; ZFP36; HES3; DDX41; UPF1; ZNF524; ZNF182
Function calcium-dependent protein serine/threonine phosphatase regulator activity
Related Protein RCAN2; RCAN3; RCAN1; RCAN1A
Function identical protein binding
Related Protein CDC42; BRAP; CLDNG; PRPF3; MYOM1; CEACAM16; GUCY2E; PYDC3; SELK; HCN2
Function protein binding
Related Protein CRMP1; KCNA3; RIN1; RCAN1; NXF1; UROD; ACTN1; NXT2; CDC42SE2; WEE1
Function transcription factor activity, sequence-specific DNA binding
Related Protein TFAP2C; NR1H5; NR2F1B; CSRNP1; RBPJB; FOXE3; FOXK2; SFPI1; EOMES; MECP2

Interacting Protein

RCAN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCAN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCAN1.
PRKACB

RCAN1 Related Articles

Kang, S; Ren, D; et al. Cell Line Profiling to Improve Monoclonal Antibody Production. BIOTECHNOLOGY AND BIOENGINEERING 111:748-760(2014).
Ermak, G; Pritchard, MA; et al. Do RCAN1 proteins link chronic stress with neurodegeneration?. FASEB JOURNAL 25:3306-3311(2011).