Recombinant Human RCAN1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RCAN1-3958H
• Product Overview: RCAN1 MS Standard C13 and N15-labeled recombinant protein (NP_004405) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 27.9 kDa
• AA Sequence: MEDGVAGPQLGAAAEAAEAAEARAR PGVTLRPFAPLSGAAEADEGGGDWS FIDCEMEEVDLQDLPSATIACHLDP RVFVDGLCRAKFESLFRTYDKDITF QYFKSFKRVRINFSNPFSAADARLQ LHKTEFLGKEMKLYFAQTLHIGSSH LAPPNPDKQFLISPPASPPVGWKQV EDATPVINYDLLYAISKLGPGEKYE LHAATDTTPSVVVHVCESDQEKEEE EEMERMRRPKPKIIQTRRPEYTPIH LSTRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RCAN1 regulator of calcineurin 1 [ Homo sapiens (human) ]
• Official Symbol: RCAN1
• Synonyms: RCAN1; regulator of calcineurin 1; Down syndrome critical region gene 1, DSCR1; calcipressin-1; near DSCR proline-rich protein; Down syndrome candidate region 1; calcium and oxidant-inducible mRNA; Down syndrome critical region gene 1; down syndrome critical region protein 1; modulatory calcineurin-interacting protein 1; myocyte-enriched calcineurin-interacting protein 1; CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78
• Gene ID: 1827
• mRNA Refseq: NM_004414
• Protein Refseq: NP_004405
• MIM: 602917
• UniProt ID: P53805