AKT2

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AKT2

Official Full Name v-akt murine thymoma viral oncogene homolog 2
Background This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
Synonyms Akt2; AKT2_HUMAN; PKB; PKB beta; PKBBETA; PRKBBy; Protein kinase Akt 2; Protein kinase Akt-2; Protein kinase B beta; RAC BETA; RAC beta serine threonine protein kinase; RAC PK beta; Rac protein kinase beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; RACbeta; V AKT Murine Thymoma Viral Oncogene Homolog 2
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKT2-102H Recombinant Human AKT2, GST-tagged, Active Sf9 Insect Cell GST
    Human AKT2-103H Recombinant Human AKT2, GST-tagged, Active Sf9 Insect Cell GST
    Human AKT2-1364H Recombinant Human AKT2 (Active), His-tagged Sf9 Insect Cell His
    Human AKT2-163H Recombinant Human AKT2, Active, His-tagged Sf9 Insect Cell His
    Human AKT2-165H Recombinant Human AKT2, His-tagged Insect Cell His
    Human AKT2-166H Recombinant Human AKT2, His-tagged Sf9 Insect Cell His
    Human AKT2-1841H Recombinant Human AKT2 protein, His & T7-tagged E.coli His/T7
    Human AKT2-248H Recombinant Human AKT2 Protein, His & GST-tagged Insect Cell His/GST
    Human AKT2-26262TH Recombinant Human AKT2, His-tagged HIS
    Human AKT2-31H Recombinant Human AKT2 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human AKT2-424H Recombinant Human AKT2 Protein, GST-His tagged Insect Cell GST/His
    Human AKT2-802H Recombinant Human AKT2, GST-tagged Sf9 Insect Cell GST
    Human AKT2-8927HCL Recombinant Human AKT2 293 Cell Lysate HEK293 N/A
    Human AKT2-985H Recombinant Human V-Akt Murine Thymoma Viral Oncogene Homolog 2, His-tagged Sf9 Insect Cell His
    Mouse Akt2-567M Recombinant Mouse Akt2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat AKT2-606R Recombinant Rat AKT2 Protein Mammalian Cell His
    Rhesus Macaque AKT2-297R Recombinant Rhesus monkey AKT2 Protein, His-tagged Mammalian Cell His
    Zebrafish AKT2-9802Z Recombinant Zebrafish AKT2 Mammalian Cell His

