AKT2 Protein

September 27-30, 2022

Boston Convention and Exhibition Center

Booth #336

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AKT2

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AKT2

Official Full Name v-akt murine thymoma viral oncogene homolog 2
Background This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
Synonyms Akt2; AKT2_HUMAN; PKB; PKB beta; PKBBETA; PRKBBy; Protein kinase Akt 2; Protein kinase Akt-2; Protein kinase B beta; RAC BETA; RAC beta serine threonine protein kinase; RAC PK beta; Rac protein kinase beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; RACbeta; V AKT Murine Thymoma Viral Oncogene Homolog 2
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • His-SUMO
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKT2-102H Recombinant Human AKT2, GST-tagged, Active Sf9 Insect Cell GST
    Human AKT2-103H Recombinant Human AKT2, GST-tagged, Active Sf9 Insect Cell GST
    Human AKT2-1364H Recombinant Human AKT2 (Active), His-tagged Sf9 Insect Cell His
    Human AKT2-163H Recombinant Human AKT2, Active, His-tagged Sf9 Insect Cell His
    Human AKT2-165H Recombinant Human AKT2, His-tagged Insect Cell His
    Human AKT2-166H Recombinant Human AKT2, His-tagged Sf9 Insect Cell His
    Human AKT2-1841H Recombinant Human AKT2 protein, His & T7-tagged E.coli His/T7
    Human AKT2-248H Recombinant Human AKT2 Protein, His & GST-tagged Insect Cell His/GST
    Human AKT2-31H Recombinant Human AKT2 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human AKT2-424H Recombinant Human AKT2 Protein, GST-His tagged Insect Cell GST/His
    Human AKT2-802H Recombinant Human AKT2, GST-tagged Sf9 Insect Cell GST
    Human AKT2-985H Recombinant Human V-Akt Murine Thymoma Viral Oncogene Homolog 2, His-tagged Sf9 Insect Cell His
    Rat AKT2-606R Recombinant Rat AKT2 Protein Mammalian Cell His
    Rhesus Macaque AKT2-297R Recombinant Rhesus monkey AKT2 Protein, His-tagged Mammalian Cell His
    Zebrafish AKT2-9802Z Recombinant Zebrafish AKT2 Mammalian Cell His
    Human AKT2-8927HCL Recombinant Human AKT2 293 Cell Lysate HEK293 N/A
    Human AKT2-2504H Recombinant Human AKT2 protein, His-SUMO-tagged E.coli His-SUMO
    Human AKT2-26262TH Recombinant Human AKT2, His-tagged HIS
    Mouse Akt2-567M Recombinant Mouse Akt2 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    AKT2 involved in several pathways and played different roles in them. We selected most pathways AKT2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CASP3B; FLNC; NR4A1; FGF13A; C11orf52; GADD45BB; MAPK14A; FASLG; IL1R2; PPP3R1
    ErbB signaling pathway PAK2B; GRB2; PIK3CG; PAK2; MAPK8; PLCG2; SRC; PIK3R2; AREG; BADB
    Ras signaling pathway RASAL3; BCL2L1; Fgf15; RASAL1; RHOA; ETS1; FGF21; GNG3; GNG12; GNG13
    Rap signaling pathway PLCE1; PIK3CD; PRKCB; Fgf15; LCP2; FGFR4; ANGPT4; FGF21; FGFR1; RAC1
    cGMP-PKG signaling pathway PPP1CC; ATP2A3; AKT2; BNP; NFATC3; PLCB2; NPR1; KCNJ8; RGS2; INSR
