| Official Full Name | superoxide dismutase 3, extracellular |
| Background | This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008] |
| Synonyms | SOD3; superoxide dismutase 3, extracellular; EC-SOD; extracellular superoxide dismutase [Cu-Zn]; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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SOD3 involved in several pathways and played different roles in them. We selected most pathways SOD3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SOD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
SOD3 has several biochemical functions, for example, SMAD binding, chromatin binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOD3 itself. We selected most functions SOD3 had, and list some proteins which have the same functions with SOD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SMAD binding | PRDM16; CREBBP; ACVR1B; MEF2A; PURB; EP300; HIPK2; SKOR1B; PURA; HMGA2 |
| chromatin binding | SREBF1; ATF5; EGFR; PRKCBP1L; NONO; GLI3; NR5A1A; FABP1; GABPA; TFAP2A |
| histone deacetylase binding | CDC20; NCOR1; KAT2A; NR2E1; HES1; YWHAB; MEF2D; BRMS1LA; HDAC5; XBP1 |
| transcription corepressor activity | RELB; DR1; SRSF2; TBL1X; RUNX1T1; ATF7IP; HDAC9; FEV; PROX1; SMYD1 |
SOD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOD3.
SGTA
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