AKT2

  • Official Full Name

    v-akt murine thymoma viral oncogene homolog 2

  • Overview

    This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
  • Synonyms

    Akt2; AKT2_HUMAN; PKB; PKB beta; PKBBETA; PRKBBy; Protein kinase Akt 2; Protein kinase Akt-2; Protein kinase B beta; RAC BETA; RAC beta serine threonine protein kinase; RAC PK beta; Rac protein kinase beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; RACbeta; V AKT Murine Thymoma Viral Oncogene Homolog 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • GST|His
  • His
  • HIS
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • SUMO
  • MYC
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKT2-1364H Active Recombinant Human AKT2, His-tagged Sf9 Insect Cell His
Human AKT2-102H Active Recombinant Human AKT2, GST-tagged Sf9 Insect Cell GST
Human AKT2-163H Active Recombinant Human AKT2, His-tagged Sf9 Insect Cell His
Human AKT2-802H Active Recombinant Human AKT2, GST-tagged Sf9 Insect Cell GST
Human AKT2-103H Active Recombinant Human AKT2, GST-tagged Sf9 Insect Cell GST
Human AKT2-424H Active Recombinant Human AKT2 Protein, GST-His tagged Insect Cell GST/His
Human AKT2-31H Recombinant Human AKT2 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human AKT2-985H Recombinant Human V-Akt Murine Thymoma Viral Oncogene Homolog 2, His-tagged Sf9 Insect Cell His
Human AKT2-166H Recombinant Human AKT2, His-tagged Sf9 Insect Cell His
Human AKT2-165H Recombinant Human AKT2, His-tagged Insect Cell His
Human AKT2-248H Active Recombinant Human AKT2 Protein, His & GST-tagged Insect Cell His/GST
Human AKT2-1841H Recombinant Human AKT2 protein, His & T7-tagged E.coli His/T7
Human AKT2-8927HCL Recombinant Human AKT2 293 Cell Lysate HEK293 N/A
Human AKT2-260HFL Active Recombinant Full Length Human AKT2 Protein, C-Flag-tagged Mammalian cells Flag
Human AKT2-26262TH Recombinant Human AKT2, His-tagged HIS
Human AKT2-307H Recombinant Human AKT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AKT2-0083H Recombinant Human AKT2 Protein (N2-E481), GST tagged Insect Cell GST
Human AKT2-307H-B Recombinant Human AKT2 Protein Pre-coupled Magnetic Beads HEK293
Human AKT2-0351H Recombinant Human AKT2 Protein (Met1-Lys146), N-His-tagged E.coli N-His
Human AKT2-0082H Recombinant Human AKT2 Protein (N2-E481), Tag Free Insect Cell No tag
Human AKT2-2504H Recombinant Human AKT2 protein, His-SUMO-tagged E.coli His-SUMO
Mouse Akt2-567M Recombinant Mouse Akt2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat AKT2-606R Recombinant Rat AKT2 Protein Mammalian Cell His
Rat AKT2-262R-B Recombinant Rat AKT2 Protein Pre-coupled Magnetic Beads HEK293
Rat AKT2-262R Recombinant Rat AKT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AKT2-297R Recombinant Rhesus monkey AKT2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AKT2-125R Recombinant Rhesus Macaque AKT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AKT2-125R-B Recombinant Rhesus Macaque AKT2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish AKT2-9802Z Recombinant Zebrafish AKT2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AKT2 Related Articles
  • AKT2 Related Gene Family
  • AKT2 Related Research Area
  • AKT2 Related Signal Pathway