    AKT2 involved in several pathways and played different roles in them. We selected most pathways AKT2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAP2K4; MAPK8B; RRAS2; MKNK2; PRKACB; CACNA1D; CACNA2D3; TGFB3; KRAS; ARR3A
    ErbB signaling pathway PIK3R3; MAPK1; ABL2; PIK3CG; PRKCA; RAF1; RPS6KB1B; CBLC; MYCB; GRB2
    Ras signaling pathway GRIN1; FGF19; GNG11; HRAS; RAC3; SHC2; MLLT4; PAK2; RELA; GAB1
    Rap signaling pathway KRAS; DOCK4; KLK1B4; F2R; VEGFA; Itgam&Itgb2; CDC42; P2RY1; PRKCI; PLCB2
    cGMP-PKG signaling pathway NPR2; PIK3R3; OPRD1; AKT1; NFATC3; PPP3R2; ATF4; INS1; GUCY1A3; PPIF
    cAMP signaling pathway SLC9A1; HTR1B; GIPR; CALML3; LIPE; BDNF; GLI1; SOX9; RAC1; FFAR2
    Chemokine signaling pathway GM13304; CCL16; CCL17; CXCL2; CCL11; PARD3; ROCK1; SHC4; WASL; GM1987
    HIF- signaling pathway ANGPT1; TCEB2; NOS3; IL6R; EPO; AKT1; MAPK3; ERBB2; PDHA1; RELA
    FoxO signaling pathway KLF2A; PDPK1B; CCNG2; GADD45AB; SMAD2; FOXO3B; NRAS; PRKAA1; IRS2; PRKAG2
    Sphingolipid signaling pathway PIK3R3; PPP2R5E; SGMS2; FCER1G; BDKRB2; BCL2; PIK3R2; PIK3CD; NFKB1; MS4A2
    Phospholipase D signaling pathway GAB2; GRM6; Adcy4; FYN; KRAS; PPAP2A; PTK2B; GAB1; AGTR1A; CYTH3
    mTOR signaling pathway PDPK1B; HIF1A; VEGFAA; VEGFA; AKT1; CAB39L; CAB39L1; AKT1S1; DEPDC6; AKT2
    PIK-Akt signaling pathway PPP2R3A; ITGB3; LAMB2; ITGA6; GNGT2; FGF2; TNXB; PRKCA; FGF12; GNGT1
    AMPK signaling pathway PPARGC1A; PCK1; PRKAA2; PIK3R3; GYS2; HMGCR; ACACB; PIK3R2; PPP2R3C; CD36
    Apoptosis CFLARA; PPP3CA; NFKBIA; HRK; CDKN2A; CASP3A; AKT1; BOK; PIK3R3; PRKACBA
    Adrenergic signaling in cardiomyocytes ATP1A1A.1; ADRB2; PPP1CBL; ATP1B2B; ADRB2A; CREB3L2; CREB3L3A; ACTC1A; MAPK3; CAMK2A
    VEGF signaling pathway CDC42; KRAS; RAF1A; PPP3R1B; MAPK12B; NOS3; SPHK2; PPP3CB; PRKCA; RAC3B
    Osteoclast differentiation MITF; FCGR2C; SQSTM1; FCGR3A; PPP3R2; TGFB2; CYLD; TNFRSF11B; NOX3; TGFBR2
    Focal adhesion ITGA3B; MYL7; PTK2AA; PXN; COL1A1; SEPP1; PRKCBA; PIK3R1; MYL2; COL4A1
    Tight junction CLDNG; SHROOM3; PRKCA; TJAP1; PPP2CB; CDC42; PARD3; MYHZ2; SRC; HCLS1
    Signaling pathways regulating pluripotency of stem cells NRAS; OTX1; PCGF5; WNT4; LHX5; WNT1; INHBA; ACVR2B; MEIS1; AXIN1
    Platelet activation TBXA2R; GNAI1; TBXAS1; GP9; ITGA2; P2RY1; PPP1CA; GNAQ; PLCG2; FERMT3
    Toll-like receptor signaling pathway IFNA3; MAP2K2; TRAF6; IKBKG; CXCL11; IL8L2; MAPK8B; IFNB1; CCL3; TLR2-2
    Jak-STAT signaling pathway IL21R.1; IFNG; STAT1B; IL27RA; IL10RA; PIAS4B; LEP; PTPN11; Ifna11; IL5RA
    T cell receptor signaling pathway NFKBIB; TNF; PIK3R2; CDC42; VAV3; CBLC; DBNLB; MAPK11; CD8B; OXSR1A
    B cell receptor signaling pathway INPP5D; PDK2; RAC3; IGHM; FCGR2B; PRKCB; CMTM3; PIK3CD; PLEKHA2; LIME1
    Fc epsilon RI signaling pathway PLCG2; FYN; MAPK9; PIK3R1; PLA2G4F; MAPK8; PIK3R5; MAP2K2; PIK3CA; AKT1
    Fc gamma R-mediated phagocytosis PRKCA; FCGR2B; PIK3R3; HCK; CFL1; PIP5K1C; CDC42; WASF2; MYO10; WASL
    TNF signaling pathway TNFAIP3; PIK3R3; CASP7; SOCS3; PIK3R5; MAPK12; MMP3; MAP3K7IP3; TRADD; MLKL
    Neurotrophin signaling pathway SH2B3; PTPN11; MAGED1; MAPK12; NTRK3; MAP2K5; PIK3CB; MAPK13; KRAS; TP53
    Cholinergic synapse GNA11; GNAO1; CHRNA6; PIK3CB; CAMK2D; GNAI3; PRKACA; MAPK1; CHRNA3; KCNJ3
    Dopaminergic synapse GNB2; ATF6B; KCNJ5; CREB3L1; CALML5; GRIA3; GNG11; CAMK2B; GNB1; PRKCG
