• Official Full Name
  • regulator of calcineurin 1
  • Background
  • The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
  • Synonyms
  • RCAN1; regulator of calcineurin 1; Down syndrome critical region gene 1 , DSCR1; calcipressin-1; Adapt 78; Adapt78; Calcipressin 1; Calcium and oxidant inducible mRNA; CSP 1; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; DSC 1; DSC1; DSCR 1; DSCR1; MCIP 1; MCIP1; Modulatory calcineurin interacting protein 1; Myocyte enriched calcineurin interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; Near DSCR proline rich protein; RCAN1_HUMAN; RCN 1; RCN1; OTTHUMP00000108619; OTTHUMP00000108620; OTTHUMP00000108621; OTTHUMP00000108622; OTTHUMP00000214669; OTTHUMP00000214670; near DSCR proline-rich protein; calcium and oxidant-inducible mRNA; Down syndrome critical regi
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human RCAN1 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RCAN1 Protein, HIS-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RCAN1
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RCAN1 Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RCAN1
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Regulator of Calcineurin 1
Source (Host):Species:Human
Product nameRecombinant Human RCAN1 cell lysate

RCAN1 Related Articles

Kang, S; Ren, D; et al. Cell Line Profiling to Improve Monoclonal Antibody Production. BIOTECHNOLOGY AND BIOENGINEERING 111:748-760(2014).
Ermak, G; Pritchard, MA; et al. Do RCAN1 proteins link chronic stress with neurodegeneration?. FASEB JOURNAL 25:3306-3311(2011).