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  • Official Full Name

    apolipoprotein C-IV

  • Overview

    This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene.
  • Synonyms

    APOC4; apolipoprotein C-IV; APO C4; Apo CIV; APOC 4; ApoC IV; Apolipoprotein C IV; apolipoprotein C4; APO-CIV; APOC-IV;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Wheat germ
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293F
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • B2M
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APOC4-9761H Recombinant Human APOC4, GST-tagged E.coli GST 26-127a.a.
Human APOC4-98HCL Recombinant Human APOC4 cell lysate N/A
Human APOC4-1334H Recombinant Human APOC4 Protein (27-127 aa), His-tagged Yeast His 27-127 aa
Human APOC4-2540H Recombinant Human APOC4 protein, His-B2M-tagged E.coli His-B2M 27-127aa
Human APOC4-224H Recombinant Human APOC4 Protein, His-tagged E.coli N-His Gln32-Gly127
Mouse APOC4-1790M Recombinant Mouse APOC4 Protein Mammalian Cell His
Mouse Apoc4-1855M Recombinant Mouse Apoc4 protein, His & GST-tagged E.coli His/GST Met28~Gly124
Mouse APOC4-636M Recombinant Mouse APOC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse APOC4-636M-B Recombinant Mouse APOC4 Protein Pre-coupled Magnetic Beads HEK293
Rat APOC4-724R Recombinant Rat APOC4 Protein Mammalian Cell His
Rat Apoc4-3570R Recombinant Rat Apoc4, GST-tagged E.Coli or Yeast GST 124
Rat Apoc4-223R Recombinant Rat Apoc4 Protein, His-tagged HEK293F N-His Met28-Gly124
Rat APOC4-380R-B Recombinant Rat APOC4 Protein Pre-coupled Magnetic Beads HEK293
Rat APOC4-380R Recombinant Rat APOC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit APOC4-3571R Recombinant Rabbit APOC4, GST-tagged E.Coli or Yeast GST 124
Wheat germ APOC4-281H Recombinant Human APOC4, GST-tagged Wheat Germ N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • APOC4 Related Articles

APOC4 involved in several pathways and played different roles in them. We selected most pathways APOC4 participated on our site, such as Statin Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Statin PathwayPDIA2;APOC1;CETP;APOC4

APOC4 has several biochemical functions, for example, lipid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APOC4 itself. We selected most functions APOC4 had, and list some proteins which have the same functions with APOC4. You can find most of the proteins on our site.

Function Related Protein
lipid transporter activityVTG6;SLCO2A1;APOA4;APOF;VTG1;APOE;APOBB.1;GM2A;APOA2

APOC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOC4.

Hu, MA; Lui, SSH; et al. Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients. PHARMACOGENETICS AND GENOMICS 20:634-637(2010).
Kim, E; Li, K; et al. Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis. JOURNAL OF HEPATOLOGY 49:787-798(2008).
  • Q&As
  • Reviews

Q&As (16)

Ask a question
Is there a link between APOC4 and cardiovascular disease? 04/11/2023

The role of APOC4 in cardiovascular disease is not as extensively studied as other apolipoproteins. However, some research suggests that elevated levels of APOC4 may be associated with increased atherosclerosis risk and other cardiovascular conditions. Further studies are needed to fully understand the impact of APOC4 on cardiovascular health.

Are there any other known functions or roles of APOC4 in the human body? 02/15/2023

While APOC4's primary role is in lipid metabolism, it may have additional functions in the human body. Some studies suggest that APOC4 could play a role in modulating inflammation and immune responses. It has been found to interact with components of the immune system and may have implications in inflammatory conditions. However, the exact mechanisms and significance of these potential functions require further investigation.

How can APOC4 levels be measured or tested? 01/14/2023

APOC4 levels can be measured in clinical settings using laboratory techniques. Similar to APOC3 testing, immunoassays such as ELISA or nephelometry can be used to quantify APOC4 concentration in blood samples. Genetic testing or sequencing can also identify genetic variants or mutations in the APOC4 gene that may affect APOC4 levels.

Are there any known genetic variations or mutations in the APOC4 gene? 07/21/2022

Yes, genetic variations and mutations in the APOC4 gene have been identified. For example, certain single nucleotide polymorphisms (SNPs) in the APOC4 gene have been associated with altered lipid levels and increased risk of cardiovascular diseases. These genetic variations can influence APOC4 protein expression or function.

Can APOC4 levels be influenced by diet or lifestyle choices? 07/10/2022

Yes, diet and lifestyle choices can influence APOC4 levels. High-fat diets, excessive alcohol consumption, and obesity have been found to increase APOC4 concentrations. Conversely, dietary changes, weight loss, physical activity, and interventions targeting lipid metabolism can potentially impact APOC4 levels. Nevertheless, the exact mechanisms and the extent of influence require further investigation.

Are there any ongoing research studies or clinical trials related to APOC4? 07/02/2022

Research studies and clinical trials related to APOC4 are continuously being conducted to explore its role in various diseases and potential therapeutic interventions. Some ongoing research focuses on understanding the molecular mechanisms of APOC4 in lipid metabolism, investigating its associations with cardiovascular disease, and exploring its potential as a therapeutic target. Clinical trials may also be investigating the effects of interventions targeting APOC4, although specific trials may vary depending on geographical location and current advancements in the field.

