Recombinant Human Annexin A1, T7-tagged
|Product Overview :||Recombinant HumanANXA1 (aa 1-346) was expessed in E. coli including a His tag. Its molecularweight is 41430 Dalton.|
- Gene Information
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|Cat. No. :||ANXA1-5277H|
|Description :||ANXA1 belongs to a familyof Ca(2+)-dependent phospholipid binding proteins which have a molecularweight of approximately 35,000 to 40,000 and are preferentially located onthe cytosolic face of the plasma membrane. ANXA1 protein has an apparentrelative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity.Since phospholipase A2 is required for the biosynthesis of the potentmediators of inflammation, prostaglandins and leukotrienes, ANXA1 may havepotential anti-inflammatory activity.|
|Source :||E. coli|
|Form :||Liquid in 20 mMTris-HCl + 0.5 M NaCl + 100 mM imidazole + 1 mM 2-mercaptoethanol, pH 8.|
|Molecular Weight :||41.43 kDa|
|Applications :||ELISA; Western Blot;Antibody Production; Protein array|
|Gene Name :||ANXA1 annexin A1 [ Homosapiens ]|
|Synonyms :||ANXA1; annexin A1;ANX1; LPC1; Annexin A1; Annexin-1; Annexin I; Lipocortin I; Calpactin II;Chromobindin-9; p35; Phospholipase A2 inhibitory protein; OTTHUMP00000021475;OTTHUMP00000021474; annexin A1; annexin I (lipocortin I); annexin-1;calpactin-2; lipocortin I; chromobindin-9; phospholipase A2 inhibitoryprotein; annexin A1; Calpactin-2|
|Gene ID :||301|
|mRNA Refseq :||NM_000700|
|Protein Refseq :||NP_000691|
|UniProt ID :||P04083|
|Chromosome Location :||9q12-q21.2; 9q21.13|
|Pathway :||Class A/1(Rhodopsin-like receptors); Formyl peptide receptors bind formyl peptides andmany other ligands; G alpha (i) signalling events; G alpha (q) signallingevents; GPCR downstream signaling; GPCR ligand binding; Peptideligand-binding receptors; Prostaglandin Synthesis and Regulation; SignalTransduction; Signaling by GPCR|
|Function :||calciumion binding; calcium-dependent phospholipid binding; phospholipase A2inhibitor activity; phospholipase inhibitor activity; protein binding,bridging; receptor binding; structural molecule activity; phospholipidbinding; protein binding; protein homodimerization activity; single-strandedDNA binding; single-stranded RNA binding|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (13)Ask a question
The expression of ANXA1 protein can be regulated at the transcriptional and post-transcriptional levels. Transcriptional regulation involves the binding of transcription factors to specific regions of the ANXA1 gene promoter, which can either promote or inhibit its expression. Post-transcriptional regulation includes processes such as mRNA stability, alternative splicing, and microRNA-mediated regulation.
ANXA1 protein has been associated with various diseases and conditions. It has been found to play a role in cancer development and progression, inflammation-related disorders, cardiovascular diseases, and neurodegenerative diseases. It is also being investigated as a potential therapeutic target in these conditions.
Yes, ANXA1 can be secreted from cells. It is typically localized in the cytoplasm and can be translocated to the cell membrane in response to various stimuli. Upon activation, ANXA1 can undergo acetylation and be released from the cell, either as a free protein or associated with membrane-derived vesicles called exosomes.
ANXA1 protein has been explored as a potential diagnostic marker for certain diseases. It has been studied as a biomarker for oral squamous cell carcinoma, breast cancer, and gastric cancer, among others. However, further research is needed to fully establish its diagnostic utility.
ANXA1 protein has diverse cellular functions. It is primarily known for its role in the resolution of inflammation. ANXA1 inhibits phospholipase A2 activity, leading to a decrease in prostaglandin and leukotriene synthesis, thereby suppressing inflammation. It also has anti-inflammatory effects by promoting neutrophil apoptosis and phagocytosis of apoptotic neutrophils by macrophages.
Currently, there are no drugs specifically targeting ANXA1 protein approved for clinical use. However, ANXA1 has been considered as a potential target for the development of therapeutic agents. Various approaches have been explored, including the use of small molecule inhibitors, peptide analogs, and antibodies that can modulate ANXA1 function or its downstream signaling pathways. These strategies aim to exploit the role of ANXA1 in diseases such as inflammation, cancer, and cardiovascular disorders.
ANXA1 protein interacts with various proteins and molecules in the cell. Some of its interacting partners include actin, S100A11, S100A6, p11, p53, and integrins. These interactions are important for its cellular functions and signaling pathways.
ANXA1 protein has been implicated in cancer progression and metastasis through various mechanisms. It promotes tumor cell migration and invasion by modulating actin cytoskeletal dynamics and facilitating adhesion to extracellular matrix proteins. ANXA1 can also enhance tumor angiogenesis by promoting endothelial cell migration and tube formation.
Yes, genetic mutations and polymorphisms in the ANXA1 gene have been reported in certain diseases, including certain types of cancer and autoimmune disorders. These genetic variations can affect the expression, structure, and function of the ANXA1 protein.
ANXA1 protein expression and activity can be regulated by various factors and signaling pathways. It can be upregulated by anti-inflammatory molecules, glucocorticoids, and certain growth factors. Conversely, it can be downregulated by pro-inflammatory cytokines and oxidative stress.
Dysregulation of ANXA1 protein has been implicated in several diseases. It has been associated with inflammation-related disorders such as asthma, inflammatory bowel disease, and rheumatoid arthritis. Alterations in ANXA1 expression and function have also been linked to cancer development, metastasis, and drug resistance. Additionally, ANXA1 dysfunction has been implicated in cardiovascular diseases, neurodegenerative disorders, and autoimmune diseases.
ANXA1 protein is considered a potential therapeutic target due to its involvement in various disease processes. Targeting ANXA1 or its downstream signaling pathways could have therapeutic implications for inflammatory diseases, cancer treatment, and other disorders where its dysregulation is associated. However, more research is required to develop effective therapies targeting ANXA1.
ANXA1 protein has potential therapeutic implications. It is being studied as a target for the development of anti-inflammatory drugs and cancer therapies. Additionally, ANXA1-based therapies, such as ANXA1 mimetics or ANXA1-derived peptides, are also being investigated for their therapeutic potential in various diseases and conditions. However, more research is needed in this area.
Customer Reviews (4)Write a review
Its purity and reliability ensure reliable and reproducible results in a variety of research applications. -
Its high quality greatly enhances the reliability and reproducibility of experimental data. -
ANXA1 protein is known for its versatility and functionality, enabling researchers to explore various biological processes and molecular interactions. -
Whether I need expertise in experimental optimization or troubleshooting, I can rely on the manufacturer's support to promptly address any concerns or queries. -
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