    cAMP signaling pathway NFKB1; PDE3B; CALM3; GNAI3; RHOA; CNGA1; NPY1R; RAC3; FXYD1; PDE4B
    Chemokine signaling pathway CCR1; STAT1; ADRBK2; RHOA; WAS; GM1987; SHC4; MAP2K1; HRAS; PF4V1
    HIF- signaling pathway ERBB2; HKDC1; PIK3CG; PIK3R2; TEK; IL6; RPS6; AKT2; Trf; ARNT
    FoxO signaling pathway RAF1A; PCK2; STK4; MAPK13; GADD45G; SMAD2; EP300; BNIP4; NLK1; S1PR4
    Sphingolipid signaling pathway PRKCB; BCL2; MAPK3; BID; PPP2R1B; SPHK1; HRAS; ABCC1; DEGS1; PPP2R2C
    Phospholipase D signaling pathway PPAP2B; CYTH4; GRM6; CYTH2; INS1; PDGFB; AVP; RALB; GAB2; GRM2
    mTOR signaling pathway EIF4E1C; RRAGD; RHEB; VEGFAA; EIF4E1B; RPS6KB1; RICTOR; PIK3R2; PRR5; AKT3A
    PIK-Akt signaling pathway IGF1R; FGFR3; FGF18; ITGAV; PPP2R2A; FGF5; AKT2; PIK3R3; PPP2R5B; NGF
    AMPK signaling pathway CPT1A; PPP2R5B; ADIPOR1; PIK3CA; G6PC; FBP2; STRADA; INSR; FOXO3; SIRT1
    Apoptosis BOK; IRAK1; MYD88; PPP3R1; BIDA; PRKACBB; HMGB2; GZMC; FASLG; CDKN2A
    Adrenergic signaling in cardiomyocytes PRKCA; TPM4A; PPP1R1A; ACTC1A; PRKACAA; CACNG2A; ADCY2B; ATP1B2A; MYH15; PPP1CC
    VEGF signaling pathway MAPK11; RAC1A; AKT2L; PPP3CC; VEGFA; PTGS2B; PXN; CDC42L; PLA2G4F; NRAS
    Osteoclast differentiation SOCS3; LILRB4; CYLD; MAPK10; FCGR1; TGFB1; STAT1; SPI1; NFKB2; LILRB5
    Focal adhesion PDPK1B; COL11A2; PXN; HRASA; PAK4; PAK2A; PRKCBA; ACTN3B; MYL9B; ITGA8
    Tight junction EXOC4; CLDN14; GNAIA; INADL; MYH1E; PPP2R2CA; CLDN10A; CLDN19; JAM3B; VMHCL
    Signaling pathways regulating pluripotency of stem cells JARID2; LIF; ID3; GRB2; INHBB; WNT1; NRAS; WNT2B; ID4; FZD6
    Platelet activation TBXA2R; FGB; LYN; GP9; SNAP23; PLA2G4D; ACTB; GNAQ; MYL12B; GUCY1B3
    Toll-like receptor signaling pathway MAPK8A; TRAF6; IRF7; PIK3CA; IFNA1; MAPK12B; IL12A; IL6; IRF5; IFNA4
    Jak-STAT signaling pathway GRB2A; IFNPHI1; CCND2; CISH; PIK3R5; SOCS3; PRLR; PIK3CB; IL13RA1; IL19
    T cell receptor signaling pathway CDC42; FOS; IKBKG; KRAS; NFKBIE; VAV3; PIK3R5; MUC1; AKT2; IL4
    B cell receptor signaling pathway NFKBIA; LAT2; NRAS; DOK3; MAP2K1; CDK4; STAP1; NFKBIB; DAPP1; PIK3R2
    Fc epsilon RI signaling pathway KRAS; HRAS; MAPK13; LAT; FCER1A; PDPK1; MAP2K2; PIK3CG; MAPK12; SYK
    Fc gamma R-mediated phagocytosis MARCKS; FCGR2A; SCIN; PAK1; FCGR3A; PLD1; SYK; PIK3R5; PLD2; MYO10
    TNF signaling pathway Ccl12; SELE; IKBKB; MMP14; PIK3CA; MAPK1; VEGFC; CASP7; PGAM5; IL18R1
    Neurotrophin signaling pathway HRAS; PRKCD; NFKB1; CALML3; SHC1; PIK3R5; SOS1; SH2B3; SORT1; MAPK10
    Cholinergic synapse ATF4; ACHE; KCNJ12; HRAS; AKT1; MAPK3; KCNJ3; CAMK2A; GNAO1; AKT2
    Dopaminergic synapse KIF5A; CAMK2A; GNG11; ATF4; PPP2R3A; ITPR1; GNB2; GRIN2B; GNG12; CAMK2G
    Insulin signaling pathway TSC2; PPP1CAA; PPP1R3CB; HK3; PIK3R3; PRKACA; RPS6; PDPK1B; G6PC; SOCS3B
    Progesterone-mediated oocyte maturation CPEB1; CDC27; MAPK13; AKT2; MAPK12B; ADCY1A; MAPK8B; FZR1A; GNAI2B; MAPK9
    Estrogen signaling pathway ATF6B; FKBP4; GNAO1; HSPA6; CREB3L2; GNAS; GRM1; GNAI3; PLCB3; SHC4
