ATP2C1

  • Official Full Name

    ATPase, Ca++ transporting, type 2C, member 1

  • Overview

    The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    ATP2C1; ATPase, Ca++ transporting, type 2C, member 1; BCPM, benign chronic pemphigus (Hailey Hailey disease); calcium-transporting ATPase type 2C member 1; ATP2C1A; KIAA1347; PMR1; secretory pathway Ca2+/Mn2+ ATPase 1; SPCA1; AW061228; D930003G21Rik; hSPCA1; OTTHUMP00000216069; OTTHUMP00000216071; OTTHUMP00000216072; OTTHUMP00000216073; OTTHUMP00000216074; 1700121J11Rik; AT2C1_HUMAN; ATP dependent Ca(2+) pump PMR1; ATP-dependent Ca(2+) pump PMR1; ATPase 2C1; BCPM; Calcium transporting ATPase type 2C member 1; HHD; HUSSY 28; MGC58010; MGC93231; OTTHUMP00000216066; OTTHUMP00000216068; OTTHUMP00000216075; PMR1L; SPCA; HUSSY-28; OTTHUMP00000216067; OTTHUMP00000216070;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP2C1-10012H Recombinant Human ATP2C1, His-tagged E.coli His 320-654a.a.
Human ATP2C1-974H Recombinant Human ATP2C1 protein, GST-tagged Wheat Germ GST
Human ATP2C1-148HCL Recombinant Human ATP2C1 cell lysate N/A
Human ATP2C1-268H Recombinant Human ATP2C1 Protein, His-tagged E.coli N-His Met1-Pro70
Human ATP2C1-0816H Recombinant Human ATP2C1 Protein (Met1-Pro70), N-GST tagged E.coli N-GST Met1-Pro70
Rhesus Macaque ATP2C1-452R Recombinant Rhesus monkey ATP2C1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATP2C1-281R Recombinant Rhesus Macaque ATP2C1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ATP2C1-281R-B Recombinant Rhesus Macaque ATP2C1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ATP2C1 involved in several pathways and played different roles in them. We selected most pathways ATP2C1 participated on our site, such as Ion channel transport, Ion transport by P-type ATPases, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ion channel transportATP2B3A;ANO9;CUTC;TRPM6;ATP1A1A.4;ATP13A5;BEST4;TCIRG1;TRDN
Ion transport by P-type ATPasesCCC2;ATP1A1A.5;ATP11C;ATP10A;ATP2C2;ATP1A1A.3;ATP7B;FXYD3;ATP2C1
Transmembrane transport of small moleculesSLC15A4;HTR3C;LCN1;RHCGL1;SLC35A2;AQP1A.2;SLC4A2A;BEST4;GSDMA2

ATP2C1 has several biochemical functions, for example, ATP binding, calcium ion binding, calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2C1 itself. We selected most functions ATP2C1 had, and list some proteins which have the same functions with ATP2C1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingIKBKB;MINK1;ABCF3;SMARCAD1;UBA3;KIF22;PDS5B;RTCD1;STK3
calcium ion bindingLTBP4;GSN;ANXA10;PVALB5;PCDHB1;CAPNS1B;MELK;JAG2B;KCNIP4
calcium-transporting ATPase activityATP2B1;ATP2A1;ATP2B3B;ATP2A3;ATP2B3A;ATP2A2B;ATP2A2A;ATP2B1B;ATP2C1
NOT calcium-transporting ATPase activity
manganese ion bindingME1;PPEF2;PPM1B;ABL2;DCP2;PPM1A;LARGE;PIM1;FAM20C
manganese-transporting ATPase activityATP2C2;ATP2C1
metal ion bindingGM5136;KLF7A;GLI4;PAPOLG;RSAD2;RC3H1;FAHD1;ARAP2;COLEC12
signal transducer activityGPR124;PLCB1;OLFR473;OLFR477;MAPKAPK2;PTGER1C;S1PR3A;TRAF2;CXCR7B

ATP2C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2C1.

STIM1

  • Q&As
  • Reviews

Q&As (6)

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What factors regulate the expression of ATP2C1? 12/21/2022

The expression of ATP2C1 may be regulated by a variety of factors, including intracellular calcium levels, cell signaling pathways, transcription factors, and so on.

What is Hailey-Hailey disease? 10/15/2021

Hailey-Hailey disease is a rare genetic skin disease characterized by skin inflammation and lesions.

What is the role of ATP2Cin skin cells? 08/09/2021

It is a calcium transporter in skin cells and is responsible for the regulation of intracellular and extracellular calcium balance.

How do mutations in ATP2Ccause Hailey-Hailey disease? 07/03/2021

The mutation of ATP2C1 may lead to the dysfunction of ATP2C1 protein and affect the calcium homeostasis in skin cells, which may lead to Hailey-Hailey disease.

How is ATP2Ctranscription and translation regulated? 01/31/2020

The transcription and translation of ATP2C1 may be affected by various regulatory mechanisms such as chromatin alterations, activation of signaling pathways, and binding of transcription factors

What are the interactions of ATP2Cwith other proteins? 06/14/2019

ATP2C1 may interact with some proteins related to intracellular calcium signaling pathway to further regulate calcium transport and intracellular balance.

Customer Reviews (3)

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Reviews
10/17/2022

    ATP2C1n's repeatability is truly exceptional, consistently delivering reliable results even under challenging conditions.

    06/11/2022

      Since the purity of the protein was indeed excellent, there were no visible impurities or contaminants.

      11/22/2021

        ATP2C1 is ideal for Western-blot analysis, with strong bands and clear specificity.

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