SFRP5
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Official Full Name
secreted frizzled-related protein 5
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Overview
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008] -
Synonyms
SFRP5; secreted frizzled-related protein 5; SARP3; FRP-1b; SARP-3; sFRP-5; frizzled-related protein 1b; secreted apoptosis related protein 3; secreted apoptosis-related protein 3;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- CHO
- E.coli
- HEK293
- Mammalian Cell
- Flag
- HA
- His
- His (Fc)
- Avi
- N
- SUMO
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | SFRP5-2620H | Recombinant Human SFRP5 protein, His-tagged | E.coli | His | 30-317aa | |
Human | SFRP5-2619H | Recombinant Human SFRP5, His-tagged | E.coli | His | 1-317aa | |
Human | SFRP5-254H | Recombinant Human SFRP5 protein, FLAG-tagged | HEK293 | Flag | ||
Human | SFRP5-2621H | Active Recombinant Human SFRP5 Protein, HA-tagged | CHO | HA | ||
Human | SFRP5-1226H | Recombinant Human SFRP5 Protein, His&SUMO-tagged | E.coli | N-His&SUMO | Glu30-His317 | |
Mouse | Sfrp5-712M | Active Recombinant Mouse Sfrp5 Protein, HA-tagged | CHO | HA | Ala22-His314 | |
Mouse | SFRP5-15012M | Recombinant Mouse SFRP5 Protein | Mammalian Cell | His | ||
Mouse | Sfrp5-8102M | Recombinant Mouse Sfrp5 protein, His-tagged | E.coli | His | Pro48~Ala161 (Accession # Q9WU66) | |
Mouse | SFRP5-8086M | Recombinant Mouse SFRP5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Sfrp5-3487M | Recombinant Mouse Sfrp5 protein, His-tagged | E.coli | His | 22-314aa | |
Mouse | SFRP5-8086M-B | Recombinant Mouse SFRP5 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | Sfrp5-8103R | Recombinant Rat Sfrp5 protein, His-tagged | E.coli | His | Ser45~Val162 (Accession # D3ZTV6) | |
Zebrafish | SFRP5-9363Z | Recombinant Zebrafish SFRP5 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- SFRP5 Related Articles
- SFRP5 Related Research Area
SFRP5 involved in several pathways and played different roles in them. We selected most pathways SFRP5 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SFRP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Wnt signaling pathway | WNT2BB;SERPINF1;WNT4;CSNK1A1L;CCND1;PRKACAB;FBXW11A;CACYBP;RHOAB |
SFRP5 has several biochemical functions, for example, contributes_to ATP binding, contributes_to ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by SFRP5 itself. We selected most functions SFRP5 had, and list some proteins which have the same functions with SFRP5. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to ATP binding | ATP1A2;ATP1B1;MSH2;MSH6;SFRP5;ATP5D;ABCG8 |
contributes_to ATPase activity | ATP5B;RUVBL2;ATP5J;ATP1A2;ATP5L;RFC3;ABCG8;ATP5D;ATP5O |
ATPase activity, coupled to transmembrane movement of substances | ABCC11;ABCA13;ABCB5;ABCB10;ABCA7;ABCA4A;ABCC12;ABCC8;ABCA1 |
contributes_to cholesterol transporter activity | ABCG5;APOA1;SFRP5;APOA2;ABCG8 |
protein binding | TERF2IP;DMC1;LCMT1;KIF2C;ZC3HAV1;HERPUD1;A2M;RNF135;MYO5B |
protein heterodimerization activity | TAF9B;ALX4;LTC4S;Bcl2a1b;HIST1H4I;ADD2;SYT16;ANO2;H3F3B |
SFRP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SFRP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SFRP5.
- Q&As
- Reviews
Q&As (5)
Ask a questionSFRP5 expression is regulated by various factors, including transcriptional regulators and microRNAs. Tissue-specific expression is influenced by developmental cues and environmental signals.
SFRP5 has a cysteine-rich domain that interacts with Wnt ligands, preventing their binding to Frizzled receptors. The structural configuration is crucial for modulating Wnt signaling.
Genetic variations in the SFRP5 gene have been identified, and certain polymorphisms are associated with altered susceptibility to diseases such as cancer and metabolic disorders.
SFRP5 plays a role in tissue regeneration by modulating Wnt signaling during repair processes. Understanding its function contributes to the development of regenerative medicine strategies.
Altered SFRP5 expression is associated with various diseases, including cancer and metabolic disorders, where dysregulated Wnt signaling plays a role in disease progression.
Customer Reviews (3)
Write a reviewSatisfied customer—great product!
Impressed with the quality control. This product is a gem in our lab experiments.
Outstanding lab product!
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