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Official Full Name activating transcription factor 4 (tax-responsive enhancer element B67)
Background This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding;protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated;and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to;a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding;proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in;protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding;domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the;X chromosome at q28 in a region containing a large inverted duplication.
Synonyms ATF4; activating transcription factor 4 (tax-responsive enhancer element B67); TXREB; cyclic AMP-dependent transcription factor ATF-4; CREB 2; TAXREB67; DNA-binding protein TAXREB67; cAMP response element-binding protein 2; cAMP-dependent transcription fa
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His&Myc
    • CaM
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rat Atf4-183R Recombinant Rat Atf4 protein, His&Myc-tagged E.coli His&Myc
    Rat Atf4-184R Recombinant Rat Atf4 protein, His&Myc-tagged E.coli His&Myc
    Human ATF4-27047TH Recombinant Human ATF4, His-tagged E.coli His
    Human ATF4-27048TH Recombinant Human ATF4, His-tagged E.coli His
    Human ATF4-3596H Recombinant Human ATF4, His Cam-tagged E.coli His/CaM
    Human ATF4-8630HCL Recombinant Human ATF4 293 Cell Lysate HEK293 N/A
    Human ATF4-939H Recombinant Human ATF4 protein, GST-tagged Wheat Germ GST
    Mouse ATF4-2067M Recombinant Mouse ATF4 Protein Mammalian Cell His
    Mouse Atf4-6891M Recombinant Mouse Atf4 protein, His & T7-tagged E.coli His/T7
    Rat Atf4-6892R Recombinant Rat Atf4 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque ATF4-438R Recombinant Rhesus monkey ATF4 Protein, His-tagged Mammalian Cell His
    Chicken ATF4-6443C Recombinant Chicken ATF4 Mammalian Cell His

    atf4 involved in several pathways and played different roles in them. We selected most pathways atf4 participated on our site, such as MAPK signaling pathway, cGMP-PKG signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with atf4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNA2D1A; CASP3B; CACNA1BA; TGFB1A; PPP5C; ELK1; CACNG7; FGF22; IKBKB; MAP2K3
    cGMP-PKG signaling pathway MAP2K1; ATP1A2; PPP3R1; PPP3CB; GNAI1; BDKRB2; IRS4; VDAC3; PDE3B; CALM1
    Protein processing in endoplasmic reticulum DNAJB11; UBE4B; UBE2E2; SEC63; SSR2; HSPA1L; SSR1; EIF2S1B; NFE2L2; BAK1
    PIK-Akt signaling pathway Gh; ATF4; INS2; TEK; ITGB6; PIK3R5; FGF12; EPOR; VEGFC; GYS2
    Adrenergic signaling in cardiomyocytes PIK3R5; ADCY3; MAPK3; ADRA1B; PLN; CALML3; CREB1A; CACNA1SA; GNAI2; CALM2A
    TNF signaling pathway MMP3; BIRC2; MAP3K7; LTA; DNM1L; RPS6KA4; MAP2K1; BCL3; PIK3CD; MLKL
    Long-term potentiation HRAS; MAP2K1; NRAS; GRIA2; CALM1; CAMK2A; MAP2K2; PLCB4; PPP1R1A; ITPR3
    Neurotrophin signaling pathway PIK3CD; PIK3R1; ZFP110; CAMK2G; MAPK13; PRKCD; SHC3; CALML3; NFKBIE; MAPKAPK2
    Cholinergic synapse PRKCG; PIK3R1; GNB2; KCNJ2; PRKACB; AKT2; Adcy4; KCNJ12; PIK3R3; KCNQ5
    Dopaminergic synapse KCNJ6; ARRB2; GNG10; MAOA; ATF6B; PPP2CA; SCN1A; CREB3L2; GNG5; GNAO1
    Insulin secretion ITPR3; SLC2A2; CREB3L3; VAMP2; PRKCB; KCNMB3; STX1A; FFAR1; PLCB4; ATP1B2
    Estrogen signaling pathway PLCB2; ATF6B; PLCB1; CALM3; CALM1; CREB3L3; FKBP4; HRAS; KCNJ5; MAP2K1
    Thyroid hormone synthesis PRKCB; LRP2; PRKACA; CREB3L1; ATP1A3; PAX8; TSHB; PLCB4; DUOX2; TSHR
    Glucagon signaling pathway CALML3; FBP1; PHKA1; G6PC3; SIRT1; CREB3L2; PRKACB; G6PC2; CALM4; ATF4
    Aldosterone synthesis and secretion NETO2; CALM3; ORAI1; CACNA1G; PLCB3; KCNK9; PLCB1; ATF6B; ATF1; PRKD3
    Non-alcoholic fatty liver disease (NAFLD) IL1B; COX7B; IL1A; CASP8; RXRA; NDUFAB1; PRKAA1; NDUFS2; GSK3B; IL6R
    Cocaine addiction GRIN2B; DDC; GPSM1; GNAS; PDYN; DLG4; GNAI3; DRD1; ATF4; ATF6B
    Amphetamine addiction PPP3R2; CALML5; FOS; CREB3L4; CREB3; CAMK4; ARC; CREB3L2; CREB5; PRKACA
    Hepatitis B FADD; BAX; PIK3R2; DDX3X; MAP2K2; MAP2K4; NFATC1; CASP12; TICAM2; MAPK1
    HTLV-I infection ANAPC5; POLB; SLC25A4; FZD5; ELK1; NFKB1; HLA-A; TRP53INP1; DLG1; FZD8
    Viral carcinogenesis HDAC9; KAT2A; H2-Q10; DDX3X; POLB; CCND1; HDAC7; CREB5; DLG1; CCNA2
    Prostate cancer ARAF; SMARCC2; RELA; PDGFC; SRD5A2; INSRR; TP53; NOXA1; MAP2K2; NKX3-1

