ATP2C1
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Official Full Name
ATPase, Ca++ transporting, type 2C, member 1
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Overview
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
ATP2C1; ATPase, Ca++ transporting, type 2C, member 1; BCPM, benign chronic pemphigus (Hailey Hailey disease); calcium-transporting ATPase type 2C member 1; ATP2C1A; KIAA1347; PMR1; secretory pathway Ca2+/Mn2+ ATPase 1; SPCA1; AW061228; D930003G21Rik; hSPCA1; OTTHUMP00000216069; OTTHUMP00000216071; OTTHUMP00000216072; OTTHUMP00000216073; OTTHUMP00000216074; 1700121J11Rik; AT2C1_HUMAN; ATP dependent Ca(2+) pump PMR1; ATP-dependent Ca(2+) pump PMR1; ATPase 2C1; BCPM; Calcium transporting ATPase type 2C member 1; HHD; HUSSY 28; MGC58010; MGC93231; OTTHUMP00000216066; OTTHUMP00000216068; OTTHUMP00000216075; PMR1L; SPCA; HUSSY-28; OTTHUMP00000216067; OTTHUMP00000216070;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rhesus Macaque
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ATP2C1-10012H | Recombinant Human ATP2C1, His-tagged | E.coli | His | 320-654a.a. | |
| Human | ATP2C1-974H | Recombinant Human ATP2C1 protein, GST-tagged | Wheat Germ | GST |
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| Human | ATP2C1-148HCL | Recombinant Human ATP2C1 cell lysate | Non |
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| Human | ATP2C1-268H | Recombinant Human ATP2C1 Protein, His-tagged | E.coli | His | Met1-Pro70 |
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| Human | ATP2C1-0816H | Recombinant Human ATP2C1 Protein (Met1-Pro70), N-GST tagged | E.coli | GST | Met1-Pro70 |
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| Rhesus Macaque | ATP2C1-452R | Recombinant Rhesus monkey ATP2C1 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | ATP2C1-281R | Recombinant Rhesus Macaque ATP2C1 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rhesus Macaque | ATP2C1-281R-B | Recombinant Rhesus Macaque ATP2C1 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
ATP2C1 involved in several pathways and played different roles in them. We selected most pathways ATP2C1 participated on our site, such as Ion channel transport, Ion transport by P-type ATPases, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ion channel transport | TTYH1;ATP13A5;TTYH3;TRPA1A;ATP10A;CLCN5;SLC9B2;UNC79;ANO10 |
| Ion transport by P-type ATPases | ATP2B3A;FXYD6;ATP10A;ATP8B1;ATP13A;CUTC;ATP1A1A.4;ATP1A1A.5;ATP1A1A.2 |
| Transmembrane transport of small molecules | ANKHA;SLC13A1;SLC6A18;MFSD7B;ANO9;SLC4A1A;LCN12;SLC38A3;SLC17A1 |
ATP2C1 has several biochemical functions, for example, ATP binding, calcium ion binding, calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2C1 itself. We selected most functions ATP2C1 had, and list some proteins which have the same functions with ATP2C1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SIK2A;DDX23;MYO7B;NLRX1;AK4;CHD1L;BLM;OAS2;UCK2B |
| calcium ion binding | EFCAB9;PADI3;RHOT1;CMLC1;PCDH2AB1;PCDH7;PCDH12;PLA2G5;LALBA |
| calcium-transporting ATPase activity | ATP2A2;ATP2B1;ATP2A1L;ATP2A2A;ATP2B3A;ATP2B1A;ATP2A3;ATP2C1;ATP2A2B |
| NOT calcium-transporting ATPase activity | |
| manganese ion binding | SLC11A2;PAPOLA;FAM20C;DYRK2;IMPA1;PPM1N;LAP3;PEPD;ME1 |
| manganese-transporting ATPase activity | ATP2C1;ATP2C2 |
| metal ion binding | GALNT18A;IKZF2;LMAN1;METAP2;EXO1;PPP6C;SGSH;ELP3;SUMF1 |
| signal transducer activity | TAAR12B;GPR52;GNB5;TAS2R202;MC5RB;VMN2R26;DRD1A;TAAR12A;MRGPRB8 |
ATP2C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2C1.
STIM1
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewATP2C1n's repeatability is truly exceptional, consistently delivering reliable results even under challenging conditions.
Since the purity of the protein was indeed excellent, there were no visible impurities or contaminants.
ATP2C1 is ideal for Western-blot analysis, with strong bands and clear specificity.
Q&As (6)
Ask a questionThe expression of ATP2C1 may be regulated by a variety of factors, including intracellular calcium levels, cell signaling pathways, transcription factors, and so on.
Hailey-Hailey disease is a rare genetic skin disease characterized by skin inflammation and lesions.
It is a calcium transporter in skin cells and is responsible for the regulation of intracellular and extracellular calcium balance.
The mutation of ATP2C1 may lead to the dysfunction of ATP2C1 protein and affect the calcium homeostasis in skin cells, which may lead to Hailey-Hailey disease.
The transcription and translation of ATP2C1 may be affected by various regulatory mechanisms such as chromatin alterations, activation of signaling pathways, and binding of transcription factors
ATP2C1 may interact with some proteins related to intracellular calcium signaling pathway to further regulate calcium transport and intracellular balance.
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