AKT2 involved in several pathways and played different roles in them. We selected most pathways AKT2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayDUSP3;TNFRSF1A;HSPA6;ELK4;PLA2G4AA;RPS6KA1;CACNB1;HRASA;SRF
ErbB signaling pathwayPIK3CB;NCK1;MAP2K2;MAPK1;PIK3CG;MAP2K4B;MAPK10;EGFRA;PAK6B
Ras signaling pathwayFGF19;ANGPT1;FGF2;RALBP1;SHC3;FLT4;GNB3;FGF11;KITLG
Rap signaling pathwayVEGFA;FGF3;MAGI1;Fgf15;GNAO1;MAP2K1;PIK3CG;LCP2;PRKD2
cGMP-PKG signaling pathwayMAP2K1;MEF2C;ATP2B1;NOS3;INS1;MEF2D;SLC25A31;SLC8A1;INS2
cAMP signaling pathwayACOX1;NPY;GABBR1;ATP1A2;CAMK2D;PTGER2;Adcy4;ARAP3;AKT1
Chemokine signaling pathwayPRKCZ;SHC1;ELMO1;WAS;BCAR1;CRK;NFKB1;PIK3R3;CCL22
HIF- signaling pathwaySLC2A1;RELA;MAPK1;NOS2;PFKL;SERPINE1;RBX1;EIF4E2;PIK3R5
FoxO signaling pathwayPLK1;MAPK14A;CDKN1BA;G6PC;AKT3A;EP300;BRAF;GABARAPL2;G6PC2
Sphingolipid signaling pathwayKRAS;SPHK1;GNA12;NSMAF;SGMS2;LASS2;RHOA;SPHK2;PLCB4
Phospholipase D signaling pathwayGRM5;DGKD;RRAS;AGTR1A;LPAR2;PDGFRA;MAPK1;PIK3R2;TSC2
mTOR signaling pathwayIKBKB;RPS6KA3A;EIF4E2;POLDIP3;PIK3R3B;STK11;PRKCB;RRAGD;EIF4BB
PIK-Akt signaling pathwayMLST8;FGF13;PPP2R5B;HRAS;G6PC;CCNE1;ITGB1;RELA;IFNB1
AMPK signaling pathwayACACB;CREB1;PIK3CA;RHEB;STRADB;AKT1S1;ADIPOQ;SREBF1;PRKAG2
ApoptosisJUN;PRKAR1AB;STK26;CDKN2A;CDK5RAP2;CAPN1;BIRC7;CYCS;CASP10
Adrenergic signaling in cardiomyocytesCACNG8;ATF2;CACNA1C;ADCY1A;BCL2;CALM1;TMEM8C;MAPK13;MAPK14
VEGF signaling pathwayRAC1A;PIK3CB;MAPK13;MAPK14B;PIK3CG;PIK3R3;MAPKAPK2A;PPP3CCA;MAP2K2A
Osteoclast differentiationMAPK3;IL1B;SQSTM1;PIK3R1;IFNG;FCGR2C;TAB2;TRAF2;MAPK12
Focal adhesionMYL12.2;PTK2;HRAS;RAP1AB;VTNA;ITGB7;PPP1CAB;CAPN2L;ITGA7
Tight junctionPPP2R2C;MYH9;NRAS;JAM2A;ACTN1;CDC42;MYH7B;AKT2L;JAM3B
Signaling pathways regulating pluripotency of stem cellsBMPR1B;IGF1R;LEFTY2;ACVR1B;IL6ST;MAP2K1;SKIL;WNT9A;WNT3A
Platelet activationFCGR2A;ITPR3;PLA2G4D;PIK3R3;APBB1IP;TLN1;VAMP8;GP6;RHOA
Toll-like receptor signaling pathwayAKT3A;TLR1LA;MAPK8A;TLR2-1;IL8L1;IL8L2;AKT2L;MAPK9;PIK3R5
Jak-STAT signaling pathwayCCND3;IFNA1;LIFR;IFNW1;IFNA16;IL22RA2;CNTFR;IL20RB;CRFB4
T cell receptor signaling pathwayNFATC1;CARD11;PAK1;CD8B1;DBNLB;CBLC;MAP3K14;DLG1;TEC
B cell receptor signaling pathwayCD72;RAC2;VAV2;PIK3R1;PIK3AP1;CMTM3;PPP3R1;cgr2b;FCGR2B
Fc epsilon RI signaling pathwayRAC1;SOS1;MAPK8;RAF1;BTK;PIK3CG;FCER1G;MAPK11;HRAS
Fc gamma R-mediated phagocytosisASAP1;MARCKSL1;SYK;CDC42;PIK3CB;PIP5K1C;WASF2;MAPK3;PIP5K1A
TNF signaling pathwayCXCL5;TRADD;MAP3K14;PIK3R2;MAGI2;Ccl12;MLKL;ATF4;CXCL2
Neurotrophin signaling pathwayTRP53;SORT1;RAF1;RHOA;NTRK1;PSEN2;SH2B2;HRAS;ARHGDIG
Cholinergic synapseGNG5;PIK3CA;CREB3;KCNJ4;GNAI1;PIK3R3;PIK3R5;PLCB2;GNG4