    Prolactin signaling pathway SOCS5; SHC4; PPIB; SOCS1; SOS1; STAT3; MAPK3; PIK3CA; STAT5A; SOCS2
    Thyroid hormone signaling pathway PRKCA; SLC16A10; TBC1D4; PDPK1; GATA4; MAP2K2; WNT4; RXRB; PIK3CG; ITGB3
    Adipocytokine signaling pathway PCK1; NFKB1; IRS1; ADIPOR1B; AGRP; CAMKK2; SOCS3; PRKAB1; ACSL3A; ACSL1
    Regulation of lipolysis in adipocytes PIK3R1; PIK3R5; INS1; NPY1R; INS; GNAI2; ABHD5; IRS2; PTGER3; AKT2
    Insulin resistance RPS6KA6; GSK3B; TBC1D4; NFKBIA; SOCS3; IL6; PRKCQ; PPP1R3B; PRKCZ; SLC27A4
    Non-alcoholic fatty liver disease (NAFLD) NDUFC1; NDUFA5; BAX; NDUFA13; RELA; CASP7; NDUFV1; ITCH; NDUFB4; SDHC
    Carbohydrate digestion and absorption PIK3R1; HK2; SLC2A5; AMY2B; AMY2A5; PIK3CD; AMY2A3; GNAT3; ATP1B3; PIK3R2
    Chagas disease (American trypanosomiasis) BDKRB2; CALR; SERPINE1; PIK3R5; RELA; TLR2; PIK3R2; IL12B; PPP2R2C; C1QC
    Toxoplasmosis HLA-DRB1; GNAI2; MAPK8; BCL2; LAMB4; MAP3K7; LAMA4; CYCS; LAMC1; ALOX5
    Tuberculosis CD74; IFNA12; HLA-DQA2; CAMP; TLR4; TNFRSF1A; BAD; TLR2; MAPK9; IFNA6
    Hepatitis C IFNA5; PIK3R3; IFNA4; TBK1; STAT2; PIK3CB; CLDN1; HRAS; PPP2R2C; CLDN9
    Hepatitis B DDX58; IFIH1; EGR3; STAT4; IKBKE; RELA; CASP12; HBXIP; IRF7; PRKCA
    Measles IFNA21; IFNA13; IFNA14; Il2; EIF2AK2; IFNAR1; PIK3R1; TP73; CCNE1; PIK3R5
    Influenza A LOC780933; IRF9; IFNA14; IFNB1; DNAJC3; IL12B; RAE1; TNFRSF1A; ADAR; IFNA13
    HTLV-I infection CRTC1; SMAD2; RRAS2; VDAC2; ZFP36; WNT1; KAT2B; TERT; EP300; SLC25A6
    Epstein-Barr virus infection SKP2; GTF2B; POLR2A; YWHAH; ENTPD3; POLR3B; FCER2; HDAC1; IFNG; HDAC5
    Pathways in cancer RALB; NFKBIA; FZD1; PPARD; FGF7; RAF1; ITGA6; PIAS2; FZD6; CDH1
    Proteoglycans in cancer TFAP4; PPP1CB; STAT3; FLNC; SDC2; CAMK2D; Casp3; THBS1; PIK3CB; WNT6
    Colorectal cancer APC; TGFB2; RAC2; MSH2; RAC1; PIK3CD; PIK3R5; KRAS; MAPK8; CYCS
    Renal cell carcinoma HIF1A; CDC42; MAPK1; FH1; PDGFB; ARNT2; PTPN11; EGLN2; NRAS; ARAF
    Pancreatic cancer ARHGEF6; RAD51; ERBB2; STAT1; PIK3CG; PLD1; MAPK1; TGFBR2; RAF1; CCND1
    Endometrial cancer BAD; LEF1; PIK3CA; PIK3R5; PIK3R1; AXIN1; MAPK3; PIK3R3; PIK3R2; CTNNA3
    Glioma PIK3CA; PIK3CD; RB1; TRP53; CALM2; CAMK2A; PLCG2; PIK3R5; MAPK3; MAP2K1
    Prostate cancer SMARCA4; ACTL6B; SMARCD1; INS1; CASP9; PDGFRB; NKX3; HRAS; PIK3R3; MAPK3
    Melanoma FGF16; PIK3R2; KRAS; PDGFD; NRAS; PDGFRB; FGF3; MITF; MAPK1; PIK3CG
    Chronic myeloid leukemia GAB2; CCND1; NRAS; BCL2L1; TGFBR2; SHC4; STAT5A; BAD; TGFB2; MAPK3
    Acute myeloid leukemia RUNX1; MAPK3; SOS1; PIK3R2; AKT2; PIM1; GRB2; KIT; CEBPA; RUNX1T1
    Small cell lung cancer BIRC8; LAMC1; PIK3R3; PIK3CD; CCNE1; LAMB3; TRAF5; RB1; PIK3R1; LAMC2
    Non-small cell lung cancer PLCG1; EML4; MAP2K2; RARB; RB1; MAP2K1; TRP53; PIK3CA; SOS1; PRKCB
    Central carbon metabolism in cancer PDGFRB; FGFR3; RAF1; FLT3; SLC1A5; MAP2K1; PGAM1; TRP53; C12orf5; SIRT6
    Choline metabolism in cancer SOS1; RPS6KB1; PLA2G4A; PLA2G4D; PIP5K1B; PLD1; PIK3R5; PIK3R2; RAC2; PIK3R1