    Insulin signaling pathway PRKAR2B; TSC2; G6PCA.2; EIF4E2; IRS4; PKLR; EIF4E1B; RPS6KB1; EXOC7; MAP2K1
    Progesterone-mediated oocyte maturation IGF1RB; PRKACAB; PIK3R3B; PLK1; MAPK8B; HSP90AA1.2; RPS6KAL; RAF1B; PIK3R3A; ADCY2B
    Estrogen signaling pathway GNAO1; Adcy4; GNAQ; AKT2; MMP9; HSPA1L; SOS1; HSP90B1; SHC3; CALML3
    Prolactin signaling pathway SOCS3; MAPK12; SHC2; PIK3R3; LHCGR; CCND2; PIK3CG; MAPK3; SOCS5; CSN2
    Thyroid hormone signaling pathway NCOA3; PDPK1; RHEB; NRAS; ACTB; NOTCH1; MED17; NCOA1; SLC16A2; STAT1
    Adipocytokine signaling pathway PRKAA1; LEPA; SLC2A4; ACSL4B; CPT1A; NFKB1; RXRA; AKT2L; POMC; PRKAG1
    Regulation of lipolysis in adipocytes PTGS2; PTGS1; NPY; PIK3R2; PIK3R3; INSR; PRKG2; NPR1; GNAI3; ABHD5
    Insulin resistance MAPK9; CREB3L3A; PRKCDA; IRS1; PIK3R1; IL6; FOXO1A; SLC2A2; PRKAB1B; GSK3B
    Non-alcoholic fatty liver disease (NAFLD) COX6A2; GSK3A; ADIPOR2; XBP1; NDUFA2; COX7A2L; PIK3R3; PRKAG1; NDUFB1; NDUFA12
    Carbohydrate digestion and absorption G6PC; AKT2; GNAT3; HKDC1; PRKCB; PIK3CD; HK3; ATP1A4; G6PC3; SLC2A2
    Chagas disease (American trypanosomiasis) C3; PIK3CA; IFNG; C1QA; IL12A; TLR2; IRAK1; IKBKB; PLCB1; TLR9
    Toxoplasmosis AKT2; IL10RB; IL10RA; AKT1; HSPA1A; LAMB2; IL12B; IFNG; BIRC2; HLA-DRB1
    Tuberculosis H2-AB1; MAPK9; HLA-DPB1; HLA-DRA; NFYB; IFNA1; CD209; IFNG; HLA-DRB1; FADD
    Hepatitis C IKBKG; CLDN3; OAS1; CXCL8; TNF; NFKBIA; MAPK9; PPP2R2B; TP53; IFNA7
    Hepatitis B FOS; IFNA8; Casp3; IFNAR1; IKBKB; TRP53; PTK2B; GRB2; CASP8; Fasl
    Measles GSK3B; TNFRSF10D; BBC3; OAS1; OAS2; MYD88; SLAMF1; Fasl; TNFSF10; IFNGR2
    Influenza A PML; HSPA8; CASP9; OAS1B; HLA-DQA2; BLB2; IFNA1; STAT1; IFNA13; HLA-DRB4
    HTLV-I infection PIK3CD; LTA; IL1R2; STAT5B; HLA-G; MAP3K14; NFATC4; Pdgfa&Pdgfb; TERT; ETS1
    Epstein-Barr virus infection TRAF3; POLR2J2; RBPJL; POLR2E; IFNG; RELB; HLA-C; PSMD1; CDK1; CSNK2A2
    Pathways in cancer CXCL12; BCL2L1; FGFR1; SKP2; NOS2; FOS; RASSF1; MITF; KRAS; FASLG
    Proteoglycans in cancer WNT9A; VEGFA; NUDT16L1; SDC1; ITPR1; FZD9; MAPK11; CBLC; RPS6; IL12B
    Colorectal cancer PIK3R5; TGFB1; BRAF; FOS; MLH1; DCC; KRAS; TCF7L2; CCND1; APC2
    Renal cell carcinoma HRAS; AKT1; BRAF; PAK2; MAPK3; TCEB2; FH1; MAP2K2; TCEB1; HIF1A
    Pancreatic cancer PIK3CG; RAC1; STAT1; ARHGEF6; PIK3R3; RB1; RALB; IKBKB; RAD51; CASP9
    Endometrial cancer ILK; APC; CASP9; ARAF; AXIN2; BRAF; MAP2K1; AKT1; PTEN; MAPK1
    Glioma PRKCA; PDGFA; CAMK2B; CALM1; CALM2; PRKCG; AKT1; CALML5; SOS1; HRAS
    Prostate cancer BRAF; Pdgfa&Pdgfb; PDGFRA; FGFR1; FGFR2; PIK3CD; CPN1; INSRR; CCNE1; NKX3-1
    Melanoma PIK3R1; PDGFRB; HRAS; FGF7; FGF22; IGF1R; PDGFRA; FGF5; Pdgfa&Pdgfb; FGF9
    Chronic myeloid leukemia MAP2K2; BCL2L1; CRK; TGFBR1; MDM2; HDAC2; NRAS; SHC2; TGFB2; PIK3CA
    Acute myeloid leukemia PIK3CD; TCF7; PIK3CG; PIM1; CHUK; SFPI1; PIK3R5; AKT2; CEBPA; NRAS
    Small cell lung cancer NOS2; ITGA3; PTK2; RXRG; LAMA2; PIK3R2; LAMB4; CCNE2; TRAF5; PIK3R1
    Non-small cell lung cancer PLCG1; KRAS; RXRG; ARAF; FOXO3; PIK3R1; EML4; MAPK1; PRKCA; MAP2K2
    Central carbon metabolism in cancer HK2; SLC2A1; PKM; SLC1A5; ERBB2; PGAM1; PFKP; NRAS; SLC7A5; IDH1
    Choline metabolism in cancer CHKB; PIK3R3; SLC22A1; DGKE; PLA2G4C; PLA2G4A; PDGFRA; PLCG1; DGKZ; DGKB

