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Official Full Name activating transcription factor 4 (tax-responsive enhancer element B67)
Background This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding;protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated;and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to;a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding;proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in;protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding;domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the;X chromosome at q28 in a region containing a large inverted duplication.
Synonyms ATF4; activating transcription factor 4 (tax-responsive enhancer element B67); TXREB; cyclic AMP-dependent transcription factor ATF-4; CREB 2; TAXREB67; DNA-binding protein TAXREB67; cAMP response element-binding protein 2; cAMP-dependent transcription fa
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • CaM
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATF4-27047TH Recombinant Human ATF4, His-tagged E.coli His
    Human ATF4-27048TH Recombinant Human ATF4, His-tagged E.coli His
    Human ATF4-3596H Recombinant Human ATF4, His Cam-tagged E.coli His/CaM
    Human ATF4-8630HCL Recombinant Human ATF4 293 Cell Lysate HEK293 N/A
    Human ATF4-939H Recombinant Human ATF4 protein, GST-tagged Wheat Germ GST
    Mouse ATF4-2067M Recombinant Mouse ATF4 Protein Mammalian Cell His
    Mouse Atf4-6891M Recombinant Mouse Atf4 protein, His & T7-tagged E.coli His/T7
    Rat Atf4-6892R Recombinant Rat Atf4 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque ATF4-438R Recombinant Rhesus monkey ATF4 Protein, His-tagged Mammalian Cell His
    Chicken ATF4-6443C Recombinant Chicken ATF4 Mammalian Cell His

    atf4 involved in several pathways and played different roles in them. We selected most pathways atf4 participated on our site, such as MAPK signaling pathway, cGMP-PKG signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with atf4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAP3K1; FGFR4; NLK1; FGF13A; MKNK1; CACNG7; AKT2L; DDIT3; DUSP8A; CACNG1
    cGMP-PKG signaling pathway INS; GNA11; GNAI2; NPR1; PLCB3; NPR2; VDAC3; PPP1CC; AGTR1A; MAP2K1
    Protein processing in endoplasmic reticulum RAD23B; UBE4B; MAPK8; UBQLN3; MBTPS2; ERO1L; CRYAB; RAD23A; CAPN2A; HSPA1B
    PIK-Akt signaling pathway FGFR4; NR4A1; G6PC3; Itga10&Itgb1; PPP2R1B; NRAS; MCL1; Il2; RPTOR; KRAS
    Adrenergic signaling in cardiomyocytes CACNB2A; KCNQ1; MYL2B; CALM4; PLCB1; PPP1CAB; CACNG1; MAPK11; ATP1A2A; PRKACBB
    TNF signaling pathway CCL5; MAPK3; MAP3K5; TRAF2; PIK3R5; MAPK13; CCL2; TRAF5; FADD; Casp3
    Long-term potentiation PLCB3; PRKACG; RPS6KA6; PPP1CC; PPP1CA; RAP1B; GRIA1; PRKCB; MAPK1; PPP1CB
    Neurotrophin signaling pathway NTRK2; PTPN11; MAPK13; GRB2; MAP2K5; MAP3K3; RAP1B; CALML5; KRAS; TP73
    Cholinergic synapse CHRM3; GNB4; CREB3L4; ATF4; Adcy4; CHRM2; GNAO1; CHRNA7; GNAI1; CAMK4
    Dopaminergic synapse PPP3CC; PPP2CB; PPP2R5C; PRKCG; DRD1; DRD4; KIF5A; PPP2CA; KIF5B; GNG7
    Insulin secretion CREB5; CAMK2G; CREB3L1; PLCB1; KCNN4; ATP1B3; CREB3L3; INS1; INS; VAMP2
    GnRH signaling pathway GNRH3; MAP2K6; MAPK13; PRKACAA; MAP2K3; ADCY2B; MAP2K4A; PLA2G4A; CDC42; PTK2BB
    Estrogen signaling pathway PRKACB; HSPA8; GPR30; CREB3L3; SP1; CALML5; ATF6B; KRAS; PIK3CA; GNAO1
    Thyroid hormone synthesis PLCB3; PRKACB; ATP1A2; TSHB; GPX6; PRKACG; GNAQ; ITPR3; GPX1; ITPR1
    Glucagon signaling pathway AKT2; AKT1; GNAQ; G6PC3; PKM; PRKACG; EP300; LDHB; LDHAL6A; PGAM2
    Aldosterone synthesis and secretion SLC14A2; CALML3; DAGLB; CREB3L4; PRKD1; ADCY8; CAMK1G; CAMK2B; ITPR2; CAMK2G
    Non-alcoholic fatty liver disease (NAFLD) NDUFA2; IRS1; NDUFB10; MAPK10; NDUFB8; PRKAB2; UQCR11; IL1A; DDIT3; PRKAG1
    Cocaine addiction CREB3L4; CREB3; RELA; GRIA2; CREB3L1; GPSM1; GRIN2C; MAOB; DRD1A; GRIN3A
    Amphetamine addiction ATF6B; PDYN; PPP1CA; SLC6A3; CALM2; FOSB; DDC; DRD1; CAMK2D; CALM3
    Alcoholism GM6026; HIST1H2BJ; GNB5; HIST1H3F; NRAS; PPP1CA; SHC4; SOS1; GNG13; PKIA
    Hepatitis B KRAS; Ifna15; DDB2; CXCL8; IL-8; AKT1; STAT3; IFN-a; MMP9; RB1
    HTLV-I infection ANAPC11; WNT6; CDC27; Fzd4; ELK1; IL1R1; PDGFA; DLG1; ATF1; VDAC1
    Viral carcinogenesis TBPL1; C3; YWHAB; HIST1H4B; GTF2A1; YWHAG; LTBR; HDAC7; HLA-C; HLA-G
    Prostate cancer CCNE2; IGF1R; HRAS; HSP90AB1; NFKBIA; NOXA1; CPN1; Ar; CREB5; PDGFRB

