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SFRP5

  • Official Full Name

    secreted frizzled-related protein 5

  • Overview

    Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]
  • Synonyms

    SFRP5; secreted frizzled-related protein 5; SARP3; FRP-1b; SARP-3; sFRP-5; frizzled-related protein 1b; secreted apoptosis related protein 3; secreted apoptosis-related protein 3;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • Mammalian Cell
  • Flag
  • HA
  • His
  • His (Fc)
  • Avi
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SFRP5-2620H Recombinant Human SFRP5 protein, His-tagged E.coli His 30-317aa
Human SFRP5-2619H Recombinant Human SFRP5, His-tagged E.coli His 1-317aa
Human SFRP5-254H Recombinant Human SFRP5 protein, FLAG-tagged HEK293 Flag
Human SFRP5-2621H Active Recombinant Human SFRP5 Protein, HA-tagged CHO HA
Human SFRP5-1226H Recombinant Human SFRP5 Protein, His&SUMO-tagged E.coli N-His&SUMO Glu30-His317
Mouse Sfrp5-712M Active Recombinant Mouse Sfrp5 Protein, HA-tagged CHO HA Ala22-His314
Mouse SFRP5-15012M Recombinant Mouse SFRP5 Protein Mammalian Cell His
Mouse Sfrp5-8102M Recombinant Mouse Sfrp5 protein, His-tagged E.coli His Pro48~Ala161 (Accession # Q9WU66)
Mouse SFRP5-8086M Recombinant Mouse SFRP5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sfrp5-3487M Recombinant Mouse Sfrp5 protein, His-tagged E.coli His 22-314aa
Mouse SFRP5-8086M-B Recombinant Mouse SFRP5 Protein Pre-coupled Magnetic Beads HEK293
Rat Sfrp5-8103R Recombinant Rat Sfrp5 protein, His-tagged E.coli His Ser45~Val162 (Accession # D3ZTV6)
Zebrafish SFRP5-9363Z Recombinant Zebrafish SFRP5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SFRP5 Related Articles
  • SFRP5 Related Research Area

SFRP5 involved in several pathways and played different roles in them. We selected most pathways SFRP5 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SFRP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayWNT2BB;SERPINF1;WNT4;CSNK1A1L;CCND1;PRKACAB;FBXW11A;CACYBP;RHOAB

SFRP5 has several biochemical functions, for example, contributes_to ATP binding, contributes_to ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by SFRP5 itself. We selected most functions SFRP5 had, and list some proteins which have the same functions with SFRP5. You can find most of the proteins on our site.

Function Related Protein
contributes_to ATP bindingATP1A2;ATP1B1;MSH2;MSH6;SFRP5;ATP5D;ABCG8
contributes_to ATPase activityATP5B;RUVBL2;ATP5J;ATP1A2;ATP5L;RFC3;ABCG8;ATP5D;ATP5O
ATPase activity, coupled to transmembrane movement of substancesABCC11;ABCA13;ABCB5;ABCB10;ABCA7;ABCA4A;ABCC12;ABCC8;ABCA1
contributes_to cholesterol transporter activityABCG5;APOA1;SFRP5;APOA2;ABCG8
protein bindingTERF2IP;DMC1;LCMT1;KIF2C;ZC3HAV1;HERPUD1;A2M;RNF135;MYO5B
protein heterodimerization activityTAF9B;ALX4;LTC4S;Bcl2a1b;HIST1H4I;ADD2;SYT16;ANO2;H3F3B

SFRP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SFRP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SFRP5.

Rulifson, IC; Majeti, JZ; et al. Inhibition of secreted frizzled-related protein 5 improves glucose metabolism. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 307:E1144-E1152(2014).
Kikuchi, R; Nakamura, K; et al. An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease. NATURE MEDICINE 20:1464-1471(2014).
You, JJ; Wen, L; et al. Expression of SFRP Family Proteins in Human Keratoconus Corneas. PLOS ONE 8:-(2013).
  • Q&As
  • Reviews

Q&As (5)

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How is SFRP5 expression regulated at the transcriptional and post-transcriptional levels, and what factors influence its expression in different tissues? 02/09/2022

SFRP5 expression is regulated by various factors, including transcriptional regulators and microRNAs. Tissue-specific expression is influenced by developmental cues and environmental signals.

Can you elaborate on the structural features of the SFRP5 protein and how they contribute to its interactions with Wnt ligands? 11/19/2021

SFRP5 has a cysteine-rich domain that interacts with Wnt ligands, preventing their binding to Frizzled receptors. The structural configuration is crucial for modulating Wnt signaling.

Are there any identified genetic variations or polymorphisms in the SFRP5 gene, and how might they influence individual susceptibility to certain diseases? 01/25/2020

Genetic variations in the SFRP5 gene have been identified, and certain polymorphisms are associated with altered susceptibility to diseases such as cancer and metabolic disorders.

How does SFRP5 contribute to tissue regeneration and repair, and what are the implications for regenerative medicine? 06/08/2019

SFRP5 plays a role in tissue regeneration by modulating Wnt signaling during repair processes. Understanding its function contributes to the development of regenerative medicine strategies.

What are the implications of altered SFRP5 expression in diseases, particularly in conditions where dysregulated Wnt signaling is implicated? 09/02/2018

Altered SFRP5 expression is associated with various diseases, including cancer and metabolic disorders, where dysregulated Wnt signaling plays a role in disease progression.

Customer Reviews (3)

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Reviews
05/20/2022

    Satisfied customer—great product!

    08/02/2019

      Impressed with the quality control. This product is a gem in our lab experiments.

      12/17/2018

        Outstanding lab product!

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