    atf4 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by atf4 itself. We selected most functions atf4 had, and list some proteins which have the same functions with atf4. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding FOXJ1A; HOXC11A; ZNF707; THAP8; C17orf49; HER9; HIST1H2AO; GCM2; MAFGA; FOXB1A
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ARNT2; EBF2; RFX5; E2F8; SRF; PLAG1; CUX2; ESRRA; GZF1; ZNF217
    RNA polymerase II regulatory region sequence-specific DNA binding PRKCBP1L; ZNF548; GATA2A; PKNOX2; MYOG; ATF2; MNT; ASCL3; DMRT1; NKX2-1
    RNA polymerase II transcription factor activity, sequence-specific DNA binding LYL1; SPDEF; FOXR1; FOXO3; FOXP1; JUN; SPI1B; SOX8A; NPAS4A; FOXI2
    RNA polymerase II transcription factor binding SFPI1; MTDH; MTA2; TOX2; TAL1; TRP53; GATA3; GATA6; DHX9; XBP1
    core promoter sequence-specific DNA binding NR1D1; SIRT1; MYOCD; PPARG; ZFP932; TOP1; MLL1; SOX1; PRMT5; NRIP1
    leucine zipper domain binding DDIT3; PAWR; KCNA3; CRX; NRL; PMF1; MKL1; ERC1; AATF; DAPK3
    protein C-terminus binding ERCC1; MID1IP1; CTBP1; SNTG1; PPP2CB; ERCC6; EP300; PEX16; JAK2; IFT52
    protein binding ZNF3; ARL4D; DNMT3L; CRYBA4; PAX8; FAM161A; IL11; TXK; CSRNP1; GAD1
    protein heterodimerization activity TAP1; TOP2A; MAFGB; SRY; SAE1; IKZF3; SOX6; SYCP2; SNX6; HER5
    sequence-specific DNA binding FOXL2; VRTN; DLX3B; GATAD1; NEUROG2; LONP1; BHLHE22; NR2E3; EF1; ZSCAN10
    transcription factor activity, RNA polymerase II transcription factor binding NACC2; TWIST2; SRF; ATF2; YAP1; MAMSTR; ZNF296; MYOCD; HIF1A; THRAA
    transcription factor activity, sequence-specific DNA binding SIM1B; ZBTB14; ZNF668; ZFP30; RXRA; BRD8; BATF; KAT7B; ZNF397; LHX8A
    transcription regulatory region DNA binding IKZF3; CTCF; SMAD6; IKZF1; TBL1XR1; DHX36; CTNNB1; FOXC2; TNF; SALL3
    contributes_to transcription regulatory region DNA binding NFYB; NR1H3; TCF3; RXRA; HDAC4; HAND1; TAF1; NFYC; ATF4; TCF12
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding PLSCR1; NFYC; SMAD1; POU2F2; TP53; ELF4; KLF13; RAX; ZIC1; TFE3A

    atf4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with atf4 here. Most of them are supplied by our site. Hope this information will be useful for your research of atf4.


    Rubovitch, V; Barak, S; et al. The Neuroprotective Effect of Salubrinal in a Mouse Model of Traumatic Brain Injury. NEUROMOLECULAR MEDICINE 17:58-70(2015).
    Hussain, H; Maldonado-Agurto, R; et al. The endoplasmic reticulum and unfolded protein response in the control of mammalian recombinant protein production. BIOTECHNOLOGY LETTERS 36:1581-1593(2014).

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