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| Cat.No.: | ADRB2-26H |
| Product Overview: | Recombinant Human ADRB2 fused with GST tag at N-terminal was expressed in Wheat Germ. |
| Description: | This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. |
| Source: | Wheat Germ |
| Species: | Human |
| Tag : | GST |
| Form: | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Molecular Mass: | 73 kDa |
| Protein length: | 1 a.a. - 413 a.a. |
| AA Sequence: | MGQPGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL |
| Applications: | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
| Notes: | Best use within three months from the date of receipt of this protein. |
| Storage: | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Gene Name: | ADRB2 adrenoceptor beta 2 [ Homo sapiens ] |
| Official Symbol: | ADRB2 |
| Synonyms: | BAR; B2AR; ADRBR; ADRB2R; BETA2AR; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor |
| Gene ID: | 154 |
| mRNA Refseq: | NM_000024 |
| Protein Refseq: | NP_000015 |
| MIM: | 109690 |
| UniProt ID: | P07550 |
| Chromosome Location: | 5q32 |
| Pathway: | Adrenergic signaling in cardiomyocytes, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Endocytosis, organism-specific biosystem |
| Function: | adenylate cyclase binding; epinephrine binding; protein binding |
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