    atf4 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by atf4 itself. We selected most functions atf4 had, and list some proteins which have the same functions with atf4. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding NR5A2; FIGLA; POU4F2; CEBPZ; YBX1; ISL1; KLF17; HOXA2; MAFA; RFX3
    RNA polymerase II regulatory region sequence-specific DNA binding PURB; SP1; GATA2B; NHLH2; CREB3; RXRG; ETV3; CUX2; RORA; ZGLP1
    RNA polymerase II transcription factor activity, sequence-specific DNA binding ATF4B1; FOXQ2; RUNX2; GATA6; ZNF434; FOXI3A; FOXK1; ATF5A; ARX; MITFB
    RNA polymerase II transcription factor binding PITX2; GATA2A; MKX; GSK3B; ZFPM2A; GATA2; ANKRD1; ZFPM1; ID4; TEAD3
    core promoter sequence-specific DNA binding NR4A3; TOP1; RORA; PROX1; MTA1; MLL1; ESR2; NFYA; CREM; SOHLH2
    leucine zipper domain binding DAPK3; ATF4; MKL1; KCNA3; CRX; AATF; PMF1; ERC1; PAWR; DDIT3
    protein C-terminus binding NPAT; NEIL1; SLC4A1; HOMER3; CTBP1; LCK; DAB2; LIG4; CEP120; ATXN2
    protein binding GADD45A; LAMP2; PTPN7; PGF; NEDD9; DZIP1; C6orf226; SORT1; APEX1; CBLB
    protein heterodimerization activity BDKRB2; NR4A2; SMC2; HIST2H2L; CLCF1; HIST1H2BA; DRD1; MAPK4; SMC3; MCL1
    sequence-specific DNA binding FOXJ2; MSXE; GATAD2AB; ESR2B; VDRA; NR3C2; FLI1B; NKX2-8; HOXA4A; DBX1
    transcription factor activity, RNA polymerase II transcription factor binding MAMSTR; GTF2E1; HIF1A; SRF; THRAA; ATF2; MYOCD; NACC2; GATA4; SMAD4
    transcription factor activity, sequence-specific DNA binding ZNF544; FOXM1; SP3A; NKX2-1; TBX24; POU1F1; MYCLB; FOSL2; TADA3; MYC
    transcription regulatory region DNA binding ARID5B; ERBB4; MTERF3; HDAC1; CARM1; TP73; TA; THRA; CDK5RAP2; MTERFD3
    contributes_to transcription regulatory region DNA binding NR1H3; NFYA; TCF3; HDAC5; HAND1; NFYB; ATF4; RXRA; TCF12; TAF1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding EGR2; TFE3; CRX; ELF4; NR3C1; IRF4; BCL11B; ZIC3; SPI1; TCF4

    atf4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with atf4 here. Most of them are supplied by our site. Hope this information will be useful for your research of atf4.


    Rubovitch, V; Barak, S; et al. The Neuroprotective Effect of Salubrinal in a Mouse Model of Traumatic Brain Injury. NEUROMOLECULAR MEDICINE 17:58-70(2015).
    Hussain, H; Maldonado-Agurto, R; et al. The endoplasmic reticulum and unfolded protein response in the control of mammalian recombinant protein production. BIOTECHNOLOGY LETTERS 36:1581-1593(2014).

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