• Official Full Name
  • retinal pigment epithelium-specific protein 65kDa
  • Background
  • This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq, Jul 2008]
  • Synonyms
  • RPE65; retinal pigment epithelium-specific protein 65kDa; LCA2; RP20; rd12; mRPE65; sRPE65; retinoid isomerohydrolase; p63; retinol isomerase; RBP-binding membrane protein; all-trans-retinyl-palmitate hydrolase; retinitis pigmentosa 20 (autosomal recessive); retinal pigment epithelium-specific 65 kDa protein;
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPE65, His-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human RPE65, MYC/DDK-tagged
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RPE65
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RPE65 Protein
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RPE65 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RPE65

Involved Pathway

RPE65 involved in several pathways and played different roles in them. We selected most pathways RPE65 participated on our site, such as Retinol metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPE65 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Retinol metabolism
CYP3A41B; SDR16C5B; RDH10B; CYP26C1; UGT2B15; ADH1; HSD17B6; CYP4A10; RPE65C; CYP2C39

Protein Function

RPE65 has several biochemical functions, for example, all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity, all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity, cardiolipin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPE65 itself. We selected most functions RPE65 had, and list some proteins which have the same functions with RPE65. You can find most of the proteins on our site.
Related Protein
Function all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
Related Protein RPE65; RPE65A
Function all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
Related Protein RPE65A; RPE65
Function cardiolipin binding
Related Protein UQCC3; ATP8B1; STOML2; RPE65
Function metal ion binding
Related Protein ZFP865; BAK1; CHAMP1; ZBTB39; MIPEP; KLF2; REST; OSR1; CHSY1; CDK5RAP1
Function phosphatidylcholine binding
Related Protein APOA4B.2; APOA4B.1; CETP; APOA4; APOA5; ESYT2; APOA1A; GPR12; NF1; GPR119
Function phosphatidylserine binding
Related Protein RPE65; GAP43; CPNE1; CD300A; MFGE8; FCHO2; AP1S2; CPNE6; OSBPL10; RS1
Function retinal isomerase activity
Related Protein RPE65

RPE65 Related Articles

Kotterman, MA; Yin, L; et al. Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates. GENE THERAPY 22:116-126(2015).
Kotterman, MA; Schaffer, DV; et al. Engineering adeno-associated viruses for clinical gene therapy. NATURE REVIEWS GENETICS 15:445-451(2014).