How is APOC4 measured in laboratory tests or clinical settings? 02/06/2020

APOC4 levels can be measured in laboratory tests or clinical settings using various techniques. One common method is immunoassay, where antibodies specific to APOC4 are used to detect and quantify its concentration in blood samples. Other techniques, such as enzyme-linked immunosorbent assay (ELISA) or mass spectrometry, can also be utilized for APOC4 measurement. These tests can provide valuable information about APOC4 levels and its potential involvement in lipid metabolism and cardiovascular health.

How does APOC4 interact with other apolipoproteins? 12/17/2019

APOC4 closely interacts with other apolipoproteins in regulating lipid metabolism. It is typically found alongside APOC2, another apolipoprotein, on the surface of triglyceride-rich lipoproteins. APOC2 activates the lipoprotein lipase (LPL) enzyme, while APOC4 acts as an inhibitor of LPL, creating a balance in triglyceride processing.

How is APOC4 linked to cardiovascular disease? 08/22/2019

Elevated levels of APOC4 have been associated with an increased risk of cardiovascular disease (CVD). APOC4 can affect lipid metabolism by inhibiting lipoprotein lipase (LPL), leading to impaired triglyceride clearance and elevated levels of triglyceride-rich lipoproteins. These elevated levels can contribute to the development of atherosclerosis, a key component of CVD. Additionally, APOC4 variants and genetic variations have been linked to altered lipid levels, which can also contribute to CVD risk.

Can the APOC4 protein be found in tissues other than the bloodstream? 05/03/2019

While the main presence of APOC4 is in the bloodstream associated with lipoproteins, it has been detected in various tissues, including adipose tissue, liver, small intestine, and brain. However, its functions outside of the bloodstream are not well understood.

Can APOC4 levels be altered through lifestyle changes or medications? 03/07/2018

Yes, APOC4 levels can be influenced by lifestyle changes and medications. Lifestyle modifications, such as adopting a healthy diet, engaging in regular exercise, and maintaining a healthy weight, can help optimize lipid metabolism and potentially lower APOC4 levels. Certain medications, such as statins, fibrates, and omega-3 fatty acids, have also been shown to have beneficial effects on lipid levels, including APOC4. However, individual responses to lifestyle changes and medications can vary, and it is important to consult with healthcare professionals for personalized recommendations and guidance.

Are there any known genetic disorders or mutations associated with APOC4? 11/02/2017

There are no known genetic disorders specifically caused by mutations in the APOC4 gene. However, there have been associations between genetic variations in the APOC4 gene and certain lipid-related traits, such as high triglyceride levels or altered lipid metabolism. The impact of these variations on APOC4 function and their contribution to disease risk are still being researched.

Is APOC4 associated with any other metabolic disorders? 10/30/2017

Though most research on APOC4 has focused on its role in lipid metabolism and cardiovascular disease, there is growing evidence suggesting its involvement in other metabolic disorders. Studies have shown associations between APOC4 variants and conditions such as obesity, insulin resistance, and type 2 diabetes. However, further research is essential to establish stronger connections.

Are there any targeted therapies or interventions for modulating APOC4? 10/17/2017

At present, there are no specific therapeutic interventions or targeted therapies to directly modulate APOC4 levels. However, ongoing research in lipid metabolism and cardiovascular disease may provide insights into potential strategies for regulating APOC4 expression or function. Currently, interventions aimed at controlling overall lipid metabolism and reducing cardiovascular risk factors, such as lifestyle modifications and medication, may indirectly affect APOC4 levels.

Are there any therapeutic interventions targeting APOC4 for cardiovascular disease? 06/28/2017

While there are currently no specific therapeutic interventions targeting APOC4 for cardiovascular disease, research is being conducted to explore its potential as a therapeutic target. Some studies have investigated the effects of reducing APOC4 levels using antisense oligonucleotides or other approaches, aiming to lower lipid levels and potentially reduce the risk of CVD. However, further research is needed to fully understand the therapeutic potential and safety profile of such interventions.

Can APOC4 be used as a biomarker for certain conditions? 09/06/2016

APOC4 has been investigated as a potential biomarker for various conditions, including metabolic disorders and cardiovascular disease. Elevated APOC4 levels have been associated with obesity, insulin resistance, and type 2 diabetes. Additionally, APOC4 levels have been linked to lipid abnormalities and increased risk of cardiovascular events. However, more research is needed to determine the utility of APOC4 as a diagnostic or prognostic biomarker and to establish standardized thresholds for different conditions.

Customer Reviews (4)

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    The APOC4 protein offered by the manufacturer excels in its quality and is an excellent match for my experimental requirements.


      Their team of experts is readily available to address any queries or concerns I may have regarding the APOC4 protein.


        With their meticulous documentation and support, I am confident that my utilization of the APOC4 protein in clinical trials will meet all necessary regulations and guidelines.


          Their team of experts is readily available to address any concerns or queries I may have regarding the APOC4 protein.

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