ACTA2

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ACTA2

Official Full Name actin, alpha 2, smooth muscle, aorta
Background The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Synonyms ACTA2; actin, alpha 2, smooth muscle, aorta; AAT6; ACTSA; MYMY5; actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ACTA2-189H Recombinant Human ACTA2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ACTA2-212H Recombinant Human ACTA2 Protein, GST-tagged Wheat Germ GST
    Human ACTA2-27340TH Recombinant Human ACTA2 Wheat Germ N/A
    Human ACTA2-7151H Recombinant Human Actin, Alpha 2, Smooth Muscle, Aorta, His-tagged E.coli His
    Human ACTA2-7153H Recombinant Human ACTA2 protein, His-tagged E.coli His
    Human ACTA2-7155H Recombinant Human ACTA2 protein, GST-tagged E.coli GST
    Human ACTA2-9066HCL Recombinant Human ACTA2 293 Cell Lysate HEK293 N/A
    Mouse Acta2-3092M Recombinant Mouse Acta2, His-tagged E.Coli or Yeast His
    Mouse Acta2-527M Recombinant Mouse Acta2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rhesus Macaque ACTA2-220R Recombinant Rhesus monkey ACTA2 Protein, His-tagged Mammalian Cell His
    Chicken ACTA2-2890C Recombinant Chicken ACTA2 Mammalian Cell His
    Zebrafish ACTA2-11898Z Recombinant Zebrafish ACTA2 Mammalian Cell His

    ACTA2 involved in several pathways and played different roles in them. We selected most pathways ACTA2 participated on our site, such as Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Vascular smooth muscle contraction NPR1A; PRKACG; PLA2G3; PRKCDA; PRKG1A; ITPR1; ADORA2AA; ROCK1; GNA11; ADCY1B

    ACTA2 has several biochemical functions, for example, ATP binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTA2 itself. We selected most functions ACTA2 had, and list some proteins which have the same functions with ACTA2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DMPK; TTLL9; DDX18; PIK3CD; TTLL2; CDC34B; TTBK2; DDX52; FPGS; ALPK1
    protein kinase binding NSF; SYN1; ARHGEF7; CDKN2C; RELA; CCNYL1; PDPK1; PFKFB2; APC; TRAF6

    ACTA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTA2.

    MYL12B; ACTN2; TTN; TFAP2A; proB; q8cwh4_yerpe; glsA1; TSC1; UL36; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; NS1; URI1; US11; ARAF; VP24; RL1; GABARAPL2; YWHAZ

    Granata, A; Bernard, WG; et al. Temporal and Embryonic Lineage-Dependent Regulation of Human Vascular SMC Development by NOTCH3. STEM CELLS AND DEVELOPMENT 24:846-856(2015).
    Kurahara, LH; Sumiyoshi, M; et al. Intestinal Myofibroblast TRPC6 Channel May Contribute to Stenotic Fibrosis in Crohn's Disease. INFLAMMATORY BOWEL DISEASES 21:496-506(2015).

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