Dopaminergic synapseGNAI3;GRIA2;PPP2R2D;PPP2R5C;GNAO1;GRIN2A;COMT;PPP2R5A;KIF5C
Insulin signaling pathwayCALM2;PRKAG3;FOXO1A;RPS6KB1B;PIK3CD;CBL;SHC4;SHC2;RAPGEF1B
Progesterone-mediated oocyte maturationADCY1A;HSP90AA1.2;PPP1R2P9;INS2;GNAI2;MAPK1;PIK3CA;MAP2K1;ANAPC5
Estrogen signaling pathwaySHC1;MMP9;MAP2K2;MMP2;ATF6B;KCNJ3;SHC4;PLCB3;NOS3
Prolactin signaling pathwayESR2;TNFSF11;PRL;GRB2;MAP2K1;MAPK10;SOCS2;ELF5;KRAS
Thyroid hormone signaling pathwayACTG1;PIK3R5;NCOA3;HIF1A;TSC2;MED4;PRKCG;ATP1A2;MAP2K1
Adipocytokine signaling pathwayNFKB1;G6PCA.2;AKT3A;JAK2A;AKT1;ACSL1;PRKAA2;PPARGC1A;CPT1C
Regulation of lipolysis in adipocytesFABP4;PIK3CA;GNAI1;PIK3R2;AKT1;TSHB;PRKG1;PRKACA;PRKACG
Insulin resistanceRPS6KA2;CRTC2;PPP1R3CB;PPARGC1A;MAPK8A;PCK1;NFKB1;PPARGC1B;PRKAB1A
Non-alcoholic fatty liver disease (NAFLD)INS2;ERN1;PRKAB2;NDUFA9;MAP3K11;NDUFV3;CASP7;NDUFA4L2;NDUFS3
Carbohydrate digestion and absorptionSLC2A5;TAS1R3;SLC2A2;PIK3R2;PIK3R1;SLC37A4;HK1;AMY2A4;PIK3CB
Chagas disease (American trypanosomiasis)IL1B2;SERPINE1;IL6;GNAI1;PIK3R2;Fasl;CALR;CD3D;MYD88
ToxoplasmosisMAPK11;IRAK4;GNAI1;LAMA4;ITGB1;IL10RB;BAD;BIRC2;HSPA1L
TuberculosisRFXAP;HLA-DMA;IRAK1;C3;TLR2;CLEC4E;HLA-DRB5;LAMP2;TNF
Hepatitis CKRAS;PPP2CB;MAPK12;CLDN16;IFN-a;CLDN9;EIF2AK1;PIAS1;IFNA10
Hepatitis BCASP9;IKBKE;IL-8;IFNA10;PTK2B;YWHAB;PIK3R3;IKBKB;EGR3
MeaslesIL1B;MSN;CD3G;TACR1;PIK3CA;NFKBIA;STAT2;IL6;CD3E; CD3D
Influenza AHLA-DPA1;BLB2;Ifna11;OAS2;PIK3CA;CPSF4;CCL2;FDPS;IFNA21
HTLV-I infectionATF3;EGR2;NFKB2;SMAD3;POLE4;HRAS;TLN1;PRKACB;APC2
Epstein-Barr virus infectionRELB;HLA-DQA2;YWHAH;PSMD3;YWHAG;MAPK13;FCER2;PSMD13;PLCG2
Pathways in cancerPTGS2;HGF;AXIN2;BIRC7;LAMA4;PTGER1;GLI2;MSH2;PLCB1
Proteoglycans in cancerVAV2;CBL;CAV2;PIK3R3;ITPR1;VTN;TRP53;PPP1R12B;PLCG2
Colorectal cancerGSK3B;TCF7;SMAD2;MSH6;RAC2;AXIN2;APC2;CCND1;PIK3CB
Renal cell carcinomaGRB2;RAPGEF1;TGFB2;AKT1;RAC1;PIK3CB;RAP1A;PIK3R3;TGFA
Pancreatic cancerSTAT3;TGFB2;PIK3R1;RALB;TP53;IKBKG;RAC2;RAF1;TGFA
Endometrial cancerBRAF;PIK3CD;ELK1;CDH1;PIK3R3;PIK3R1;ERBB2;AKT2;PDPK1
GliomaCALML3;CALM2;PDGFB;CALML5;KRAS;PIK3CG;TP53;IGF1;PLCG2
Prostate cancerMAPK1;TRP53;FGFR2;CREB3L1;CASP9;GRB2;FGFR1;INS;CCNE1
MelanomaPDGFD;RB1;MAP2K2;CDH1;PIK3R1;FGF9;FGF22;MAPK3;RAF1
Chronic myeloid leukemiaNRAS;MAP2K2;PIK3CB;TGFBR2;GRB2;MDM2;CRK;CBL;STAT5A
Acute myeloid leukemiaPIK3R5;PML;RAF1;STAT5B;RPS6KB1;RELA;MAPK1;CCND1;PIK3R3
Small cell lung cancerCYCS;IKBKG;PTK2;RB1;PTGS2;ITGAV;LAMA5;LAMA2;PIK3R1
Non-small cell lung cancerRASSF1;PIK3R3;MAPK3;BRAF;PIK3CG;RXRA;GRB2;PRKCA;MAP2K2
Central carbon metabolism in cancerPDGFRA;FGFR3;PDHB;FGFR1;PGAM2;G6PD;PIK3R2;PDGFRB;PFKL
Choline metabolism in cancerEGF;HRAS;SLC5A7;SLC22A5;PDGFD;MAPK8;PLA2G4B;AKT2;PLA2G4F

