Recombinant Human RCAN1
Cat.No. : | RCAN1-27792TH |
Product Overview : | Recombinant fragment: MKLYFAQTLHIGSSHLAPP N PDKQFLIS PP ASPPVGW KQV EDATPV INYD LLYAI SKLGP , corresponding to N terminal amino acids 1-117 of Human Calcipressin 1 |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. |
Source : | E. coli |
Tissue specificity : | Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 0.1M Sodium chloride, 20mM Tris 7.5, 1mM DTT |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGPGEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS |
Sequence Similarities : | Belongs to the RCAN family. |
Gene Name : | RCAN1 regulator of calcineurin 1 [ Homo sapiens ] |
Official Symbol : | RCAN1 |
Synonyms : | RCAN1; regulator of calcineurin 1; Down syndrome critical region gene 1 , DSCR1; calcipressin-1; |
Gene ID : | 1827 |
mRNA Refseq : | NM_004414 |
Protein Refseq : | NP_004405 |
MIM : | 602917 |
Uniprot ID : | P53805 |
Chromosome Location : | 21q22.1-q22.2 |
Pathway : | Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem; |
Function : | DNA binding; protein binding; sequence-specific DNA binding transcription factor activity; |
Products Types
◆ Recombinant Protein | ||
RCAN1-4631R | Recombinant Rat RCAN1 Protein, His (Fc)-Avi-tagged | +Inquiry |
RCAN1-4029H | Recombinant Human RCAN1 Protein, GST-tagged | +Inquiry |
Rcan1-5433M | Recombinant Mouse Rcan1 Protein, Myc/DDK-tagged | +Inquiry |
RCAN1-5347C | Recombinant Chicken RCAN1 | +Inquiry |
RCAN1-088H | Recombinant Human RCAN1 Protein, HIS-tagged | +Inquiry |
◆ Lysates | ||
RCAN1-510HCL | Recombinant Human RCAN1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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