• Official Full Name
  • secreted frizzled-related protein 5
  • Background
  • Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SFRP5; secreted frizzled-related protein 5; SARP3; FRP-1b; SARP-3; sFRP-5; frizzled-related protein 1b; secreted apoptosis related protein 3; secreted apoptosis-related protein 3;
Source (Host):CHOSpecies:Human
Product nameRecombinant Human SFRP5 Protein, HA-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human SFRP5 protein, FLAG-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SFRP5, His-tagged
Source (Host):HumanSpecies:Human
Product nameRecombinant Human SFRP5 protein, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SFRP5 Protein
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Sfrp5 Protein, HA-tagged
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sfrp5 protein, His-tagged
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sfrp5 protein, His-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SFRP5

Involved Pathway

SFRP5 involved in several pathways and played different roles in them. We selected most pathways SFRP5 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SFRP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway

Protein Function

SFRP5 has several biochemical functions, for example, contributes_to ATP binding, contributes_to ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by SFRP5 itself. We selected most functions SFRP5 had, and list some proteins which have the same functions with SFRP5. You can find most of the proteins on our site.
Related Protein
Function contributes_to ATP binding
Related Protein ATP1A2; ABCG8; ATP5D; MSH6; SFRP5; ATP1B1; MSH2
Function contributes_to ATPase activity
Related Protein ATP5J; ATP5D; ATP1A2; ATP5A1; MSH2; ATP5L; ATP5O; ATP5B; ABCA7; ATP5C1
Function ATPase activity, coupled to transmembrane movement of substances
Related Protein ABCB4; ABCB6; ABCA4A; ABCC8; ABCG2D; ABCD4; ABCB10; ABCB1A; Abcb1b; ABCA3
Function contributes_to cholesterol transporter activity
Related Protein SFRP5; APOA1; ABCG8; ABCG5; APOA2
Function protein binding
Related Protein MTAP; CHERP; FAM151B; FAM125B; TRIM71; UBL7; MAP3K7; GPANK1; TXNL4B; GRID2IP
Function protein heterodimerization activity
Related Protein TAF13; TGFB2; NR2C2; TAF8; GRIN2A; BMP2; HIST1H47; HER5; HIST1H2B5; BTBD11

SFRP5 Related Articles

Rulifson, IC; Majeti, JZ; et al. Inhibition of secreted frizzled-related protein 5 improves glucose metabolism. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 307:E1144-E1152(2014).
Kikuchi, R; Nakamura, K; et al. An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease. NATURE MEDICINE 20:1464-1471(2014).
You, JJ; Wen, L; et al. Expression of SFRP Family Proteins in Human Keratoconus Corneas. PLOS ONE 8:-(2013).