AKT2 has several biochemical functions, for example, ATP binding, protein binding, protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT2 itself. We selected most functions AKT2 had, and list some proteins which have the same functions with AKT2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingENTPD8;MCM9;ATP8A1;EHD1;CAMKV;STK17B;PAK4;TLK2;CLK2
protein bindingANG;NOS2;COA3;SHISA5;S100A1;HERPUD1;COMMD9;SYT11;KREMEN1
protein kinase C bindingTIRAP;SQSTM1;DACT1;TRPV4;GNB2L1;PICK1;DACT2;PKP2;AVPR1A
protein serine/threonine kinase activityRAF1;GM7168;DYRK1A;MAP3K2;TSSK4;PHKG1A;TTBK1;WNK2;RAF1B

AKT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT2.

HSP90AB1; crosstide; CASP3; GSK3B; LRRK2; SH3RF1; MYH13; VIM; SETDB1; CDC37; SORBS2; APOA1; APOB

van de Luijtgaarden, ACM; Roeffen, MHS; et al. IGF signaling pathway analysis of osteosarcomas reveals the prognostic value of pAKT localization. FUTURE ONCOLOGY 9:1733-1740(2013).
Marchbank, T; Mahmood, A; et al. Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F382-F389(2013).
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  • Q&As
  • Reviews

Q&As (10)

Ask a question
How is AKT2 protein activated? 03/30/2022

AKT2 can be activated through a process called phosphorylation. When growth factors or hormones such as insulin bind to their receptors on the cell surface, it triggers a signaling cascade resulting in the activation of phosphoinositide 3-kinase (PI3K). PI3K produces a lipid product, which recruits AKT2 to the cell membrane. At the membrane, AKT2 undergoes phosphorylation by activating kinases, leading to its full activation. Once activated, AKT2 phosphorylates downstream targets, initiating various cellular responses.

How is AKT2 protein studied in research? 01/11/2022

Researchers use various molecular and cellular techniques to study AKT2 protein and its functions. This includes techniques like Western blotting to detect and quantify AKT2 protein levels, immunofluorescence microscopy to examine its cellular localization, and kinase activity assays to measure its enzymatic activity.