    AKT2 has several biochemical functions, for example, ATP binding, protein binding, protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT2 itself. We selected most functions AKT2 had, and list some proteins which have the same functions with AKT2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PAPSS1; P2RY4; GUCY2C; MADD; EIF4A1; PFKL; EIF2AK2; Atp8a2; XRCC3; ACSS1
    protein binding IRF3; FMO4; SLC22A5; GSE1; TMEM147; RILP; KLHL38; C1orf94; HIST1H2BE; NR5A1
    protein kinase C binding TOP2B; TRPV4; AVPR1B; SDPRB; ADAM9; PKP2; PRKCSH; PARD3; HDAC9; PRKCB
    protein serine/threonine kinase activity AKT1; CSNK1G2; CDK14; MAPK12B; NUAK2; SLK; SNRK; CDK1; STK25; LIMK1

    AKT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT2.

    HSP90AB1; crosstide; CASP3; GSK3B; LRRK2; SH3RF1; MYH13; VIM; SETDB1; CDC37; SORBS2; APOA1; APOB

    van de Luijtgaarden, ACM; Roeffen, MHS; et al. IGF signaling pathway analysis of osteosarcomas reveals the prognostic value of pAKT localization. FUTURE ONCOLOGY 9:1733-1740(2013).
    Marchbank, T; Mahmood, A; et al. Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F382-F389(2013).

    TGF

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