    AKT2 has several biochemical functions, for example, ATP binding, protein binding, protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT2 itself. We selected most functions AKT2 had, and list some proteins which have the same functions with AKT2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TNIKB; PRKD3; STK32B; CARS; CDK18; PIM2; NLRP4E; RPS6KA4; ERBB3A; MYO1F
    protein binding CDK20; NR1H3; AICDA; USP1; MGAT5B; TOM1L1; TDRD1; ANAPC4; MRPS9; EFHC2
    protein kinase C binding PLEK; SDPRA; TDG; PEA15A; ADD3; TWF2; DACT3; TOP2A; DACT1; TOP2B
    protein serine/threonine kinase activity RAF1; PRKACBA; MAP3K2; WNK1; DSTYK; MYLK4; NLK1; MARK4; STK10; TRIOA

    AKT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT2.

    HSP90AB1; crosstide; CASP3; GSK3B; LRRK2; SH3RF1; MYH13; VIM; SETDB1; CDC37; SORBS2; APOA1; APOB

    van de Luijtgaarden, ACM; Roeffen, MHS; et al. IGF signaling pathway analysis of osteosarcomas reveals the prognostic value of pAKT localization. FUTURE ONCOLOGY 9:1733-1740(2013).
    Marchbank, T; Mahmood, A; et al. Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F382-F389(2013).

    TGF

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