What are some inhibitors or activators of AKT2 protein? 03/11/2021

Several small molecule inhibitors and activators have been developed to modulate AKT2 activity. Some commonly used AKT inhibitors include LY294002, MK-2206, and GSK2141795. These inhibitors block AKT2 phosphorylation and downstream signaling, leading to the inhibition of cell survival and proliferation. On the other hand, some activators of AKT2 include insulin and growth factors like insulin-like growth factor 1 (IGF-1). These molecules activate the insulin signaling pathway and stimulate AKT2 phosphorylation and activity.

Are there any clinical trials targeting AKT2 protein? 01/20/2021

Clinical trials targeting AKT2 are still in the early stages, and most current trials are focused on AKT inhibitors rather than specifically targeting AKT2. These trials aim to evaluate the safety and efficacy of AKT inhibitors in treating various cancers, including breast, lung, and ovarian cancers.

What role does AKT2 play in insulin signaling? 07/25/2020

AKT2 is a critical component of the insulin signaling pathway. Insulin binds to its receptor on cell surfaces, activating the receptor's intracellular domains. This, in turn, triggers the activation of PI3K and subsequent recruitment and activation of AKT2. Activated AKT2 facilitates the translocation of glucose transporter proteins (GLUT4) to the cell membrane, allowing for the uptake of glucose from the bloodstream into the cells. AKT2 also promotes glycogen synthesis and inhibits glucose production, ultimately maintaining glucose homeostasis.

Are there any genetic mutations associated with AKT2? 04/01/2020

Yes, genetic mutations in the AKT2 gene have been identified and linked to human diseases. These mutations can lead to abnormal AKT2 function and contribute to the development of insulin resistance and type 2 diabetes. Some studies have also suggested that AKT2 mutations might play a role in certain cancers, although further research is needed to clarify the significance of these mutations in cancer development.

Can AKT2 protein be targeted for therapeutic purposes? 09/23/2019

Yes, AKT2 is considered a potential therapeutic target for various diseases, particularly those related to glucose metabolism and insulin resistance. Modulating AKT2 activity can help regulate glucose homeostasis and improve insulin sensitivity. Developing drugs that specifically target AKT2 can potentially lead to more effective treatments for conditions like type 2 diabetes and obesity. However, further research is necessary to fully understand the complexities of AKT2 signaling and its potential as a therapeutic target.

What functions does AKT2 protein have in the body? 03/13/2019

AKT2 has several important functions in the body. It plays a key role in insulin signaling and glucose metabolism by promoting the uptake of glucose into cells and regulating its utilization. AKT2 also contributes to cell survival, growth, and proliferation through various intracellular signaling pathways. Additionally, AKT2 is involved in regulating lipid metabolism, protein synthesis, and cell migration.

Can AKT2 protein be detected in biological samples? 07/23/2016

Yes, AKT2 protein can be detected in various biological samples such as tissue lysates, cell cultures, and body fluids. Techniques like Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA) are commonly used to detect and quantify AKT2 protein levels. These methods rely on specific antibodies that recognize and bind to AKT2, allowing for its detection and measurement. Such assays are invaluable in research and clinical settings for understanding AKT2 expression and its potential implications in disease states.

What happens when AKT2 is dysregulated or dysfunctional? 04/17/2016

Dysregulation or dysfunction of AKT2 can have significant implications for cellular processes and overall health. Reduced or impaired AKT2 signaling is associated with insulin resistance, a condition where cells become less responsive to insulin, resulting in elevated blood glucose levels. Insulin resistance can lead to the development of metabolic disorders like type 2 diabetes, obesity, and cardiovascular diseases. Abnormal AKT2 activity has also been linked to cancer, as it can promote uncontrolled cell growth, survival, and resistance to apoptosis.

Customer Reviews (5)

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Reviews
12/04/2021

    the AKT2 protein is highly recommended for its superior performance in ELISA and its utility in protein electron microscopy structure analysis.

    02/19/2020

      Incorporating the AKT2 protein into research endeavors ensures accurate and comprehensive results, bringing us closer to unraveling the complexities of cellular processes.

      06/24/2017

        Its exceptional reliability and compatibility with various research methodologies make it an invaluable asset for scientists seeking to delve into protein-protein interactions, signaling pathways, and structural investigations.

        03/27/2017

          Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.

          05/27/2016

            Its robust nature and stability make it suitable for imaging studies, providing researchers with a detailed understanding of the protein's structural characteristics.

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