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RPE65

  • Official Full Name

    retinal pigment epithelium-specific protein 65kDa

  • Overview

    This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq, Jul 2008]
  • Synonyms

    RPE65; retinal pigment epithelium-specific protein 65kDa; LCA2; RP20; rd12; mRPE65; sRPE65; retinoid isomerohydrolase; p63; retinol isomerase; RBP-binding membrane protein; all-trans-retinyl-palmitate hydrolase; retinitis pigmentosa 20 (autosomal recessive); retinal pigment epithelium-specific 65 kDa protein;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human cells
  • Mamanlian cells
  • Mammalian Cell
  • DYKDDDDK
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RPE65-351H Recombinant Human RPE65 Mammalian Cell His
Human RPE65-2371H Recombinant Human RPE65, His-tagged E.coli His 204-533aa
Human RPE65-246H Recombinant Human RPE65, MYC/DDK-tagged HEK293 Myc/DDK
Human RPE65-3583H Recombinant Human RPE65 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RPE65-2372H Recombinant Human RPE65 protein, His-tagged E.coli His Ser2~Ser533
Human RPE65-01HCL Recombinant Human RPE65 Over-expression Lysate, Myc/DDK-tagged HEK293T Myc/DDK
Human RPE65-4003H Recombinant Human RPE65 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RPE65-01H Recombinant Human RPE65 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human RPE65-02H Recombinant Human RPE65 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human RPE65-9843HFL Recombinant Full Length Human RPE65, Flag-tagged Mamanlian cells Flag
Human RPE65-4003H-B Recombinant Human RPE65 Protein Pre-coupled Magnetic Beads HEK293
Mouse Rpe65-5581M Recombinant Mouse Rpe65 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Rpe65-2031M Recombinant Mouse Rpe65 Protein, His-tagged E.coli N-His Ser2-Ser533
Rat RPE65-5104R Recombinant Rat RPE65 Protein Mammalian Cell His
Rat RPE65-4763R Recombinant Rat RPE65 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RPE65-4763R-B Recombinant Rat RPE65 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey RPE65-866C Recombinant Cynomolgus RPE65 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey RPE65-609C-B Recombinant Cynomolgus Monkey RPE65 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey RPE65-609C Recombinant Cynomolgus Monkey RPE65 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken RPE65-6447C Recombinant Chicken RPE65 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RPE65 Related Articles

RPE65 involved in several pathways and played different roles in them. We selected most pathways RPE65 participated on our site, such as Retinol metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPE65 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Retinol metabolismRDH8B;PNPLA4;AOX4;RPE65;DHRS3;AOX2P;RDH11;ALDH1A1;CYP2C37

RPE65 has several biochemical functions, for example, all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity, all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity, cardiolipin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPE65 itself. We selected most functions RPE65 had, and list some proteins which have the same functions with RPE65. You can find most of the proteins on our site.

Function Related Protein
all-trans-retinyl-ester hydrolase, 11-cis retinol forming activityRPE65;RPE65A
all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activityRPE65A;RPE65
cardiolipin bindingRPE65;STOML2;ATP8B1;UQCC3
metal ion bindingPPTC7;ZDHHC20A;Ar;ACVR2AA;MICALL2;ZNF79;SHHA;HPD;FTR50
phosphatidylcholine bindingAPOA4A;GPR12;APOA5;APOA4;PCTP;RASGRP1;APOA4B.1;SERPINA5;NF1
phosphatidylserine bindingAXL;CD300A;GAP43;MARK1;GAS6;TRIM72;PLCD1;RS1;THBS1
retinal isomerase activity

RPE65 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPE65 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPE65.

Kotterman, MA; Yin, L; et al. Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates. GENE THERAPY 22:116-126(2015).
Kotterman, MA; Schaffer, DV; et al. Engineering adeno-associated viruses for clinical gene therapy. NATURE REVIEWS GENETICS 15:445-451(2014).
  • Q&As
  • Reviews

Q&As (7)

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What is the impact of gene therapy targeting RPE65 on inherited retinal dystrophies? 02/05/2022

Gene therapy targeting RPE65 shows promise in treating inherited retinal dystrophies, restoring some visual functions.

What role does RPE65 play in the conversion of vitamin A derivatives in the retina? 01/31/2022

RPE65 facilitates the conversion of vitamin A derivatives, essential for the regeneration of visual pigments.

What are the mechanisms by which RPE65 mutations affect visual acuity and night vision? 10/15/2021

Mutations in RPE65 impact visual acuity and night vision, leading to difficulties in low-light conditions.

How do alterations in RPE65 expression or activity affect age-related macular degeneration? 06/02/2021

Changes in RPE65 may contribute to the progression of age-related macular degeneration, affecting central vision.

How does RPE65 influence the regeneration of photoreceptors and visual pigment? 03/18/2021

RPE65 is involved in the regeneration of photoreceptors and visual pigments, key for maintaining healthy vision.

How does RPE65 (Retinal Pigment Epithelium-Specific 65kDa Protein) function in the visual cycle and retinal health? 09/02/2020

RPE65 is crucial in the visual cycle, converting vitamin A derivatives necessary for retinal function and vision.

How does RPE65 deficiency contribute to retinal diseases like Leber congenital amaurosis and retinitis pigmentosa? 04/16/2018

RPE65 deficiency leads to retinal diseases by disrupting the visual cycle, affecting vision from an early age.

Customer Reviews (3)

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Reviews
09/04/2022

    High-quality protein sequencing, an essential tool in our lab.

    12/29/2020

      Critical expertise in protein engineering, a trusted research resource.

      02/01/2018

        Reliable protein crystallization services, consistently delivers exceptional results.

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