Recombinant Human ADRB2 protein

• Cat.No.: ADRB2-25H
• Product Overview: Recombinant Human ADRB2 was expressed in Wheat Germ.

Specification

• Description: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
• Source: Wheat Germ
• Species: Human
• Form: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.
• Molecular Mass: 46.6 kDa
• AA Sequence: MGQPGNGSAFLLAPNRSHAPDHDVT QQRDEVWVVGMGIVMSLIVLAIVFG NVLVITAIAKFERLQTVTNYFITSL ACADLVMGLAVVPFGAAHILMKMWT FGNFWCEFWTSIDVLCVTASIETLC VIAVDRYFAITSPFKYQSLLTKNKA RVIILMVWIVSGLTSFLPIQMHWYR ATHQEAINCYANETCCDFFTNQAYA IASSIVSFYVPLVIMVFVYSRVFQE AKRQLQKIDKSEGRFHVQNLSQVEQ DGRTGHGLRRSSKFCLKEHKALKTL GIIMGTFTLCWLPFFIVNIVHVIQD NLIRKEVYILLNWIGYVNSGFNPLI YCRSPDFRIAFQELLCLRRSSLKAY GNGYSSNGNTGEQSGYHVEQEKENK LLCEDLPGTEDFVGHQGTVPSDNID SQGRNCSTNDSLL
• Applications: Antibody Production; Functional Study; Compound Screening
• Notes: Heating may cause protein aggregation. Please do not heat this product before electrophoresis. Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: ADRB2 adrenoceptor beta 2 [ Homo sapiens ]
• Official Symbol: ADRB2
• Synonyms: BAR; B2AR; ADRBR; ADRB2R; BETA2AR; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor
• Gene ID: 154
• mRNA Refseq: NM_000024
• Protein Refseq: NP_000015
• MIM: 109690
• UniProt ID: P07550
• Chromosome Location: 5q32
• Pathway: Adrenergic signaling in cardiomyocytes, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Endocytosis, organism-specific biosystem
• Function: adenylate cyclase binding; epinephrine binding; protein binding